Please enable Javascript

Labmeeting uses lots of Javascript - basically you can't use the site without it. So please enable Javascript in your browser. If your browser does not support Javascript, we recommend Firefox.

Papers authored by Kopito RR

Collect these papers and discover other ones on Labmeeting. Learn more.

SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.

+ cite this

+ View Abstract

Wang Y, Pearce MM, Sliter DA, Olzmann JA, Christianson JC, Kopito RR, Boeckmann S, Gagen C, Leichner GS, Roitelman J, and Wojcikiewicz RJ

Biochimica et biophysica acta 1793(11):1710-8, 2009 Nov - Who cited this? | PubMed ID: 19751772 | Fulltext

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates.

+ cite this

+ View Abstract

Ren PH, Lauckner JE, Kachirskaia I, Heuser JE, Melki R, and Kopito RR

Nature cell biology 11(2):219-25, 2009 Feb - Who cited this? | PubMed ID: 19151706 | Fulltext

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene.

+ cite this

+ View Abstract

Ryu KY, Garza JC, Lu XY, Barsh GS, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 105(10):4016, 2008 Mar 11 - Who cited this? | PubMed ID: 18299572 | Fulltext

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

+ cite this

+ View Abstract

Christianson JC, Shaler TA, Tyler RE, and Kopito RR

Nature cell biology 10(3):272, 2008 Mar - Who cited this? | PubMed ID: 18264092 | Fulltext

The mouse polyubiquitin gene Ubb is essential for meiotic progression.

+ cite this

+ View Abstract

Ryu KY, Sinnar SA, Reinholdt LG, Vaccari S, Hall S, Garcia MA, Zaitseva TS, Bouley DM, Boekelheide K, Handel MA, Conti M, and Kopito RR

Molecular and cellular biology 28(3):1136, 2008 Feb - Who cited this? | PubMed ID: 18070917 | Fulltext

Global changes to the ubiquitin system in Huntington's disease.

+ cite this

+ View Abstract

Bennett EJ, Shaler TA, Woodman B, Ryu KY, Zaitseva TS, Becker CH, Bates GP, Schulman H, and Kopito RR

Nature 448(7154):704, 2007 Aug 9 - Who cited this? | PubMed ID: 17687326 | Fulltext

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.

+ cite this

+ View Abstract

Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, and Kopito RR

The EMBO journal 26(11):2693, 2007 Jun 6 - Who cited this? | PubMed ID: 17491588 | Fulltext

Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutants.

+ cite this

+ View Abstract

Bruns CK and Kopito RR

The EMBO journal 26(3):855, 2007 Feb 7 - Who cited this? | PubMed ID: 17255946 | Fulltext

Cellular mechanisms of protein quality control.

+ cite this

Bennett EJ, Shaler T, Gonzalez-Zulueta M, Schulman HF, Iwata A, Riley BE, Johnston JA, Bucci M, Nukina N, Ellerby L, and Kopito RR

Rinshō shinkeigaku = Clinical neurology 46(11):805, 2006 Nov - Who cited this? | PubMed ID: 17432184 | Fulltext

Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens.

+ cite this

Ryu KY, Baker RT, and Kopito RR

Analytical biochemistry 353(1):153, 2006 Jun 1 - Who cited this? | PubMed ID: 16643835 | Fulltext

Central pore residues mediate the p97/VCP activity required for ERAD.

+ cite this

+ View Abstract

DeLaBarre B, Christianson JC, Kopito RR, and Brunger AT

Molecular cell 22(4):451, 2006 May 19 - Who cited this? | PubMed ID: 16713576 | Fulltext

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

+ cite this

+ View Abstract

Iwata A, Riley BE, Johnston JA, and Kopito RR

The Journal of biological chemistry 280(48):40282, 2005 Dec 2 - Who cited this? | PubMed ID: 16192271 | Fulltext

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.

+ cite this

+ View Abstract

Iwata A, Christianson JC, Bucci M, Ellerby LM, Nukina N, Forno LS, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 102(37):13135, 2005 Sep 13 - Who cited this? | PubMed ID: 16141322 | Fulltext

Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells.

+ cite this

+ View Abstract

Mukai H, Isagawa T, Goyama E, Tanaka S, Bence NF, Tamura A, Ono Y, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 102(31):10887, 2005 Aug 2 - Who cited this? | PubMed ID: 16040812 | Fulltext

Subversion of cellular autophagosomal machinery by RNA viruses.

+ cite this

+ View Abstract

Jackson WT, Giddings TH, Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, and Kirkegaard K

PLoS biology 3(5):0, 2005 May - Who cited this? | PubMed ID: 15884975 | Fulltext

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

+ cite this

+ View Abstract

Bennett EJ, Bence NF, Jayakumar R, and Kopito RR

Molecular cell 17(3):351, 2005 Feb 4 - Who cited this? | PubMed ID: 15694337 | Fulltext

Effect of ubiquitin expression on neuropathogenesis in a mouse model of familial amyotrophic lateral sclerosis.

+ cite this

+ View Abstract

Gilchrist CA, Gray DA, Stieber A, Gonatas NK, and Kopito RR

Neuropathology and applied neurobiology 31(1):20, 2005 Feb - Who cited this? | PubMed ID: 15634228 | Fulltext

Suppression of wild-type rhodopsin maturation by mutants linked to autosomal dominant retinitis pigmentosa.

+ cite this

+ View Abstract

Rajan RS and Kopito RR

The Journal of biological chemistry 280(2):1284, 2005 Jan 14 - Who cited this? | PubMed ID: 15509574 | Fulltext

Application and analysis of the GFPu family of ubiquitin-proteasome system reporters.

+ cite this

+ View Abstract

Bence NF, Bennett EJ, and Kopito RR

Methods in enzymology 399:481, 2005 - Who cited this? | PubMed ID: 16338377 | Fulltext

The missing linker: an unexpected role for a histone deacetylase.

+ cite this

+ View Abstract

Kopito RR

Molecular cell 12(6):1349, 2003 Dec - Who cited this? | PubMed ID: 14690590 | Fulltext

Immunoglobulin light chains dictate vesicular transport-dependent and -independent routes for IgM degradation by the ubiquitin-proteasome pathway.

+ cite this

+ View Abstract

Elkabetz Y, Kerem A, Tencer L, Winitz D, Kopito RR, and Bar-Nun S

The Journal of biological chemistry 278(21):18922, 2003 May 23 - Who cited this? | PubMed ID: 12754269 | Fulltext

Recognition of a single transmembrane degron by sequential quality control checkpoints.

+ cite this

+ View Abstract

Fayadat L and Kopito RR

Molecular biology of the cell 14(3):1268, 2003 Mar - Who cited this? | PubMed ID: 12631739 | Fulltext

The 56th Annual Meeting and Symposium of the Society of General Physiologists: trafficking of transporters.

+ cite this

Kopito RR, Green WN, and Andersen O

The Journal of general physiology 121(2):73, 2003 Feb - Who cited this? | PubMed ID: 12566536 | Fulltext

Cystic fibrosis: premature degradation of mutant proteins as a molecular disease mechanism.

+ cite this

Gelman MS and Kopito RR

Methods in molecular biology (Clifton, N.J.) 232:27, 2003 - Who cited this? | PubMed ID: 12840537 | Fulltext

Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis.

+ cite this

Gelman MS and Kopito RR

The Journal of clinical investigation 110(11):1591, 2002 Dec - Who cited this? | PubMed ID: 12464661 | Fulltext

A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system.

+ cite this

+ View Abstract

Illing ME, Rajan RS, Bence NF, and Kopito RR

The Journal of biological chemistry 277(37):34150, 2002 Sep 13 - Who cited this? | PubMed ID: 12091393 | Fulltext

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes.

+ cite this

+ View Abstract

Johnston JA, Illing ME, and Kopito RR

Cell motility and the cytoskeleton 53(1):26, 2002 Sep - Who cited this? | PubMed ID: 12211113 | Fulltext

A role for mammalian Ubc6 homologues in ER-associated protein degradation.

+ cite this

+ View Abstract

Lenk U, Yu H, Walter J, Gelman MS, Hartmann E, Kopito RR, and Sommer T

Journal of cell science 115(Pt 14):3007, 2002 Jul 15 - Who cited this? | PubMed ID: 12082160 | Fulltext

A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator.

+ cite this

+ View Abstract

Gelman MS, Kannegaard ES, and Kopito RR

The Journal of biological chemistry 277(14):11709, 2002 Apr 5 - Who cited this? | PubMed ID: 11812794 | Fulltext

Cysteine residues in the nucleotide binding domains regulate the conductance state of CFTR channels.

+ cite this

+ View Abstract

Harrington MA and Kopito RR

Biophysical journal 82(3):1278, 2002 Mar - Who cited this? | PubMed ID: 11867445 | Fulltext

Specificity in intracellular protein aggregation and inclusion body formation.

+ cite this

+ View Abstract

Rajan RS, Illing ME, Bence NF, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 98(23):13060, 2001 Nov 6 - Who cited this? | PubMed ID: 11687604 | Fulltext

Impairment of the ubiquitin-proteasome system by protein aggregation.

+ cite this

+ View Abstract

Bence NF, Sampat RM, and Kopito RR

Science (New York, N.Y.) 292(5521):1552, 2001 May 25 - Who cited this? | PubMed ID: 11375494 | Fulltext

Aggresomes, inclusion bodies and protein aggregation.

+ cite this

+ View Abstract

Kopito RR

Trends in cell biology 10(12):524, 2000 Dec - Who cited this? | PubMed ID: 11121744 | Fulltext

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

+ cite this

+ View Abstract

Johnston JA, Dalton MJ, Gurney ME, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 97(23):12571, 2000 Nov 7 - Who cited this? | PubMed ID: 11050163 | Fulltext

Conformational disease.

+ cite this

+ View Abstract

Kopito RR and Ron D

Nature cell biology 2(11):0, 2000 Nov - Who cited this? | PubMed ID: 11056553 | Fulltext

Aggresomes and Russell bodies. Symptoms of cellular indigestion?.

+ cite this

+ View Abstract

Kopito RR and Sitia R

EMBO reports 1(3):225, 2000 Sep - Who cited this? | PubMed ID: 11256604 | Fulltext

The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor.

+ cite this

+ View Abstract

Yu H and Kopito RR

The Journal of biological chemistry 274(52):36852, 1999 Dec 24 - Who cited this? | PubMed ID: 10601236 | Fulltext

Redox reagents and divalent cations alter the kinetics of cystic fibrosis transmembrane conductance regulator channel gating.

+ cite this

+ View Abstract

Harrington MA, Gunderson KL, and Kopito RR

The Journal of biological chemistry 274(39):27536, 1999 Sep 24 - Who cited this? | PubMed ID: 10488089 | Fulltext

Biosynthesis and degradation of CFTR.

+ cite this

+ View Abstract

Kopito RR

Physiological reviews 79(1 Suppl):0, 1999 Jan - Who cited this? | PubMed ID: 9922380 | Fulltext

Aggresomes: a cellular response to misfolded proteins.

+ cite this

+ View Abstract

Johnston JA, Ward CL, and Kopito RR

The Journal of cell biology 143(7):1883, 1998 Dec 28 - Who cited this? | PubMed ID: 9864362 | Fulltext

Cytosolic pH regulates GCl through control of phosphorylation states of CFTR.

+ cite this

+ View Abstract

Reddy MM, Kopito RR, and Quinton PM

The American journal of physiology 275(4 Pt 1):0, 1998 Oct - Who cited this? | PubMed ID: 9755057 | Fulltext

Cotranslational ubiquitination of cystic fibrosis transmembrane conductance regulator in vitro.

+ cite this

+ View Abstract

Sato S, Ward CL, and Kopito RR

The Journal of biological chemistry 273(13):7189, 1998 Mar 27 - Who cited this? | PubMed ID: 9516408 | Fulltext

A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger.

+ cite this

Kobayashi S and Kopito RR

Cell 90(6):following 1159, 1997 Sep 19 - Who cited this? | PubMed ID: 9340197 | Fulltext

Cytosolic degradation of T-cell receptor alpha chains by the proteasome.

+ cite this

+ View Abstract

Yu H, Kaung G, Kobayashi S, and Kopito RR

The Journal of biological chemistry 272(33):20800-4, 1997 Aug 15 - Who cited this? | PubMed ID: 9252404 | Fulltext

ER quality control: the cytoplasmic connection.

+ cite this

Kopito RR

Cell 88(4):427-30, 1997 Feb 21 - Who cited this? | PubMed ID: 9038332 | Fulltext

A cluster of cytoplasmic histidine residues specifies pH dependence of the AE2 plasma membrane anion exchanger.

+ cite this

+ View Abstract

Sekler I, Kobayashi S, and Kopito RR

Cell 86(6):929-35, 1996 Sep 20 - Who cited this? | PubMed ID: 8808628 | Fulltext

Immunocytochemical localization of vacuolar H+-ATPase and Cl--HCO3- anion exchanger (erythrocyte band-3 protein) in avian osteoclasts: effect of calcium-deficient diet on polar expression of the H+-ATPase pump.

+ cite this

+ View Abstract

Bastani B, Ross FP, Kopito RR, and Gluck SL

Calcified tissue international 58(5):332, 1996 May - Who cited this? | PubMed ID: 8661962 | Fulltext

Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP.

+ cite this

+ View Abstract

Reddy MM, Quinton PM, Haws C, Wine JJ, Grygorczyk R, Tabcharani JA, Hanrahan JW, Gunderson KL, and Kopito RR

Science (New York, N.Y.) 271(5257):1876-9, 1996 Mar 29 - Who cited this? | PubMed ID: 8596959 | Fulltext

Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

+ cite this

+ View Abstract

Sato S, Ward CL, Krouse ME, Wine JJ, and Kopito RR

The Journal of biological chemistry 271(2):635, 1996 Jan 12 - Who cited this? | PubMed ID: 8557666 | Fulltext

A conserved glutamate is responsible for ion selectivity and pH dependence of the mammalian anion exchangers AE1 and AE2.

+ cite this

+ View Abstract

Sekler I, Lo RS, and Kopito RR

The Journal of biological chemistry 270(48):28751-8, 1995 Dec 1 - Who cited this? | PubMed ID: 7499397 | Fulltext

Search Google Scholar for Kopito RR

Join Labmeeting

Organize and search your PDF collection
Collect papers
Search millions of papers
Keep up to date with paper alerts
Read your papers from anywhere
Recommend papers to colleagues
Manage your lab

Labmeeting is a web service for researchers. Sign up with your academic email address.

Individuals or corporations not affiliated with an academic institution can request a trial subscription.

Got a question?
The Labmeeting Network
has the answer.
Ask scientists at top universities like Harvard, Stanford, and MIT for their expert opinion!