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Papers authored by Lenz EM

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Analysis of time course 1H NMR metabolomics data by multivariate curve resolution.

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Karakach TK, Knight R, Lenz EM, Viant MR, and Walter JA

Magnetic resonance in chemistry : MRC 47 Suppl 1:S105-17, 2009 Dec - Who cited this? | PubMed ID: 19899105 | Fulltext

Disposition and metabolism of the colchicine derivative [14C]-ZD6126 in rat and dog.

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Partridge EA, D'Souza RA, Lenz EM, Smith SM, Clarkson-Jones J, and Roberts DW

Xenobiotica; the fate of foreign compounds in biological systems 38(4):399, 2008 Apr - Who cited this? | PubMed ID: 18340564 | Fulltext

In vitro metabolism of a triclyclic alkaloid (M445526) in human liver microsomes and hepatocytes.

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McCormick AD, Slamon DL, Lenz EM, Phillips PJ, King CD, McKillop D, and Roberts DW

Xenobiotica; the fate of foreign compounds in biological systems 37(9):972-85, 2007 Sep - Who cited this? | PubMed ID: 17896324 | Fulltext

The application of microbore UPLC/oa-TOF-MS and 1H NMR spectroscopy to the metabonomic analysis of rat urine following the intravenous administration of pravastatin.

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Lenz EM, Williams RE, Sidaway J, Smith BW, Plumb RS, Johnson KA, Rainville P, Shockcor J, Stumpf CL, Granger JH, and Wilson ID

Journal of pharmaceutical and biomedical analysis 44(4):845-52, 2007 Aug 15 - Who cited this? | PubMed ID: 17561363 | Fulltext

HPLC-NMR with severe column overloading: fast-track metabolite identification in urine and bile samples from rat and dog treated with [14C]-ZD6126.

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Lenz EM, D'Souza RA, Jordan AC, King CD, Smith SM, Phillips PJ, McCormick AD, and Roberts DW

Journal of pharmaceutical and biomedical analysis 43(3):1065-77, 2007 Feb 19 - Who cited this? | PubMed ID: 17030109 | Fulltext

Analytical strategies in metabonomics.

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Lenz EM and Wilson ID

Journal of proteome research 6(2):443-58, 2007 Feb - Who cited this? | PubMed ID: 17269702 | Fulltext

A metabonomic study of strain- and age-related differences in the Zucker rat.

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Granger JH, Williams R, Lenz EM, Plumb RS, Stumpf CL, and Wilson ID

Rapid communications in mass spectrometry : RCM 21(13):2039-45, 2007 - Who cited this? | PubMed ID: 17534859 | Fulltext

A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats.

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Williams R, Lenz EM, Wilson AJ, Granger J, Wilson ID, Major H, Stumpf C, and Plumb R

Molecular bioSystems 2(3-4):174-83, 2006 Mar - Who cited this? | PubMed ID: 16880935 | Fulltext

The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats.

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Williams RE, Lenz EM, Rantalainen M, and Wilson ID

Molecular bioSystems 2(3-4):193-202, 2006 Mar - Who cited this? | PubMed ID: 16880937 | Fulltext

A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats.

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Williams RE, Lenz EM, Evans JA, Wilson ID, Granger JH, Plumb RS, and Stumpf CL

Journal of pharmaceutical and biomedical analysis 38(3):465-71, 2005 Jul 1 - Who cited this? | PubMed ID: 15925248 | Fulltext

The metabonomics of aging and development in the rat: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS.

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Williams RE, Lenz EM, Lowden JS, Rantalainen M, and Wilson ID

Molecular bioSystems 1(2):166-75, 2005 Jul - Who cited this? | PubMed ID: 16880980 | Fulltext

HPLC-MS-based methods for the study of metabonomics.

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Wilson ID, Plumb R, Granger J, Major H, Williams R, and Lenz EM

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 817(1):67-76, 2005 Mar 5 - Who cited this? | PubMed ID: 15680789 | Fulltext

D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach.

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Williams RE, Major H, Lock EA, Lenz EM, and Wilson ID

Toxicology 207(2):179-90, 2005 Feb 14 - Who cited this? | PubMed ID: 15596249 | Fulltext

Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.

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Chienthavorn O, Smith RM, Wilson ID, Wright B, and Lenz EM

Phytochemical analysis : PCA 16(3):217-21, 2005 - Who cited this? | PubMed ID: 15997856 | Fulltext

Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat.

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Lenz EM, Bright J, Knight R, Westwood FR, Davies D, Major H, and Wilson ID

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 10(2-3):173-87, 2005 - Who cited this? | PubMed ID: 16076731 | Fulltext

Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects.

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Lenz EM, Bright J, Wilson ID, Hughes A, Morrisson J, Lindberg H, and Lockton A

Journal of pharmaceutical and biomedical analysis 36(4):841-9, 2004 Nov 19 - Who cited this? | PubMed ID: 15533678 | Fulltext

Superheated water chromatography-nuclear magnetic resonance spectroscopy and mass spectrometry of vitamins.

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Chienthavorn O, Smith RM, Saha S, Wilson ID, Wright B, Taylor SD, and Lenz EM

Journal of pharmaceutical and biomedical analysis 36(3):477-82, 2004 Nov 15 - Who cited this? | PubMed ID: 15522520 | Fulltext

A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity.

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Lenz EM, Bright J, Knight R, Wilson ID, and Major H

The Analyst 129(6):535-41, 2004 Jun - Who cited this? | PubMed ID: 15152332 | Fulltext

Cyclosporin A-induced changes in endogenous metabolites in rat urine: a metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics.

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Lenz EM, Bright J, Knight R, Wilson ID, and Major H

Journal of pharmaceutical and biomedical analysis 35(3):599-608, 2004 May 28 - Who cited this? | PubMed ID: 15137985 | Fulltext

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse.

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Coen M, Ruepp SU, Lindon JC, Nicholson JK, Pognan F, Lenz EM, and Wilson ID

Journal of pharmaceutical and biomedical analysis 35(1):93-105, 2004 Apr 1 - Who cited this? | PubMed ID: 15030884 | Fulltext

A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects.

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Lenz EM, Bright J, Wilson ID, Morgan SR, and Nash AF

Journal of pharmaceutical and biomedical analysis 33(5):1103-15, 2003 Dec 4 - Who cited this? | PubMed ID: 14656601 | Fulltext

Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences.

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Plumb R, Granger J, Stumpf C, Wilson ID, Evans JA, and Lenz EM

The Analyst 128(7):819-23, 2003 Jul - Who cited this? | PubMed ID: 12894816 | Fulltext

An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy.

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Coen M, Lenz EM, Nicholson JK, Wilson ID, Pognan F, and Lindon JC

Chemical research in toxicology 16(3):295-303, 2003 Mar - Who cited this? | PubMed ID: 12641429 | Fulltext

19F NMR spectroscopic investigation into the absorption and metabolism of 3-trifluoromethylaniline in Eisenia veneta.

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Lenz EM, Lindon JC, Nicholson JK, Weeks JM, and Osborn D

Ecotoxicology and environmental safety 54(2):157-68, 2003 Feb - Who cited this? | PubMed ID: 12550093 | Fulltext

The metabolism of 2-trifluormethylaniline and its acetanilide in the rat by 19F NMR monitored enzyme hydrolysis and 1H/19F HPLC-NMR spectroscopy.

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Tugnait M, Lenz EM, Hofmann M, Spraul M, Wilson ID, Lindon JC, and Nicholson JK

Journal of pharmaceutical and biomedical analysis 30(5):1561-74, 2003 Jan 1 - Who cited this? | PubMed ID: 12467928 | Fulltext

Metabonomic assessment of toxicity of 4-fluoroaniline, 3,5-difluoroaniline and 2-fluoro-4-methylaniline to the earthworm Eisenia veneta (Rosa): identification of new endogenous biomarkers.

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Bundy JG, Lenz EM, Bailey NJ, Gavaghan CL, Svendsen C, Spurgeon D, Hankard PK, Osborn D, Weeks JM, Trauger SA, Speir P, Sanders I, Lindon JC, Nicholson JK, and Tang H

Environmental toxicology and chemistry / SETAC 21(9):1966-72, 2002 Sep - Who cited this? | PubMed ID: 12206438 | Fulltext

The metabolism of 4-trifluoromethoxyaniline and [13C]-4-trifluoromethoxyacetanilide in the rat: detection and identification of metabolites excreted in the urine by NMR and HPLC-NMR.

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Tugnait M, Lenz EM, Phillips P, Hofmann M, Spraul M, Lindon JC, Nicholson JK, and Wilson ID

Journal of pharmaceutical and biomedical analysis 28(5):875-85, 2002 Jun 1 - Who cited this? | PubMed ID: 12039629 | Fulltext

Metabolism of 4-fluoroaniline and 4-fluorobiphenyl in the earthworm Eisenia veneta characterized by high-resolution NMR spectroscopy with directly coupled HPLC-NMR and HPLC-MS.

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Bundy JG, Lenz EM, Osborn D, Weeks JM, Lindon JC, and Nicholson JK

Xenobiotica; the fate of foreign compounds in biological systems 32(6):479-90, 2002 Jun - Who cited this? | PubMed ID: 12160481 | Fulltext

19F-NMR and directly coupled 19F/1H-HPLC-NMR spectroscopic investigations of the metabolism of the model ecotoxin 3-trifluoromethylaniline in the earthworm species Eisenia veneta.

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Lenz EM, Lindon JC, Nicholson JK, Weeks JM, and Osborn D

Xenobiotica; the fate of foreign compounds in biological systems 32(6):535-46, 2002 Jun - Who cited this? | PubMed ID: 12160485 | Fulltext

A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat.

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Lenz EM, Wilson ID, Wright B, Partridge EA, Rodgers CT, Haycock PR, Lindon JC, and Nicholson JK

Journal of pharmaceutical and biomedical analysis 28(1):31-43, 2002 Apr 1 - Who cited this? | PubMed ID: 11861106 | Fulltext

High resolution 1H NMR spectroscopic studies of the composition of the haemolymph of crowd- and solitary-reared nymphs of the desert locust, Schistocerca gregaria.

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Lenz EM, Hägele BF, Wilson ID, and Simpson SJ

Insect biochemistry and molecular biology 32(1):51-6, 2001 Dec - Who cited this? | PubMed ID: 11719068 | Fulltext

Application of directly coupled HPLC-NMR-MS/MS to the identification of metabolites of 5-trifluoromethylpyridone (2-hydroxy-5-trifluoromethylpyridine) in hydroponically grown plants.

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Bailey NJ, Cooper P, Hadfield ST, Lenz EM, Lindon JC, Nicholson JK, Stanley PD, Wilson ID, Wright B, and Taylor SD

Journal of agricultural and food chemistry 48(1):42-6, 2000 Jan - Who cited this? | PubMed ID: 10637049 | Fulltext

Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulfur detection.

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Corcoran O, Nicholson JK, Lenz EM, Abou-Shakra F, Castro-Perez J, Sage AB, and Wilson ID

Rapid communications in mass spectrometry : RCM 14(24):2377-84, 2000 - Who cited this? | PubMed ID: 11114054 | Fulltext

Direct characterization of drug glucuronide isomers in human urine by HPLC-NMR spectroscopy: application to the positional isomers of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid glucuronide.

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Lenz EM, Greatbanks D, Wilson ID, Spraul M, Hofmann M, Troke J, Lindon JC, and Nicholson JK

Analytical chemistry 68(17):2832-7, 1996 Sep 1 - Who cited this? | PubMed ID: 8794920 | Fulltext

Nuclear magnetic resonance and high-performance liquid chromatography-nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide.

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Foxall PJ, Lenz EM, Lindon JC, Neild GH, Wilson ID, and Nicholson JK

Therapeutic drug monitoring 18(4):498-505, 1996 Aug - Who cited this? | PubMed ID: 8857575 | Fulltext

750 MHz HPLC-NMR spectroscopic studies on the separation and characterization of the positional isomers of the glucuronides of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid.

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Sidelmann UG, Lenz EM, Spraul M, Hofmann M, Troke J, Sanderson PN, Lindon JC, Wilson ID, and Nicholson JK

Analytical chemistry 68(1):106-10, 1996 Jan 1 - Who cited this? | PubMed ID: 8779427 | Fulltext

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