Papers authored by Larner AC

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Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.
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Gough DJ, Corlett A, Schlessinger K, Wegrzyn J, Larner AC, and Levy DE
Science (New York, N.Y.) 324(5935):1713-6, 2009 Jun 26 - Who cited this? | PubMed ID: 19556508 | Fulltext
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Function of mitochondrial Stat3 in cellular respiration.
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Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, 
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Science (New York, N.Y.) 323(5915):793-7, 2009 Feb 6 - Who cited this? | PubMed ID: 19131594 | Fulltext
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Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes.
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Potla R, Koeck T, Wegrzyn J, Cherukuri S, Shimoda K, Baker DP, Wolfman J, Planchon SM, Esposito C, Hoit B, Dulak J, Wolfman A, Stuehr D, and Larner AC
Molecular and cellular biology 26(22):8562-71, 2006 Nov - Who cited this? | PubMed ID: 16982690 | Fulltext
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Type I interferons activate apoptosis in a Jurkat cell variant by caspase-dependent and independent mechanisms.
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Gamero AM, Potla R, Sakamoto S, Baker DP, Abraham R, and Larner AC
Cellular signalling 18(8):1299-308, 2006 Aug - Who cited this? | PubMed ID: 16337360 | Fulltext
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Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells.
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Gamero AM, Potla R, Wegrzyn J, Szelag M, Edling AE, Shimoda K, Link DC, Dulak J, Baker DP, Tanabe Y, Grayson JM, and Larner AC
The Journal of biological chemistry 281(24):16238-44, 2006 Jun 16 - Who cited this? | PubMed ID: 16601124 | Fulltext
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Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes.
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Sakamoto S, Potla R, and Larner AC
The Journal of biological chemistry 279(39):40362-7, 2004 Sep 24 - Who cited this? | PubMed ID: 15194680 | Fulltext
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Identification of a novel conserved motif in the STAT family that is required for tyrosine phosphorylation.
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Gamero AM, Sakamoto S, Montenegro J, and Larner AC
The Journal of biological chemistry 279(13):12379-85, 2004 Mar 26 - Who cited this? | PubMed ID: 14722125 | Fulltext
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Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells.
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Sakamoto S, Qin J, Navarro A, Gamero A, Potla R, Yi T, Zhu W, Baker DP, Feldman G, and Larner AC
The Journal of biological chemistry 279(5):3245-53, 2004 Jan 30 - Who cited this? | PubMed ID: 14600148 | Fulltext
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Thrombomodulin RNA is destabilized through its 3'-untranslated element in cells exposed to IFN-gamma.
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Navarro A, Frevel M, Gamero AM, Williams BR, Feldman G, and Larner AC
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 23(12):723-8, 2003 Dec - Who cited this? | PubMed ID: 14769148 | Fulltext
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A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion.
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Navarro A, Anand-Apte B, Tanabe Y, Feldman G, and Larner AC
Journal of leukocyte biology 73(4):540-5, 2003 Apr - Who cited this? | PubMed ID: 12660229 | Fulltext
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The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation.
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Dong F, Qiu Y, Yi T, Touw IP, and Larner AC
Journal of immunology (Baltimore, Md. : 1950) 167(11):6447-52, 2001 Dec 1 - Who cited this? | PubMed ID: 11714811 | Fulltext
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Vanadate facilitates interferon alpha-mediated apoptosis that is dependent on the Jak/Stat pathway.
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Gamero AM and Larner AC
The Journal of biological chemistry 276(17):13547-53, 2001 Apr 27 - Who cited this? | PubMed ID: 11278370 | Fulltext
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Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival.
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Dong F, Gutkind JS, and Larner AC
The Journal of biological chemistry 276(14):10811-6, 2001 Apr 6 - Who cited this? | PubMed ID: 11278431 | Fulltext
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Signaling via the T cell antigen receptor induces phosphorylation of Stat1 on serine 727.
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Gamero AM and Larner AC
The Journal of biological chemistry 275(22):16574-8, 2000 Jun 2 - Who cited this? | PubMed ID: 10748192 | Fulltext
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Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): evidence for the role of a tyrosine kinase activity distinct from the Janus kinases.
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Dong F and Larner AC
Blood 95(5):1656-62, 2000 Mar 1 - Who cited this? | PubMed ID: 10688821 | Fulltext
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Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.
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Wojnowski L, Stancato LF, Larner AC, Rapp UR, and Zimmer A
Mechanisms of development 91(1-2):97-104, 2000 Mar 1 - Who cited this? | PubMed ID: 10704835 | Fulltext
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A lymphoma growth inhibitor blocks some but not all prolactin-stimulated signaling pathways.
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Yamashita H, Xu J, Erwin RA, Larner AC, and Rui H
The Journal of biological chemistry 274(21):14699-705, 1999 May 21 - Who cited this? | PubMed ID: 10329665 | Fulltext
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Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.
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Ito S, Ansari P, Sakatsume M, Dickensheets H, Vazquez N, Donnelly RP, Larner AC, and Finbloom DS
Blood 93(5):1456-63, 1999 Mar 1 - Who cited this? | PubMed ID: 10029571 | Fulltext
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Craf-1 protein kinase is essential for mouse development.
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Wojnowski L, Stancato LF, Zimmer AM, Hahn H, Beck TW, Larner AC, Rapp UR, and Zimmer A
Mechanisms of development 76(1-2):141-9, 1998 Aug - Who cited this? | PubMed ID: 9767153 | Fulltext
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Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factor.
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Stancato LF, Yu CR, Petricoin EF, and Larner AC
The Journal of biological chemistry 273(30):18701-4, 1998 Jul 24 - Who cited this? | PubMed ID: 9668040 | Fulltext
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Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.
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Wei S, Gamero AM, Liu JH, Daulton AA, Valkov NI, Trapani JA, Larner AC, Weber MJ, and Djeu JY
The Journal of experimental medicine 187(11):1753-65, 1998 Jun 1 - Who cited this? | PubMed ID: 9607917 | Fulltext
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Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.
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Gadina M, Stancato LM, Bacon CM, Larner AC, and O'Shea JJ
Journal of immunology (Baltimore, Md. : 1950) 160(10):4657-61, 1998 May 15 - Who cited this? | PubMed ID: 9590209 | Fulltext
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Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent.
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Sakatsume M, Stancato LF, David M, Silvennoinen O, Saharinen P, Pierce J, Larner AC, and Finbloom DS
The Journal of biological chemistry 273(5):3021-6, 1998 Jan 30 - Who cited this? | PubMed ID: 9446616 | Fulltext
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Antiproliferative action of interferon-alpha requires components of T-cell-receptor signalling.
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Petricoin EF, Ito S, Williams BL, Audet S, Stancato LF, Gamero A, Clouse K, Grimley P, Weiss A, Beeler J, Finbloom DS, Shores EW, Abraham R, and Larner AC
Nature 390(6660):629-32, 1997 Dec 11 - Who cited this? | PubMed ID: 9403695 | Fulltext
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Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway.
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Stancato LF, Sakatsume M, David M, Dent P, Dong F, Petricoin EF, Krolewski JJ, Silvennoinen O, Saharinen P, Pierce J, Marshall CJ, Sturgill T, Finbloom DS, and Larner AC
Molecular and cellular biology 17(7):3833-40, 1997 Jul - Who cited this? | PubMed ID: 9199317 | Fulltext
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Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.
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Kirken RA, Malabarba MG, Xu J, Liu X, Farrar WL, Hennighausen L, Larner AC, Grimley PM, and Rui H
The Journal of biological chemistry 272(22):14098-103, 1997 May 30 - Who cited this? | PubMed ID: 9162035 | Fulltext
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Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins.
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Hackett RH, Wang YD, Sweitzer S, Feldman G, Wood WI, and Larner AC
The Journal of biological chemistry 272(17):11128-32, 1997 Apr 25 - Who cited this? | PubMed ID: 9111009 | Fulltext
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Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA.
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Sharf R, Meraro D, Azriel A, Thornton AM, Ozato K, Petricoin EF, Larner AC, Schaper F, Hauser H, and Levi BZ
The Journal of biological chemistry 272(15):9785-92, 1997 Apr 11 - Who cited this? | PubMed ID: 9092512 | Fulltext
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The SH2 domain-containing tyrosine phosphatase PTP1D is required for interferon alpha/beta-induced gene expression.
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David M, Zhou G, Pine R, Dixon JE, and Larner AC
The Journal of biological chemistry 271(27):15862-5, 1996 Jul 5 - Who cited this? | PubMed ID: 8663536 | Fulltext
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STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1.
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David M, Wong L, Flavell R, Thompson SA, Wells A, Larner AC, and Johnson GR
The Journal of biological chemistry 271(16):9185-8, 1996 Apr 19 - Who cited this? | PubMed ID: 8621573 | Fulltext
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Inhibition of alpha interferon but not gamma interferon signal transduction by phorbol esters is mediated by a tyrosine phosphatase.
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Petricoin E, David M, Igarashi K, Benjamin C, Ling L, Goelz S, Finbloom DS, and Larner AC
Molecular and cellular biology 16(4):1419-24, 1996 Apr - Who cited this? | PubMed ID: 8657115 | Fulltext
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Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580.
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DaSilva L, Rui H, Erwin RA, Howard OM, Kirken RA, Malabarba MG, Hackett RH, Larner AC, and Farrar WL
Molecular and cellular endocrinology 117(2):131-40, 1996 Mar 25 - Who cited this? | PubMed ID: 8737372 | Fulltext
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Activation of protein kinase A inhibits interferon induction of the Jak/Stat pathway in U266 cells.
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David M, Petricoin E, and Larner AC
The Journal of biological chemistry 271(9):4585-8, 1996 Mar 1 - Who cited this? | PubMed ID: 8617715 | Fulltext
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Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation.
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Stancato LF, David M, Carter-Su C, Larner AC, and Pratt WB
The Journal of biological chemistry 271(8):4134-7, 1996 Feb 23 - Who cited this? | PubMed ID: 8626752 | Fulltext
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Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.
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David M, Chen HE, Goelz S, Larner AC, and Neel BG
Molecular and cellular biology 15(12):7050-8, 1995 Dec - Who cited this? | PubMed ID: 8524272 | Fulltext
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Regulation of the Jak/STAT signalling pathway.
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Finbloom DS and Larner AC
Cellular signalling 7(8):739-45, 1995 Nov - Who cited this? | PubMed ID: 8593242 | Fulltext
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Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins.
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David M, Petricoin E, Benjamin C, Pine R, Weber MJ, and Larner AC
Science (New York, N.Y.) 269(5231):1721-3, 1995 Sep 22 - Who cited this? | PubMed ID: 7569900 | Fulltext
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Mapping of the cytoplasmic domain of the human growth hormone receptor required for the activation of Jak2 and Stat proteins.
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Hackett RH, Wang YD, and Larner AC
The Journal of biological chemistry 270(36):21326-30, 1995 Sep 8 - Who cited this? | PubMed ID: 7673169 | Fulltext
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Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
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Bacon CM, Petricoin EF, Ortaldo JR, Rees RC, Larner AC, Johnston JA, and O'Shea JJ
Proceedings of the National Academy of Sciences of the United States of America 92(16):7307-11, 1995 Aug 1 - Who cited this? | PubMed ID: 7638186 | Fulltext
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The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors.
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Sakatsume M, Igarashi K, Winestock KD, Garotta G, Larner AC, and Finbloom DS
The Journal of biological chemistry 270(29):17528-34, 1995 Jul 21 - Who cited this? | PubMed ID: 7615558 | Fulltext
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Characterization of a Stat-like DNA binding activity in Drosophila melanogaster.
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Sweitzer SM, Calvo S, Kraus MH, Finbloom DS, and Larner AC
The Journal of biological chemistry 270(28):16510-3, 1995 Jul 14 - Who cited this? | PubMed ID: 7622453 | Fulltext
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Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.
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Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, and Jove R
Science (New York, N.Y.) 269(5220):81-3, 1995 Jul 7 - Who cited this? | PubMed ID: 7541555 | Fulltext
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Induction of early response genes by interferons, interleukins, and growth factors by the tyrosine phosphorylation of latent transcription factors. Implications for chronic inflammatory diseases.
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Finbloom DS and Larner AC
Arthritis and rheumatism 38(7):877-89, 1995 Jul - Who cited this? | PubMed ID: 7541992 | Fulltext
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Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes.
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Larner AC and Finbloom DS
Biochimica et biophysica acta 1266(3):278-87, 1995 May 12 - Who cited this? | PubMed ID: 7539296 | Fulltext
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Prolactin activates the interferon-regulated p91 transcription factor and the Jak2 kinase by tyrosine phosphorylation.
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David M, Petricoin EF, Igarashi K, Feldman GM, Finbloom DS, and Larner AC
Proceedings of the National Academy of Sciences of the United States of America 91(15):7174-8, 1994 Jul 19 - Who cited this? | PubMed ID: 7518927 | Fulltext
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Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.
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Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Larner AC, and Finbloom DS
The Journal of biological chemistry 269(20):14333-6, 1994 May 20 - Who cited this? | PubMed ID: 7514165 | Fulltext
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Cytokines that associate with the signal transducer gp130 activate the interferon-induced transcription factor p91 by tyrosine phosphorylation.
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Feldman GM, Petricoin EF, David M, Larner AC, and Finbloom DS
The Journal of biological chemistry 269(14):10747-52, 1994 Apr 8 - Who cited this? | PubMed ID: 8144663 | Fulltext
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Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor.
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Meyer DJ, Campbell GS, Cochran BH, Argetsinger LS, Larner AC, Finbloom DS, Carter-Su C, and Schwartz J
The Journal of biological chemistry 269(7):4701-4, 1994 Feb 18 - Who cited this? | PubMed ID: 7508925 | Fulltext
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Human cancer cell lines express a negative transcriptional regulator of the interferon regulatory factor family of DNA binding proteins.
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Petricoin E, David M, Fang H, Grimley P, Larner AC, and Vande Pol S
Molecular and cellular biology 14(2):1477-86, 1994 Feb - Who cited this? | PubMed ID: 8289823 | Fulltext
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A nuclear tyrosine phosphatase downregulates interferon-induced gene expression.
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David M, Grimley PM, Finbloom DS, and Larner AC
Molecular and cellular biology 13(12):7515-21, 1993 Dec - Who cited this? | PubMed ID: 8246969 | Fulltext
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