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Papers authored by Ktorza A

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4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.

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Parmenon C, Guillard J, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Dacquet C, Ktorza A, and Viaud-Massuard MC

Bioorganic & medicinal chemistry letters 19(10):2683-7, 2009 May 15 - Who cited this? | PubMed ID: 19376700 | Fulltext

S26948, a new specific peroxisome proliferator activated receptor gamma modulator improved in vivo hepatic insulin sensitivity in 48 h lipid infused rats.

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Sohn KA, Cruciani-Guglielmacci C, Kassis N, Clément L, Ouali F, Caüzac M, Lebègue N, Berthelot P, Caignard DH, Pégorier JP, Renard P, Dacquet C, Ktorza A, Magnan C, and Consortium of the French Ministry of Research and Technology

European journal of pharmacology 608(1-3):104-11, 2009 Apr 17 - Who cited this? | PubMed ID: 19250932 | Fulltext

Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.

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Leloup C, Tourrel-Cuzin C, Magnan C, Karaca M, Castel J, Carneiro L, Colombani AL, Ktorza A, Casteilla L, and Pénicaud L

Diabetes 58(3):673-81, 2009 Mar - Who cited this? | PubMed ID: 19073765 | Fulltext

Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice.

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Carmona MC, Lefebvre P, Lefebvre B, Galinier A, Benani A, Jeanson Y, Louche K, Flajollet S, Ktorza A, Dacquet C, Pénicaud L, Casteilla L, and Consortium of the French Ministry of Research and Technology: 'Molecules and New Therapeutic Targets'

International journal of obesity (2005) 33(2):204-11, 2009 Feb - Who cited this? | PubMed ID: 19125161 | Fulltext

Exploring Functional beta-Cell Heterogeneity In Vivo Using PSA-NCAM as a Specific Marker.

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Karaca M, Castel J, Tourrel-Cuzin C, Brun M, Géant A, Dubois M, Catesson S, Rodriguez M, Luquet S, Cattan P, Lockhart B, Lang J, Ktorza A, Magnan C, and Kargar C

PLoS ONE 4(5):e5555, 2009 - Who cited this? | PubMed ID: 19440374 | Fulltext

Anatomical versus functional beta-cell mass in experimental diabetes.

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Kargar C and Ktorza A

Diabetes, obesity & metabolism 10 Suppl 4:43-53, 2008 Nov - Who cited this? | PubMed ID: 18834432 | Fulltext

4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.

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Parmenon C, Guillard J, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Dacquet C, Ktorza A, and Viaud-Massuard MC

Bioorganic & medicinal chemistry letters 18(5):1617, 2008 Mar 1 - Who cited this? | PubMed ID: 18255290 | Fulltext

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

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Wallis RH, Collins SC, Kaisaki PJ, Argoud K, Wilder SP, Wallace KJ, Ria M, Ktorza A, Rorsman P, Bihoreau MT, and Gauguier D

PLoS ONE 3(8), 2008 - Who cited this? | PubMed ID: 18698428 | Fulltext

[Anatomical and functional plasticity of pancreatic beta-cells and type 2 diabetes].

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Cerasi E and Ktorza A

Medecine sciences : M/S 23(10):885-94, 2007 Oct - Who cited this? | PubMed ID: 17937902 | Fulltext

Transgenic expression of human INS gene in Ins1/Ins2 double knockout mice leads to insulin underproduction and diabetes in some male mice.

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Karaca M, Durel B, Languille L, Lamotte L, Tourrel-Cuzin C, Leroux L, Abou Sleymane G, Saint-Just S, Bucchini D, Ktorza A, and Joshi RL

Frontiers in bioscience : a journal and virtual library 12:1586-93, 2007 - Who cited this? | PubMed ID: 17127405 | Fulltext

Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes.

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Crane L, Anastassiadou M, El Hage S, Stigliani JL, Baziard-Mouysset G, Payard M, Leger JM, Bizot-Espiard JG, Ktorza A, Caignard DH, and Renard P

Bioorganic & medicinal chemistry 14(22):7419-33, 2006 Nov 15 - Who cited this? | PubMed ID: 16889967 | Fulltext

Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats.

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Argoud K, Wilder SP, McAteer MA, Bihoreau MT, Ouali F, Woon PY, Wallis RH, Ktorza A, and Gauguier D

Diabetologia 49(11):2679-88, 2006 Nov - Who cited this? | PubMed ID: 16983556 | Fulltext

Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing.

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Leloup C, Magnan C, Benani A, Bonnet E, Alquier T, Offer G, Carriere A, Périquet A, Fernandez Y, Ktorza A, Casteilla L, and Pénicaud L

Diabetes 55(7):2084, 2006 Jul - Who cited this? | PubMed ID: 16804079 | Fulltext

Psammomys obesus, a model for environment-gene interactions in type 2 diabetes.

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Kaiser N, Nesher R, Donath MY, Fraenkel M, Behar V, Magnan C, Ktorza A, Cerasi E, and Leibowitz G

Diabetes 54 Suppl 2:S137-44, 2005 Dec - Who cited this? | PubMed ID: 16306331 | Fulltext

Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue.

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Uçkaya G, Delagrange P, Chavanieu A, Grassy G, Berthault MF, Ktorza A, Cerasi E, Leibowitz G, and Kaiser N

The Journal of endocrinology 184(3):505-13, 2005 Mar - Who cited this? | PubMed ID: 15749809 | Fulltext

Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone.

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Cruciani-Guglielmacci C, Vincent-Lamon M, Rouch C, Orosco M, Ktorza A, and Magnan C

American journal of physiology. Endocrinology and metabolism 288(1):E148-54, 2005 Jan - Who cited this? | PubMed ID: 15353406 | Fulltext

Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.

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Kaiser N, Yuli M, Uçkaya G, Oprescu AI, Berthault MF, Kargar C, Donath MY, Cerasi E, and Ktorza A

Diabetes 54(1):138-45, 2005 Jan - Who cited this? | PubMed ID: 15616021 | Fulltext

Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats.

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Cruciani-Guglielmacci C, Hervalet A, Douared L, Sanders NM, Levin BE, Ktorza A, and Magnan C

Diabetologia 47(11):2032-8, 2004 Nov - Who cited this? | PubMed ID: 15599702 | Fulltext

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.

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Wallace KJ, Wallis RH, Collins SC, Argoud K, Kaisaki PJ, Ktorza A, Woon PY, Bihoreau MT, and Gauguier D

Physiological genomics 19(1):1-10, 2004 Sep 16 - Who cited this? | PubMed ID: 15266047 | Fulltext

Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.

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Broca C, Breil V, Cruciani-Guglielmacci C, Manteghetti M, Rouault C, Derouet M, Rizkalla S, Pau B, Petit P, Ribes G, Ktorza A, Gross R, Reach G, and Taouis M

American journal of physiology. Endocrinology and metabolism 287(3), 2004 Sep - Who cited this? | PubMed ID: 15082420 | Fulltext

Intrauterine hyperglycemia increases insulin binding sites but not glucose transporter expression in discrete brain areas in term rat fetuses.

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Leloup C, Magnan C, Alquier T, Mistry S, Offer G, Arnaud E, Kassis N, Ktorza A, and Pénicaud L

Pediatric research 56(2):263-7, 2004 Aug - Who cited this? | PubMed ID: 15181191 | Fulltext

Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production.

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Sarrauste de Menthière C, Chavanieu A, Grassy G, Dalle S, Salazar G, Kervran A, Pfeiffer B, Renard P, Delagrange P, Manechez D, Bakes D, Ktorza A, and Calas B

European journal of medicinal chemistry 39(6):473-80, 2004 Jun - Who cited this? | PubMed ID: 15183905 | Fulltext

Review: pancreatic beta-cell neogenesis revisited.

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Paris M, Tourrel-Cuzin C, Plachot C, and Ktorza A

Experimental diabesity research 5(2):111-21, 2004 - Who cited this? | PubMed ID: 15203882 | Fulltext

Role of glucose in IRS signaling in rat pancreatic islets: specific effects and interplay with insulin.

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Paris M, Bernard-Kargar C, Vilar J, Kassis N, and Ktorza A

Experimental diabesity research 5(4):257-63, 2004 - Who cited this? | PubMed ID: 15763940 | Fulltext

Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats.

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Paris M, Bernard-Kargar C, Berthault MF, Bouwens L, and Ktorza A

Endocrinology 144(6):2717-27, 2003 Jun - Who cited this? | PubMed ID: 12746336 | Fulltext

Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats.

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Clément L, Cruciani-Guglielmacci C, Magnan C, Vincent M, Douared L, Orosco M, Assimacopoulos-Jeannet F, Pénicaud L, and Ktorza A

Pflugers Archiv : European journal of physiology 445(3):375-80, 2002 Dec - Who cited this? | PubMed ID: 12466940 | Fulltext

Pancreatic beta-cell alpha2A adrenoceptor and phospholipid changes in hyperlipidemic rats.

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Clément L, Kim-Sohn KA, Magnan C, Kassis N, Adnot P, Kergoat M, Assimacopoulos-Jeannet F, Pénicaud L, Hsu F, Turk J, and Ktorza A

Lipids 37(5):501-6, 2002 May - Who cited this? | PubMed ID: 12056593 | Fulltext

Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma norepinephrine concentration and urinary excretion.

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Magnan C, Cruciani C, Clément L, Adnot P, Vincent M, Kergoat M, Girard A, Elghozi JL, Velho G, Beressi N, Bresson JL, and Ktorza A

The Journal of clinical endocrinology and metabolism 86(10):4901-7, 2001 Oct - Who cited this? | PubMed ID: 11600560 | Fulltext

Endocrine pancreas plasticity under physiological and pathological conditions.

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Bernard-Kargar C and Ktorza A

Diabetes 50 Suppl 1:S30-5, 2001 Feb - Who cited this? | PubMed ID: 11272194 | Fulltext

Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity.

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Bernard-Kargar C, Kassis N, Berthault MF, Pralong W, and Ktorza A

Diabetes 50 Suppl 1:S125-30, 2001 Feb - Who cited this? | PubMed ID: 11272170 | Fulltext

Glucose regulates proinsulin and prosomatostatin but not proglucagon messenger ribonucleic acid levels in rat pancreatic islets.

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Dumonteil E, Magnan C, Ritz-Laser B, Ktorza A, Meda P, and Philippe J

Endocrinology 141(1):174-80, 2000 Jan - Who cited this? | PubMed ID: 10614637 | Fulltext

Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats.

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Kassis N, Bernard C, Pusterla A, Casteilla L, Pénicaud L, Richard D, Ricquier D, and Ktorza A

International journal of experimental diabetes research 1(3):185-93, 2000 - Who cited this? | PubMed ID: 11467409 | Fulltext

Chronic exposure to high glucose concentrations increases proglucagon messenger ribonucleic acid levels and glucagon release from InR1G9 cells.

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Dumonteil E, Ritz-Laser B, Magnan C, Grigorescu I, Ktorza A, and Philippe J

Endocrinology 140(10):4644-50, 1999 Oct - Who cited this? | PubMed ID: 10499521 | Fulltext

Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.

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Ritz-Laser B, Meda P, Constant I, Klages N, Charollais A, Morales A, Magnan C, Ktorza A, and Philippe J

Endocrinology 140(9):4005-14, 1999 Sep - Who cited this? | PubMed ID: 10465270 | Fulltext

Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats.

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Pelé-Tounian A, Chan SL, Rondu F, Le Bihan G, Giroix MH, Lamouri A, Touboul E, Pfeiffer B, Manechez D, Renard P, Guardiola-Lemaître B, Godfroid JJ, Pénicaud L, Morgan NG, and Ktorza A

European journal of pharmacology 377(1):81-7, 1999 Jul 14 - Who cited this? | PubMed ID: 10448930 | Fulltext

Neogenesis vs. apoptosis As main components of pancreatic beta cell ass changes in glucose-infused normal and mildly diabetic adult rats.

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Bernard C, Berthault MF, Saulnier C, and Ktorza A

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 13(10):1195-205, 1999 Jul - Who cited this? | PubMed ID: 10385610 | Fulltext

Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 2. Syntheses and biological activities of 1,4-dialkyl-, 1,4-dibenzyl, and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines and isosteric analogues of imidazoline.

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Le Bihan G, Rondu F, Pelé-Tounian A, Wang X, Lidy S, Touboul E, Lamouri A, Dive G, Huet J, Pfeiffer B, Renard P, Guardiola-Lemaître B, Manéchez D, Pénicaud L, Ktorza A, and Godfroid JJ

Journal of medicinal chemistry 42(9):1587-603, 1999 May 6 - Who cited this? | PubMed ID: 10229628 | Fulltext

Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose.

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Magnan C, Collins S, Berthault MF, Kassis N, Vincent M, Gilbert M, Pénicaud L, Ktorza A, and Assimacopoulos-Jeannet F

The Journal of clinical investigation 103(3):413-9, 1999 Feb - Who cited this? | PubMed ID: 9927503 | Fulltext

Lack of melatonin effects on insulin action in normal rats.

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Bizot-Espiard JG, Doublé A, Cousin B, Lesieur D, Guardiola-Lemaître B, Delagrange P, Ktorza A, and Pénicaud L

Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme 30(12):711-6, 1998 Dec - Who cited this? | PubMed ID: 9930627 | Fulltext

Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes.

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Dumonteil E, Magnan C, Ritz-Laser B, Meda P, Dussoix P, Gilbert M, Ktorza A, and Philippe J

Endocrinology 139(11):4540-6, 1998 Nov - Who cited this? | PubMed ID: 9794463 | Fulltext

Rilmenidine normalizes fructose-induced insulin resistance and hypertension in rats.

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Pénicaud L, Berthault MF, Morin J, Dubar M, Ktorza A, and Ferre P

Journal of hypertension. Supplement : official journal of the International Society of Hypertension 16(3):S45-9, 1998 Aug - Who cited this? | PubMed ID: 9747910 | Fulltext

Potent antihyperglycaemic property of a new imidazoline derivative S-22068 (PMS 847) in a rat model of NIDDM.

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Pelé-Tounian A, Wang X, Rondu F, Lamouri A, Touboul E, Marc S, Dokhan R, Pfeiffer B, Manechez D, Renard P, Guardiola-Lemaître B, Godfroid JJ, Pénicaud L, and Ktorza A

British journal of pharmacology 124(8):1591-6, 1998 Aug - Who cited this? | PubMed ID: 9756373 | Fulltext

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.

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Bernard C, Thibault C, Berthault MF, Magnan C, Saulnier C, Portha B, Pralong WF, Pénicaud L, and Ktorza A

Diabetes 47(7):1058-65, 1998 Jul - Who cited this? | PubMed ID: 9648829 | Fulltext

Diurnal rhythms in plasma glucose, insulin, growth hormone and melatonin levels in fasted and hyperglycaemic rats.

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Bizot-Espiard JG, Doublé A, Guardiola-Lemaitre B, Delagrange P, Ktorza A, and Pénicaud L

Diabetes & metabolism 24(3):235-40, 1998 Jun - Who cited this? | PubMed ID: 9690056 | Fulltext

Hormonal counterregulation failure in rats is related to previous hyperglycaemia-hyperinsulinaemia.

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Magnan C, Laury MC, Adnot P, Doaré L, Boucontet L, Kergoat M, Pénicaud L, Ktorza A, and Gilbert M

Diabetes & metabolism 24(1):46-54, 1998 Feb - Who cited this? | PubMed ID: 9534009 | Fulltext

Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benzyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines .

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Rondu F, Le Bihan G, Wang X, Lamouri A, Touboul E, Dive G, Bellahsene T, Pfeiffer B, Renard P, Guardiola-Lemaitre B, Manechez D, Penicaud L, Ktorza A, and Godfroid JJ

Journal of medicinal chemistry 40(23):3793-803, 1997 Nov 7 - Who cited this? | PubMed ID: 9371245 | Fulltext

Increased pancreatic islet blood flow in 48-hour glucose-infused rats: involvement of central and autonomic nervous systems.

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Atef N, Laury MC, N'Guyen JM, Mokhtar N, Ktorza A, and Penicaud L

Endocrinology 138(5):1836-40, 1997 May - Who cited this? | PubMed ID: 9112376 | Fulltext

Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans?.

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Ktorza A, Bernard C, Parent V, Penicaud L, Froguel P, Lathrop M, and Gauguier D

Diabetes & metabolism 23 Suppl 2:38-46, 1997 Mar - Who cited this? | PubMed ID: 9105782 | Fulltext

[Possible contribution of hyperglycemia in utero to glucose homeostasis disorders in the adult].

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Ktorza A, Gauguier D, Bihoreau MT, Berthault MF, Marfaing P, and Penicaud L

Journees annuelles de diabetologie de l'Hotel-Dieu:55-68, 1997 - Who cited this? | PubMed ID: 9296992 | Fulltext

[Effects of rilmenidine on rats made insulin resistant and hypertensive by a high fructose diet].

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Berthault MF, Morin J, Dubar M, Ktorza A, Ferré P, and Pénicaud L

Archives des maladies du coeur et des vaisseaux 89(8):1103-6, 1996 Aug - Who cited this? | PubMed ID: 8949387 | Fulltext

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