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Papers authored by Kliewer SA

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Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release.

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Hofmann AF, Mangelsdorf DJ, and Kliewer SA

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 7(11):1151-4, 2009 Nov - Who cited this? | PubMed ID: 19665580 | Fulltext

FGF21 induces PGC-1{alpha} and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.

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Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, and Burgess SC

Proceedings of the National Academy of Sciences of the United States of America 106(26):10853-8, 2009 Jun 30 - Who cited this? | PubMed ID: 19541642 | Fulltext

Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.

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Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, and Mangelsdorf DJ

Proceedings of the National Academy of Sciences of the United States of America 106(23):9138-43, 2009 Jun 9 - Who cited this? | PubMed ID: 19497877 | Fulltext

MicroRNA let-7 Regulates 3T3-L1 Adipogenesis.

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Sun T, Fu M, Bookout AL, Kliewer SA, and Mangelsdorf DJ

Molecular endocrinology (Baltimore, Md.) 23(6):925-31, 2009 Jun - Who cited this? | PubMed ID: 19324969 | Fulltext

Structural Basis of Human PXR Activation by the Hops Constituent Colupulone.

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Teotico DG, Bischof JJ, Peng L, Kliewer SA, and Redinbo MR

Molecular pharmacology, 2008 Sep 2 - Who cited this? | PubMed ID: 18768384 | Fulltext

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

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Satapati S, He T, Inagaki T, Potthoff M, Merritt ME, Esser V, Mangelsdorf DJ, Kliewer SA, Browning JD, and Burgess SC

Diabetes 57(8):2012, 2008 Aug - Who cited this? | PubMed ID: 18469201 | Fulltext

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

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Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, and Kliewer SA

Cell metabolism 8(1):77, 2008 Jul - Who cited this? | PubMed ID: 18585098 | Fulltext

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

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Lee YK, Schmidt DR, Cummins CL, Choi M, Peng L, Zhang Y, Goodwin B, Hammer RE, Mangelsdorf DJ, and Kliewer SA

Molecular endocrinology (Baltimore, Md.) 22(6):1345, 2008 Jun - Who cited this? | PubMed ID: 18323469 | Fulltext

Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.

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Zhao G, Jeoung NH, Burgess SC, Rosaaen-Stowe KA, Inagaki T, Latif S, Shelton JM, McAnally J, Bassel-Duby R, Harris RA, Richardson JA, and Kliewer SA

American journal of physiology. Heart and circulatory physiology 294(2):H936-43, 2008 Feb - Who cited this? | PubMed ID: 18083902 | Fulltext

FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.

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Jung D, Inagaki T, Gerard RD, Dawson PA, Kliewer SA, Mangelsdorf DJ, and Moschetta A

Journal of lipid research 48(12):2693, 2007 Dec - Who cited this? | PubMed ID: 17823457 | Fulltext

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine.

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Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, Kliewer SA, and Gonzalez FJ

Journal of lipid research 48(12):2664-72, 2007 Dec - Who cited this? | PubMed ID: 17720959 | Fulltext

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.

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Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, and Kuro-o M

The Journal of biological chemistry 282(37):26687, 2007 Sep 14 - Who cited this? | PubMed ID: 17623664 | Fulltext

Endocrine Regulation of the Fasting Response by PPARalpha-Mediated Induction of Fibroblast Growth Factor 21.

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Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, and Kliewer SA

Cell metabolism 5(6):415-25, 2007 Jun - Who cited this? | PubMed ID: 17550777 | Fulltext

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.

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Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, Xu C, Neubert TA, Zhang F, Linhardt RJ, Yu X, White KE, Inagaki T, Kliewer SA, Yamamoto M, Kurosu H,

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Molecular and cellular biology 27(9):3417, 2007 May - Who cited this? | PubMed ID: 17339340 | Fulltext

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.

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Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, and Redinbo MR

Molecular endocrinology (Baltimore, Md.) 21(5):1028-38, 2007 May - Who cited this? | PubMed ID: 17327420 | Fulltext

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

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Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, and Kliewer SA

Pharmacological reviews 58(4):742, 2006 Dec - Who cited this? | PubMed ID: 17132852 | Fulltext

Identification of a hormonal basis for gallbladder filling.

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Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, Mangelsdorf DJ, and Kliewer SA

Nature medicine 12(11):1253-5, 2006 Nov - Who cited this? | PubMed ID: 17072310 | Fulltext

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

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Inagaki T, Moschetta A, Lee YK, Peng L, Zhao G, Downes M, Yu RT, Shelton JM, Richardson JA, Repa JJ, Mangelsdorf DJ, and Kliewer SA

Proceedings of the National Academy of Sciences of the United States of America 103(10):3920-5, 2006 Mar 7 - Who cited this? | PubMed ID: 16473946 | Fulltext

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

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Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, and Kliewer SA

Cell metabolism 2(4):217, 2005 Oct - Who cited this? | PubMed ID: 16213224 | Fulltext

Weaving betaKlotho into bile acid metabolism.

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Moschetta A and Kliewer SA

The Journal of clinical investigation 115(8):2075-7, 2005 Aug - Who cited this? | PubMed ID: 16075052 | Fulltext

Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.

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Li Y, Choi M, Suino K, Kovach A, Daugherty J, Kliewer SA, and Xu HE

Proceedings of the National Academy of Sciences of the United States of America 102(27):9505, 2005 Jul 5 - Who cited this? | PubMed ID: 15976031 | Fulltext

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.

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Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, and Redinbo MR

Molecular endocrinology (Baltimore, Md.) 19(5):1125, 2005 May - Who cited this? | PubMed ID: 15705662 | Fulltext

Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development.

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Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, and Cooney AJ

Molecular and cellular biology 25(9):3492-505, 2005 May - Who cited this? | PubMed ID: 15831456 | Fulltext

Cholesterol detoxification by the nuclear pregnane X receptor.

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Kliewer SA

Proceedings of the National Academy of Sciences of the United States of America 102(8):2675-6, 2005 Feb 22 - Who cited this? | PubMed ID: 15710871 | Fulltext

Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.

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Li Y, Choi M, Cavey G, Daugherty J, Suino K, Kovach A, Bingham NC, Kliewer SA, and Xu HE

Molecular cell 17(4):491, 2005 Feb 18 - Who cited this? | PubMed ID: 15721253 | Fulltext

Pregnane X receptor: predicting and preventing drug interactions.

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Kliewer SA

Thrombosis research 117(1-2):133-6; discussion 145-51, 2005 - Who cited this? | PubMed ID: 16087223 | Fulltext

The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.

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Suino K, Peng L, Reynolds R, Li Y, Cha JY, Repa JJ, Kliewer SA, and Xu HE

Molecular cell 16(6):893-905, 2004 Dec 22 - Who cited this? | PubMed ID: 15610733 | Fulltext

Enhanced acetaminophen toxicity by activation of the pregnane X receptor.

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Guo GL, Moffit JS, Nicol CJ, Ward JM, Aleksunes LA, Slitt AL, Kliewer SA, Manautou JE, and Gonzalez FJ

Toxicological sciences : an official journal of the Society of Toxicology 82(2):374, 2004 Dec - Who cited this? | PubMed ID: 15456926 | Fulltext

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.

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Liu Y, Binz J, Numerick MJ, Dennis S, Luo G, Desai B, MacKenzie KI, Mansfield TA, Kliewer SA, Goodwin B, and Jones SA

The Journal of clinical investigation 112(11):1678-87, 2003 Dec - Who cited this? | PubMed ID: 14623915 | Fulltext

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.

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Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB, Kliewer SA, Gonzalez FJ, and Sinal CJ

The Journal of biological chemistry 278(46):45062-71, 2003 Nov 14 - Who cited this? | PubMed ID: 12923173 | Fulltext

Anthrax mounts a nuclear attack on glucocorticoid signaling.

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Kliewer SA

Trends in pharmacological sciences 24(11):558-9, 2003 Nov - Who cited this? | PubMed ID: 14607073 | Fulltext

The nuclear pregnane X receptor regulates xenobiotic detoxification.

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Kliewer SA

The Journal of nutrition 133(7 Suppl):2444S-2447S, 2003 Jul - Who cited this? | PubMed ID: 12840222 | Fulltext

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.

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Holt JA, Luo G, Billin AN, Bisi J, McNeill YY, Kozarsky KF, Donahee M, Wang DY, Mansfield TA, Kliewer SA, Goodwin B, and Jones SA

Genes & development 17(13):1581-91, 2003 Jul 1 - Who cited this? | PubMed ID: 12815072 | Fulltext

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.

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Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, and Moore JT

The Journal of biological chemistry 278(19):17277-83, 2003 May 9 - Who cited this? | PubMed ID: 12611900 | Fulltext

Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha.

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Goodwin B, Watson MA, Kim H, Miao J, Kemper JK, and Kliewer SA

Molecular endocrinology (Baltimore, Md.) 17(3):386-94, 2003 Mar - Who cited this? | PubMed ID: 12554795 | Fulltext

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.

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Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, and Redinbo MR

Biochemistry 42(6):1430-8, 2003 Feb 18 - Who cited this? | PubMed ID: 12578355 | Fulltext

Functional and structural comparison of PXR and CAR.

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Moore JT, Moore LB, Maglich JM, and Kliewer SA

Biochimica et biophysica acta 1619(3):235-8, 2003 Feb 17 - Who cited this? | PubMed ID: 12573482 | Fulltext

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.

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Goodwin B, Gauthier KC, Umetani M, Watson MA, Lochansky MI, Collins JL, Leitersdorf E, Mangelsdorf DJ, Kliewer SA, and Repa JJ

Proceedings of the National Academy of Sciences of the United States of America 100(1):223-8, 2003 Jan 7 - Who cited this? | PubMed ID: 12509506 | Fulltext

Cell-free ligand binding assays for nuclear receptors.

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Jones SA, Parks DJ, and Kliewer SA

Methods in enzymology 364:53-71, 2003 - Who cited this? | PubMed ID: 14631839 | Fulltext

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

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Kliewer SA, Goodwin B, and Willson TM

Endocrine reviews 23(5):687-702, 2002 Oct - Who cited this? | PubMed ID: 12372848 | Fulltext

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

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Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, and Kliewer SA

Molecular pharmacology 62(3):638-46, 2002 Sep - Who cited this? | PubMed ID: 12181440 | Fulltext

Nuclear receptors. I. Nuclear receptors and bile acid homeostasis.

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Goodwin B and Kliewer SA

American journal of physiology. Gastrointestinal and liver physiology 282(6):G926-31, 2002 Jun - Who cited this? | PubMed ID: 12016116 | Fulltext

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.

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Whitney KD, Watson MA, Collins JL, Benson WG, Stone TM, Numerick MJ, Tippin TK, Wilson JG, Winegar DA, and Kliewer SA

Molecular endocrinology (Baltimore, Md.) 16(6):1378-85, 2002 Jun - Who cited this? | PubMed ID: 12040022 | Fulltext

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.

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Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA, and Willson TM

Journal of medicinal chemistry 45(10):1963-6, 2002 May 9 - Who cited this? | PubMed ID: 11985463 | Fulltext

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.

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Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, and Moore JT

Molecular endocrinology (Baltimore, Md.) 16(5):977, 2002 May - Who cited this? | PubMed ID: 11981033 | Fulltext

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells.

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Muoio DM, Way JM, Tanner CJ, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, and Dohm GL

Diabetes 51(4):901-9, 2002 Apr - Who cited this? | PubMed ID: 11916905 | Fulltext

PXR, CAR and drug metabolism.

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Willson TM and Kliewer SA

Nature reviews. Drug discovery 1(4):259-66, 2002 Apr - Who cited this? | PubMed ID: 12120277 | Fulltext

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor.

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Kliewer SA and Willson TM

Journal of lipid research 43(3):359-64, 2002 Mar - Who cited this? | PubMed ID: 11893771 | Fulltext

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.

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Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, Parks DJ, Moore JT, Kliewer SA, Willson TM, and Stimmel JB

Nature 415(6873):813-7, 2002 Feb 14 - Who cited this? | PubMed ID: 11845213 | Fulltext

Regulation of cyp3a gene transcription by the pregnane x receptor.

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Goodwin B, Redinbo MR, and Kliewer SA

Annual review of pharmacology and toxicology 42:1-23, 2002 - Who cited this? | PubMed ID: 11807162 | Fulltext

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Papers authored by Kliewer SA

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