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Papers authored by Magdolen V

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Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells.

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Gratio V, Beaufort N, Seiz L, Maier J, Virca GD, Debela M, Grebenchtchikov N, Magdolen V, and Darmoul D

The American journal of pathology 176(3):1452-61, 2010 Mar - Who cited this? | PubMed ID: 20056842 | Fulltext

Co-detection of members of the urokinase plasminogen activator system in tumour tissue and serum correlates with a poor prognosis for soft-tissue sarcoma patients.

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Taubert H, Würl P, Greither T, Kappler M, Bache M, Lautenschläger C, Füssel S, Meye A, Eckert AW, Holzhausen HJ, Magdolen V, and Kotzsch M

British journal of cancer 102(4):731-7, 2010 Feb 16 - Who cited this? | PubMed ID: 20051950 | Fulltext

Using kallikrein-related peptidases (KLK) as novel cancer biomarkers.

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Schmitt M and Magdolen V

Thrombosis and haemostasis 101(2):222-4, 2009 Feb - Who cited this? | PubMed ID: 19190801 | Fulltext

Development of a small molecule peptidomimetic affinity ligand for efficient purification of the large protein factor VIII.

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Knör S, Laufer B, Khrenov A, Benhida A, Grailly SC, Beaufort N, Magdolen V, Hauser CA, Saenko EL, Saint-Remy JM, and Kessler H

Advances in experimental medicine and biology 611:151-2, 2009 - Who cited this? | PubMed ID: 19400135 | Fulltext

Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase.

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Ruppert C, Mahavadi P, Wygrecka M, Weaver TE, Magdolen V, Idell S, Preissner KT, Seeger W, Günther A, and Markart P

Thrombosis and haemostasis 100(6):1185-92, 2008 Dec - Who cited this? | PubMed ID: 19132247 | Fulltext

Protein kinase Cdelta expression in breast cancer as measured by real-time PCR, western blotting and ELISA.

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McKiernan E, O'Brien K, Grebenchtchikov N, Geurts-Moespot A, Sieuwerts AM, Martens JW, Magdolen V, Evoy D, McDermott E, Crown J, Sweep FC, and Duffy MJ

British journal of cancer 99(10):1644-50, 2008 Nov 18 - Who cited this? | PubMed ID: 19002183 | Fulltext

DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients.

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Nimmrich I, Sieuwerts AM, Meijer-van Gelder ME, Schwope I, Bolt-de Vries J, Harbeck N, Koenig T, Hartmann O, Kluth A, Dietrich D, Magdolen V, Portengen H, Look MP, Klijn JG, Lesche R, Schmitt M,

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Breast cancer research and treatment 111(3):429-37, 2008 Oct - Who cited this? | PubMed ID: 17965955 | Fulltext

Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor.

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Kotzsch M, Sieuwerts AM, Grosser M, Meye A, Fuessel S, Meijer-van Gelder ME, Smid M, Schmitt M, Baretton G, Luther T, Magdolen V, and Foekens JA

Breast cancer research and treatment 111(2):229, 2008 Sep - Who cited this? | PubMed ID: 17952591 | Fulltext

Structures and specificity of the human kallikrein-related peptidases KLKs 4, 5, 6, and 7.

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Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, and Goettig P

Biological chemistry, 2008 Jun 20 - Who cited this? | PubMed ID: 18627297 | Fulltext

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

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Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, and Goettig P

Biological chemistry 389(6):623-32, 2008 Jun - Who cited this? | PubMed ID: 18627343 | Fulltext

Efficient factor VIII affinity purification using a small synthetic ligand.

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Knör S, Khrenov A, Laufer B, Benhida A, Grailly SC, Schwaab R, Oldenburg J, Beaufort N, Magdolen V, Saint-Remy JM, Saenko EL, Hauser CA, and Kessler H

Journal of thrombosis and haemostasis : JTH 6(3):470, 2008 Mar - Who cited this? | PubMed ID: 18194422 | Fulltext

The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin.

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Beaufort N, Wojciechowski P, Sommerhoff CP, Szmyd G, Dubin G, Eick S, Kellermann J, Schmitt M, Potempa J, and Magdolen V

The Biochemical journal 410(1):157-65, 2008 Feb 15 - Who cited this? | PubMed ID: 17973626 | Fulltext

Quantitative RT-PCR assays for the determination of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 mRNA in primary tumor tissue of breast cancer patients: Comparison to antigen quantification by ELISA.

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Biermann JC, Holzscheiter L, Kotzsch M, Luther T, Kiechle-Bahat M, Sweep FC, Span PN, Schmitt M, and Magdolen V

International journal of molecular medicine 21(2):251-9, 2008 Feb - Who cited this? | PubMed ID: 18204793 | Fulltext

Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer.

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Knör S, Sato S, Huber T, Morgenstern A, Bruchertseifer F, Schmitt M, Kessler H, Senekowitsch-Schmidtke R, Magdolen V, and Seidl C

European journal of nuclear medicine and molecular imaging 35(1):53-64, 2008 Jan - Who cited this? | PubMed ID: 17891393 | Fulltext

Structural basis of the zinc inhibition of human tissue kallikrein 5.

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Debela M, Goettig P, Magdolen V, Huber R, Schechter NM, and Bode W

Journal of molecular biology 373(4):1017-31, 2007 Nov 2 - Who cited this? | PubMed ID: 17881000 | Fulltext

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.

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Debela M, Hess P, Magdolen V, Schechter NM, Steiner T, Huber R, Bode W, and Goettig P

Proceedings of the National Academy of Sciences of the United States of America 104(41):16086-91, 2007 Oct 9 - Who cited this? | PubMed ID: 17909180 | Fulltext

The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation.

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Becker-Pauly C, Höwel M, Walker T, Vlad A, Aufenvenne K, Oji V, Lottaz D, Sterchi EE, Debela M, Magdolen V, Traupe H, and Stöcker W

The Journal of investigative dermatology 127(5):1115-25, 2007 May - Who cited this? | PubMed ID: 17195012 | Fulltext

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.

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Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, and Goettig P

Journal of molecular biology 362(5):1094-107, 2006 Oct 6 - Who cited this? | PubMed ID: 16950394 | Fulltext

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences.

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Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, and Goettig P

The Journal of biological chemistry 281(35):25678-88, 2006 Sep 1 - Who cited this? | PubMed ID: 16740631 | Fulltext

Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma.

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Dorn J, Harbeck N, Kates R, Magdolen V, Grass L, Soosaipillai A, Schmalfeldt B, Diamandis EP, and Schmitt M

Biological chemistry 387(8):1121-8, 2006 Aug - Who cited this? | PubMed ID: 16895483 | Fulltext

Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer.

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Holzscheiter L, Biermann JC, Kotzsch M, Prezas P, Farthmann J, Baretton G, Luther T, Tjan-Heijnen VC, Talieri M, Schmitt M, Sweep FC, Span PN, and Magdolen V

Clinical chemistry 52(6):1070-9, 2006 Jun - Who cited this? | PubMed ID: 16627559 | Fulltext

Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells.

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Prezas P, Arlt MJ, Viktorov P, Soosaipillai A, Holzscheiter L, Schmitt M, Talieri M, Diamandis EP, Krüger A, and Magdolen V

Biological chemistry 387(6):807-11, 2006 Jun - Who cited this? | PubMed ID: 16800744 | Fulltext

Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR).

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Beaufort N, Debela M, Creutzburg S, Kellermann J, Bode W, Schmitt M, Pidard D, and Magdolen V

Biological chemistry 387(2):217-22, 2006 Feb - Who cited this? | PubMed ID: 16497155 | Fulltext

Methods to analyze the effects of the urokinase system on cancer cell adhesion, proliferation, migration, and signal transduction events.

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Reuning U, Schmitt M, Luber B, Beck V, and Magdolen V

Methods in molecular medicine 120:427-40, 2006 - Who cited this? | PubMed ID: 16491616 | Fulltext

Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.

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Kotzsch M, Farthmann J, Meye A, Fuessel S, Baretton G, Tjan-Heijnen VC, Schmitt M, Luther T, Sweep FC, Magdolen V, and Span PN

European journal of cancer (Oxford, England : 1990) 41(17):2760-8, 2005 Nov - Who cited this? | PubMed ID: 16256342 | Fulltext

[Tumor-associated prognostic factors of the plasminogen activator family: determination and clinical value of u-PA, t-PA, PAI-1, and PAI-2].

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Mengele K, Harbeck N, Reuning U, Magdolen V, and Schmitt M

Hamostaseologie 25(3):301-10, 2005 Aug - Who cited this? | PubMed ID: 16113755 | Fulltext

Suppression of rat breast cancer metastasis and reduction of primary tumour growth by the small synthetic urokinase inhibitor WX-UK1.

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Setyono-Han B, Stürzebecher J, Schmalix WA, Muehlenweg B, Sieuwerts AM, Timmermans M, Magdolen V, Schmitt M, Klijn JG, and Foekens JA

Thrombosis and haemostasis 93(4):779-86, 2005 Apr - Who cited this? | PubMed ID: 15841327 | Fulltext

Clinical course of sarcoidosis in dependence on HLA-DRB1 allele frequencies, inflammatory markers, and the presence of M. tuberculosis DNA fragments.

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Grosser M, Luther T, Fuessel M, Bickhardt J, Magdolen V, and Baretton G

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 22(1):66-74, 2005 Mar - Who cited this? | PubMed ID: 15881283 | Fulltext

Non-muscle alpha-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1).

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Magdolen U, Schroeck F, Creutzburg S, Schmitt M, and Magdolen V

Biological chemistry 385(9):801-8, 2004 Sep - Who cited this? | PubMed ID: 15493875 | Fulltext

Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer.

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Harbeck N, Kates RE, Gauger K, Willems A, Kiechle M, Magdolen V, and Schmitt M

Thrombosis and haemostasis 91(3):450-6, 2004 Mar - Who cited this? | PubMed ID: 14983219 | Fulltext

Combination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness.

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Boyd DD, Wang H, Avila H, Parikh NU, Kessler H, Magdolen V, and Gallick GE

Clinical cancer research : an official journal of the American Association for Cancer Research 10(4):1545-55, 2004 Feb 15 - Who cited this? | PubMed ID: 14977859 | Fulltext

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G.

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Beaufort N, Leduc D, Rousselle JC, Magdolen V, Luther T, Namane A, Chignard M, and Pidard D

Journal of immunology (Baltimore, Md. : 1950) 172(1):540-9, 2004 Jan 1 - Who cited this? | PubMed ID: 14688365 | Fulltext

Cathepsin B, plasminogenactivator-inhibitor (PAI-1) and plasminogenactivator-receptor (uPAR) are prognostic factors for patients with non-small cell lung cancer.

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Werle B, Kotzsch M, Lah TT, Kos J, Gabrijelcic-Geiger D, Spiess E, Schirren J, Ebert W, Fiehn W, Luther T, Magdolen V, Schmitt M, and Harbeck N

Anticancer research 24(6):4147-61, 2004 - Who cited this? | PubMed ID: 15736466 | Fulltext

Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins.

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Reuning U, Magdolen V, Hapke S, and Schmitt M

Biological chemistry 384(8):1119-31, 2003 Aug - Who cited this? | PubMed ID: 12974381 | Fulltext

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems.

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Krol J, Sato S, Rettenberger P, Assfalg-Machleidt I, Schmitt M, Magdolen V, and Magdolen U

Biological chemistry 384(7):1085-96, 2003 Jul - Who cited this? | PubMed ID: 12956425 | Fulltext

Inhibition of intraperitoneal tumor growth of human ovarian cancer cells by bi- and trifunctional inhibitors of tumor-associated proteolytic systems.

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Krol J, Kopitz C, Kirschenhofer A, Schmitt M, Magdolen U, Krüger A, and Magdolen V

Biological chemistry 384(7):1097-102, 2003 Jul - Who cited this? | PubMed ID: 12956426 | Fulltext

Theme Issue: update on the role of the fibrinolysis/plasminogen activation system in a cellular context.

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Schmitt M, Magdolen V, and Reuning U

Thrombosis and haemostasis 89(4):596-8, 2003 Apr - Who cited this? | PubMed ID: 12669111 | Fulltext

Identification of a novel urokinase receptor splice variant and its prognostic relevance in breast cancer.

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Luther T, Kotzsch M, Meye A, Langerholc T, Füssel S, Olbricht N, Albrecht S, Ockert D, Muehlenweg B, Friedrich K, Grosser M, Schmitt M, Baretton G, and Magdolen V

Thrombosis and haemostasis 89(4):705-17, 2003 Apr - Who cited this? | PubMed ID: 12669126 | Fulltext

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis.

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Schuh T, Besch R, Braungart E, Flaig MJ, Douwes K, Sander CA, Magdolen V, Probst C, Wosikowski K, and Degitz K

Biological chemistry 384(2):311-5, 2003 Feb - Who cited this? | PubMed ID: 12675525 | Fulltext

The urokinase receptor (uPAR, CD87) as a target for tumor therapy: uPA-silica particles (SP-uPA) as a new tool for assessing synthetic peptides to interfere with uPA/uPA-receptor interaction.

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Guthaus E, Schmiedeberg N, Bürgle M, Magdolen V, Kessler H, and Schmitt M

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 162:3-14, 2003 - Who cited this? | PubMed ID: 12790317 | Fulltext

Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo.

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Magdolen V, Krüger A, Sato S, Nagel J, Sperl S, Reuning U, Rettenberger P, Magdolen U, and Schmitt M

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 162:43-63, 2003 - Who cited this? | PubMed ID: 12790320 | Fulltext

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo.

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Reuning U, Sperl S, Kopitz C, Kessler H, Krüger A, Schmitt M, and Magdolen V

Current pharmaceutical design 9(19):1529-43, 2003 - Who cited this? | PubMed ID: 12871066 | Fulltext

Soluble tissue actor interferes with angiostatin-mediated inhibition of endothelial cell proliferation by lysine-specific interaction with plasminogen kringle domains.

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Albrecht S, Magdolen V, Herzog U, Miles L, Kirschenhofer A, Baretton G, and Luther T

Thrombosis and haemostasis 88(6):1054-9, 2002 Dec - Who cited this? | PubMed ID: 12529759 | Fulltext

Synthesis, solution structure, and biological evaluation of urokinase type plasminogen activator (uPA)-derived receptor binding domain mimetics.

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Schmiedeberg N, Schmitt M, Rölz C, Truffault V, Sukopp M, Bürgle M, Wilhelm OG, Schmalix W, Magdolen V, and Kessler H

Journal of medicinal chemistry 45(23):4984-94, 2002 Nov 7 - Who cited this? | PubMed ID: 12408709 | Fulltext

High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread.

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Sato S, Kopitz C, Schmalix WA, Muehlenweg B, Kessler H, Schmitt M, Krüger A, and Magdolen V

FEBS letters 528(1-3):212-6, 2002 Sep 25 - Who cited this? | PubMed ID: 12297307 | Fulltext

Cortical neurons of Creutzfeldt-Jakob disease patients express the urokinase-type plasminogen activator receptor.

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Deininger MH, Trautmann K, Magdolen V, Luther T, Schluesener HJ, and Meyermann R

Neuroscience letters 324(1):80-2, 2002 May 10 - Who cited this? | PubMed ID: 11983300 | Fulltext

Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin.

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Arroyo De Prada N, Schroeck F, Sinner EK, Muehlenweg B, Twellmeyer J, Sperl S, Wilhelm OG, Schmitt M, and Magdolen V

European journal of biochemistry / FEBS 269(1):184-92, 2002 Jan - Who cited this? | PubMed ID: 11784312 | Fulltext

uPA-silica-Particles (SP-uPA): a novel analytical system to investigate uPA-uPAR interaction and to test synthetic uPAR antagonists as potential cancer therapeutics.

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Guthaus E, Bürgle M, Schmiedeberg N, Hocke S, Eickler A, Kramer MD, Sweep CG, Magdolen V, Kessler H, and Schmitt M

Biological chemistry 383(1):207-16, 2002 Jan - Who cited this? | PubMed ID: 11930939 | Fulltext

The uPA/uPA receptor system as a target for tumor therapy.

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Sperl S, Mueller MM, Wilhelm OG, Schmitt M, Magdolen V, and Moroder L

Drug news & perspectives 14(7):401-11, 2001 Sep - Who cited this? | PubMed ID: 12813583 | Fulltext

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87).

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Magdolen V, Bürgle M, de Prada NA, Schmiedeberg N, Riemer C, Schroeck F, Kellermann J, Degitz K, Wilhelm OG, Schmitt M, and Kessler H

Biological chemistry 382(8):1197-205, 2001 Aug - Who cited this? | PubMed ID: 11592401 | Fulltext

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