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Papers authored by Lea SM

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Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system.

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Tarry MJ, Schäfer E, Chen S, Buchanan G, Greene NP, Lea SM, Palmer T, Saibil HR, and Berks BC

Proceedings of the National Academy of Sciences of the United States of America 106(32):13284-9, 2009 Aug 11 - Who cited this? | PubMed ID: 19666509 | Fulltext

Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase SoxB.

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Sauvé V, Roversi P, Leath KJ, Garman EF, Antrobus R, Lea SM, and Berks BC

The Journal of biological chemistry 284(32):21707-18, 2009 Aug 7 - Who cited this? | PubMed ID: 19535341 | Fulltext

Corrigendum: Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout.

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Hodgkinson JL, Horsley A, Stabat D, Simon M, Johnson S, da Fonseca PC, Morris EP, Wall JS, Lea SM, and Blocker AJ

Nature structural & molecular biology 16(8):897, 2009 Aug - Who cited this? | PubMed ID: 19654620 | Fulltext

A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol.

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Pettigrew DM, Roversi P, Davies SG, Russell AJ, and Lea SM

Acta crystallographica. Section D, Biological crystallography 65(Pt 6):513-22, 2009 Jun - Who cited this? | PubMed ID: 19465765 | Fulltext

Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout.

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Hodgkinson JL, Horsley A, Stabat D, Simon M, Johnson S, da Fonseca PC, Morris EP, Wall JS, Lea SM, and Blocker AJ

Nature structural & molecular biology 16(5):477-85, 2009 May - Who cited this? | PubMed ID: 19396171 | Fulltext

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates.

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Schneider MC, Prosser BE, Caesar JJ, Kugelberg E, Li S, Zhang Q, Quoraishi S, Lovett JE, Deane JE, Sim RB, Roversi P, Johnson S, Tang CM, and Lea SM

Nature 458(7240):890-3, 2009 Apr 16 - Who cited this? | PubMed ID: 19225461 | Fulltext

Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H.

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Kraiczy P, Hanssen-Hübner C, Kitiratschky V, Brenner C, Besier S, Brade V, Simon MM, Skerka C, Roversi P, Lea SM, Stevenson B, Wallich R, and Zipfel PF

International journal of medical microbiology : IJMM 299(4):255-68, 2009 Apr - Who cited this? | PubMed ID: 19138559 | Fulltext

The Escherichia coli Cell Division Protein and Model Tat Substrate SufI (FtsP) Localizes to the Septal Ring and Has a Multicopper Oxidase-Like Structure.

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Tarry M, Arends SJ, Roversi P, Piette E, Sargent F, Berks BC, Weiss DS, and Lea SM

Journal of molecular biology 386(2):504-19, 2009 Feb 20 - Who cited this? | PubMed ID: 19135451 | Fulltext

Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase.

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Barry ER, Lovett JE, Costa A, Lea SM, and Bell SD

Proceedings of the National Academy of Sciences of the United States of America 106(4):1051-6, 2009 Jan 27 - Who cited this? | PubMed ID: 19164574 | Fulltext

Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5.

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Fredslund F, Laursen NS, Roversi P, Jenner L, Oliveira CL, Pedersen JS, Nunn MA, Lea SM, Discipio R, Sottrup-Jensen L, and Andersen GR

Nature immunology 9(8):945, 2008 Aug - Who cited this? | PubMed ID: 18645593 | Fulltext

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.

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Cordle J, Johnson S, Zi Yan Tay J, Roversi P, Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P, Jin B, Redfield C, Baron M, Lea SM, and Handford PA

Nature structural & molecular biology, 2008 Jul 27 - Who cited this? | PubMed ID: 18660822 | Fulltext

Structure of and influence of a tick complement inhibitor on human complement component 5.

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Fredslund F, Laursen NS, Roversi P, Jenner L, Oliveira CL, Pedersen JS, Nunn MA, Lea SM, Discipio R, Sottrup-Jensen L, and Andersen GR

Nature immunology 9(7):753-60, 2008 Jul - Who cited this? | PubMed ID: 18536718 | Fulltext

Crystal structure of Spa40, the specificity switch for the Shigella flexneri type III secretion system.

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Deane JE, Graham SC, Mitchell EP, Flot D, Johnson S, and Lea SM

Molecular microbiology 69(1):267-76, 2008 Jul - Who cited this? | PubMed ID: 18485071 | Fulltext

What's the point of the type III secretion system needle?.

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Blocker AJ, Deane JE, Veenendaal AK, Roversi P, Hodgkinson JL, Johnson S, and Lea SM

Proceedings of the National Academy of Sciences of the United States of America 105(18):6507-13, 2008 May 6 - Who cited this? | PubMed ID: 18458349 | Fulltext

Structures of the Shigella flexneri Type 3 Secretion System Protein MxiC Reveal Conformational Variability Amongst Homologues.

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Deane JE, Roversi P, King C, Johnson S, and Lea SM

Journal of molecular biology 377(4):985-92, 2008 Apr 4 - Who cited this? | PubMed ID: 18304577 | Fulltext

Complement factor H: using atomic resolution structure to illuminate disease mechanisms.

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Barlow PN, Hageman GS, and Lea SM

Advances in experimental medicine and biology 632:117-42, 2008 - Who cited this? | PubMed ID: 19025119 | Fulltext

Structural basis for complement factor H linked age-related macular degeneration.

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Prosser BE, Johnson S, Roversi P, Herbert AP, Blaum BS, Tyrrell J, Jowitt TA, Clark SJ, Tarelli E, Uhrín D, Barlow PN, Sim RB, Day AJ, and Lea SM

The Journal of experimental medicine 204(10):2277, 2007 Oct 1 - Who cited this? | PubMed ID: 17893204 | Fulltext

TatBC, TatB, and TatC form structurally autonomous units within the twin arginine protein transport system of Escherichia coli.

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Orriss GL, Tarry MJ, Ize B, Sargent F, Lea SM, Palmer T, and Berks BC

FEBS letters 581(21):4091, 2007 Aug 21 - Who cited this? | PubMed ID: 17686475 | Fulltext

High-resolution structures of bacterially expressed soluble human CD59.

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Leath KJ, Johnson S, Roversi P, Hughes TR, Smith RA, Mackenzie L, Morgan BP, and Lea SM

Acta crystallographica. Section F, Structural biology and crystallization communications 63(Pt 8):648, 2007 Aug 1 - Who cited this? | PubMed ID: 17671359 | Fulltext

Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.

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Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, and Lea SM

The Journal of biological chemistry 282(30):22023, 2007 Jul 27 - Who cited this? | PubMed ID: 17449467 | Fulltext

The structure of OMCI, a novel lipocalin inhibitor of the complement system.

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Roversi P, Lissina O, Johnson S, Ahmat N, Paesen GC, Ploss K, Boland W, Nunn MA, and Lea SM

Journal of molecular biology 369(3):784-93, 2007 Jun 8 - Who cited this? | PubMed ID: 17445829 | Fulltext

Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8.

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Prosser BE, Johnson S, Roversi P, Clark SJ, Tarelli E, Sim RB, Day AJ, and Lea SM

Acta crystallographica. Section F, Structural biology and crystallization communications 63(Pt 6):480, 2007 Jun 1 - Who cited this? | PubMed ID: 17554167 | Fulltext

Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.

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Johnson S, Roversi P, Espina M, Olive A, Deane JE, Birket S, Field T, Picking WD, Blocker AJ, Galyov EE, Picking WL, and Lea SM

The Journal of biological chemistry 282(6):4035, 2007 Feb 9 - Who cited this? | PubMed ID: 17077085 | Fulltext

Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay.

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Harris CL, Pettigrew DM, Lea SM, and Morgan BP

Journal of immunology (Baltimore, Md. : 1950) 178(1):352, 2007 Jan 1 - Who cited this? | PubMed ID: 17182573 | Fulltext

Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides.

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Tsiftsoglou SA, Arnold JN, Roversi P, Crispin MD, Radcliffe C, Lea SM, Dwek RA, Rudd PM, and Sim RB

Biochimica et biophysica acta 1764(11):1757-66, 2006 Nov - Who cited this? | PubMed ID: 17055788 | Fulltext

Expression, purification, crystallization and preliminary crystallographic analysis of BipD, a component of the Burkholderia pseudomallei type III secretion system.

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Roversi P, Johnson S, Field T, Deane JE, Galyov EE, and Lea SM

Acta crystallographica. Section F, Structural biology and crystallization communications 62(Pt 9):861-4, 2006 Sep 1 - Who cited this? | PubMed ID: 16946464 | Fulltext

Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system.

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Johnson S, Roversi P, Espina M, Deane JE, Birket S, Picking WD, Blocker A, Picking WL, and Lea SM

Acta crystallographica. Section F, Structural biology and crystallization communications 62(Pt 9):865-8, 2006 Sep 1 - Who cited this? | PubMed ID: 16946465 | Fulltext

His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form.

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Clark SJ, Higman VA, Mulloy B, Perkins SJ, Lea SM, Sim RB, and Day AJ

The Journal of biological chemistry 281(34):24713-20, 2006 Aug 25 - Who cited this? | PubMed ID: 16787919 | Fulltext

Molecular model of a type III secretion system needle: Implications for host-cell sensing.

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Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, and Lea SM

Proceedings of the National Academy of Sciences of the United States of America 103(33):12529-33, 2006 Aug 15 - Who cited this? | PubMed ID: 16888041 | Fulltext

Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi.

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Cordes FS, Kraiczy P, Roversi P, Simon MM, Brade V, Jahraus O, Wallis R, Goodstadt L, Ponting CP, Skerka C, Zipfel PF, Wallich R, and Lea SM

International journal of medical microbiology : IJMM 296 Suppl 40:177-84, 2006 May - Who cited this? | PubMed ID: 16530476 | Fulltext

Expression, purification, crystallization and preliminary crystallographic analysis of MxiH, a subunit of the Shigella flexneri type III secretion system needle.

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Deane JE, Cordes FS, Roversi P, Johnson S, Kenjale R, Picking WD, Picking WL, Lea SM, and Blocker A

Acta crystallographica. Section F, Structural biology and crystallization communications 62(Pt 3):302, 2006 Mar 1 - Who cited this? | PubMed ID: 16511329 | Fulltext

Structural and functional insights into the interaction of echoviruses and decay-accelerating factor.

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Pettigrew DM, Williams DT, Kerrigan D, Evans DJ, Lea SM, and Bhella D

The Journal of biological chemistry 281(8):5169, 2006 Feb 24 - Who cited this? | PubMed ID: 16272562 | Fulltext

The characterization of weak protein-protein interactions: evidence from DEER for the trimerization of a von Willebrand Factor A domain in solution.

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Banham JE, Timmel CR, Abbott RJ, Lea SM, and Jeschke G

Angewandte Chemie (International ed. in English) 45(7):1058-61, 2006 Feb 6 - Who cited this? | PubMed ID: 16402415 | Fulltext

The type III needle and the damage done.

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Johnson S, Deane JE, and Lea SM

Current opinion in structural biology 15(6):700-7, 2005 Dec - Who cited this? | PubMed ID: 16263265 | Fulltext

Helical packing of needles from functionally altered Shigella type III secretion systems.

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Cordes FS, Daniell S, Kenjale R, Saurya S, Picking WL, Picking WD, Booy F, Lea SM, and Blocker A

Journal of molecular biology 354(2):206-11, 2005 Nov 25 - Who cited this? | PubMed ID: 16243352 | Fulltext

An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction.

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Dey AK, Khati M, Tang M, Wyatt R, Lea SM, and James W

Journal of virology 79(21):13806-10, 2005 Nov - Who cited this? | PubMed ID: 16227301 | Fulltext

Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation.

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Fry EE, Newman JW, Curry S, Najjam S, Jackson T, Blakemore W, Lea SM, Miller L, Burman A, King AM, and Stuart DI

The Journal of general virology 86(Pt 7):1909, 2005 Jul - Who cited this? | PubMed ID: 15958669 | Fulltext

Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.

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Dey AK, Griffiths C, Lea SM, and James W

RNA (New York, N.Y.) 11(6):873-84, 2005 Jun - Who cited this? | PubMed ID: 15923374 | Fulltext

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.

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Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, and Lea SM

Nature structural & molecular biology 12(3):276-7, 2005 Mar - Who cited this? | PubMed ID: 15711564 | Fulltext

Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55).

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Harris CL, Abbott RJ, Smith RA, Morgan BP, and Lea SM

The Journal of biological chemistry 280(4):2569, 2005 Jan 28 - Who cited this? | PubMed ID: 15536079 | Fulltext

Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT.

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Blanc E, Roversi P, Vonrhein C, Flensburg C, Lea SM, and Bricogne G

Acta crystallographica. Section D, Biological crystallography 60(Pt 12 Pt 1):2210-21, 2004 Dec - Who cited this? | PubMed ID: 15572774 | Fulltext

High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol.

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Pettigrew D, Anderson KL, Billington J, Cota E, Simpson P, Urvil P, Rabuzin F, Roversi P, Nowicki B, du Merle L, Le Bouguénec C, Matthews S, and Lea SM

The Journal of biological chemistry 279(45):46851-7, 2004 Nov 5 - Who cited this? | PubMed ID: 15331605 | Fulltext

Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli.

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White J, Lukacik P, Esser D, Steward M, Giddings N, Bright JR, Fritchley SJ, Morgan BP, Lea SM, Smith GP, and Smith RA

Protein science : a publication of the Protein Society 13(9):2406-15, 2004 Sep - Who cited this? | PubMed ID: 15322283 | Fulltext

An atomic resolution model for assembly, architecture, and function of the Dr adhesins.

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Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguénec C, Lea SM, and Matthews S

Molecular cell 15(4):647-57, 2004 Aug 27 - Who cited this? | PubMed ID: 15327779 | Fulltext

Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi.

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Cordes FS, Kraiczy P, Roversi P, Skerka C, Kirschfink M, Simon MM, Brade V, Lowe ED, Zipfel P, Wallich R, and Lea SM

Acta crystallographica. Section D, Biological crystallography 60(Pt 5):929-32, 2004 May - Who cited this? | PubMed ID: 15103142 | Fulltext

Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule.

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Abbott RJ, Knott V, Roversi P, Neudeck S, Lukacik P, Handford PA, and Lea SM

Acta crystallographica. Section D, Biological crystallography 60(Pt 5):936-8, 2004 May - Who cited this? | PubMed ID: 15103144 | Fulltext

The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55).

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Bhella D, Goodfellow IG, Roversi P, Pettigrew D, Chaudhry Y, Evans DJ, and Lea SM

The Journal of biological chemistry 279(9):8325-32, 2004 Feb 27 - Who cited this? | PubMed ID: 14634014 | Fulltext

Complement regulation at the molecular level: the structure of decay-accelerating factor.

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Lukacik P, Roversi P, White J, Esser D, Smith GP, Billington J, Williams PA, Rudd PM, Wormald MR, Harvey DJ, Crispin MD, Radcliffe CM, Dwek RA, Evans DJ, Morgan BP, Smith RA,

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Proceedings of the National Academy of Sciences of the United States of America 101(5):1279-84, 2004 Feb 3 - Who cited this? | PubMed ID: 14734808 | Fulltext

Helical structure of the needle of the type III secretion system of Shigella flexneri.

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Cordes FS, Komoriya K, Larquet E, Yang S, Egelman EH, Blocker A, and Lea SM

The Journal of biological chemistry 278(19):17103-7, 2003 May 9 - Who cited this? | PubMed ID: 12571230 | Fulltext

Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection.

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Stuart AD, McKee TA, Williams PA, Harley C, Shen S, Stuart DI, Brown TD, and Lea SM

Journal of virology 76(15):7694-704, 2002 Aug - Who cited this? | PubMed ID: 12097583 | Fulltext

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