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Papers authored by Malley MF

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Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer.

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Dhar TG, Yang G, Davies P, Malley MF, Gougoutas JZ, Wu DR, Barrish JC, and Carter PH

Bioorganic & medicinal chemistry letters 19(1):96-9, 2009 Jan 1 - Who cited this? | PubMed ID: 19010676 | Fulltext

Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.

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Wacker DA, Varnes JG, Malmstrom SE, Cao X, Hung CP, Ung T, Wu G, Zhang G, Zuvich E, Thomas MA, Keim WJ, Cullen MJ, Rohrbach KW, Qu Q, Narayanan R, Rossi K,

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Journal of medicinal chemistry 50(6):1365-79, 2007 Mar 22 - Who cited this? | PubMed ID: 17315987 | Fulltext

Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.

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Sun C, Robl JA, Wang TC, Huang Y, Kuhns JE, Lupisella JA, Beehler BC, Golla R, Sleph PG, Seethala R, Fura A, Krystek SR, An Y, Malley MF, Sack JS, Salvati ME,

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Journal of medicinal chemistry 49(26):7596-9, 2006 Dec 28 - Who cited this? | PubMed ID: 17181141 | Fulltext

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.

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Potin D, Launay M, Monatlik F, Malabre P, Fabreguettes M, Fouquet A, Maillet M, Nicolai E, Dorgeret L, Chevallier F, Besse D, Dufort M, Caussade F, Ahmad SZ, Stetsko DK, Skala S,

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Journal of medicinal chemistry 49(24):6946-9, 2006 Nov 30 - Who cited this? | PubMed ID: 17125246 | Fulltext

Novel 1,4-homofragmentation via an alpha-lactone.

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Godfrey JD, Fox RT, Buono FG, Gougoutas JZ, and Malley MF

The Journal of organic chemistry 71(22):8647-50, 2006 Oct 27 - Who cited this? | PubMed ID: 17064050 | Fulltext

A switch in enantiomer preference between mitochondrial F1F0-ATPase chemotypes.

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Bisaha SN, Malley MF, Pudzianowski A, Monshizadegan H, Wang P, Madsen CS, Gougoutas JZ, and Stein PD

Bioorganic & medicinal chemistry letters 15(11):2749-51, 2005 Jun 2 - Who cited this? | PubMed ID: 15878269 | Fulltext

Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.

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Magnin DR, Robl JA, Sulsky RB, Augeri DJ, Huang Y, Simpkins LM, Taunk PC, Betebenner DA, Robertson JG, Abboa-Offei BE, Wang A, Cap M, Xin L, Tao L, Sitkoff DF, Malley MF,

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Journal of medicinal chemistry 47(10):2587-98, 2004 May 6 - Who cited this? | PubMed ID: 15115400 | Fulltext

One-pot synthesis and conformational features of n,n'-disubstituted ketene aminals.

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Shi Y, Zhang J, Grazier N, Stein PD, Atwal KS, Traeger SC, Callahan SP, Malley MF, Galella MA, and Gougoutas JZ

The Journal of organic chemistry 69(1):188-91, 2004 Jan 9 - Who cited this? | PubMed ID: 14703396 | Fulltext

Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.

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Das J, Kimball SD, Hall SE, Han WC, Iwanowicz E, Lin J, Moquin RV, Reid JA, Sack JS, Malley MF, Chang CY, Chong S, Wang-Iverson DB, Roberts DG, Seiler SM, Schumacher WA,

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Bioorganic & medicinal chemistry letters 12(1):45-9, 2002 Jan 7 - Who cited this? | PubMed ID: 11738570 | Fulltext

Technetium(V) oxo complexes of substituted propylene diamine dioxime (PnAO) ligands: water-dependent interconversion between syn and anti isomers.

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Cyr JE, Nowotnik DP, Pan Y, Gougoutas JZ, Malley MF, Di Marco J, Nunn AD, and Linder KE

Inorganic chemistry 40(14):3555-61, 2001 Jul 2 - Who cited this? | PubMed ID: 11421705 | Fulltext

Characterization of NADP+ binding to perdeuterated MurB: backbone atom NMR assignments and chemical-shift changes.

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Constantine KL, Mueller L, Goldfarb V, Wittekind M, Metzler WJ, Yanchunas J, Robertson JG, Malley MF, Friedrichs MS, and Farmer BT

Journal of molecular biology 267(5):1223-46, 1997 Apr 18 - Who cited this? | PubMed ID: 9150408 | Fulltext

Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.

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Malley MF, Tabernero L, Chang CY, Ohringer SL, Roberts DG, Das J, and Sack JS

Protein science : a publication of the Protein Society 5(2):221-8, 1996 Feb - Who cited this? | PubMed ID: 8745399 | Fulltext

Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.

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Stein PD, Floyd DM, Bisaha S, Dickey J, Girotra RN, Gougoutas JZ, Kozlowski M, Lee VG, Liu EC, and Malley MF

Journal of medicinal chemistry 38(8):1344-54, 1995 Apr 14 - Who cited this? | PubMed ID: 7731020 | Fulltext

TcO(PnA.O-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction.

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Linder KE, Chan YW, Cyr JE, Malley MF, Nowotnik DP, and Nunn AD

Journal of medicinal chemistry 37(1):9-17, 1994 Jan 7 - Who cited this? | PubMed ID: 8289205 | Fulltext

Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid.

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Meanwell NA, Romine JL, Rosenfeld MJ, Martin SW, Trehan AK, Wright JJ, Malley MF, Gougoutas JZ, Brassard CL, and Buchanan JO

Journal of medicinal chemistry 36(24):3884-903, 1993 Nov 26 - Who cited this? | PubMed ID: 7504734 | Fulltext

Conformationally constrained calcium channel blockers: novel mimics of 1-benzazepin-2-ones.

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Barrish JC, Spergel SH, Moreland S, Grover G, Hedberg SA, Pudzianowski AT, Gougoutas JZ, and Malley MF

Bioorganic & medicinal chemistry 1(4):309-25, 1993 Oct - Who cited this? | PubMed ID: 8081861 | Fulltext

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.

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Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, O'Reilly BC, Schwartz J, and Malley MF

Journal of medicinal chemistry 35(17):3254-63, 1992 Aug 21 - Who cited this? | PubMed ID: 1387168 | Fulltext

Benzazepinone calcium channel blockers. 3. Synthesis and structure-activity studies of 3-alkylbenzazepinones.

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Das J, Floyd DM, Kimball SD, Duff KJ, Vu TC, Lago MW, Moquin RV, Lee VG, Gougoutas JZ, and Malley MF

Journal of medicinal chemistry 35(4):773-80, 1992 Feb 21 - Who cited this? | PubMed ID: 1542103 | Fulltext

Substitution of lysine at position 104 or 240 of TEM-1pTZ18R beta-lactamase enhances the effect of serine-164 substitution on hydrolysis or affinity for cephalosporins and the monobactam aztreonam.

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Sowek JA, Singer SB, Ohringer S, Malley MF, Dougherty TJ, Gougoutas JZ, and Bush K

Biochemistry 30(13):3179-88, 1991 Apr 2 - Who cited this? | PubMed ID: 1901218 | Fulltext

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues.

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Bisacchi GS, Braitman A, Cianci CW, Clark JM, Field AK, Hagen ME, Hockstein DR, Malley MF, Mitt T, and Slusarchyk WA

Journal of medicinal chemistry 34(4):1415-21, 1991 Apr - Who cited this? | PubMed ID: 1849998 | Fulltext

Technetium labeling of monoclonal antibodies with functionalized BATOs. 1. TcCl(DMG)3PITC.

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Linder KE, Wen MD, Nowotnik DP, Malley MF, Gougoutas JZ, Nunn AD, and Eckelman WC

Bioconjugate chemistry 2(3):160-70, 1991 - Who cited this? | PubMed ID: 1932215 | Fulltext

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

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Atwal KS, Rovnyak GC, Kimball SD, Floyd DM, Moreland S, Swanson BN, Gougoutas JZ, Schwartz J, Smillie KM, and Malley MF

Journal of medicinal chemistry 33(9):2629-35, 1990 Sep - Who cited this? | PubMed ID: 2391701 | Fulltext

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

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Atwal KS, Rovnyak GC, Schwartz J, Moreland S, Hedberg A, Gougoutas JZ, Malley MF, and Floyd DM

Journal of medicinal chemistry 33(5):1510-5, 1990 May - Who cited this? | PubMed ID: 2329573 | Fulltext

Aerocavin, a new antibiotic produced by Chromobacterium violaceum.

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Singh PD, Liu WC, Gougoutas JZ, Malley MF, Porubcan MA, Trejo WH, Wells JS, and Sykes RB

The Journal of antibiotics 41(4):446-53, 1988 Apr - Who cited this? | PubMed ID: 3372350 | Fulltext

Synthesis and in vitro pharmacology of 7-oxabicyclo[2.2.1]heptane analogues of thromboxane A2/PGH2.

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Sprague PW, Heikes JE, Gougoutas JZ, Malley MF, Harris DN, and Greenberg R

Journal of medicinal chemistry 28(11):1580-90, 1985 Nov - Who cited this? | PubMed ID: 4067988 | Fulltext

Gas chromatography/selected ion monitoring mass spectrometric determination of captopril in human blood.

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Funke PT, Ivashkiv E, Malley MF, and Cohen AI

Analytical chemistry 52(7):1086-9, 1980 Jun - Who cited this? | PubMed ID: 7008647 | Fulltext

Determination of serum nadolol levels by GLC--selected ion monitoring mass spectrometry: comparison with a spectrofluorometric method.

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Funke PT, Malley MF, Ivashkiv E, and Cohen AI

Journal of pharmaceutical sciences 67(5):653-7, 1978 May - Who cited this? | PubMed ID: 25332 | Fulltext

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