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Papers authored by Magnin DR

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Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.

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Simpkins LM, Bolton S, Pi Z, Sutton JC, Kwon C, Zhao G, Magnin DR, Augeri DJ, Gungor T, Rotella DP, Sun Z, Liu Y, Slusarchyk WS, Marcinkeviciene J, Robertson JG, Wang A,

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Bioorganic & medicinal chemistry letters 17(23):6476-80, 2007 Dec 1 - Who cited this? | PubMed ID: 17937986 | Fulltext

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

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Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL,

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Bioorganic & medicinal chemistry letters 17(12):3511-5, 2007 Jun 15 - Who cited this? | PubMed ID: 17502136 | Fulltext

NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

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McDonnell PA, Constantine KL, Goldfarb V, Johnson SR, Sulsky R, Magnin DR, Robl JA, Caulfield TJ, Parker RA, Taylor DS, Adam LP, Metzler WJ, Mueller L, and Farmer BT

Journal of medicinal chemistry 49(16):5013-7, 2006 Aug 10 - Who cited this? | PubMed ID: 16884313 | Fulltext

Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1.

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Magnin DR, Taunk PC, Robertson JG, Wang A, Marcinkeviciene J, Kirby MS, and Hamann LG

Bioorganic & medicinal chemistry letters 16(6):1731-4, 2006 Mar 15 - Who cited this? | PubMed ID: 16376077 | Fulltext

Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors.

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Zhao G, Taunk PC, Magnin DR, Simpkins LM, Robl JA, Wang A, Robertson JG, Marcinkeviciene J, Sitkoff DF, Parker RA, Kirby MS, and Hamann LG

Bioorganic & medicinal chemistry letters 15(18):3992-5, 2005 Sep 15 - Who cited this? | PubMed ID: 16046120 | Fulltext

Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

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Augeri DJ, Robl JA, Betebenner DA, Magnin DR, Khanna A, Robertson JG, Wang A, Simpkins LM, Taunk P, Huang Q, Han SP, Abboa-Offei B, Cap M, Xin L, Tao L, Tozzo E,

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Journal of medicinal chemistry 48(15):5025-37, 2005 Jul 28 - Who cited this? | PubMed ID: 16033281 | Fulltext

Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.

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Magnin DR, Robl JA, Sulsky RB, Augeri DJ, Huang Y, Simpkins LM, Taunk PC, Betebenner DA, Robertson JG, Abboa-Offei BE, Wang A, Cap M, Xin L, Tao L, Sitkoff DF, Malley MF,

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Journal of medicinal chemistry 47(10):2587-98, 2004 May 6 - Who cited this? | PubMed ID: 15115400 | Fulltext

Application of robotics to steady state enzyme kinetics: analysis of tight-binding inhibitors of dipeptidyl peptidase IV.

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Wang A, Huang Y, Taunk P, Magnin DR, Ghosh K, and Robertson JG

Analytical biochemistry 321(2):157-66, 2003 Oct 15 - Who cited this? | PubMed ID: 14511679 | Fulltext

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.

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Magnin DR, Biller SA, Wetterau J, Robl JA, Dickson JK, Taunk P, Harrity TW, Lawrence RM, Sun CQ, Wang T, Logan J, Fryszman O, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 13(7):1337-40, 2003 Apr 7 - Who cited this? | PubMed ID: 12657277 | Fulltext

Palladium-catalyzed microwave-assisted amination of 1-bromonaphthalenes and 5- and 8-bromoquinolines.

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Wang T, Magnin DR, and Hamann LG

Organic letters 5(6):897-900, 2003 Mar 20 - Who cited this? | PubMed ID: 12633100 | Fulltext

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

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Robl JA, Sulsky R, Sun CQ, Simpkins LM, Wang T, Dickson JK, Chen Y, Magnin DR, Taunk P, Slusarchyk WA, Biller SA, Lan SJ, Connolly F, Kunselman LK, Sabrah T, Jamil H,

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Journal of medicinal chemistry 44(6):851-6, 2001 Mar 15 - Who cited this? | PubMed ID: 11300866 | Fulltext

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

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Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois KG, Kunselman LK, Lan SJ, Maccagnan TJ, Ricci B, Yan M,

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Science (New York, N.Y.) 282(5389):751-4, 1998 Oct 23 - Who cited this? | PubMed ID: 9784135 | Fulltext

alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.

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Magnin DR, Biller SA, Chen Y, Dickson JK, Fryszman OM, Lawrence RM, Logan JV, Sieber-McMaster ES, Sulsky RB, Traeger SC, Hsieh DC, Lan SJ, Rinehart JK, Harrity TW, Jolibois KG, Kunselman LK,

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Journal of medicinal chemistry 39(3):657-60, 1996 Feb 2 - Who cited this? | PubMed ID: 8576905 | Fulltext

Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety.

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Dickson JK, Biller SA, Magnin DR, Petrillo EW, Hillyer JW, Hsieh DC, Lan SJ, Rinehart JK, Gregg RE, Harrity TW, Jolibois KG, Kalinowski SS, Kunselman LK, Mookhtiar KA, and Ciosek CP

Journal of medicinal chemistry 39(3):661-4, 1996 Feb 2 - Who cited this? | PubMed ID: 8576906 | Fulltext

1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate.

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Magnin DR, Biller SA, Dickson JK, Logan JV, Lawrence RM, Chen Y, Sulsky RB, Ciosek CP, Harrity TW, and Jolibois KG

Journal of medicinal chemistry 38(14):2596-605, 1995 Jul 7 - Who cited this? | PubMed ID: 7629799 | Fulltext

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo.

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Ciosek CP, Magnin DR, Harrity TW, Logan JV, Dickson JK, Gordon EM, Hamilton KA, Jolibois KG, Kunselman LK, and Lawrence RM

The Journal of biological chemistry 268(33):24832-7, 1993 Nov 25 - Who cited this? | PubMed ID: 8227045 | Fulltext

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