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Papers authored by Mcmahon JB

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Botryllamides: Natural Product Inhibitors of ABCG2.

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Henrich CJ, Robey RW, Takada K, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, McMahon JB, and Gustafson KR

ACS chemical biology 4(8):637-47, 2009 Aug 21 - Who cited this? | PubMed ID: 19555120 | Fulltext

A cell-based high-throughput screen to identify synergistic TRAIL sensitizers.

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Booth NL, Sayers TJ, Brooks AD, Thomas CL, Jacobsen K, Goncharova EI, McMahon JB, and Henrich CJ

Cancer immunology, immunotherapy : CII 58(8):1229-44, 2009 Aug - Who cited this? | PubMed ID: 19089423 | Fulltext

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.

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Yun SM, Moulaei T, Lim D, Bang JK, Park JE, Shenoy SR, Liu F, Kang YH, Liao C, Soung NK, Lee S, Yoon DY, Lim Y, Lee DH, Otaka A, Appella E,

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Nature structural & molecular biology 16(8):876-82, 2009 Aug - Who cited this? | PubMed ID: 19597481 | Fulltext

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.

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O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, and Palmer KE

Proceedings of the National Academy of Sciences of the United States of America 106(15):6099-104, 2009 Apr 14 - Who cited this? | PubMed ID: 19332801 | Fulltext

A selective small-molecule nuclear factor-{kappa}B inhibitor from a high-throughput cell-based assay for "activator protein-1 hits".

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Kang MI, Henrich CJ, Bokesch HR, Gustafson KR, McMahon JB, Baker AR, Young MR, and Colburn NH

Molecular cancer therapeutics 8(3):571-81, 2009 Mar - Who cited this? | PubMed ID: 19258426 | Fulltext

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.

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Clement JA, Kitagaki J, Yang Y, Saucedo CJ, O'Keefe BR, Weissman AM, McKee TC, and McMahon JB

Bioorganic & medicinal chemistry, 2008 Oct 14 - Who cited this? | PubMed ID: 18977148 | Fulltext

HIV-1 Ribonuclease H Inhibitory Phenolic Glycosides from Eugenia hyemalis.

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Bokesch HR, Wamiru A, Le Grice SF, Beutler JA, McKee TC, and McMahon JB

Journal of natural products, 2008 Sep 3 - Who cited this? | PubMed ID: 18763827 | Fulltext

Identification of Inhibitors for MDM2 Ubiquitin Ligase Activity from Natural Product Extracts by a Novel High-Throughput Electrochemiluminescent Screen.

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Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, and O'Keefe BR

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 13(3):229-37, 2008 Apr - Who cited this? | PubMed ID: 18270365 | Fulltext

New inhibitors of ABCG2 identified by high-throughput screening.

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Henrich CJ, Robey RW, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, Dean M, and McMahon JB

Molecular cancer therapeutics 6(12 Pt 1):3271, 2007 Dec - Who cited this? | PubMed ID: 18089721 | Fulltext

An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.

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Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, and McMahon JB

Journal of natural products 70(10):1647-9, 2007 Oct - Who cited this? | PubMed ID: 17935297 | Fulltext

Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide.

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Emau P, Tian B, O'keefe BR, Mori T, McMahon JB, Palmer KE, Jiang Y, Bekele G, and Tsai CC

Journal of medical primatology 36(4-5):244-53, 2007 Aug - Who cited this? | PubMed ID: 17669213 | Fulltext

The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors.

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McFeeters RL, Xiong C, O'Keefe BR, Bokesch HR, McMahon JB, Ratner DM, Castelli R, Seeberger PH, and Byrd RA

Journal of molecular biology 369(2):451-61, 2007 Jun 1 - Who cited this? | PubMed ID: 17434526 | Fulltext

Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.

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Giomarelli B, Washington VA, Chisholm MM, Quigley L, McMahon JB, Mori T, and McVicar DW

Thrombosis and haemostasis 97(6):955-63, 2007 Jun - Who cited this? | PubMed ID: 17549298 | Fulltext

Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.

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Ziółkowska NE, Shenoy SR, O'Keefe BR, McMahon JB, Palmer KE, Dwek RA, Wormald MR, and Wlodawer A

Proteins 67(3):661-70, 2007 May 15 - Who cited this? | PubMed ID: 17340634 | Fulltext

A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.

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Dat NT, Bae K, Wamiru A, McMahon JB, Le Grice SF, Bona M, Beutler JA, and Kim YH

Journal of natural products 70(5):839-41, 2007 May - Who cited this? | PubMed ID: 17397219 | Fulltext

Natural products active in aberrant c-Kit signaling.

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Henrich CJ, Goncharova EI, Wilson JA, Gardella RS, Johnson TR, McMahon JB, Takada K, Bokesch HR, and Gustafson KR

Chemical biology & drug design 69(5):321-30, 2007 May - Who cited this? | PubMed ID: 17539824 | Fulltext

Structural assignment of poecillastrins B and C, macrolide lactams from the deep-water Caribbean sponge Poecillastra species.

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Takada K, Choi BW, Rashid MA, Gamble WR, Cardellina JH, Van QN, Lloyd JR, McMahon JB, and Gustafson KR

Journal of natural products 70(3):428-31, 2007 Mar - Who cited this? | PubMed ID: 17378533 | Fulltext

A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1.

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Ruocco KM, Goncharova EI, Young MR, Colburn NH, McMahon JB, and Henrich CJ

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 12(1):133-9, 2007 Feb - Who cited this? | PubMed ID: 17175522 | Fulltext

Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library.

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Krumpe LR, Schumacher KM, McMahon JB, Makowski L, and Mori T

BMC biotechnology 7:65, 2007 - Who cited this? | PubMed ID: 17919322 | Fulltext

Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression.

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Woldemichael GM, Vasselli JR, Gardella RS, McKee TC, Linehan WM, and McMahon JB

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 11(6):678-87, 2006 Sep - Who cited this? | PubMed ID: 16858007 | Fulltext

T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries.

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Krumpe LR, Atkinson AJ, Smythers GW, Kandel A, Schumacher KM, McMahon JB, Makowski L, and Mori T

Proteomics 6(15):4210-22, 2006 Aug - Who cited this? | PubMed ID: 16819727 | Fulltext

Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.

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Ziółkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, and Wlodawer A

Structure (London, England : 1993) 14(7):1127, 2006 Jul - Who cited this? | PubMed ID: 16843894 | Fulltext

Potent anti-HIV activity of scytovirin domain 1 peptide.

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Xiong C, O'Keefe BR, Byrd RA, and McMahon JB

Peptides 27(7):1668-75, 2006 Jul - Who cited this? | PubMed ID: 16647158 | Fulltext

Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture.

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Giomarelli B, Schumacher KM, Taylor TE, Sowder RC, Hartley JL, McMahon JB, and Mori T

Protein expression and purification 47(1):194-202, 2006 May - Who cited this? | PubMed ID: 16300962 | Fulltext

Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium.

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Xiong C, O'Keefe BR, Botos I, Wlodawer A, and McMahon JB

Protein expression and purification 46(2):233-9, 2006 Apr - Who cited this? | PubMed ID: 16289703 | Fulltext

A high-throughput cell-based assay for inhibitors of ABCG2 activity.

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Henrich CJ, Bokesch HR, Dean M, Bates SE, Robey RW, Goncharova EI, Wilson JA, and McMahon JB

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 11(2):176-83, 2006 Mar - Who cited this? | PubMed ID: 16490770 | Fulltext

Complete stereochemistry of neamphamide A and absolute configuration of the beta-methoxytyrosine residue in papuamide B.

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Oku N, Krishnamoorthy R, Benson AG, Ferguson RL, Lipton MA, Phillips LR, Gustafson KR, and McMahon JB

The Journal of organic chemistry 70(17):6842-7, 2005 Aug 19 - Who cited this? | PubMed ID: 16095304 | Fulltext

Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.

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Mori T, O'Keefe BR, Sowder RC, Bringans S, Gardella R, Berg S, Cochran P, Turpin JA, Buckheit RW, McMahon JB, and Boyd MR

The Journal of biological chemistry 280(10):9345-53, 2005 Mar 11 - Who cited this? | PubMed ID: 15613479 | Fulltext

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones.

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Budihas SR, Gorshkova I, Gaidamakov S, Wamiru A, Bona MK, Parniak MA, Crouch RJ, McMahon JB, Beutler JA, and Le Grice SF

Nucleic acids research 33(4):1249-56, 2005 - Who cited this? | PubMed ID: 15741178 | Fulltext

A capillary electrophoretic assay for ribonuclease H activity.

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Chan KC, Budihas SR, Le Grice SF, Parniak MA, Crouch RJ, Gaidamakov SA, Isaaq HJ, Wamiru A, McMahon JB, and Beutler JA

Analytical biochemistry 331(2):296-302, 2004 Aug 15 - Who cited this? | PubMed ID: 15265735 | Fulltext

Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi.

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Oku N, Gustafson KR, Cartner LK, Wilson JA, Shigematsu N, Hess S, Pannell LK, Boyd MR, and McMahon JB

Journal of natural products 67(8):1407-11, 2004 Aug - Who cited this? | PubMed ID: 15332865 | Fulltext

Monanchorin, a bicyclic alkaloid from the sponge Monanchora ungiculata.

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Meragelman KM, McKee TC, and McMahon JB

Journal of natural products 67(7):1165-7, 2004 Jul - Who cited this? | PubMed ID: 15270573 | Fulltext

Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea.

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Bokesch HR, Charan RD, Meragelman KM, Beutler JA, Gardella R, O'Keefe BR, McKee TC, and McMahon JB

FEBS letters 567(2-3):287-90, 2004 Jun 4 - Who cited this? | PubMed ID: 15178338 | Fulltext

Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions.

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Adams EW, Ratner DM, Bokesch HR, McMahon JB, O'Keefe BR, and Seeberger PH

Chemistry & biology 11(6):875-81, 2004 Jun - Who cited this? | PubMed ID: 15217620 | Fulltext

Gymnangiamide, a cytotoxic pentapeptide from the marine hydroid Gymnangium regae.

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Milanowski DJ, Gustafson KR, Rashid MA, Pannell LK, McMahon JB, and Boyd MR

The Journal of organic chemistry 69(9):3036-42, 2004 Apr 30 - Who cited this? | PubMed ID: 15104441 | Fulltext

Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinones from the marine bryozoan Caulibugula intermis.

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Milanowski DJ, Gustafson KR, Kelley JA, and McMahon JB

Journal of natural products 67(1):70-3, 2004 Jan - Who cited this? | PubMed ID: 14738389 | Fulltext

Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.

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Pettit GR, Ducki S, Tan R, Gardella RS, McMahon JB, Boyd MR, Pettit GR, Blumberg PM, Lewin NE, Doubek DL, Tackett LP, and Williams MD

Journal of natural products 65(9):1262-5, 2002 Sep - Who cited this? | PubMed ID: 12350143 | Fulltext

The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1.

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Giomarelli B, Provvedi R, Meacci F, Maggi T, Medaglini D, Pozzi G, Mori T, McMahon JB, Gardella R, and Boyd MR

AIDS (London, England) 16(10):1351-6, 2002 Jul 5 - Who cited this? | PubMed ID: 12131211 | Fulltext

High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41.

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Beutler JA, McMahon JB, Johnson TR, O'Keefe BR, Buzzell RA, Robbins D, Gardella R, Wilson J, and Boyd MR

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 7(2):105-10, 2002 Apr - Who cited this? | PubMed ID: 12006108 | Fulltext

Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner.

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Bolmstedt AJ, O'Keefe BR, Shenoy SR, McMahon JB, and Boyd MR

Molecular pharmacology 59(5):949, 2001 May - Who cited this? | PubMed ID: 11306674 | Fulltext

Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence.

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McMahon JB, Beutler JA, O'Keefe BR, Goodrum CB, Myers MA, and Boyd MR

Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 5(3):169-76, 2000 Jun - Who cited this? | PubMed ID: 10894760 | Fulltext

The HIV-inactivating protein, cyanovirin-N, does not block gp120-mediated virus-to-cell binding.

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Mariner JM, McMahon JB, O'Keefe BR, Nagashima K, and Boyd MR

Biochemical and biophysical research communications 248(3):841-5, 1998 Jul 30 - Who cited this? | PubMed ID: 9704015 | Fulltext

Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp.

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O'Keefe BR, Erim T, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Johnson DG, Buckheit RW, Halliday S, and Boyd MR

FEBS letters 431(1):85-90, 1998 Jul 10 - Who cited this? | PubMed ID: 9684871 | Fulltext

Recombinant production of cyanovirin-N, a potent human immunodeficiency virus-inactivating protein derived from a cultured cyanobacterium.

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Mori T, Gustafson KR, Pannell LK, Shoemaker RH, Wu L, McMahon JB, and Boyd MR

Protein expression and purification 12(2):151-8, 1998 Mar - Who cited this? | PubMed ID: 9518455 | Fulltext

Construction and enhanced cytotoxicity of a [cyanovirin-N]-[Pseudomonas exotoxin] conjugate against human immunodeficiency virus-infected cells.

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Mori T, Shoemaker RH, McMahon JB, Gulakowski RJ, Gustafson KR, and Boyd MR

Biochemical and biophysical research communications 239(3):884-8, 1997 Oct 29 - Who cited this? | PubMed ID: 9367864 | Fulltext

Analysis of sequence requirements for biological activity of cyanovirin-N, a potent HIV (human immunodeficiency virus)-inactivating protein.

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Mori T, Shoemaker RH, Gulakowski RJ, Krepps BL, McMahon JB, Gustafson KR, Pannell LK, and Boyd MR

Biochemical and biophysical research communications 238(1):218-22, 1997 Sep 8 - Who cited this? | PubMed ID: 9299482 | Fulltext

Isolation, primary sequence determination, and disulfide bond structure of cyanovirin-N, an anti-HIV (human immunodeficiency virus) protein from the cyanobacterium Nostoc ellipsosporum.

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Gustafson KR, Sowder RC, Henderson LE, Cardellina JH, McMahon JB, Rajamani U, Pannell LK, and Boyd MR

Biochemical and biophysical research communications 238(1):223-8, 1997 Sep 8 - Who cited this? | PubMed ID: 9299483 | Fulltext

Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

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Boyd MR, Gustafson KR, McMahon JB, Shoemaker RH, O'Keefe BR, Mori T, Gulakowski RJ, Wu L, Rivera MI, Laurencot CM, Currens MJ, Cardellina JH, Buckheit RW, Nara PL, Pannell LK, Sowder RC,

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Antimicrobial agents and chemotherapy 41(7):1521-30, 1997 Jul - Who cited this? | PubMed ID: 9210678 | Fulltext

Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.

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Hallock YF, Manfredi KP, Dai JR, Cardellina JH, Gulakowski RJ, McMahon JB, Schäffer M, Stahl M, Gulden KP, Bringmann G, François G, and Boyd MR

Journal of natural products 60(7):677-83, 1997 Jul - Who cited this? | PubMed ID: 9249970 | Fulltext

Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta.

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O'Keefe BR, Beutler JA, Cardellina JH, Gulakowski RJ, Krepps BL, McMahon JB, Sowder RC, Henderson LE, Pannell LK, Pomponi SA, and Boyd MR

European journal of biochemistry / FEBS 245(1):47-53, 1997 Apr 1 - Who cited this? | PubMed ID: 9128723 | Fulltext

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