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Papers authored by Mcglade CJ

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Numb regulates post-endocytic trafficking and degradation of Notch1.

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McGill MA, Dho SE, Weinmaster G, and McGlade CJ

The Journal of biological chemistry 284(39):26427-38, 2009 Sep 25 - Who cited this? | PubMed ID: 19567869 | Fulltext

Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.

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Laprise P, Lau KM, Harris KP, Silva-Gagliardi NF, Paul SM, Beronja S, Beitel GJ, McGlade CJ, and Tepass U

Nature 459(7250):1141-5, 2009 Jun 25 - Who cited this? | PubMed ID: 19553998 | Fulltext

Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells.

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Pardossi-Piquard R, Chen F, Silva-Gagliardi NF, Szego M, McInnes R, McGlade CJ, St George-Hyslop P, and Fraser PE

Biochemistry 46(48):13704-10, 2007 Dec 4 - Who cited this? | PubMed ID: 17988153 | Fulltext

The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.

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Pakuts B, Debonneville C, Liontos LM, Loreto MP, and McGlade CJ

The Journal of biological chemistry 282(25):17953-63, 2007 Jun 22 - Who cited this? | PubMed ID: 17353186 | Fulltext

The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.

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Lee JD, Silva-Gagliardi NF, Tepass U, McGlade CJ, and Anderson KV

Development (Cambridge, England) 134(11):2007, 2007 Jun - Who cited this? | PubMed ID: 17507402 | Fulltext

Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.

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Seet BT, Berry DM, Maltzman JS, Shabason J, Raina M, Koretzky GA, McGlade CJ, and Pawson T

The EMBO journal 26(3):678-89, 2007 Feb 7 - Who cited this? | PubMed ID: 17235283 | Fulltext

aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.

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Smith CA, Lau KM, Rahmani Z, Dho SE, Brothers G, She YM, Berry DM, Bonneil E, Thibault P, Schweisguth F, Le Borgne R, and McGlade CJ

The EMBO journal 26(2):468, 2007 Jan 24 - Who cited this? | PubMed ID: 17203073 | Fulltext

The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size.

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Laprise P, Beronja S, Silva-Gagliardi NF, Pellikka M, Jensen AM, McGlade CJ, and Tepass U

Developmental cell 11(3):363, 2006 Sep - Who cited this? | PubMed ID: 16950127 | Fulltext

Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane.

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Dho SE, Trejo J, Siderovski DP, and McGlade CJ

Molecular biology of the cell 17(9):4142-55, 2006 Sep - Who cited this? | PubMed ID: 16837553 | Fulltext

PTP1B and TC-PTP: novel roles in immune-cell signaling.

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Simoncic PD, McGlade CJ, and Tremblay ML

Canadian journal of physiology and pharmacology 84(7):667-75, 2006 Jul - Who cited this? | PubMed ID: 16998530 | Fulltext

T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation.

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Simoncic PD, Bourdeau A, Lee-Loy A, Rohrschneider LR, Tremblay ML, Stanley ER, and McGlade CJ

Molecular and cellular biology 26(11):4149-60, 2006 Jun - Who cited this? | PubMed ID: 16705167 | Fulltext

Cluster analysis of protein array results via similarity of Gene Ontology annotation.

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Wolting C, McGlade CJ, and Tritchler D

BMC bioinformatics 7:338, 2006 - Who cited this? | PubMed ID: 16836750 | Fulltext

LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2.

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Young P, Nie J, Wang X, McGlade CJ, Rich MM, and Feng G

Molecular and cellular neurosciences 30(2):238-48, 2005 Oct - Who cited this? | PubMed ID: 16122940 | Fulltext

The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades.

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Zhu YX, Benn S, Li ZH, Wei E, Masih-Khan E, Trieu Y, Bali M, McGlade CJ, Claudio JO, and Stewart AK

The Journal of experimental medicine 200(6):737-47, 2004 Sep 20 - Who cited this? | PubMed ID: 15381729 | Fulltext

The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling.

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Smith CA, Dho SE, Donaldson J, Tepass U, and McGlade CJ

Molecular biology of the cell 15(8):3698, 2004 Aug - Who cited this? | PubMed ID: 15155807 | Fulltext

A novel PTB-PDZ domain interaction mediates isoform-specific ubiquitylation of mammalian Numb.

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Nie J, Li SS, and McGlade CJ

The Journal of biological chemistry 279(20):20807-15, 2004 May 14 - Who cited this? | PubMed ID: 14990566 | Fulltext

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain.

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McGill MA and McGlade CJ

The Journal of biological chemistry 278(25):23196-203, 2003 Jun 20 - Who cited this? | PubMed ID: 12682059 | Fulltext

Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells.

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Yamasaki S, Nishida K, Sakuma M, Berry D, McGlade CJ, Hirano T, and Saito T

Molecular and cellular biology 23(7):2515-29, 2003 Apr - Who cited this? | PubMed ID: 12640133 | Fulltext

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.

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Calderwood DA, Fujioka Y, De Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, and Ginsberg MH

Proceedings of the National Academy of Sciences of the United States of America 100(5):2272, 2003 Mar 4 - Who cited this? | PubMed ID: 12606711 | Fulltext

Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition.

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Liu Q, Berry D, Nash P, Pawson T, McGlade CJ, and Li SS

Molecular cell 11(2):471-81, 2003 Feb - Who cited this? | PubMed ID: 12620234 | Fulltext

Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v.

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Loreto MP and McGlade CJ

Oncogene 22(2):266-73, 2003 Jan 16 - Who cited this? | PubMed ID: 12527895 | Fulltext

Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells.

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Woods SA, McGlade CJ, and Guha A

Neuro-oncology 4(4):242-52, 2002 Oct - Who cited this? | PubMed ID: 12356354 | Fulltext

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.

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Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, and Samelson LE

The Journal of cell biology 158(7):1263-75, 2002 Sep 30 - Who cited this? | PubMed ID: 12356870 | Fulltext

A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.

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Berry DM, Nash P, Liu SK, Pawson T, and McGlade CJ

Current biology : CB 12(15):1336-41, 2002 Aug 6 - Who cited this? | PubMed ID: 12176364 | Fulltext

Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.

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Loreto MP, Berry DM, and McGlade CJ

Molecular and cellular biology 22(12):4241-55, 2002 Jun - Who cited this? | PubMed ID: 12024036 | Fulltext

Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification.

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French MB, Koch U, Shaye RE, McGill MA, Dho SE, Guidos CJ, and McGlade CJ

Journal of immunology (Baltimore, Md. : 1950) 168(7):3173-80, 2002 Apr 1 - Who cited this? | PubMed ID: 11907069 | Fulltext

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

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Cheng A, Uetani N, Simoncic PD, Chaubey VP, Lee-Loy A, McGlade CJ, Kennedy BP, and Tremblay ML

Developmental cell 2(4):497-503, 2002 Apr - Who cited this? | PubMed ID: 11970899 | Fulltext

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

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Simoncic PD, Lee-Loy A, Barber DL, Tremblay ML, and McGlade CJ

Current biology : CB 12(6):446-53, 2002 Mar 19 - Who cited this? | PubMed ID: 11909529 | Fulltext

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.

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Pellikka M, Tanentzapf G, Pinto M, Smith C, McGlade CJ, Ready DF, and Tepass U

Nature 416(6877):143, 2002 Mar 14 - Who cited this? | PubMed ID: 11850625 | Fulltext

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation.

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Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, and McGlade CJ

The EMBO journal 21(1-2):93-102, 2002 Jan 15 - Who cited this? | PubMed ID: 11782429 | Fulltext

Neuralized functions as an E3 ubiquitin ligase during Drosophila development.

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Yeh E, Dermer M, Commisso C, Zhou L, McGlade CJ, and Boulianne GL

Current biology : CB 11(21):1675-9, 2001 Oct 30 - Who cited this? | PubMed ID: 11696324 | Fulltext

The role of Gads in hematopoietic cell signalling.

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Liu SK, Berry DM, and McGlade CJ

Oncogene 20(44):6284-90, 2001 Oct 1 - Who cited this? | PubMed ID: 11607830 | Fulltext

HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells.

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Claudio JO, Zhu YX, Benn SJ, Shukla AH, McGlade CJ, Falcioni N, and Stewart AK

Oncogene 20(38):5373-7, 2001 Aug 30 - Who cited this? | PubMed ID: 11536050 | Fulltext

Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor.

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Berry DM, Benn SJ, Cheng AM, and McGlade CJ

Oncogene 20(10):1203-11, 2001 Mar 8 - Who cited this? | PubMed ID: 11313864 | Fulltext

Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.

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Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, and Watson SP

The Journal of biological chemistry 275(43):33427-34, 2000 Oct 27 - Who cited this? | PubMed ID: 10942756 | Fulltext

The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.

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Liu SK, Smith CA, Arnold R, Kiefer F, and McGlade CJ

Journal of immunology (Baltimore, Md. : 1950) 165(3):1417-26, 2000 Aug 1 - Who cited this? | PubMed ID: 10903746 | Fulltext

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.

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Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, and Samelson LE

The Journal of biological chemistry 275(30):23355-61, 2000 Jul 28 - Who cited this? | PubMed ID: 10811803 | Fulltext

Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

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Dho SE, French MB, Woods SA, and McGlade CJ

The Journal of biological chemistry 274(46):33097-104, 1999 Nov 12 - Who cited this? | PubMed ID: 10551880 | Fulltext

Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells.

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Schmandt R, Liu SK, and McGlade CJ

Oncogene 18(10):1867-79, 1999 Mar 11 - Who cited this? | PubMed ID: 10086341 | Fulltext

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.

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Liu SK, Fang N, Koretzky GA, and McGlade CJ

Current biology : CB 9(2):67-75, 1999 Jan 28 - Who cited this? | PubMed ID: 10021361 | Fulltext

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.

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Liu SK and McGlade CJ

Oncogene 17(24):3073-82, 1998 Dec 17 - Who cited this? | PubMed ID: 9872323 | Fulltext

Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity.

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Li SC, Zwahlen C, Vincent SJ, McGlade CJ, Kay LE, Pawson T, and Forman-Kay JD

Nature structural biology 5(12):1075-83, 1998 Dec - Who cited this? | PubMed ID: 9846878 | Fulltext

Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family.

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Wolting CD and McGlade CJ

Mammalian genome : official journal of the International Mammalian Genome Society 9(6):463-8, 1998 Jun - Who cited this? | PubMed ID: 9585435 | Fulltext

The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.

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Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, and McGlade CJ

The Journal of biological chemistry 273(15):9179-87, 1998 Apr 10 - Who cited this? | PubMed ID: 9535908 | Fulltext

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate.

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Verdi JM, Schmandt R, Bashirullah A, Jacob S, Salvino R, Craig CG, Program AE, Lipshitz HD, and McGlade CJ

Current biology : CB 6(9):1134-45, 1996 Sep 1 - Who cited this? | PubMed ID: 8805372 | Fulltext

Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity.

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Charest A, Wagner J, Jacob S, McGlade CJ, and Tremblay ML

The Journal of biological chemistry 271(14):8424-9, 1996 Apr 5 - Who cited this? | PubMed ID: 8626541 | Fulltext

SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.

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McGlade CJ, Ellis C, Reedijk M, Anderson D, Mbamalu G, Reith AD, Panayotou G, End P, Bernstein A, and Kazlauskas A

Molecular and cellular biology 12(3):991-7, 1992 Mar - Who cited this? | PubMed ID: 1372092 | Fulltext

Individual adenovirus E1B proteins induce transformation independently but by additive pathways.

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McLorie W, McGlade CJ, Takayesu D, and Branton PE

The Journal of general virology 72 ( Pt 6):1467-71, 1991 Jun - Who cited this? | PubMed ID: 1828498 | Fulltext

Mapping of a phosphorylation site in the 176R (19 kDa) early region 1B protein of human adenovirus type 5.

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McGlade CJ, Tremblay ML, and Branton PE

Virology 168(1):119-27, 1989 Jan - Who cited this? | PubMed ID: 2521265 | Fulltext

Identification of the phosphorylation sites in early region 1A proteins of adenovirus type 5 by amino acid sequencing of peptide fragments.

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Tremblay ML, McGlade CJ, Gerber GE, and Branton PE

The Journal of biological chemistry 263(13):6375-83, 1988 May 5 - Who cited this? | PubMed ID: 2966155 | Fulltext

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