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Papers authored by Malek TR

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Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance.

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Adeegbe D, Levy RB, and Malek TR

Blood 115(10):1932-40, 2010 Mar 11 - Who cited this? | PubMed ID: 20040758 | Fulltext

CD4+ CD25+ Foxp3+ T Regulatory Cells with Limited TCR Diversity in Control of Autoimmunity.

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Adeegbe D, Matsutani T, Yang J, Altman NH, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 184(1):56-66, 2010 Jan 1 - Who cited this? | PubMed ID: 19949075 | Fulltext

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.

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Yu A, Zhu L, Altman NH, and Malek TR

Immunity 30(2):204-17, 2009 Feb - Who cited this? | PubMed ID: 19185518 | Fulltext

IL-2 Family of Cytokines in T Regulatory Cell Development and Homeostasis.

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Malek TR, Yu A, Zhu L, Matsutani T, Adeegbe D, and Bayer AL

Journal of clinical immunology 28(6):635-9, 2008 Nov - Who cited this? | PubMed ID: 18726679 | Fulltext

Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment following experimental HCT.

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Bayer AL, Jones M, Chirinos J, de Armas L, Schreiber TH, Malek TR, and Levy RB

Blood, 2008 Oct 2 - Who cited this? | PubMed ID: 18832651 | Fulltext

A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells.

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Bayer AL, Lee JY, de la Barrera A, Surh CD, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 181(1):225, 2008 Jul 1 - Who cited this? | PubMed ID: 18566388 | Fulltext

Modeling the CD8+ T effector to memory transition in adoptive T-cell antitumor immunotherapy.

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Rolle CE, Carrio R, and Malek TR

Cancer research 68(8):2984-92, 2008 Apr 15 - Who cited this? | PubMed ID: 18413768 | Fulltext

The biology of interleukin-2.

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Malek TR

Annual review of immunology 26:453-79, 2008 - Who cited this? | PubMed ID: 18062768 | Fulltext

Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells.

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Carrio R, Rolle CE, and Malek TR

European journal of immunology 37(11):3078-88, 2007 Nov - Who cited this? | PubMed ID: 17935075 | Fulltext

Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.

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Bayer AL, Yu A, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 178(7):4062, 2007 Apr 1 - Who cited this? | PubMed ID: 17371960 | Fulltext

Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.

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Gong D and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 178(1):242-52, 2007 Jan 1 - Who cited this? | PubMed ID: 17182561 | Fulltext

Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21.

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Jin H and Malek TR

Journal of leukocyte biology 80(6):1416-23, 2006 Dec - Who cited this? | PubMed ID: 16943384 | Fulltext

Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells.

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Yu A and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 177(8):5115-21, 2006 Oct 15 - Who cited this? | PubMed ID: 17015695 | Fulltext

Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance.

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Adeegbe D, Bayer AL, Levy RB, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 176(12):7149-53, 2006 Jun 15 - Who cited this? | PubMed ID: 16751356 | Fulltext

Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo.

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Jin H, Gong D, Adeegbe D, Bayer AL, Rolle C, Yu A, and Malek TR

International immunology 18(4):565-72, 2006 Apr - Who cited this? | PubMed ID: 16540525 | Fulltext

Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.

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Bayer AL, Yu A, Adeegbe D, and Malek TR

The Journal of experimental medicine 201(5):769-77, 2005 Mar 7 - Who cited this? | PubMed ID: 15753210 | Fulltext

Tolerance, not immunity, crucially depends on IL-2.

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Malek TR and Bayer AL

Nature reviews. Immunology 4(9):665-74, 2004 Sep - Who cited this? | PubMed ID: 15343366 | Fulltext

Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis.

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Jin H, Carrio R, Yu A, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 173(1):657-65, 2004 Jul 1 - Who cited this? | PubMed ID: 15210829 | Fulltext

Initial antigen encounter programs CD8+ T cells competent to develop into memory cells that are activated in an antigen-free, IL-7- and IL-15-rich environment.

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Carrio R, Bathe OF, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 172(12):7315-23, 2004 Jun 15 - Who cited this? | PubMed ID: 15187107 | Fulltext

The main function of IL-2 is to promote the development of T regulatory cells.

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Malek TR

Journal of leukocyte biology 74(6):961-5, 2003 Dec - Who cited this? | PubMed ID: 12960253 | Fulltext

Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment.

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Bathe OF, Dalyot-Herman N, and Malek TR

BMC cancer 3:21, 2003 Jul 28 - Who cited this? | PubMed ID: 12882650 | Fulltext

Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody.

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Molano RD, Pileggi A, Berney T, Poggioli R, Zahr E, Oliver R, Malek TR, Ricordi C, and Inverardi L

Transplantation 75(11):1812-9, 2003 Jun 15 - Who cited this? | PubMed ID: 12811239 | Fulltext

Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors.

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Yu A, Zhou J, Marten N, Bergmann CC, Mammolenti M, Levy RB, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 170(1):236-42, 2003 Jan 1 - Who cited this? | PubMed ID: 12496405 | Fulltext

T helper cells, IL-2 and the generation of cytotoxic T-cell responses.

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Malek TR

Trends in immunology 23(10):465-7, 2002 Oct - Who cited this? | PubMed ID: 12297409 | Fulltext

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.

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Malek TR, Yu A, Vincek V, Scibelli P, and Kong L

Immunity 17(2):167-78, 2002 Aug - Who cited this? | PubMed ID: 12196288 | Fulltext

On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response.

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Demirci G, Gao W, Zheng XX, Malek TR, Strom TB, and Li XC

Journal of immunology (Baltimore, Md. : 1950) 168(9):4382-90, 2002 May 1 - Who cited this? | PubMed ID: 11970980 | Fulltext

Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.

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Olosz F and Malek TR

The Journal of biological chemistry 277(14):12047-52, 2002 Apr 5 - Who cited this? | PubMed ID: 11815609 | Fulltext

IL-2 during in vitro priming promotes subsequent engraftment and successful adoptive tumor immunotherapy by persistent memory phenotypic CD8(+) T cells.

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Bathe OF, Dalyot-Herman N, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 167(8):4511-7, 2001 Oct 15 - Who cited this? | PubMed ID: 11591778 | Fulltext

Measurement of lymphokine receptors.

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Lowenthal JW, Malek TR, and Saragovi H

Current protocols in immunology / edited by John E. Coligan ... [et al.] Chapter 6:Unit 6.1, 2001 May - Who cited this? | PubMed ID: 18432801 | Fulltext

Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells.

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Malek TR, Yu A, Scibelli P, Lichtenheld MG, and Codias EK

Journal of immunology (Baltimore, Md. : 1950) 166(3):1675-83, 2001 Feb 1 - Who cited this? | PubMed ID: 11160210 | Fulltext

The proteasome regulates receptor-mediated endocytosis of interleukin-2.

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Yu A and Malek TR

The Journal of biological chemistry 276(1):381-5, 2001 Jan 5 - Who cited this? | PubMed ID: 11032838 | Fulltext

Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail.

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Porter BO, Scibelli P, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 166(1):262-9, 2001 Jan 1 - Who cited this? | PubMed ID: 11123301 | Fulltext

IL-15 and IL-2: a matter of life and death for T cells in vivo.

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Li XC, Demirci G, Ferrari-Lacraz S, Groves C, Coyle A, Malek TR, and Strom TB

Nature medicine 7(1):114-8, 2001 Jan - Who cited this? | PubMed ID: 11135625 | Fulltext

Reversal of CD8+ T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC.

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Dalyot-Herman N, Bathe OF, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 165(12):6731-7, 2000 Dec 15 - Who cited this? | PubMed ID: 11120791 | Fulltext

Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammac-dependent cytokines IL-2, IL-7, and IL-15.

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Porter BO and Malek TR

Seminars in immunology 12(5):465-74, 2000 Oct - Who cited this? | PubMed ID: 11085179 | Fulltext

Three loops of the common gamma chain ectodomain required for the binding of interleukin-2 and interleukin-7.

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Olosz F and Malek TR

The Journal of biological chemistry 275(39):30100-5, 2000 Sep 29 - Who cited this? | PubMed ID: 10887198 | Fulltext

Efficient internalization of IL-2 depends on the distal portion of the cytoplasmic tail of the IL-2R common gamma-chain and a lymphoid cell environment.

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Yu A, Olosz F, Choi CY, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 165(5):2556-62, 2000 Sep 1 - Who cited this? | PubMed ID: 10946282 | Fulltext

Genomic organization and 5' regulatory region of the mouse IL-2 receptor beta-chain gene (IL-2Rb).

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Codias EK, Olosz F, and Malek TR

Immunogenetics 51(6):508-12, 2000 May - Who cited this? | PubMed ID: 10866121 | Fulltext

Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors.

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Malek TR, Porter BO, Codias EK, Scibelli P, and Yu A

Journal of immunology (Baltimore, Md. : 1950) 164(6):2905-14, 2000 Mar 15 - Who cited this? | PubMed ID: 10706676 | Fulltext

Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival.

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Li XC, Ima A, Li Y, Zheng XX, Malek TR, and Strom TB

Journal of immunology (Baltimore, Md. : 1950) 164(3):1193-9, 2000 Feb 1 - Who cited this? | PubMed ID: 10640730 | Fulltext

IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development.

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Porter BO and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 163(11):5906-12, 1999 Dec 1 - Who cited this? | PubMed ID: 10570276 | Fulltext

Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function.

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Marmor MD, Bachmann MF, Ohashi PS, Malek TR, and Julius M

International immunology 11(9):1381-93, 1999 Sep - Who cited this? | PubMed ID: 10464159 | Fulltext

Prostaglandin E2 inhibits T cell activation-induced apoptosis and Fas-mediated cellular cytotoxicity by blockade of Fas-ligand induction.

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Porter BO and Malek TR

European journal of immunology 29(7):2360-5, 1999 Jul - Who cited this? | PubMed ID: 10427999 | Fulltext

Multiple gamma c-dependent cytokines regulate T-cell development.

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Malek TR, Porter BO, and He YW

Immunology today 20(2):71-6, 1999 Feb - Who cited this? | PubMed ID: 10098325 | Fulltext

IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection.

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Li XC, Roy-Chaudhury P, Hancock WW, Manfro R, Zand MS, Li Y, Zheng XX, Nickerson PW, Steiger J, Malek TR, and Strom TB

Journal of immunology (Baltimore, Md. : 1950) 161(2):890-6, 1998 Jul 15 - Who cited this? | PubMed ID: 9670967 | Fulltext

Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development.

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Malek TR, Levy RB, Adkins B, and He YW

Journal of leukocyte biology 63(6):643-9, 1998 Jun - Who cited this? | PubMed ID: 9620654 | Fulltext

The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis.

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He YW and Malek TR

Critical reviews in immunology 18(6):503-24, 1998 - Who cited this? | PubMed ID: 9862091 | Fulltext

Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-kappa B.

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Ivanov VN, Lee RK, Podack ER, and Malek TR

Oncogene 14(20):2455-64, 1997 May 22 - Who cited this? | PubMed ID: 9188860 | Fulltext

Distribution of Ly-6C on lymphocyte subsets: I. Influence of allotype on T lymphocyte expression.

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Schlueter AJ, Malek TR, Hostetler CN, Smith PA, deVries P, and Waldschmidt TJ

Journal of immunology (Baltimore, Md. : 1950) 158(9):4211-22, 1997 May 1 - Who cited this? | PubMed ID: 9126982 | Fulltext

The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.

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He YW, Nakajima H, Leonard WJ, Adkins B, and Malek TR

Journal of immunology (Baltimore, Md. : 1950) 158(6):2592-9, 1997 Mar 15 - Who cited this? | PubMed ID: 9058791 | Fulltext

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