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Papers authored by Laird ER

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Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors.

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Shiozaki M, Imai H, Maeda K, Miura T, Yasue K, Suma A, Yokota M, Ogoshi Y, Haas J, Fryer AM, Laird ER, Littmann NM, Andrews SW, Josey JA, Mimura T, Shinozaki Y,

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Bioorganic & medicinal chemistry letters 19(21):6213-7, 2009 Nov 1 - Who cited this? | PubMed ID: 19767207 | Fulltext

Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.

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Robinson RP, Buckbinder L, Haugeto AI, McNiff PA, Millham ML, Reese MR, Schaefer JF, Abramov YA, Bordner J, Chantigny YA, Kleinman EF, Laird ER, Morgan BP, Murray JC, Salter ED, Wessel MD,

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Journal of medicinal chemistry 52(6):1731-43, 2009 Mar 26 - Who cited this? | PubMed ID: 19239259 | Fulltext

Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors.

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Shiozaki M, Maeda K, Miura T, Ogoshi Y, Haas J, Fryer AM, Laird ER, Littmann NM, Andrews SW, Josey JA, Mimura T, Shinozaki Y, Yoshiuchi H, and Inaba T

Bioorganic & medicinal chemistry letters 19(6):1575-80, 2009 Mar 15 - Who cited this? | PubMed ID: 19243944 | Fulltext

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.

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Freeman-Cook KD, Reiter LA, Noe MC, Antipas AS, Danley DE, Datta K, Downs JT, Eisenbeis S, Eskra JD, Garmene DJ, Greer EM, Griffiths RJ, Guzman R, Hardink JR, Janat F, Jones CS,

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Bioorganic & medicinal chemistry letters 17(23):6529-34, 2007 Dec 1 - Who cited this? | PubMed ID: 17935984 | Fulltext

Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors.

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Eary CT, Jones ZS, Groneberg RD, Burgess LE, Mareska DA, Drew MD, Blake JF, Laird ER, Balachari D, O'Sullivan M, Allen A, and Marsh V

Bioorganic & medicinal chemistry letters 17(9):2608-13, 2007 May 1 - Who cited this? | PubMed ID: 17331716 | Fulltext

Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity.

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D'Amico DC, Aya T, Human J, Fotsch C, Chen JJ, Biswas K, Riahi B, Norman MH, Willoughby CA, Hungate R, Reider PJ, Biddlecome G, Lester-Zeiner D, Staden CV, Johnson E, Kamassah A,

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Journal of medicinal chemistry 50(4):607-10, 2007 Feb 22 - Who cited this? | PubMed ID: 17243660 | Fulltext

Potent, selective pyrimidinetrione-based inhibitors of MMP-13.

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Reiter LA, Freeman-Cook KD, Jones CS, Martinelli GJ, Antipas AS, Berliner MA, Datta K, Downs JT, Eskra JD, Forman MD, Greer EM, Guzman R, Hardink JR, Janat F, Keene NF, Laird ER,

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Bioorganic & medicinal chemistry letters 16(22):5822-6, 2006 Nov 15 - Who cited this? | PubMed ID: 16942871 | Fulltext

Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.

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McClure KF, Letavic MA, Kalgutkar AS, Gabel CA, Audoly L, Barberia JT, Braganza JF, Carter D, Carty TJ, Cortina SR, Dombroski MA, Donahue KM, Elliott NC, Gibbons CP, Jordan CK, Kuperman AV,

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Bioorganic & medicinal chemistry letters 16(16):4339-44, 2006 Aug 15 - Who cited this? | PubMed ID: 16759861 | Fulltext

Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.

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McClure KF, Abramov YA, Laird ER, Barberia JT, Cai W, Carty TJ, Cortina SR, Danley DE, Dipesa AJ, Donahue KM, Dombroski MA, Elliott NC, Gabel CA, Han S, Hynes TR, Lemotte PK,

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Journal of medicinal chemistry 48(18):5728, 2005 Sep 8 - Who cited this? | PubMed ID: 16134941 | Fulltext

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

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Blagg JA, Noe MC, Wolf-Gouveia LA, Reiter LA, Laird ER, Chang SP, Danley DE, Downs JT, Elliott NC, Eskra JD, Griffiths RJ, Hardink JR, Haugeto AI, Jones CS, Liras JL, Lopresti-Morrow LL,

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Bioorganic & medicinal chemistry letters 15(7):1807-10, 2005 Apr 1 - Who cited this? | PubMed ID: 15780611 | Fulltext

Structure-based generation of viable leads from small combinatorial libraries.

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Laird ER and Blake JF

Current opinion in drug discovery & development 7(3):354-9, 2004 May - Who cited this? | PubMed ID: 15216940 | Fulltext

Specificity determinants of human cathepsin s revealed by crystal structures of complexes.

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Pauly TA, Sulea T, Ammirati M, Sivaraman J, Danley DE, Griffor MC, Kamath AV, Wang IK, Laird ER, Seddon AP, Ménard R, Cygler M, and Rath VL

Biochemistry 42(11):3203-13, 2003 Mar 25 - Who cited this? | PubMed ID: 12641451 | Fulltext

Engineering autoactivating forms of matrix metalloproteinase-9 and expression of the active enzyme in cultured cells and transgenic mouse brain.

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Fisher KE, Fei Q, Laird ER, Stock JL, Allen MR, Sahagan BG, and Strick CA

Biochemistry 41(26):8289-97, 2002 Jul 2 - Who cited this? | PubMed ID: 12081477 | Fulltext

Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.

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Letavic MA, Axt MZ, Barberia JT, Carty TJ, Danley DE, Geoghegan KF, Halim NS, Hoth LR, Kamath AV, Laird ER, Lopresti-Morrow LL, McClure KF, Mitchell PG, Natarajan V, Noe MC, Pandit J,

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Bioorganic & medicinal chemistry letters 12(10):1387-90, 2002 May 20 - Who cited this? | PubMed ID: 11992783 | Fulltext

Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors.

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Robinson RP, Laird ER, Donahue KM, Lopresti-Morrow LL, Mitchell PG, Reese MR, Reeves LM, Rouch AI, Stam EJ, and Yocum SA

Bioorganic & medicinal chemistry letters 11(9):1211-3, 2001 May 7 - Who cited this? | PubMed ID: 11354379 | Fulltext

Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold.

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Robinson RP, Laird ER, Blake JF, Bordner J, Donahue KM, Lopresti-Morrow LL, Mitchell PG, Reese MR, Reeves LM, Stam EJ, and Yocum SA

Journal of medicinal chemistry 43(12):2293-6, 2000 Jun 15 - Who cited this? | PubMed ID: 10882354 | Fulltext

Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket.

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Reiter LA, Rizzi JP, Pandit J, Lasut MJ, McGahee SM, Parikh VD, Blake JF, Danley DE, Laird ER, Lopez-Anaya A, Lopresti-Morrow LL, Mansour MN, Martinelli GJ, Mitchell PG, Owens BS, Pauly TA,

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Bioorganic & medicinal chemistry letters 9(2):127-32, 1999 Jan 18 - Who cited this? | PubMed ID: 10021913 | Fulltext

Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.

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Narula SS, Yuan RW, Adams SE, Green OM, Green J, Philips TB, Zydowsky LD, Botfield MC, Hatada M, and Laird ER

Structure (London, England : 1993) 3(10):1061-73, 1995 Oct 15 - Who cited this? | PubMed ID: 8590001 | Fulltext

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.

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Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, and Theriault K

Nature 377(6544):32-8, 1995 Sep 7 - Who cited this? | PubMed ID: 7659156 | Fulltext

Reflection of Soft X-Rays.

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Henderson JE and Laird ER

Proceedings of the National Academy of Sciences of the United States of America 14(10):773-7, 1928 Oct - Who cited this? | PubMed ID: 16587406 | Fulltext

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