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Papers authored by Manning BD

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Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1.

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Dibble CC, Asara JM, and Manning BD

Molecular and cellular biology 29(21):5657-70, 2009 Nov - Who cited this? | PubMed ID: 19720745 | Fulltext

A molecular link between AKT regulation and chemotherapeutic response.

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Dibble CC and Manning BD

Cancer cell 16(3):178-80, 2009 Sep 8 - Who cited this? | PubMed ID: 19732717 | Fulltext

NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.

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James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, and Ramesh V

Molecular and cellular biology 29(15):4250-61, 2009 Aug - Who cited this? | PubMed ID: 19451225 | Fulltext

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.

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Huang J, Wu S, Wu CL, and Manning BD

Cancer research 69(15):6107-14, 2009 Aug 1 - Who cited this? | PubMed ID: 19602587 | Fulltext

A complex interplay between Akt, TSC2 and the two mTOR complexes.

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Huang J and Manning BD

Biochemical Society transactions 37(Pt 1):217-22, 2009 Feb - Who cited this? | PubMed ID: 19143635 | Fulltext

Challenges and opportunities in defining the essential cancer kinome.

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Manning BD

Science signaling 2(63):pe15, 2009 - Who cited this? | PubMed ID: 19318621 | Fulltext

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

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Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, and Manning BD

PLoS ONE 4(7):e6189, 2009 - Who cited this? | PubMed ID: 19593385 | Fulltext

The mTOR complex 1 regulates leptin biosynthesis in adipocytes at the level of translation. The role of the 5'-UTR in the expression of leptin mRNA.

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Chakrabarti P, Anno T, Manning BD, Luo Z, and Kandror KV

Molecular endocrinology (Baltimore, Md.), 2008 Jul 24 - Who cited this? | PubMed ID: 18653778 | Fulltext

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

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Huang J and Manning BD

The Biochemical journal 412(2):179, 2008 Jun 1 - Who cited this? | PubMed ID: 18466115 | Fulltext

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

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Huang J, Dibble CC, Matsuzaki M, and Manning BD

Molecular and cellular biology 28(12):4104-15, 2008 Jun - Who cited this? | PubMed ID: 18411301 | Fulltext

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

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Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, and Hotamisligil GS

Molecular cell 29(5):541, 2008 Mar 14 - Who cited this? | PubMed ID: 18342602 | Fulltext

AKT/PKB signaling: navigating downstream.

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Manning BD and Cantley LC

Cell 129(7):1261-74, 2007 Jun 29 - Who cited this? | PubMed ID: 17604717 | Fulltext

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

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Zhang HH, Lipovsky AI, Dibble CC, Sahin M, and Manning BD

Molecular cell 24(2):185-97, 2006 Oct 20 - Who cited this? | PubMed ID: 17052453 | Fulltext

The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.

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Sodhi A, Chaisuparat R, Hu J, Ramsdell AK, Manning BD, Sausville EA, Sawai ET, Molinolo A, Gutkind JS, and Montaner S

Cancer cell 10(2):133-43, 2006 Aug - Who cited this? | PubMed ID: 16904612 | Fulltext

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

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Kwiatkowski DJ and Manning BD

Human molecular genetics 14 Spec No. 2, 2005 Oct 15 - Who cited this? | PubMed ID: 16244323 | Fulltext

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

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Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, and Cantley LC

Genes & development 19(15):1773-8, 2005 Aug 1 - Who cited this? | PubMed ID: 16027169 | Fulltext

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

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Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, and Kaelin WG

Genes & development 18(23):2893-904, 2004 Dec 1 - Who cited this? | PubMed ID: 15545625 | Fulltext

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.

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Manning BD

The Journal of cell biology 167(3):399-403, 2004 Nov 8 - Who cited this? | PubMed ID: 15533996 | Fulltext

The LKB1 tumor suppressor negatively regulates mTOR signaling.

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Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, Depinho RA, and Cantley LC

Cancer cell 6(1):91, 2004 Jul - Who cited this? | PubMed ID: 15261145 | Fulltext

Rheb fills a GAP between TSC and TOR.

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Manning BD and Cantley LC

Trends in biochemical sciences 28(11):573-6, 2003 Nov - Who cited this? | PubMed ID: 14607085 | Fulltext

Targeting the PI3K-Akt pathway in human cancer: rationale and promise.

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Luo J, Manning BD, and Cantley LC

Cancer cell 4(4):257-62, 2003 Oct - Who cited this? | PubMed ID: 14585353 | Fulltext

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

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Tee AR, Manning BD, Roux PP, Cantley LC, and Blenis J

Current biology : CB 13(15):1259, 2003 Aug 5 - Who cited this? | PubMed ID: 12906785 | Fulltext

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling.

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Manning BD and Cantley LC

Biochemical Society transactions 31(Pt 3):573-8, 2003 Jun - Who cited this? | PubMed ID: 12773158 | Fulltext

Hitting the target: emerging technologies in the search for kinase substrates.

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Manning BD and Cantley LC

Science's STKE : signal transduction knowledge environment 2002(162):PE49, 2002 Dec 10 - Who cited this? | PubMed ID: 12475999 | Fulltext

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

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Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, and Blenis J

Proceedings of the National Academy of Sciences of the United States of America 99(21):13571-6, 2002 Oct 15 - Who cited this? | PubMed ID: 12271141 | Fulltext

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

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Manning BD, Tee AR, Logsdon MN, Blenis J, and Cantley LC

Molecular cell 10(1):151-62, 2002 Jul - Who cited this? | PubMed ID: 12150915 | Fulltext

Drivers and passengers wanted! the role of kinesin-associated proteins.

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Manning BD and Snyder M

Trends in cell biology 10(7):281-9, 2000 Jul - Who cited this? | PubMed ID: 10856931 | Fulltext

The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p.

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Barrett JG, Manning BD, and Snyder M

Molecular biology of the cell 11(7):2373-85, 2000 Jul - Who cited this? | PubMed ID: 10888675 | Fulltext

Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p.

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Manning BD, Barrett JG, Wallace JA, Granok H, and Snyder M

The Journal of cell biology 144(6):1219-33, 1999 Mar 22 - Who cited this? | PubMed ID: 10087265 | Fulltext

The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae.

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Manning BD, Padmanabha R, and Snyder M

Molecular biology of the cell 8(10):1829-44, 1997 Oct - Who cited this? | PubMed ID: 9348527 | Fulltext

Genomic complexity and plasticity of Burkholderia cepacia.

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Lessie TG, Hendrickson W, Manning BD, and Devereux R

FEMS microbiology letters 144(2-3):117-28, 1996 Nov 1 - Who cited this? | PubMed ID: 8900054 | Fulltext

Kynurenine metabolism in rats: some hormonal factors affecting enzyme activities.

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Manning BD and Mason M

Life sciences 17(2):225-32, 1975 Jul 15 - Who cited this? | PubMed ID: 1172171 | Fulltext

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