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Papers authored by Melki R

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Prion Fibrils of Ure2p Assembled under Physiological Conditions Contain Highly Ordered, Natively Folded Modules.

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Loquet A, Bousset L, Gardiennet C, Sourigues Y, Wasmer C, Habenstein B, Schütz A, Meier BH, Melki R, and Böckmann A

Journal of molecular biology 394(1):108-18, 2009 Nov 20 - Who cited this? | PubMed ID: 19748512 | Fulltext

Synthetic lipid vesicles recruit native-like aggregates and affect the aggregation process of the prion Ure2p: insights on vesicle permeabilization and charge selectivity.

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Pieri L, Bucciantini M, Guasti P, Savistchenko J, Melki R, and Stefani M

Biophysical journal 96(8):3319-30, 2009 Apr 22 - Who cited this? | PubMed ID: 19383475 | Fulltext

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates.

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Ren PH, Lauckner JE, Kachirskaia I, Heuser JE, Melki R, and Kopito RR

Nature cell biology 11(2):219-25, 2009 Feb - Who cited this? | PubMed ID: 19151706 | Fulltext

Different roles of two gamma-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii.

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Marziale F, Pucciarelli S, Ballarini P, Melki R, Uzun A, Ilyin VA, Detrich Iii HW, and Miceli C

The FEBS journal 275(21):5367-82, 2008 Nov - Who cited this? | PubMed ID: 18959762 | Fulltext

Assembly of the asparagine- and glutamine-rich yeast prions into protein fibrils.

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Bousset L, Savistchenko J, and Melki R

Current Alzheimer research 5(3):251-9, 2008 Jun - Who cited this? | PubMed ID: 18537542 | Fulltext

Oligomerization of the SPP1 scaffolding protein.

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Poh SL, El Khadali F, Berrier C, Lurz R, Melki R, and Tavares P

Journal of molecular biology 378(3):551, 2008 May 2 - Who cited this? | PubMed ID: 18377930 | Fulltext

Molecular chaperones and the assembly of the prion URE2p in vitro.

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Savistchenko J, Krzewska J, Fay N, and Melki R

The Journal of biological chemistry, 2008 Apr 8 - Who cited this? | PubMed ID: 18400756 | Fulltext

Hydrogen/deuterium exchange mass spectrometric analysis of conformational changes accompanying the assembly of the yeast prion Ure2p into protein fibrils.

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Redeker V, Halgand F, Le Caer JP, Bousset L, Laprévote O, and Melki R

Journal of molecular biology 369(4):1113-25, 2007 Jun 15 - Who cited this? | PubMed ID: 17482207 | Fulltext

Protein misfolding and aggregation in ageing and disease: molecular processes and therapeutic perspectives.

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Tuite MF and Melki R

Prion 1(2):116-20, 2007 Apr - Who cited this? | PubMed ID: 19164925 | Fulltext

Biochemical and functional analysis of the assembly of full-length Sup35p and its prion-forming domain.

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Krzewska J, Tanaka M, Burston SG, and Melki R

The Journal of biological chemistry 282(3):1679-86, 2007 Jan 19 - Who cited this? | PubMed ID: 17121860 | Fulltext

Characterization of the cytoplasmic chaperonin containing TCP-1 from the Antarctic fish Notothenia coriiceps.

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Pucciarelli S, Parker SK, Detrich HW, and Melki R

Extremophiles : life under extreme conditions 10(6):537, 2006 Dec - Who cited this? | PubMed ID: 16770691 | Fulltext

Insights into the architecture of the Ure2p yeast protein assemblies from helical twisted fibrils.

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Ranson N, Stromer T, Bousset L, Melki R, and Serpell LC

Protein science : a publication of the Protein Society 15(11):2481-7, 2006 Nov - Who cited this? | PubMed ID: 17001037 | Fulltext

The yeast prion Ure2p native-like assemblies are toxic to mammalian cells regardless of their aggregation state.

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Pieri L, Bucciantini M, Nosi D, Formigli L, Savistchenko J, Melki R, and Stefani M

The Journal of biological chemistry 281(22):15337, 2006 Jun 2 - Who cited this? | PubMed ID: 16571726 | Fulltext

The ectodomain of the viral receptor YueB forms a fiber that triggers ejection of bacteriophage SPP1 DNA.

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São-José C, Lhuillier S, Lurz R, Melki R, Lepault J, Santos MA, and Tavares P

The Journal of biological chemistry 281(17):11464-70, 2006 Apr 28 - Who cited this? | PubMed ID: 16481324 | Fulltext

A molecular dynamics approach to the structural characterization of amyloid aggregation.

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Cecchini M, Curcio R, Pappalardo M, Melki R, and Caflisch A

Journal of molecular biology 357(4):1306-21, 2006 Apr 7 - Who cited this? | PubMed ID: 16483608 | Fulltext

Genetic and functional analysis of the Nkt1 locus using congenic NOD mice: improved Valpha14-NKT cell performance but failure to protect against type 1 diabetes.

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Rocha-Campos AC, Melki R, Zhu R, Deruytter N, Damotte D, Dy M, Herbelin A, and Garchon HJ

Diabetes 55(4):1163, 2006 Apr - Who cited this? | PubMed ID: 16567543 | Fulltext

PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.

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Stirling PC, Cuéllar J, Alfaro GA, El Khadali F, Beh CT, Valpuesta JM, Melki R, and Leroux MR

The Journal of biological chemistry 281(11):7012, 2006 Mar 17 - Who cited this? | PubMed ID: 16415341 | Fulltext

Packing of the prion Ure2p in protein fibrils probed by fluorescence X-ray near-edge structure spectroscopy at sulfur K-edge.

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Fayard B, Fay N, David G, Doucet J, and Melki R

Journal of molecular biology 356(4):843-9, 2006 Mar 3 - Who cited this? | PubMed ID: 16405906 | Fulltext

Molecular chaperones and the assembly of the prion Sup35p, an in vitro study.

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Krzewska J and Melki R

The EMBO journal 25(4):822-33, 2006 Feb 22 - Who cited this? | PubMed ID: 16467849 | Fulltext

Structure of the prion Ure2p in protein fibrils assembled in vitro.

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Fay N, Redeker V, Savistchenko J, Dubois S, Bousset L, and Melki R

The Journal of biological chemistry 280(44):37149-58, 2005 Nov 4 - Who cited this? | PubMed ID: 16131495 | Fulltext

PA700, the regulatory complex of the 26S proteasome, interferes with alpha-synuclein assembly.

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Ghee M, Melki R, Michot N, and Mallet J

The FEBS journal 272(16):4023, 2005 Aug - Who cited this? | PubMed ID: 16098186 | Fulltext

Association of a common coding polymorphism (N453S) of the cytochrome P450 1B1 (CYP1B1) gene with optic disc cupping and visual field alteration in French patients with primary open-angle glaucoma.

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Melki R, Lefort N, Brézin AP, and Garchon HJ

Molecular vision 11:1012, 2005 - Who cited this? | PubMed ID: 16319821 | Fulltext

[Prion proteins: folding and aggregation properties].

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Bousset L and Melki R

Medecine sciences : M/S 21(6-7):634-40, 2005 - Who cited this? | PubMed ID: 15985207 | Fulltext

CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma.

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Melki R, Colomb E, Lefort N, Brézin AP, and Garchon HJ

Journal of medical genetics 41(9):647-51, 2004 Sep - Who cited this? | PubMed ID: 15342693 | Fulltext

Structural characterization of the fibrillar form of the yeast Saccharomyces cerevisiae prion Ure2p.

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Bousset L, Redeker V, Decottignies P, Dubois S, Le Maréchal P, and Melki R

Biochemistry 43(17):5022-32, 2004 May 4 - Who cited this? | PubMed ID: 15109261 | Fulltext

The M98K variant of the OPTINEURIN (OPTN) gene modifies initial intraocular pressure in patients with primary open angle glaucoma.

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Melki R, Belmouden A, Akhayat O, Brézin A, and Garchon HJ

Journal of medical genetics 40(11):842-4, 2003 Nov - Who cited this? | PubMed ID: 14627677 | Fulltext

Mutational analysis of the Myocilin gene in patients with primary open-angle glaucoma in Morocco.

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Melki R, Idhajji A, Driouiche S, Hassani M, Boukabboucha A, Akhayat O, Garchon H, and Belmouden A

Ophthalmic genetics 24(3):153-60, 2003 Sep - Who cited this? | PubMed ID: 12868033 | Fulltext

Age-associated changes in quantitative ultrasonometry (QUS) of the os calcis in Lebanese women-assessment of a Lebanese reference population.

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Wehbe J, Cortbaoui C, Chidiac RM, Nehme A, Melki R, Bedran F, Atallah P, Cooper C, Hadji P, and Maalouf G

Journal of musculoskeletal & neuronal interactions 3(3):232-9, 2003 Sep - Who cited this? | PubMed ID: 15758346 | Fulltext

The cytosolic chaperonin CCT associates to cytoplasmic microtubular structures during mammalian spermiogenesis and to heterochromatin in germline and somatic cells.

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Souès S, Kann ML, Fouquet JP, and Melki R

Experimental cell research 288(2):363, 2003 Aug 15 - Who cited this? | PubMed ID: 12915127 | Fulltext

Assembly of the yeast prion Ure2p into protein fibrils. Thermodynamic and kinetic characterization.

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Fay N, Inoue Y, Bousset L, Taguchi H, and Melki R

The Journal of biological chemistry 278(32):30199-205, 2003 Aug 8 - Who cited this? | PubMed ID: 12777380 | Fulltext

Myocilin analysis by DHPLC in French POAG patients: increased prevalence of Q368X mutation.

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Melki R, Belmouden A, Brézin A, and Garchon HJ

Human mutation 22(2):179, 2003 Aug - Who cited this? | PubMed ID: 12872267 | Fulltext

The native-like conformation of Ure2p in fibrils assembled under physiologically relevant conditions switches to an amyloid-like conformation upon heat-treatment of the fibrils.

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Bousset L, Briki F, Doucet J, and Melki R

Journal of structural biology 141(2):132-42, 2003 Feb - Who cited this? | PubMed ID: 12615539 | Fulltext

Heterologous expression and folding analysis of a beta-tubulin isotype from the Antarctic ciliate Euplotes focardii.

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Pucciarelli S, Miceli C, and Melki R

European journal of biochemistry / FEBS 269(24):6271-7, 2002 Dec - Who cited this? | PubMed ID: 12473123 | Fulltext

A novel frameshift founder mutation in the cytochrome P450 1B1 (CYP1B1) gene is associated with primary congenital glaucoma in Morocco.

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Belmouden A, Melki R, Hamdani M, Zaghloul K, Amraoui A, Nadifi S, Akhayat O, and Garchon HJ

Clinical genetics 62(4):334-9, 2002 Oct - Who cited this? | PubMed ID: 12372064 | Fulltext

The yeast prion Ure2p retains its native alpha-helical conformation upon assembly into protein fibrils in vitro.

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Bousset L, Thomson NH, Radford SE, and Melki R

The EMBO journal 21(12):2903-11, 2002 Jun 17 - Who cited this? | PubMed ID: 12065404 | Fulltext

Similar and divergent features in mammalian and yeast prions.

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Bousset L and Melki R

Microbes and infection / Institut Pasteur 4(4):461-9, 2002 Apr - Who cited this? | PubMed ID: 11932197 | Fulltext

Structure and assembly properties of the yeast prion Ure2p.

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Bousset L, Thual C, Belrhali H, Morera S, and Melki R

Comptes rendus biologies 325(1):3-8, 2002 Jan - Who cited this? | PubMed ID: 11862619 | Fulltext

Crystal structures of the yeast prion Ure2p functional region in complex with glutathione and related compounds.

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Bousset L, Belrhali H, Melki R, and Morera S

Biochemistry 40(45):13564-73, 2001 Nov 13 - Who cited this? | PubMed ID: 11695904 | Fulltext

Review: nucleotide-dependent conformational changes of the chaperonin containing TCP-1.

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Melki R

Journal of structural biology 135(2):170-5, 2001 Aug - Who cited this? | PubMed ID: 11580266 | Fulltext

Stability, folding, dimerization, and assembly properties of the yeast prion Ure2p.

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Thual C, Bousset L, Komar AA, Walter S, Buchner J, Cullin C, and Melki R

Biochemistry 40(6):1764-73, 2001 Feb 13 - Who cited this? | PubMed ID: 11327838 | Fulltext

Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae.

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Bousset L, Belrhali H, Janin J, Melki R, and Morera S

Structure (London, England : 1993) 9(1):39-46, 2001 Jan 10 - Who cited this? | PubMed ID: 11342133 | Fulltext

Monomeric gamma -tubulin nucleates microtubules.

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Leguy R, Melki R, Pantaloni D, and Carlier MF

The Journal of biological chemistry 275(29):21975-80, 2000 Jul 21 - Who cited this? | PubMed ID: 10764751 | Fulltext

ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis.

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Fouquet J, Kann M, Souès S, and Melki R

Journal of cell science 113 ( Pt 5):877-86, 2000 Mar - Who cited this? | PubMed ID: 10671377 | Fulltext

The [URE3] yeast prion: from genetics to biochemistry.

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Komar AA, Melki R, and Cullin C

Biochemistry. Biokhimiia 64(12):1401-7, 1999 Dec - Who cited this? | PubMed ID: 10648964 | Fulltext

Structural characterization of Saccharomyces cerevisiae prion-like protein Ure2.

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Thual C, Komar AA, Bousset L, Fernandez-Bellot E, Cullin C, and Melki R

The Journal of biological chemistry 274(19):13666-74, 1999 May 7 - Who cited this? | PubMed ID: 10224139 | Fulltext

The cytosolic class II chaperonin CCT recognizes delineated hydrophobic sequences in its target proteins.

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Rommelaere H, De Neve M, Melki R, Vandekerckhove J, and Ampe C

Biochemistry 38(11):3246-57, 1999 Mar 16 - Who cited this? | PubMed ID: 10079067 | Fulltext

Dynamic localization of CLIP-170 to microtubule plus ends is coupled to microtubule assembly.

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Diamantopoulos GS, Perez F, Goodson HV, Batelier G, Melki R, Kreis TE, and Rickard JE

The Journal of cell biology 144(1):99-112, 1999 Jan 11 - Who cited this? | PubMed ID: 9885247 | Fulltext

Gamma-tubulin during the differentiation of spermatozoa in various mammals and man.

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Fouquet JP, Kann ML, Combeau C, and Melki R

Molecular human reproduction 4(12):1122-9, 1998 Dec - Who cited this? | PubMed ID: 9872362 | Fulltext

The chaperone cofactor Hop/p60 interacts with the cytosolic chaperonin-containing TCP-1 and affects its nucleotide exchange and protein folding activities.

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Gebauer M, Melki R, and Gehring U

The Journal of biological chemistry 273(45):29475-80, 1998 Nov 6 - Who cited this? | PubMed ID: 9792653 | Fulltext

Structure-function studies on small heat shock protein oligomeric assembly and interaction with unfolded polypeptides.

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Leroux MR, Melki R, Gordon B, Batelier G, and Candido EP

The Journal of biological chemistry 272(39):24646-56, 1997 Sep 26 - Who cited this? | PubMed ID: 9305934 | Fulltext

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