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Papers authored by Kool ET

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Efficient nucleic Acid detection by templated reductive quencher release.

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Franzini RM and Kool ET

Journal of the American Chemical Society 131(44):16021-3, 2009 Nov 11 - Who cited this? | PubMed ID: 19886694 | Fulltext

Polyfluorophore labels on DNA: dramatic sequence dependence of quenching.

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Teo YN, Wilson JN, and Kool ET

Chemistry (Weinheim an der Bergstrasse, Germany) 15(43):11551-8, 2009 Nov 2 - Who cited this? | PubMed ID: 19780115 | Fulltext

Evolving a polymerase for hydrophobic base analogues.

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Loakes D, Gallego J, Pinheiro VB, Kool ET, and Holliger P

Journal of the American Chemical Society 131(41):14827-37, 2009 Oct 21 - Who cited this? | PubMed ID: 19778048 | Fulltext

Structure and Replication of yDNA: A Novel Genetic Set Widened by Benzo-Homologation.

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Lu H, Lynch SR, Lee AH, and Kool ET

Chembiochem : a European journal of chemical biology 10(15):2530-8, 2009 Oct 12 - Who cited this? | PubMed ID: 19780073 | Fulltext

Enhanced Base Pairing and Replication Efficiency of Thiothymidines, Expanded-size Variants of Thymidine.

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Sintim HO and Kool ET

Journal of the American Chemical Society 131(31):11270, 2009 Aug 12 - Who cited this? | PubMed ID: 19621895 | Fulltext

Redesigning the architecture of the base pair: toward biochemical and biological function of new genetic sets.

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Krueger AT and Kool ET

Chemistry & biology 16(3):242-8, 2009 Mar 27 - Who cited this? | PubMed ID: 19318205 | Fulltext

Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one wavelength.

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Teo YN, Wilson JN, and Kool ET

Journal of the American Chemical Society 131(11):3923-33, 2009 Mar 25 - Who cited this? | PubMed ID: 19254023 | Fulltext

RNA major groove modifications improve siRNA stability and biological activity.

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Terrazas M and Kool ET

Nucleic acids research 37(2):346-53, 2009 Feb - Who cited this? | PubMed ID: 19042976 | Fulltext

Efficient replication bypass of size-expanded DNA base pairs in bacterial cells.

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Delaney JC, Gao J, Liu H, Shrivastav N, Essigmann JM, and Kool ET

Angewandte Chemie (International ed. in English) 48(25):4524-7, 2009 - Who cited this? | PubMed ID: 19444841 | Fulltext

7-azidomethoxy-coumarins as profluorophores for templated nucleic Acid detection.

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Franzini RM and Kool ET

Chembiochem : a European journal of chemical biology 9(18):2981-8, 2008 Dec 15 - Who cited this? | PubMed ID: 19035374 | Fulltext

Polymerase Amplification, Cloning, and Gene Expression of Benzo-Homologous "yDNA" Base Pairs.

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Chelliserrykattil J, Lu H, Lee AH, and Kool ET

Chembiochem : a European journal of chemical biology 9(18):2976-80, 2008 Dec 15 - Who cited this? | PubMed ID: 19053129 | Fulltext

Visualization of Long Human Telomere Mimics by Single-Molecule Fluorescence Imaging.

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Pomerantz AK, Kool ET, and Moerner WE

The journal of physical chemistry. B, 2008 Sep 26 - Who cited this? | PubMed ID: 18817431 | Fulltext

Organometallic activation of a fluorogen for templated nucleic Acid detection.

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Franzini RM and Kool ET

Organic letters 10(14):2935, 2008 Jul 17 - Who cited this? | PubMed ID: 18549220 | Fulltext

Steric Effects in RNA Interference: Probing the Influence of Nucleobase Size and Shape.

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Somoza A, Silverman AP, Miller RM, Chelliserrykattil J, and Kool ET

Chemistry (Weinheim an der Bergstrasse, Germany), 2008 Jul 15 - Who cited this? | PubMed ID: 18624291 | Fulltext

Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase.

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Lee HR, Helquist SA, Kool ET, and Johnson KA

The Journal of biological chemistry 283(21):14411, 2008 May 23 - Who cited this? | PubMed ID: 17650503 | Fulltext

Importance of hydrogen bonding for efficiency and specificity of the human mitochondrial DNA polymerase.

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Lee HR, Helquist SA, Kool ET, and Johnson KA

The Journal of biological chemistry 283(21):14402, 2008 May 23 - Who cited this? | PubMed ID: 17650502 | Fulltext

Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis.

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Silverman AP, Garforth SJ, Prasad VR, and Kool ET

Biochemistry 47(16):4800, 2008 Apr 22 - Who cited this? | PubMed ID: 18366188 | Fulltext

Fluorescence of size-expanded DNA bases: reporting on DNA sequence and structure with an unnatural genetic set.

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Krueger AT and Kool ET

Journal of the American Chemical Society 130(12):3989, 2008 Mar 26 - Who cited this? | PubMed ID: 18311973 | Fulltext

Quenching of fluorescent nucleobases by neighboring DNA: the "insulator" concept.

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Wilson JN, Cho Y, Tan S, Cuppoletti A, and Kool ET

Chembiochem : a European journal of chemical biology 9(2):279, 2008 Jan 25 - Who cited this? | PubMed ID: 18072185 | Fulltext

Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY.

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Livingston AL, O'Shea VL, Kim T, Kool ET, and David SS

Nature chemical biology 4(1):51, 2008 Jan - Who cited this? | PubMed ID: 18026095 | Fulltext

Quenched autoligation probes.

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Silverman AP, Abe H, and Kool ET

Methods in molecular biology (Clifton, N.J.) 429:161, 2008 - Who cited this? | PubMed ID: 18695965 | Fulltext

New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA.

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Miller GP, Silverman AP, and Kool ET

Bioorganic & medicinal chemistry 16(1):56, 2008 Jan 1 - Who cited this? | PubMed ID: 17502150 | Fulltext

Studies of oligodeoxyfluorosides (ODFs) as FRET probes for DNA hybridization.

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Teo YN and Kool ET

Nucleic acids symposium series (2004)(52):233, 2008 - Who cited this? | PubMed ID: 18776339 | Fulltext

Towards the Replication of xDNA, a Size-expanded Unnatural Genetic System.

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Krueger AT, Lu H, Højland T, Liu H, Gao J, and Kool ET

Nucleic acids symposium series (2004)(52):455-6, 2008 - Who cited this? | PubMed ID: 18776450 | Fulltext

Efficient quenching of oligomeric fluorophores on a DNA backbone.

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Wilson JN, Teo YN, and Kool ET

Journal of the American Chemical Society 129(50):15426, 2007 Dec 19 - Who cited this? | PubMed ID: 18027944 | Fulltext

Steric and electrostatic effects in DNA synthesis by the SOS-induced DNA polymerases II and IV of Escherichia coli.

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Silverman AP, Jiang Q, Goodman MF, and Kool ET

Biochemistry 46(48):13874, 2007 Dec 4 - Who cited this? | PubMed ID: 17988102 | Fulltext

Model systems for understanding DNA base pairing.

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Krueger AT and Kool ET

Current opinion in chemical biology 11(6):588, 2007 Dec - Who cited this? | PubMed ID: 17967435 | Fulltext

RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase.

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Silverman AP and Kool ET

Journal of the American Chemical Society 129(35):10626, 2007 Sep 5 - Who cited this? | PubMed ID: 17696348 | Fulltext

Nonpolar isosteres of damaged DNA bases: effective mimicry of mutagenic properties of 8-oxopurines.

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Taniguchi Y and Kool ET

Journal of the American Chemical Society 129(28):8836, 2007 Jul 18 - Who cited this? | PubMed ID: 17592846 | Fulltext

Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission.

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Wilson JN, Gao J, and Kool ET

Tetrahedron 63(17):3427, 2007 Apr 23 - Who cited this? | PubMed ID: 17940588 | Fulltext

Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems.

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Krueger AT, Lu H, Lee AH, and Kool ET

Accounts of chemical research 40(2):141, 2007 Feb - Who cited this? | PubMed ID: 17309194 | Fulltext

The model student: what chemical model systems can teach us about biology.

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Kool ET and Waters ML

Nature chemical biology 3(2):70, 2007 Feb - Who cited this? | PubMed ID: 17235337 | Fulltext

Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection.

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Garforth SJ, Kim TW, Parniak MA, Kool ET, and Prasad VR

Journal of molecular biology 365(1):38, 2007 Jan 5 - Who cited this? | PubMed ID: 17055529 | Fulltext

Oligonucleotide probes for RNA-targeted fluorescence in situ hybridization.

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Silverman AP and Kool ET

Advances in clinical chemistry 43:79, 2007 - Who cited this? | PubMed ID: 17249381 | Fulltext

Syntheses and properties of low-polarity shape mimics of 8-oxopurines.

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Taniguchi Y and Kool ET

Nucleic acids symposium series (2004)(51):217, 2007 - Who cited this? | PubMed ID: 18029664 | Fulltext

Fluorescent DNA base replacements: Reporters and sensors for biological systems.

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Wilson JN and Kool ET

Organic & biomolecular chemistry 4(23):4265, 2006 Dec 7 - Who cited this? | PubMed ID: 17102869 | Fulltext

RNA-templated chemistry in cells: discrimination of Escherichia, Shigella and Salmonella bacterial strains with a new two-color FRET strategy.

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Silverman AP, Baron EJ, and Kool ET

Chembiochem : a European journal of chemical biology 7(12):1890, 2006 Dec - Who cited this? | PubMed ID: 17031884 | Fulltext

Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase.

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Yakovleva L, Lai J, Kool ET, and Shuman S

The Journal of biological chemistry 281(47):35914, 2006 Nov 24 - Who cited this? | PubMed ID: 17005552 | Fulltext

Toward a designed, functioning genetic system with expanded-size base pairs: solution structure of the eight-base xDNA double helix.

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Lynch SR, Liu H, Gao J, and Kool ET

Journal of the American Chemical Society 128(45):14704, 2006 Nov 15 - Who cited this? | PubMed ID: 17090058 | Fulltext

The difluorotoluene debate--a decade later.

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Kool ET and Sintim HO

Chemical communications (Cambridge, England)(35):3665, 2006 Sep 21 - Who cited this? | PubMed ID: 17047807 | Fulltext

Detecting RNA and DNA with templated chemical reactions.

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Silverman AP and Kool ET

Chemical reviews 106(9):3775, 2006 Sep - Who cited this? | PubMed ID: 16967920 | Fulltext

The roles of hydrogen bonding and sterics in RNA interference.

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Somoza A, Chelliserrykattil J, and Kool ET

Angewandte Chemie (International ed. in English) 45(30):4994, 2006 Jul 24 - Who cited this? | PubMed ID: 16802393 | Fulltext

Exploring the limits of DNA size: naphtho-homologated DNA bases and pairs.

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Lee AH and Kool ET

Journal of the American Chemical Society 128(28):9219, 2006 Jul 19 - Who cited this? | PubMed ID: 16834396 | Fulltext

Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides.

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Kim SJ and Kool ET

Journal of the American Chemical Society 128(18):6164, 2006 May 10 - Who cited this? | PubMed ID: 16669686 | Fulltext

Enzymatic synthesis of fluorescent oligomers assembled on a DNA backbone.

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Cho Y and Kool ET

Chembiochem : a European journal of chemical biology 7(4):669, 2006 Apr - Who cited this? | PubMed ID: 16502476 | Fulltext

Remarkable sensitivity to DNA base shape in the DNA polymerase active site.

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Sintim HO and Kool ET

Angewandte Chemie (International ed. in English) 45(12):1974, 2006 Mar 13 - Who cited this? | PubMed ID: 16506248 | Fulltext

Varying DNA base-pair size in subangstrom increments: evidence for a loose, not large, active site in low-fidelity Dpo4 polymerase.

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Mizukami S, Kim TW, Helquist SA, and Kool ET

Biochemistry 45(9):2772, 2006 Mar 7 - Who cited this? | PubMed ID: 16503632 | Fulltext

Dynamics of nucleotide incorporation: snapshots revealed by 2-aminopurine fluorescence studies.

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Hariharan C, Bloom LB, Helquist SA, Kool ET, and Reha-Krantz LJ

Biochemistry 45(9):2836, 2006 Mar 7 - Who cited this? | PubMed ID: 16503638 | Fulltext

Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs.

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Kim TW, Brieba LG, Ellenberger T, and Kool ET

The Journal of biological chemistry 281(4):2289, 2006 Jan 27 - Who cited this? | PubMed ID: 16311403 | Fulltext

DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics.

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Potapova O, Chan C, DeLucia AM, Helquist SA, Kool ET, Grindley ND, and Joyce CM

Biochemistry 45(3):890, 2006 Jan 24 - Who cited this? | PubMed ID: 16411765 | Fulltext

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