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Papers authored by Metcalf B

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Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety.

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Li YL, Shi E, Burns D, Li Y, Covington MB, Pan M, Scherle P, Friedman S, Metcalf B, and Yao W

Bioorganic & medicinal chemistry letters 19(17):5037-42, 2009 Sep 1 - Who cited this? | PubMed ID: 19635666 | Fulltext

Periodontal and periimplant maintenance: a critical factor in long-term treatment success.

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Shumaker ND, Metcalf BT, Toscano NT, and Holtzclaw DJ

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) 30(7):388-90, 392, 394 passim; quiz 407, 418, 2009 Sep - Who cited this? | PubMed ID: 19757733 | Fulltext

Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.

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Burns DM, Li YL, Shi E, He C, Xu M, Zhuo J, Zhang C, Qian DQ, Li Y, Wynn R, Covington MB, Katiyar K, Marando CA, Fridman JS, Scherle P, Friedman S,

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Bioorganic & medicinal chemistry letters 19(13):3525-30, 2009 Jul 1 - Who cited this? | PubMed ID: 19457660 | Fulltext

Assortative weight gain in mother-daughter and father-son pairs: an emerging source of childhood obesity. Longitudinal study of trios (EarlyBird 43).

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Perez-Pastor EM, Metcalf BS, Hosking J, Jeffery AN, Voss LD, and Wilkin TJ

International journal of obesity (2005) 33(7):727-35, 2009 Jul - Who cited this? | PubMed ID: 19434065 | Fulltext

Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction.

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Lin Q, Meloni D, Pan Y, Xia M, Rodgers J, Shepard S, Li M, Galya L, Metcalf B, Yue TY, Liu P, and Zhou J

Organic letters 11(9):1999-2002, 2009 May 7 - Who cited this? | PubMed ID: 19385672 | Fulltext

Glucose allostasis: emperor's new clothes?.

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Wilkin TJ and Metcalf BS

Diabetologia 52(5):776-8, 2009 May - Who cited this? | PubMed ID: 19225752 | Fulltext

The association of quadriceps strength with the knee adduction moment in medial knee osteoarthritis.

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Lim BW, Kemp G, Metcalf B, Wrigley TV, Bennell KL, Crossley KM, and Hinman RS

Arthritis and rheumatism 61(4):451-8, 2009 Apr 15 - Who cited this? | PubMed ID: 19333982 | Fulltext

Gender differences in the relationship between heart rate control and adiposity in young children: a cross-sectional study (EarlyBird 33).

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Krishnan B, Jeffery A, Metcalf B, Hosking J, Voss L, Wilkin T, and Flanagan DE

Pediatric diabetes 10(2):127-34, 2009 Apr - Who cited this? | PubMed ID: 19017283 | Fulltext

Objectively Measured Physical Activity and Its Association With Adiponectin and Other Novel Metabolic Markers: A longitudinal study in children (EarlyBird 38).

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Metcalf BS, Jeffery AN, Hosking J, Voss LD, Sattar N, and Wilkin TJ

Diabetes care 32(3):468-73, 2009 Mar - Who cited this? | PubMed ID: 19033408 | Fulltext

Contribution of early weight gain to childhood overweight and metabolic health: a longitudinal study (EarlyBird 36).

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Gardner DS, Hosking J, Metcalf BS, Jeffery AN, Voss LD, and Wilkin TJ

Pediatrics 123(1):e67-73, 2009 Jan - Who cited this? | PubMed ID: 19117849 | Fulltext

Physical activity at the government-recommended level and obesity-related health outcomes: a longitudinal study (Early Bird 37).

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Metcalf BS, Voss LD, Hosking J, Jeffery AN, and Wilkin TJ

Archives of disease in childhood 93(9):772, 2008 Sep - Who cited this? | PubMed ID: 18591181 | Fulltext

Children from low-income families have less access to sports facilities, but are no less physically active: cross-sectional study (EarlyBird 35).

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Voss LD, Hosking J, Metcalf BS, Jeffery AN, and Wilkin TJ

Child: care, health and development 34(4):470-4, 2008 Jul - Who cited this? | PubMed ID: 18485026 | Fulltext

Distribution of Adiponectin, Leptin, and Metabolic Correlates of Insulin Resistance: A Longitudinal Study in British Children. 1. Prepuberty (EarlyBird 15).

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Murphy MJ, Hosking J, Metcalf BS, Voss LD, Jeffery AN, Sattar N, Williams R, Jeffery J, and Wilkin TJ

Clinical chemistry, 2008 Jun 6 - Who cited this? | PubMed ID: 18539644 | Fulltext

Trends, associations and predictions of insulin resistance in prepubertal children (EarlyBird 29).

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Gardner DS, Metcalf BS, Hosking J, Jeffery AN, Voss LD, and Wilkin TJ

Pediatric diabetes 9(3 Pt 1):214-20, 2008 Jun - Who cited this? | PubMed ID: 18331409 | Fulltext

Reducing joint loading in medial knee osteoarthritis: Shoes and canes.

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Kemp G, Crossley KM, Wrigley TV, Metcalf BR, and Hinman RS

Arthritis and rheumatism 59(5):609-14, 2008 May 15 - Who cited this? | PubMed ID: 18438932 | Fulltext

Low-intensity pulsed ultrasound for chronic patellar tendinopathy: a randomized, double-blind, placebo-controlled trial.

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Warden SJ, Metcalf BR, Kiss ZS, Cook JL, Purdam CR, Bennell KL, and Crossley KM

Rheumatology (Oxford, England) 47(4):467-71, 2008 Apr - Who cited this? | PubMed ID: 18270224 | Fulltext

Lateral wedges in knee osteoarthritis: What are their immediate clinical and biomechanical effects and can these predict a three-month clinical outcome?.

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Hinman RS, Payne C, Metcalf BR, Wrigley TV, and Bennell KL

Arthritis and rheumatism 59(3):408-15, 2008 Mar 15 - Who cited this? | PubMed ID: 18311763 | Fulltext

Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2.

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Degottardi MQ, Specht A, Metcalf B, Kaur A, Kirchhoff F, and Evans DT

Journal of virology 82(6):3139-46, 2008 Mar - Who cited this? | PubMed ID: 18199657 | Fulltext

Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P(1)(') permutations.

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Burns DM, He C, Li Y, Scherle P, Liu X, Marando CA, Covington MB, Yang G, Pan M, Turner S, Fridman JS, Hollis G, Vaddi K, Yeleswaram S, Newton R, Friedman S,

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Bioorganic & medicinal chemistry letters 18(2):560-4, 2008 Jan 15 - Who cited this? | PubMed ID: 18068976 | Fulltext

Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.

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Yao W, Zhuo J, Burns DM, Li YL, Qian DQ, Zhang C, He C, Xu M, Shi E, Li Y, Marando CA, Covington MB, Yang G, Liu X, Pan M, Fridman JS,

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Bioorganic & medicinal chemistry letters 18(1):159-63, 2008 Jan 1 - Who cited this? | PubMed ID: 18036818 | Fulltext

Adiponectin in childhood.

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Jeffery AN, Murphy MJ, Metcalf BS, Hosking J, Voss LD, English P, Sattar N, and Wilkin TJ

International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity 3(3):130-40, 2008 - Who cited this? | PubMed ID: 19086185 | Fulltext

Behavior of insulin resistance and its metabolic correlates in prepubertal children: a longitudinal study (EarlyBird 32).

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Jeffery AN, Alba S, Murphy MJ, Voss LD, Metcalf BS, Hosking J, Gardner DS, Sattar N, and Wilkin TJ

Diabetes care 30(11):2962-4, 2007 Nov - Who cited this? | PubMed ID: 17712029 | Fulltext

Clinical features of patellar tendinopathy and their implications for rehabilitation.

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Crossley KM, Thancanamootoo K, Metcalf BR, Cook JL, Purdam CR, and Warden SJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 25(9):1164-75, 2007 Sep - Who cited this? | PubMed ID: 17469196 | Fulltext

Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.

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Yao W, Zhuo J, Burns DM, Xu M, Zhang C, Li YL, Qian DQ, He C, Weng L, Shi E, Lin Q, Agrios C, Burn TC, Caulder E, Covington MB, Fridman JS,

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Journal of medicinal chemistry 50(4):603, 2007 Feb 22 - Who cited this? | PubMed ID: 17256836 | Fulltext

Validation of foot-to-foot bioelectrical impedance analysis with dual-energy X-ray absorptiometry in the assessment of body composition in young children: the EarlyBird cohort.

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Hosking J, Metcalf BS, Jeffery AN, Voss LD, and Wilkin TJ

The British journal of nutrition 96(6):1163-8, 2006 Dec - Who cited this? | PubMed ID: 17181893 | Fulltext

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

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Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, Voss LD, Jeffery AN, Metcalf B, Ferrucci L, Corsi AM, Murray A,

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American journal of human genetics 79(6):991-1001, 2006 Dec - Who cited this? | PubMed ID: 17186458 | Fulltext

The quest for meaning in aging.

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Moore SL, Metcalf B, and Schow E

Geriatric nursing (New York, N.Y.) 27(5):293 - Who cited this? | PubMed ID: 17045128 | Fulltext

Little evidence for early programming of weight and insulin resistance for contemporary children: EarlyBird Diabetes Study report 19.

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Jeffery AN, Metcalf BS, Hosking J, Murphy MJ, Voss LD, and Wilkin TJ

Pediatrics 118(3):1118, 2006 Sep - Who cited this? | PubMed ID: 16951006 | Fulltext

Does lean rather than fat mass provide the link between birth weight, BMI, and metabolic risk? EarlyBird 23.

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Murphy MJ, Metcalf BS, Jeffery AN, Voss LD, and Wilkin TJ

Pediatric diabetes 7(4):211-4, 2006 Aug - Who cited this? | PubMed ID: 16911008 | Fulltext

Variation in physical activity lies with the child, not his environment: evidence for an 'activitystat' in young children (EarlyBird 16).

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Wilkin TJ, Mallam KM, Metcalf BS, Jeffery AN, and Voss LD

International journal of obesity (2005) 30(7):1050-5, 2006 Jul - Who cited this? | PubMed ID: 16801942 | Fulltext

Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.

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Combs AP, Zhu W, Crawley ML, Glass B, Polam P, Sparks RB, Modi D, Takvorian A, McLaughlin E, Yue EW, Wasserman Z, Bower M, Wei M, Rupar M, Ala PJ, Reid BM,

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Journal of medicinal chemistry 49(13):3774-89, 2006 Jun 29 - Who cited this? | PubMed ID: 16789735 | Fulltext

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.

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Liu PC, Liu X, Li Y, Covington M, Wynn R, Huber R, Hillman M, Yang G, Ellis D, Marando C, Katiyar K, Bradley J, Abremski K, Stow M, Rupar M, Zhuo J,

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Cancer biology & therapy 5(6):657-64, 2006 Jun - Who cited this? | PubMed ID: 16627989 | Fulltext

IOTF thresholds for overweight and obesity and their relation to metabolic risk in children (EarlyBird 20).

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Voss LD, Metcalf BS, Jeffery AN, and Wilkin TJ

International journal of obesity (2005) 30(4):606-9, 2006 Apr - Who cited this? | PubMed ID: 16314873 | Fulltext

Th-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys.

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Wang Z, Metcalf B, Ribeiro RM, McClure H, and Kaur A

Journal of virology 80(6):2771-83, 2006 Mar - Who cited this? | PubMed ID: 16501086 | Fulltext

Temporal shift in methyl-CpG binding protein 2 expression in a mouse model of Rett syndrome.

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Metcalf BM, Mullaney BC, Johnston MV, and Blue ME

Neuroscience 139(4):1449-60, 2006 - Who cited this? | PubMed ID: 16549272 | Fulltext

Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans.

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Chandak GR, Ward KJ, Yajnik CS, Pandit AN, Bavdekar A, Joglekar CV, Fall CH, Mohankrishna P, Wilkin TJ, Metcalf BS, Weedon MN, Frayling TM, and Hattersley AT

BMC medical genetics 7:76, 2006 - Who cited this? | PubMed ID: 17032446 | Fulltext

Physical activity and BMI in adolescence.

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Wilkin T, Metcalf B, Murphy M, Voss L, and EarlyBird Study

Lancet 366(9502):2003; author reply 2003-4, 2005 Dec 10 - Who cited this? | PubMed ID: 16338447 | Fulltext

Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.

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Combs AP, Yue EW, Bower M, Ala PJ, Wayland B, Douty B, Takvorian A, Polam P, Wasserman Z, Zhu W, Crawley ML, Pruitt J, Sparks R, Glass B, Modi D, McLaughlin E,

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Journal of medicinal chemistry 48(21):6544-8, 2005 Oct 20 - Who cited this? | PubMed ID: 16220970 | Fulltext

Efficacy of physiotherapy management of knee joint osteoarthritis: a randomised, double blind, placebo controlled trial.

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Bennell KL, Hinman RS, Metcalf BR, Buchbinder R, McConnell J, McColl G, Green S, and Crossley KM

Annals of the rheumatic diseases 64(6):906, 2005 Jun - Who cited this? | PubMed ID: 15897310 | Fulltext

Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.

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Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L, Wilkin TJ, McCarthy A, Ben-Shlomo Y, Davey Smith G, Ring S, Jones R, Golding J, Byberg L, Mann V,

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Diabetes 54(2):576-81, 2005 Feb - Who cited this? | PubMed ID: 15677518 | Fulltext

Weight loss composition: the effects of exercise following obesity surgery as measured by bioelectrical impedance analysis.

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Metcalf B, Rabkin RA, Rabkin JM, Metcalf LJ, and Lehman-Becker LB

Obesity surgery 15(2):183-6, 2005 Feb - Who cited this? | PubMed ID: 15802058 | Fulltext

Parents' awareness of overweight in themselves and their children: cross sectional study within a cohort (EarlyBird 21).

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Jeffery AN, Voss LD, Metcalf BS, Alba S, and Wilkin TJ

BMJ (Clinical research ed.) 330(7481):23-4, 2005 Jan 1 - Who cited this? | PubMed ID: 15567804 | Fulltext

Metabolic risk in early childhood: the EarlyBird Study.

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Wilkin TJ, Voss LD, Metcalf BS, Mallam K, Jeffery AN, Alba S, and Murphy MJ

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 28 Suppl 3:S64-9, 2004 Nov - Who cited this? | PubMed ID: 15543222 | Fulltext

Physical activity cost of the school run: impact on schoolchildren of being driven to school (EarlyBird 22).

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Metcalf B, Voss L, Jeffery A, Perkins J, and Wilkin T

BMJ (Clinical research ed.) 329(7470):832-3, 2004 Oct 9 - Who cited this? | PubMed ID: 15317729 | Fulltext

The impact of pregnancy weight and glucose on the metabolic health of mother and child in the south west of the UK.

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Jeffery AN, Voss LD, Metcalf BS, and Wilkin TJ

Midwifery 20(3):281-9, 2004 Sep - Who cited this? | PubMed ID: 15337284 | Fulltext

Sex differences in resting energy expenditure and their relation to insulin resistance in children (EarlyBird 13).

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Kirkby J, Metcalf BS, Jeffery AN, O'Riordan CF, Perkins J, Voss LD, and Wilkin TJ

The American journal of clinical nutrition 80(2):430-5, 2004 Aug - Who cited this? | PubMed ID: 15277166 | Fulltext

Is the Human Activity Profile a useful measure in people with knee osteoarthritis?.

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Bennell KL, Hinman RS, Crossley KM, Metcalf BR, Buchbinder R, Green S, and McColl G

Journal of rehabilitation research and development 41(4):621-30, 2004 Jul - Who cited this? | PubMed ID: 15558390 | Fulltext

Association of sensorimotor function with knee joint kinematics during locomotion in knee osteoarthritis.

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Bennell KL, Hinman RS, and Metcalf BR

American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 83(6):455-63; quiz 464-6, 491, 2004 Jun - Who cited this? | PubMed ID: 15166690 | Fulltext

Girls at five are intrinsically more insulin resistant than boys: The Programming Hypotheses Revisited--The EarlyBird Study (EarlyBird 6).

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Murphy MJ, Metcalf BS, Voss LD, Jeffery AN, Kirkby J, Mallam KM, Wilkin TJ, and The EarlyBird Study (EarlyBird 6)

Pediatrics 113(1 Pt 1):82-6, 2004 Jan - Who cited this? | PubMed ID: 14702453 | Fulltext

Lack of support for a role of the insulin gene variable number of tandem repeats minisatellite (INS-VNTR) locus in fetal growth or type 2 diabetes-related intermediate traits in United Kingdom populations.

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Mitchell SM, Hattersley AT, Knight B, Turner T, Metcalf BS, Voss LD, Davies D, McCarthy A, Wilkin TJ, Smith GD, Ben-Shlomo Y, and Frayling TM

The Journal of clinical endocrinology and metabolism 89(1):310-7, 2004 Jan - Who cited this? | PubMed ID: 14715866 | Fulltext

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