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Papers authored by Kunselman L

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Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

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Zhang H, Ryono DE, Devasthale P, Wang W, O'Malley K, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Locke K, Zhang L, Lippy J, Kunselman L, Morgan N, Flynn N,

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Bioorganic & medicinal chemistry letters 19(5):1451-6, 2009 Mar 1 - Who cited this? | PubMed ID: 19201606 | Fulltext

Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.

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Wang W, Devasthale P, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Kunselman L, Morgan N, Ponticiello R, Zebo R, Zhang L, Locke K, Lippy J, O'Malley K, Hosagrahara V,

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Bioorganic & medicinal chemistry letters 18(6):1939, 2008 Mar 15 - Who cited this? | PubMed ID: 18291645 | Fulltext

The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.

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Madsen CS, Janovitz E, Zhang R, Nguyen-Tran V, Ryan CS, Yin X, Monshizadegan H, Chang M, D'Arienzo C, Scheer S, Setters R, Search D, Chen X, Zhuang S, Kunselman L, Peters A,

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The Journal of pharmacology and experimental therapeutics 324(2):576-86, 2008 Feb - Who cited this? | PubMed ID: 17986646 | Fulltext

The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.

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Tozzo E, Ponticiello R, Swartz J, Farrelly D, Zebo R, Welzel G, Egan D, Kunselman L, Peters A, Gu L, French M, Chen S, Devasthale P, Janovitz E, Staal A, Harrity T,

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The Journal of pharmacology and experimental therapeutics 321(1):107, 2007 Apr - Who cited this? | PubMed ID: 17259449 | Fulltext

Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.

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Harrity T, Farrelly D, Tieman A, Chu C, Kunselman L, Gu L, Ponticiello R, Cap M, Qu F, Shao C, Wang W, Zhang H, Fenderson W, Chen S, Devasthale P, Jeon Y,

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Diabetes 55(1):240-8, 2006 Jan - Who cited this? | PubMed ID: 16380499 | Fulltext

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

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Sulsky R, Robl JA, Biller SA, Harrity TW, Wetterau J, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 14(20):5067-70, 2004 Oct 18 - Who cited this? | PubMed ID: 15380200 | Fulltext

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.

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Magnin DR, Biller SA, Wetterau J, Robl JA, Dickson JK, Taunk P, Harrity TW, Lawrence RM, Sun CQ, Wang T, Logan J, Fryszman O, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 13(7):1337-40, 2003 Apr 7 - Who cited this? | PubMed ID: 12657277 | Fulltext

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

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Robl JA, Sulsky R, Sun CQ, Simpkins LM, Wang T, Dickson JK, Chen Y, Magnin DR, Taunk P, Slusarchyk WA, Biller SA, Lan SJ, Connolly F, Kunselman LK, Sabrah T, Jamil H,

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Journal of medicinal chemistry 44(6):851-6, 2001 Mar 15 - Who cited this? | PubMed ID: 11300866 | Fulltext

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

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Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois KG, Kunselman LK, Lan SJ, Maccagnan TJ, Ricci B, Yan M,

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Science (New York, N.Y.) 282(5389):751-4, 1998 Oct 23 - Who cited this? | PubMed ID: 9784135 | Fulltext

alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.

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Magnin DR, Biller SA, Chen Y, Dickson JK, Fryszman OM, Lawrence RM, Logan JV, Sieber-McMaster ES, Sulsky RB, Traeger SC, Hsieh DC, Lan SJ, Rinehart JK, Harrity TW, Jolibois KG, Kunselman LK,

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Journal of medicinal chemistry 39(3):657-60, 1996 Feb 2 - Who cited this? | PubMed ID: 8576905 | Fulltext

Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety.

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Dickson JK, Biller SA, Magnin DR, Petrillo EW, Hillyer JW, Hsieh DC, Lan SJ, Rinehart JK, Gregg RE, Harrity TW, Jolibois KG, Kalinowski SS, Kunselman LK, Mookhtiar KA, and Ciosek CP

Journal of medicinal chemistry 39(3):661-4, 1996 Feb 2 - Who cited this? | PubMed ID: 8576906 | Fulltext

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo.

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Ciosek CP, Magnin DR, Harrity TW, Logan JV, Dickson JK, Gordon EM, Hamilton KA, Jolibois KG, Kunselman LK, and Lawrence RM

The Journal of biological chemistry 268(33):24832-7, 1993 Nov 25 - Who cited this? | PubMed ID: 8227045 | Fulltext

Amphotericin B lipid complex therapy of experimental fungal infections in mice.

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Clark JM, Whitney RR, Olsen SJ, George RJ, Swerdel MR, Kunselman L, and Bonner DP

Antimicrobial agents and chemotherapy 35(4):615-21, 1991 Apr - Who cited this? | PubMed ID: 2069367 | Fulltext

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