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Papers authored by Kopito R

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SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.

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Wang Y, Pearce MM, Sliter DA, Olzmann JA, Christianson JC, Kopito RR, Boeckmann S, Gagen C, Leichner GS, Roitelman J, and Wojcikiewicz RJ

Biochimica et biophysica acta 1793(11):1710-8, 2009 Nov - Who cited this? | PubMed ID: 19751772 | Fulltext

Nucleocytoplasmic transport: a thermodynamic mechanism.

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Kopito RB and Elbaum M

HFSP Journal 3(2):130-41, 2009 Apr - Who cited this? | PubMed ID: 19794817 | Fulltext

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates.

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Ren PH, Lauckner JE, Kachirskaia I, Heuser JE, Melki R, and Kopito RR

Nature cell biology 11(2):219-25, 2009 Feb - Who cited this? | PubMed ID: 19151706 | Fulltext

Protein dynamics in individual human cells: experiment and theory.

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Cohen AA, Kalisky T, Mayo A, Geva-Zatorsky N, Danon T, Issaeva I, Kopito RB, Perzov N, Milo R, Sigal A, and Alon U

PLoS ONE 4(4):e4901, 2009 - Who cited this? | PubMed ID: 19381343 | Fulltext

Misfolded proteins partition between two distinct quality control compartments.

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Kaganovich D, Kopito R, and Frydman J

Nature 454(7208):1088, 2008 Aug 28 - Who cited this? | PubMed ID: 18756251 | Fulltext

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene.

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Ryu KY, Garza JC, Lu XY, Barsh GS, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 105(10):4016, 2008 Mar 11 - Who cited this? | PubMed ID: 18299572 | Fulltext

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

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Christianson JC, Shaler TA, Tyler RE, and Kopito RR

Nature cell biology 10(3):272, 2008 Mar - Who cited this? | PubMed ID: 18264092 | Fulltext

The mouse polyubiquitin gene Ubb is essential for meiotic progression.

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Ryu KY, Sinnar SA, Reinholdt LG, Vaccari S, Hall S, Garcia MA, Zaitseva TS, Bouley DM, Boekelheide K, Handel MA, Conti M, and Kopito RR

Molecular and cellular biology 28(3):1136, 2008 Feb - Who cited this? | PubMed ID: 18070917 | Fulltext

Diffusion of anionic and neutral GFP derivatives through plasmodesmata in epidermal cells of Nicotiana benthamiana.

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Dashevskaya S, Kopito RB, Friedman R, Elbaum M, and Epel BL

Protoplasma 234(1-4):13-23, 2008 - Who cited this? | PubMed ID: 18797983 | Fulltext

[Ocular response analyzer: feasibility study and correlation with normal eyes].

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Montard R, Kopito R, Touzeau O, Allouch C, Letaief I, Borderie V, and Laroche L

Journal français d'ophtalmologie 30(10):978, 2007 Dec - Who cited this? | PubMed ID: 18268436 | Fulltext

Global changes to the ubiquitin system in Huntington's disease.

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Bennett EJ, Shaler TA, Woodman B, Ryu KY, Zaitseva TS, Becker CH, Bates GP, Schulman H, and Kopito RR

Nature 448(7154):704, 2007 Aug 9 - Who cited this? | PubMed ID: 17687326 | Fulltext

Reversibility in nucleocytoplasmic transport.

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Kopito RB and Elbaum M

Proceedings of the National Academy of Sciences of the United States of America 104(31):12743, 2007 Jul 31 - Who cited this? | PubMed ID: 17646647 | Fulltext

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance.

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Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, and Kopito RR

The EMBO journal 26(11):2693, 2007 Jun 6 - Who cited this? | PubMed ID: 17491588 | Fulltext

Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutants.

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Bruns CK and Kopito RR

The EMBO journal 26(3):855, 2007 Feb 7 - Who cited this? | PubMed ID: 17255946 | Fulltext

Cellular mechanisms of protein quality control.

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Bennett EJ, Shaler T, Gonzalez-Zulueta M, Schulman HF, Iwata A, Riley BE, Johnston JA, Bucci M, Nukina N, Ellerby L, and Kopito RR

Rinshō shinkeigaku = Clinical neurology 46(11):805, 2006 Nov - Who cited this? | PubMed ID: 17432184 | Fulltext

Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens.

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Ryu KY, Baker RT, and Kopito RR

Analytical biochemistry 353(1):153, 2006 Jun 1 - Who cited this? | PubMed ID: 16643835 | Fulltext

Central pore residues mediate the p97/VCP activity required for ERAD.

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DeLaBarre B, Christianson JC, Kopito RR, and Brunger AT

Molecular cell 22(4):451, 2006 May 19 - Who cited this? | PubMed ID: 16713576 | Fulltext

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.

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Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR,

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Neurobiology of disease 22(2):404, 2006 May - Who cited this? | PubMed ID: 16439141 | Fulltext

[Advantages of the autorefractometer and the Orbscan for measuring pupil diameter].

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Allouch C, Touzeau O, Kopito R, Borderie V, and Laroche L

Journal français d'ophtalmologie 29(4):373, 2006 Apr - Who cited this? | PubMed ID: 16885803 | Fulltext

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

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Iwata A, Riley BE, Johnston JA, and Kopito RR

The Journal of biological chemistry 280(48):40282, 2005 Dec 2 - Who cited this? | PubMed ID: 16192271 | Fulltext

[Crystalline lens biometry using A-scan ultrasound and the Orbscan device].

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Allouch C, Touzeau O, Kopito R, Borderie V, and Laroche L

Journal français d'ophtalmologie 28(9):925, 2005 Nov - Who cited this? | PubMed ID: 16395217 | Fulltext

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.

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Iwata A, Christianson JC, Bucci M, Ellerby LM, Nukina N, Forno LS, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 102(37):13135, 2005 Sep 13 - Who cited this? | PubMed ID: 16141322 | Fulltext

CD8 kinetically promotes ligand binding to the T-cell antigen receptor.

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Gakamsky DM, Luescher IF, Pramanik A, Kopito RB, Lemonnier F, Vogel H, Rigler R, and Pecht I

Biophysical journal 89(3):2121, 2005 Sep - Who cited this? | PubMed ID: 15980174 | Fulltext

Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells.

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Mukai H, Isagawa T, Goyama E, Tanaka S, Bence NF, Tamura A, Ono Y, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 102(31):10887, 2005 Aug 2 - Who cited this? | PubMed ID: 16040812 | Fulltext

Subversion of cellular autophagosomal machinery by RNA viruses.

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Jackson WT, Giddings TH, Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, and Kirkegaard K

PLoS biology 3(5):0, 2005 May - Who cited this? | PubMed ID: 15884975 | Fulltext

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

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Bennett EJ, Bence NF, Jayakumar R, and Kopito RR

Molecular cell 17(3):351, 2005 Feb 4 - Who cited this? | PubMed ID: 15694337 | Fulltext

Effect of ubiquitin expression on neuropathogenesis in a mouse model of familial amyotrophic lateral sclerosis.

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Gilchrist CA, Gray DA, Stieber A, Gonatas NK, and Kopito RR

Neuropathology and applied neurobiology 31(1):20, 2005 Feb - Who cited this? | PubMed ID: 15634228 | Fulltext

Suppression of wild-type rhodopsin maturation by mutants linked to autosomal dominant retinitis pigmentosa.

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Rajan RS and Kopito RR

The Journal of biological chemistry 280(2):1284, 2005 Jan 14 - Who cited this? | PubMed ID: 15509574 | Fulltext

Application and analysis of the GFPu family of ubiquitin-proteasome system reporters.

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Bence NF, Bennett EJ, and Kopito RR

Methods in enzymology 399:481, 2005 - Who cited this? | PubMed ID: 16338377 | Fulltext

The missing linker: an unexpected role for a histone deacetylase.

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Kopito RR

Molecular cell 12(6):1349, 2003 Dec - Who cited this? | PubMed ID: 14690590 | Fulltext

Immunoglobulin light chains dictate vesicular transport-dependent and -independent routes for IgM degradation by the ubiquitin-proteasome pathway.

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Elkabetz Y, Kerem A, Tencer L, Winitz D, Kopito RR, and Bar-Nun S

The Journal of biological chemistry 278(21):18922, 2003 May 23 - Who cited this? | PubMed ID: 12754269 | Fulltext

[Correlation between refraction and ocular biometry].

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Touzeau O, Allouch C, Borderie V, Kopito R, and Laroche L

Journal français d'ophtalmologie 26(4):355, 2003 Apr - Who cited this? | PubMed ID: 12843892 | Fulltext

Recognition of a single transmembrane degron by sequential quality control checkpoints.

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Fayadat L and Kopito RR

Molecular biology of the cell 14(3):1268, 2003 Mar - Who cited this? | PubMed ID: 12631739 | Fulltext

The 56th Annual Meeting and Symposium of the Society of General Physiologists: trafficking of transporters.

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Kopito RR, Green WN, and Andersen O

The Journal of general physiology 121(2):73, 2003 Feb - Who cited this? | PubMed ID: 12566536 | Fulltext

Cystic fibrosis: premature degradation of mutant proteins as a molecular disease mechanism.

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Gelman MS and Kopito RR

Methods in molecular biology (Clifton, N.J.) 232:27, 2003 - Who cited this? | PubMed ID: 12840537 | Fulltext

Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis.

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Gelman MS and Kopito RR

The Journal of clinical investigation 110(11):1591, 2002 Dec - Who cited this? | PubMed ID: 12464661 | Fulltext

A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system.

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Illing ME, Rajan RS, Bence NF, and Kopito RR

The Journal of biological chemistry 277(37):34150, 2002 Sep 13 - Who cited this? | PubMed ID: 12091393 | Fulltext

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes.

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Johnston JA, Illing ME, and Kopito RR

Cell motility and the cytoskeleton 53(1):26, 2002 Sep - Who cited this? | PubMed ID: 12211113 | Fulltext

A role for mammalian Ubc6 homologues in ER-associated protein degradation.

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Lenk U, Yu H, Walter J, Gelman MS, Hartmann E, Kopito RR, and Sommer T

Journal of cell science 115(Pt 14):3007, 2002 Jul 15 - Who cited this? | PubMed ID: 12082160 | Fulltext

A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator.

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Gelman MS, Kannegaard ES, and Kopito RR

The Journal of biological chemistry 277(14):11709, 2002 Apr 5 - Who cited this? | PubMed ID: 11812794 | Fulltext

Cysteine residues in the nucleotide binding domains regulate the conductance state of CFTR channels.

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Harrington MA and Kopito RR

Biophysical journal 82(3):1278, 2002 Mar - Who cited this? | PubMed ID: 11867445 | Fulltext

Specificity in intracellular protein aggregation and inclusion body formation.

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Rajan RS, Illing ME, Bence NF, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 98(23):13060, 2001 Nov 6 - Who cited this? | PubMed ID: 11687604 | Fulltext

Impairment of the ubiquitin-proteasome system by protein aggregation.

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Bence NF, Sampat RM, and Kopito RR

Science (New York, N.Y.) 292(5521):1552, 2001 May 25 - Who cited this? | PubMed ID: 11375494 | Fulltext

Aggresomes, inclusion bodies and protein aggregation.

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Kopito RR

Trends in cell biology 10(12):524, 2000 Dec - Who cited this? | PubMed ID: 11121744 | Fulltext

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

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Johnston JA, Dalton MJ, Gurney ME, and Kopito RR

Proceedings of the National Academy of Sciences of the United States of America 97(23):12571, 2000 Nov 7 - Who cited this? | PubMed ID: 11050163 | Fulltext

Conformational disease.

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Kopito RR and Ron D

Nature cell biology 2(11):0, 2000 Nov - Who cited this? | PubMed ID: 11056553 | Fulltext

Aggresomes and Russell bodies. Symptoms of cellular indigestion?.

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Kopito RR and Sitia R

EMBO reports 1(3):225, 2000 Sep - Who cited this? | PubMed ID: 11256604 | Fulltext

The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor.

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Yu H and Kopito RR

The Journal of biological chemistry 274(52):36852, 1999 Dec 24 - Who cited this? | PubMed ID: 10601236 | Fulltext

Redox reagents and divalent cations alter the kinetics of cystic fibrosis transmembrane conductance regulator channel gating.

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Harrington MA, Gunderson KL, and Kopito RR

The Journal of biological chemistry 274(39):27536, 1999 Sep 24 - Who cited this? | PubMed ID: 10488089 | Fulltext

Biosynthesis and degradation of CFTR.

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Kopito RR

Physiological reviews 79(1 Suppl):0, 1999 Jan - Who cited this? | PubMed ID: 9922380 | Fulltext

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