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Papers authored by Kipling D

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Microwave-assisted Ullmann C-S bond formation: synthesis of the P38alpha MAPK clinical candidate VX-745.

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Bagley MC, Davis T, Dix MC, Fusillo V, Pigeaux M, Rokicki MJ, and Kipling D

The Journal of organic chemistry 74(21):8336-42, 2009 Nov 6 - Who cited this? | PubMed ID: 19778055 | Fulltext

Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification.

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Burton DG, Giles PJ, Sheerin AN, Smith SK, Lawton JJ, Ostler EL, Rhys-Williams W, Kipling D, and Faragher RG

Experimental gerontology 44(10):659-65, 2009 Oct - Who cited this? | PubMed ID: 19631729 | Fulltext

Increased oral fibroblast lifespan is telomerase-independent.

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Enoch S, Wall I, Peake M, Davies L, Farrier J, Giles P, Baird D, Kipling D, Price P, Moseley R, Thomas D, and Stephens P

Journal of dental research 88(10):916-21, 2009 Oct - Who cited this? | PubMed ID: 19783799 | Fulltext

Text-based over-representation analysis of microarray gene lists with annotation bias.

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Leong HS and Kipling D

Nucleic acids research 37(11):e79, 2009 Jun - Who cited this? | PubMed ID: 19429895 | Fulltext

B-cell diversity decreases in old age and is correlated with poor health status.

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Gibson KL, Wu YC, Barnett Y, Duggan O, Vaughan R, Kondeatis E, Nilsson BO, Wikby A, Kipling D, and Dunn-Walters DK

Aging cell 8(1):18-25, 2009 Feb - Who cited this? | PubMed ID: 18986373 | Fulltext

A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence.

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Kipling D, Jones DL, Smith SK, Giles PJ, Jennert-Burston K, Ibrahim B, Sheerin AN, Evans AJ, Rhys-Willams W, and Faragher RG

Experimental eye research 88(2):277-85, 2009 Feb - Who cited this? | PubMed ID: 19087878 | Fulltext

Mechanisms of immunosenescence.

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Caruso C, Buffa S, Candore G, Colonna-Romano G, Dunn-Walters D, Kipling D, and Pawelec G

Immunity & ageing : I & A 6:10, 2009 - Who cited this? | PubMed ID: 19624841 | Fulltext

Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers.

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Wall IB, Moseley R, Baird DM, Kipling D, Giles P, Laffafian I, Price PE, Thomas DW, and Stephens P

The Journal of investigative dermatology 128(10):2526-40, 2008 Oct - Who cited this? | PubMed ID: 18449211 | Fulltext

Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of Ataxia Telangiectasia and Werner syndrome fibroblasts.

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Davis T and Kipling D

Biogerontology, 2008 Oct 1 - Who cited this? | PubMed ID: 18830681 | Fulltext

Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells.

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Bagley MC, Davis T, Dix MC, Murziani PG, Rokicki MJ, and Kipling D

Bioorganic & medicinal chemistry letters 18(13):3745-8, 2008 Jul 1 - Who cited this? | PubMed ID: 18539026 | Fulltext

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey.

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Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, and Abraham CR

Glia 56(1):106-17, 2008 Jan 1 - Who cited this? | PubMed ID: 17963266 | Fulltext

Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells.

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Davis T, Bagley MC, Dix MC, Murziani PG, Rokicki MJ, Widdowson CS, Zayed JM, Bachler MA, and Kipling D

Bioorganic & medicinal chemistry letters 17(24):6832-5, 2007 Dec 15 - Who cited this? | PubMed ID: 17964780 | Fulltext

Cyclin d1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cells.

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Burton DG, Sheerin AN, Ostler EL, Smith K, Giles PJ, Lowe J, Rhys-Williams W, Kipling DG, and Faragher RG

Annals of the New York Academy of Sciences 1119:20-31, 2007 Dec - Who cited this? | PubMed ID: 18056951 | Fulltext

Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.

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Bagley MC, Davis T, Dix MC, Rokicki MJ, and Kipling D

Bioorganic & medicinal chemistry letters 17(18):5107-10, 2007 Sep 15 - Who cited this? | PubMed ID: 17659871 | Fulltext

The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging.

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Davis T, Wyllie FS, Rokicki MJ, Bagley MC, and Kipling D

Annals of the New York Academy of Sciences 1100:455-69, 2007 Apr - Who cited this? | PubMed ID: 17460211 | Fulltext

Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing.

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Bagley MC, Davis T, Dix MC, Widdowson CS, and Kipling D

Organic & biomolecular chemistry 4(22):4158-64, 2006 Nov 21 - Who cited this? | PubMed ID: 17312972 | Fulltext

Prevention of accelerated cell aging in the Werner syndrome.

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Davis T, Haughton MF, Jones CJ, and Kipling D

Annals of the New York Academy of Sciences 1067:243-7, 2006 May - Who cited this? | PubMed ID: 16803993 | Fulltext

Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans.

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Britt-Compton B, Rowson J, Locke M, Mackenzie I, Kipling D, and Baird DM

Human molecular genetics 15(5):725-33, 2006 Mar 1 - Who cited this? | PubMed ID: 16421168 | Fulltext

Comparison of differential gene expression of hot and cold thyroid nodules with primary epithelial cell culture models by investigation of co-regulated gene sets.

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Eszlinger M, Krohn K, Beck M, Kipling D, Forbes-Robertson S, Läuter J, Toenjes A, Wynford-Thomas D, and Paschke R

Biochimica et biophysica acta 1763(3):263-71, 2006 Mar - Who cited this? | PubMed ID: 16545470 | Fulltext

Telomere instability in the male germline.

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Baird DM, Britt-Compton B, Rowson J, Amso NN, Gregory L, and Kipling D

Human molecular genetics 15(1):45, 2006 Jan 1 - Who cited this? | PubMed ID: 16311252 | Fulltext

Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome?.

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Davis T and Kipling D

Rejuvenation research 9(3):402-7, 2006 - Who cited this? | PubMed ID: 16859481 | Fulltext

Telomeres and telomerase biology in vertebrates: progress towards a non-human model for replicative senescence and ageing.

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Davis T and Kipling D

Biogerontology 6(6):371-85, 2005 Dec - Who cited this? | PubMed ID: 16518699 | Fulltext

Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.

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Davis T, Baird DM, Haughton MF, Jones CJ, and Kipling D

The journals of gerontology. Series A, Biological sciences and medical sciences 60(11):1386-93, 2005 Nov - Who cited this? | PubMed ID: 16339323 | Fulltext

Replicative senescence in sheep fibroblasts is a p53 dependent process.

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Davis T, Skinner JW, Faragher RG, Jones CJ, and Kipling D

Experimental gerontology 40(1-2):17-26, 2005 - Who cited this? | PubMed ID: 15664728 | Fulltext

What can progeroid syndromes tell us about human aging?.

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Kipling D, Davis T, Ostler EL, and Faragher RG

Science (New York, N.Y.) 305(5689):1426-31, 2004 Sep 3 - Who cited this? | PubMed ID: 15353794 | Fulltext

Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells.

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Baird DM, Davis T, Rowson J, Jones CJ, and Kipling D

Human molecular genetics 13(14):1515-24, 2004 Jul 15 - Who cited this? | PubMed ID: 15150162 | Fulltext

Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses.

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Stephens P, Grenard P, Aeschlimann P, Langley M, Blain E, Errington R, Kipling D, Thomas D, and Aeschlimann D

Journal of cell science 117(Pt 15):3389-403, 2004 Jul 1 - Who cited this? | PubMed ID: 15199098 | Fulltext

The extent and significance of telomere loss with age.

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Baird DM and Kipling D

Annals of the New York Academy of Sciences 1019:265-8, 2004 Jun - Who cited this? | PubMed ID: 15247026 | Fulltext

Investigation of the signaling pathways involved in the proliferative life span barriers in werner syndrome fibroblasts.

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Davis T, Faragher RG, Jones CJ, and Kipling D

Annals of the New York Academy of Sciences 1019:274-7, 2004 Jun - Who cited this? | PubMed ID: 15247028 | Fulltext

Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy.

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Preto A, Singhrao SK, Haughton MF, Kipling D, Wynford-Thomas D, and Jones CJ

Oncogene 23(23):4136-45, 2004 May 20 - Who cited this? | PubMed ID: 15064743 | Fulltext

Fibroblast clones from patients with Hutchinson-Gilford progeria can senesce despite the presence of telomerase.

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Wallis CV, Sheerin AN, Green MH, Jones CJ, Kipling D, and Faragher RG

Experimental gerontology 39(4):461-7, 2004 Apr - Who cited this? | PubMed ID: 15050279 | Fulltext

Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation.

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Bond J, Jones C, Haughton M, DeMicco C, Kipling D, and Wynford-Thomas D

Experimental cell research 292(1):151-6, 2004 Jan 1 - Who cited this? | PubMed ID: 14720514 | Fulltext

The role of replicative senescence in cancer and human ageing: utility (or otherwise) of murine models.

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Smith SK and Kipling D

Cytogenetic and genome research 105(2-4):455-63, 2004 - Who cited this? | PubMed ID: 15237234 | Fulltext

Normality of oligonucleotide microarray data and implications for parametric statistical analyses.

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Giles PJ and Kipling D

Bioinformatics (Oxford, England) 19(17):2254-62, 2003 Nov 22 - Who cited this? | PubMed ID: 14630654 | Fulltext

A P53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development.

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Evans RJ, Wyllie FS, Wynford-Thomas D, Kipling D, and Jones CJ

Cancer research 63(16):4854-61, 2003 Aug 15 - Who cited this? | PubMed ID: 12941806 | Fulltext

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

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Sviderskaya EV, Gray-Schopfer VC, Hill SP, Smit NP, Evans-Whipp TJ, Bond J, Hill L, Bataille V, Peters G, Kipling D, Wynford-Thomas D, and Bennett DC

Journal of the National Cancer Institute 95(10):723-32, 2003 May 21 - Who cited this? | PubMed ID: 12759390 | Fulltext

Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.

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Davis T, Singhrao SK, Wyllie FS, Haughton MF, Smith PJ, Wiltshire M, Wynford-Thomas D, Jones CJ, Faragher RG, and Kipling D

Journal of cell science 116(Pt 7):1349-57, 2003 Apr 1 - Who cited this? | PubMed ID: 12615976 | Fulltext

Extensive allelic variation and ultrashort telomeres in senescent human cells.

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Baird DM, Rowson J, Wynford-Thomas D, and Kipling D

Nature genetics 33(2):203-7, 2003 Feb - Who cited this? | PubMed ID: 12539050 | Fulltext

An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype.

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Stephens P, Cook H, Hilton J, Jones CJ, Haughton MF, Wyllie FS, Skinner JW, Harding KG, Kipling D, and Thomas DW

Experimental cell research 283(1):22-35, 2003 Feb 1 - Who cited this? | PubMed ID: 12565817 | Fulltext

Telomere-based therapy for immunosenescence.

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Lord JM, Akbar AN, and Kipling D

Trends in immunology 23(4):175-6, 2002 Apr - Who cited this? | PubMed ID: 11923106 | Fulltext

Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus.

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McSharry BP, Jones CJ, Skinner JW, Kipling D, and Wilkinson GW

The Journal of general virology 82(Pt 4):855-63, 2001 Apr - Who cited this? | PubMed ID: 11257191 | Fulltext

Telomeres, replicative senescence and human ageing.

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Kipling D

Maturitas 38(1):25-37; discussion 37-8, 2001 Feb 28 - Who cited this? | PubMed ID: 11311583 | Fulltext

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells.

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Jones CJ, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie FS, Ivan M, Bartek J, Wynford-Thomas D, and Bond JA

Molecular and cellular biology 20(15):5690-9, 2000 Aug - Who cited this? | PubMed ID: 10891505 | Fulltext

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts.

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Wyllie FS, Jones CJ, Skinner JW, Haughton MF, Wallis C, Wynford-Thomas D, Faragher RG, and Kipling D

Nature genetics 24(1):16-7, 2000 Jan - Who cited this? | PubMed ID: 10615119 | Fulltext

Telomere-dependent senescence.

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Kipling D, Wynford-Thomas D, Jones CJ, Akbar A, Aspinall R, Bacchetti S, Blasco MA, Broccoli D, DePinho RA, Edwards DR, Effros RB, Harley CB, Lansdorp PM, Linskens MH, Prowse KR, Newbold RF,

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Nature biotechnology 17(4):313-4, 1999 Apr - Who cited this? | PubMed ID: 10207859 | Fulltext

Telomeres. Ageing hard or hardly ageing?.

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Kipling D and Faragher RG

Nature 398(6724):191, 193, 1999 Mar 18 - Who cited this? | PubMed ID: 10094039 | Fulltext

How might replicative senescence contribute to human ageing?.

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Faragher RG and Kipling D

BioEssays : news and reviews in molecular, cellular and developmental biology 20(12):985, 1998 Dec - Who cited this? | PubMed ID: 10048298 | Fulltext

Isolation of a microsatellite that reveals paralogy between the subtelomeric regions of mouse chromosomes 17 and 19: further evidence for telomere-telomere exchange in the mouse.

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Chambers DM, Kipling D, and Abbott CM

Genomics 53(1):113-4, 1998 Oct 1 - Who cited this? | PubMed ID: 9787084 | Fulltext

Telomerase and cellular lifespan: ending the debate?.

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Faragher RG, Jones CJ, and Kipling D

Nature biotechnology 16(8):701-2, 1998 Aug - Who cited this? | PubMed ID: 9702755 | Fulltext

Mammalian telomerase: catalytic subunit and knockout mice.

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Kipling D

Human molecular genetics 6(12):1999-2004, 1997 Nov - Who cited this? | PubMed ID: 9328462 | Fulltext

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