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Papers authored by Megens A

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Harris Infant Neuromotor Test: Comparison of US and Canadian Normative Data and Examination of Concurrent Validity With the Ages and Stages Questionnaire.

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Westcott McCoy S, Bowman A, Smith-Blockley J, Sanders K, Megens AM, and Harris SR

Physical therapy 89(2):173-80, 2009 Feb - Who cited this? | PubMed ID: 19131397 | Fulltext

Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain.

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Peremans K, De Spiegeleer B, Buntinx E, Dobbeleir A, Vermeire S, Vandermeulen E, De Vos F, Megens A, Eersels J, and Audenaert K

Nuclear medicine communications 29(8):724-9, 2008 Aug - Who cited this? | PubMed ID: 18753826 | Fulltext

Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior.

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Geldof M, Freijer J, van Beijsterveldt L, Vermote PC, Megens AA, and Danhof M

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 32(3):200-8, 2007 Nov - Who cited this? | PubMed ID: 17825539 | Fulltext

Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.

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Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Bakker MH, Biesmans I, Cid JM, De Lucas AI, Drinkenburg W, Fernández J, Font LM, Iturrino L, Langlois X, Lenaerts I, Martínez S, Megens AA,

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Bioorganic & medicinal chemistry 15(11):3649-60, 2007 Jun 1 - Who cited this? | PubMed ID: 17407815 | Fulltext

Known-groups analysis of the harris infant neuromotor test.

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Megens AM, Harris SR, Backman CL, and Hayes VE

Physical therapy 87(2):164-9, 2007 Feb - Who cited this? | PubMed ID: 17213408 | Fulltext

Attentional performance of (C57BL/6Jx129Sv)F2 mice in the five-choice serial reaction time task.

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de Bruin NM, Fransen F, Duytschaever H, Grantham C, and Megens AA

Physiology & behavior 89(5):692-703, 2006 Dec 30 - Who cited this? | PubMed ID: 16987534 | Fulltext

Performance of F2 B6x129 hybrid mice in the Morris water maze, latent inhibition and prepulse inhibition paradigms: Comparison with C57Bl/6J and 129sv inbred mice.

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de Bruin N, Mahieu M, Patel T, Willems R, Lesage A, and Megens A

Behavioural brain research 172(1):122-34, 2006 Sep 15 - Who cited this? | PubMed ID: 16764948 | Fulltext

Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities.

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Andrés JI, Alcázar J, Alonso JM, De Lucas AI, Iturrino L, Biesmans I, and Megens AA

Bioorganic & medicinal chemistry 14(13):4361-72, 2006 Jul 1 - Who cited this? | PubMed ID: 16540335 | Fulltext

Preclinical assessment of the feasibility of applying controlled release oral drug delivery to a lead series of atypical antipsychotics.

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Eichenbaum G, Pollock-Dove C, Nguyen J, Li S, Evans J, Borghys H, Kennis L, Dong L, van Osdol W, Dai W, Scicinski J, Chen J, Xu Y, Ashton D, Mackie C, and Megens A

Journal of pharmaceutical sciences 95(4):883-95, 2006 Apr - Who cited this? | PubMed ID: 16489607 | Fulltext

Stability of the Bayley II Scales of Infant Development in a sample of low-risk and high-risk infants.

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Harris SR, Megens AM, Backman CL, and Hayes VE

Developmental medicine and child neurology 47(12):820, 2005 Dec - Who cited this? | PubMed ID: 16288672 | Fulltext

Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism.

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Bartolomé JM, Alcudia A, Andrés JI, Cid JM, García M, Megens A, Toledo MA, and Trabanco AA

Bioorganic & medicinal chemistry letters 15(11):2898-901, 2005 Jun 2 - Who cited this? | PubMed ID: 15911276 | Fulltext

Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test.

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Steckler T, Lavreysen H, Oliveira AM, Aerts N, Van Craenendonck H, Prickaerts J, Megens A, and Lesage AS

Psychopharmacology 179(1):198-206, 2005 Apr - Who cited this? | PubMed ID: 15821950 | Fulltext

Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.

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Fernández J, Alonso JM, Andrés JI, Cid JM, Díaz A, Iturrino L, Gil P, Megens A, Sipido VK, and Trabanco AA

Journal of medicinal chemistry 48(6):1709-12, 2005 Mar 24 - Who cited this? | PubMed ID: 15771415 | Fulltext

Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.

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Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Bakker MH, Biesmans I, Cid JM, De Lucas AI, Fernández J, Font LM, Hens KA, Iturrino L, Lenaerts I, Martínez S, Megens AA, Pastor J,

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Journal of medicinal chemistry 48(6):2054-71, 2005 Mar 24 - Who cited this? | PubMed ID: 15771448 | Fulltext

Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.

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Janssens F, Leenaerts J, Diels G, De Boeck B, Megens A, Langlois X, van Rossem K, Beetens J, and Borgers M

Journal of medicinal chemistry 48(6):2154-66, 2005 Mar 24 - Who cited this? | PubMed ID: 15771458 | Fulltext

Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives as potential anxiolytic agents. Part 2: substitutions by methyl groups on the tetrahydrofuran ring.

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Trabanco AA, Alonso JM, Cid JM, Font LM, and Megens A

Farmaco (Societa chimica italiana : 1989) 60(3):241-8, 2005 Mar - Who cited this? | PubMed ID: 15784244 | Fulltext

Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT(2A/2C) receptor antagonists.

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Cid J, Alonso JM, Andrés JI, Fernández J, Gil P, Iturrino L, Matesanz E, Meert TF, Megens A, Sipido VK, and Trabanco AA

Bioorganic & medicinal chemistry letters 14(11):2765-71, 2004 Jun 7 - Who cited this? | PubMed ID: 15125929 | Fulltext

Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.

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Pastor J, Alcázar J, Alvarez RM, Andrés JI, Cid JM, De Lucas AI, Díaz A, Fernández J, Font LM, Iturrino L, Lafuente C, Martínez S, Bakker MH, Biesmans I, Heylen LI, and Megens AA

Bioorganic & medicinal chemistry letters 14(11):2917-22, 2004 Jun 7 - Who cited this? | PubMed ID: 15125959 | Fulltext

Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin derivatives as potential anxiolytic agents.

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Trabanco AA, Alonso JM, Andrés JI, Cid JM, Fernández J, Iturrino L, and Megens A

Chemical & pharmaceutical bulletin 52(2):262-5, 2004 Feb - Who cited this? | PubMed ID: 14758015 | Fulltext

Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.

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Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Cid JM, De Lucas AI, Fernández J, Martínez S, Nieto C, Pastor J, Bakker MH, Biesmans I, Heylen LI, and Megens AA

Bioorganic & medicinal chemistry letters 13(16):2719-25, 2003 Aug 18 - Who cited this? | PubMed ID: 12873501 | Fulltext

Functional study of rat 5-HT2A receptors using antisense oligonucleotides.

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Van Oekelen D, Megens A, Meert T, Luyten WH, and Leysen JE

Journal of neurochemistry 85(5):1087-100, 2003 Jun - Who cited this? | PubMed ID: 12753068 | Fulltext

The atypical antipsychotics risperidone, clozapine and olanzapine differ regarding their sedative potency in rats.

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Ahnaou A, Megens AA, and Drinkenburg WH

Neuropsychobiology 48(1):47-54, 2003 - Who cited this? | PubMed ID: 12886041 | Fulltext

The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats.

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Kapur S, Langlois X, Vinken P, Megens AA, De Coster R, and Andrews JS

The Journal of pharmacology and experimental therapeutics 302(3):1129-34, 2002 Sep - Who cited this? | PubMed ID: 12183672 | Fulltext

Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist.

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Megens AA, Ashton D, Vermeire JC, Vermote PC, Hens KA, Hillen LC, Fransen JF, Mahieu M, Heylen L, Leysen JE, Jurzak MR, and Janssens F

The Journal of pharmacology and experimental therapeutics 302(2):696-709, 2002 Aug - Who cited this? | PubMed ID: 12130734 | Fulltext

Role of 5-HT(2) receptors in the tryptamine-induced 5-HT syndrome in rats.

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Van Oekelen D, Megens A, Meert T, Luyten WH, and Leysen JE

Behavioural pharmacology 13(4):313-8, 2002 Jul - Who cited this? | PubMed ID: 12218512 | Fulltext

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.

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Andrés JI, Alonso JM, Díaz A, Fernández J, Iturrino L, Martínez P, Matesanz E, Freyne EJ, Deroose F, Boeckx G, Petit D, Diels G, Megens A, Somers M, Van Wauwe J, Stoppie P,

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Bioorganic & medicinal chemistry letters 12(4):653-8, 2002 Feb 25 - Who cited this? | PubMed ID: 11844693 | Fulltext

Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.

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Andrés JI, Alcázar J, Alonso JM, Díaz A, Fernández J, Gil P, Iturrino L, Matesanz E, Meert TF, Megens A, and Sipido VK

Bioorganic & medicinal chemistry letters 12(2):243-8, 2002 Jan 21 - Who cited this? | PubMed ID: 11755364 | Fulltext

Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2.

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Andrés JI, Alcázar J, Alonso JM, Díaz A, Fernández J, Gil P, Iturrino L, Matesanz E, Meert TF, Megens A, and Sipido VK

Bioorganic & medicinal chemistry letters 12(2):249-53, 2002 Jan 21 - Who cited this? | PubMed ID: 11755365 | Fulltext

Measurement of upper extremity volume in women after axillary dissection for breast cancer.

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Megens AM, Harris SR, Kim-Sing C, and McKenzie DC

Archives of physical medicine and rehabilitation 82(12):1639-44, 2001 Dec - Who cited this? | PubMed ID: 11733875 | Fulltext

Sexual origins of placental dysfunction.

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Edwards A, Megens A, Peek M, and Wallace EM

Lancet 355(9199):203-4, 2000 Jan 15 - Who cited this? | PubMed ID: 10675126 | Fulltext

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants.

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Kennis LE, Bischoff FP, Mertens CJ, Love CJ, Van den Keybus FA, Pieters S, Braeken M, Megens AA, and Leysen JE

Bioorganic & medicinal chemistry letters 10(1):71-4, 2000 Jan 3 - Who cited this? | PubMed ID: 10636247 | Fulltext

Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization.

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Bonaventure P, Umans L, Bakker MH, Cras P, Langlois X, Luyten WH, Megens AA, Serneels L, Van Leuven F, and Leysen JE

Molecular pharmacology 56(1):54-67, 1999 Jul - Who cited this? | PubMed ID: 10385684 | Fulltext

Physical therapist management of lymphedema following treatment for breast cancer: a critical review of its effectiveness.

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Megens A and Harris SR

Physical therapy 78(12):1302-11, 1998 Dec - Who cited this? | PubMed ID: 9859949 | Fulltext

Comparison of the analgesic and intestinal effects of fentanyl and morphine in rats.

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Megens AA, Artois K, Vermeire J, Meert T, and Awouters FH

Journal of pain and symptom management 15(4):253-7, 1998 Apr - Who cited this? | PubMed ID: 9601161 | Fulltext

Risperidone and related 5HT2/D2 antagonists: a new type of antipsychotic agent?.

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Megens AA and Kennis LE

Progress in medicinal chemistry 33:185-232, 1996 - Who cited this? | PubMed ID: 8776944 | Fulltext

Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.

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Leysen JE, Janssen PM, Megens AA, and Schotte A

The Journal of clinical psychiatry 55 Suppl:5-12, 1994 May - Who cited this? | PubMed ID: 7520908 | Fulltext

Regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidone in the rat.

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van Beijsterveldt LE, Geerts RJ, Leysen JE, Megens AA, Van den Eynde HM, Meuldermans WE, and Heykants JJ

Psychopharmacology 114(1):53-62, 1994 Feb - Who cited this? | PubMed ID: 7531352 | Fulltext

Survey on the pharmacodynamics of the new antipsychotic risperidone.

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Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, and Leysen JE

Psychopharmacology 114(1):9-23, 1994 Feb - Who cited this? | PubMed ID: 7531353 | Fulltext

Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography.

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Schotte A, Janssen PF, Megens AA, and Leysen JE

Brain research 631(2):191-202, 1993 Dec 24 - Who cited this? | PubMed ID: 7510574 | Fulltext

Loperamide. Survey of studies on mechanism of its antidiarrheal activity.

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Awouters F, Megens A, Verlinden M, Schuurkes J, Niemegeers C, and Janssen PA

Digestive diseases and sciences 38(6):977-95, 1993 Jun - Who cited this? | PubMed ID: 8508715 | Fulltext

Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors.

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Leysen JE, Janssen PM, Schotte A, Luyten WH, and Megens AA

Psychopharmacology 112(1 Suppl):S40-54, 1993 - Who cited this? | PubMed ID: 7530377 | Fulltext

Levocabastine: pharmacological profile of a highly effective inhibitor of allergic reactions.

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Awouters F, Niemegeers CJ, Jansen T, Megens AA, and Janssen PA

Agents and actions 35(1-2):12-8, 1992 Jan - Who cited this? | PubMed ID: 1354927 | Fulltext

Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598).

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Megens AA, Awouters FH, Meert TF, Schellekens KH, Niemegeers CJ, and Janssen PA

The Journal of pharmacology and experimental therapeutics 260(1):146-59, 1992 Jan - Who cited this? | PubMed ID: 1370538 | Fulltext

Behavioral disinhibition and depression in amphetaminized rats: a comparison of risperidone, ocaperidone and haloperidol.

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Megens AA, Niemegeers CJ, and Awouters FH

The Journal of pharmacology and experimental therapeutics 260(1):160-7, 1992 Jan - Who cited this? | PubMed ID: 1370539 | Fulltext

General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride.

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Megens AA, Awouters FH, and Niemegeers CJ

Arzneimittel-Forschung 41(6):631-4, 1991 Jun - Who cited this? | PubMed ID: 1930352 | Fulltext

Functional interaction between serotonin-S2 and dopamine-D2 neurotransmission as revealed by selective antagonism of hyper-reactivity to tryptamine and apomorphine.

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Awouters F, Niemegeers CJ, Megens AA, and Janssen PA

The Journal of pharmacology and experimental therapeutics 254(3):945-51, 1990 Sep - Who cited this? | PubMed ID: 1697623 | Fulltext

Normalization of small intestinal propulsion with loperamide-like antidiarrheals in rats.

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Megens AA, Canters LL, Awouters FH, and Niemegeers CJ

European journal of pharmacology 178(3):357-64, 1990 Mar 27 - Who cited this? | PubMed ID: 2340864 | Fulltext

Is in vivo dissociation between the antipropulsive and antidiarrheal properties of opioids in rats related to gut selectivity?.

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Megens AA, Canters LL, Awouters FH, and Niemegeers CJ

Archives internationales de pharmacodynamie et de therapie 298:220-9, 1989 - Who cited this? | PubMed ID: 2569297 | Fulltext

Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

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Janssen PA, Niemegeers CJ, Awouters F, Schellekens KH, Megens AA, and Meert TF

The Journal of pharmacology and experimental therapeutics 244(2):685-93, 1988 Feb - Who cited this? | PubMed ID: 2450200 | Fulltext

Differential effects of the new antipsychotic risperidone on large and small motor movements in rats: a comparison with haloperidol.

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Megens AA, Awouters FH, and Niemegeers CJ

Psychopharmacology 95(4):493-6, 1988 - Who cited this? | PubMed ID: 2463650 | Fulltext

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