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Papers authored by Kiener PA

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The design and characterization of oligospecific antibodies for simultaneous targeting of multiple disease mediators.

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Dimasi N, Gao C, Fleming R, Woods RM, Yao XT, Shirinian L, Kiener PA, and Wu H

Journal of molecular biology 393(3):672-92, 2009 Oct 30 - Who cited this? | PubMed ID: 19699208 | Fulltext

Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors.

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Bruckheimer EM, Fazenbaker CA, Gallagher S, Mulgrew K, Fuhrmann S, Coffman KT, Walsh W, Ready S, Cook K, Damschroder M, Kinch M, Kiener PA, Woods R, Gao C, Dall'Acqua W, Wu H,

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Neoplasia (New York, N.Y.) 11(6):509-17, 2 p following 517, 2009 Jun - Who cited this? | PubMed ID: 19484140 | Fulltext

Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus.

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Yao Y, Richman L, Higgs BW, Morehouse CA, de Los Reyes M, Brohawn P, Zhang J, White B, Coyle AJ, Kiener PA, and Jallal B

Arthritis and rheumatism 60(6):1785-96, 2009 Jun - Who cited this? | PubMed ID: 19479852 | Fulltext

Potent control of tumor growth by CEA/CD3-bispecific single-chain antibody constructs that are not competitively inhibited by soluble CEA.

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Lutterbuese R, Raum T, Kischel R, Lutterbuese P, Schlereth B, Schaller E, Mangold S, Rau D, Meier P, Kiener PA, Mulgrew K, Oberst MD, Hammond SA, Baeuerle PA, and Kufer P

Journal of immunotherapy (Hagerstown, Md. : 1997) 32(4):341-52, 2009 May - Who cited this? | PubMed ID: 19342971 | Fulltext

Erratum.

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Yao Y, Richman L, Morehouse C, de Los Reyes M, Higgs BW, Boutrin A, White B, Coyle A, Krueger J, Kiener PA, and Jallal B

PLoS ONE 4(3), 2009 - Who cited this? | PubMed ID: 19347056 | Fulltext

Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis.

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Reed JL, Brewah YA, Delaney T, Welliver T, Burwell T, Benjamin E, Kuta E, Kozhich A, McKinney L, Suzich J, Kiener PA, Avendano L, Velozo L, Humbles A, Welliver RC, and Coyle AJ

The Journal of infectious diseases 198(12):1783-93, 2008 Dec 15 - Who cited this? | PubMed ID: 18980502 | Fulltext

Identification of antibody neutralization epitopes on the fusion protein of human metapneumovirus.

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Ulbrandt ND, Ji H, Patel NK, Barnes AS, Wilson S, Kiener PA, Suzich J, and McCarthy MP

The Journal of general virology 89(Pt 12):3113-8, 2008 Dec - Who cited this? | PubMed ID: 19008400 | Fulltext

A Human Antibody-Drug Conjugate Targeting EphA2 Inhibits Tumor Growth In vivo.

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Jackson D, Gooya J, Mao S, Kinneer K, Xu L, Camara M, Fazenbaker C, Fleming R, Swamynathan S, Meyer D, Senter PD, Gao C, Wu H, Kinch M, Coats S, Kiener PA,

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Cancer research 68(22):9367-74, 2008 Nov 15 - Who cited this? | PubMed ID: 19010911 | Fulltext

YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages.

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Létuvé S, Kozhich A, Arouche N, Grandsaigne M, Reed J, Dombret MC, Kiener PA, Aubier M, Coyle AJ, and Pretolani M

Journal of immunology (Baltimore, Md. : 1950) 181(7):5167-73, 2008 Oct 1 - Who cited this? | PubMed ID: 18802121 | Fulltext

Genomic-Based High Throughput Screening Identifies Small Molecules That Differentially Inhibit the Antiviral and Immunomodulatory Effects of IFN-alpha.

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Chen B, Zong Q, Cibotti R, Morris C, Castaneda J, Naiman B, Liu D, Glodek A, Sims GP, Herbst R, Horrigan SK, Kiener PA, Soppet D, Coyle AJ, and Audoly L

Molecular medicine (Cambridge, Mass.) 14(7-8):374 - Who cited this? | PubMed ID: 18475307 | Fulltext

Type I interferon: potential therapeutic target for psoriasis?.

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Yao Y, Richman L, Morehouse C, de los Reyes M, Higgs BW, Boutrin A, White B, Coyle A, Krueger J, Kiener PA, and Jallal B

PLoS ONE 3(7), 2008 - Who cited this? | PubMed ID: 18648529 | Fulltext

Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab.

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Wu H, Pfarr DS, Losonsky GA, and Kiener PA

Current topics in microbiology and immunology 317:103-23, 2008 - Who cited this? | PubMed ID: 17990791 | Fulltext

Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis.

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Walsh RJ, Kong SW, Yao Y, Jallal B, Kiener PA, Pinkus JL, Beggs AH, Amato AA, and Greenberg SA

Arthritis and rheumatism 56(11):3784-92, 2007 Nov - Who cited this? | PubMed ID: 17968926 | Fulltext

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract.

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Wu H, Pfarr DS, Johnson S, Brewah YA, Woods RM, Patel NK, White WI, Young JF, and Kiener PA

Journal of molecular biology 368(3):652-65, 2007 May 4 - Who cited this? | PubMed ID: 17362988 | Fulltext

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.

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Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, Hua J, An LL, Audoly L, La Rosa G, Bierhaus A, Naworth P,

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Nature immunology 8(5):487, 2007 May - Who cited this? | PubMed ID: 17417641 | Fulltext

Selective targeting and potent control of tumor growth using an EphA2/CD3-Bispecific single-chain antibody construct.

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Hammond SA, Lutterbuese R, Roff S, Lutterbuese P, Schlereth B, Bruckheimer E, Kinch MS, Coats S, Baeuerle PA, Kufer P, and Kiener PA

Cancer research 67(8):3927-35, 2007 Apr 15 - Who cited this? | PubMed ID: 17440108 | Fulltext

Motavizumab, a neutralizing anti-Respiratory Syncytial Virus (Rsv) monoclonal antibody significantly modifies the local and systemic cytokine responses induced by Rsv in the mouse model.

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Mejías A, Chávez-Bueno S, Raynor MB, Connolly J, Kiener PA, Jafri HS, and Ramilo O

Virology journal 4:109, 2007 - Who cited this? | PubMed ID: 17961258 | Fulltext

Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin.

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Mulgrew K, Kinneer K, Yao XT, Ward BK, Damschroder MM, Walsh B, Mao SY, Gao C, Kiener PA, Coats S, Kinch MS, and Tice DA

Molecular cancer therapeutics 5(12):3122, 2006 Dec - Who cited this? | PubMed ID: 17172415 | Fulltext

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

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Dall'Acqua WF, Kiener PA, and Wu H

The Journal of biological chemistry 281(33):23514-24, 2006 Aug 18 - Who cited this? | PubMed ID: 16793771 | Fulltext

Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphoma.

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Hentschel N, Krusch M, Kiener PA, Kolb HJ, Salih HR, and Schmetzer HM

European journal of haematology 77(2):91-101, 2006 Aug - Who cited this? | PubMed ID: 16800841 | Fulltext

Isolation and characterization of monoclonal antibodies which neutralize human metapneumovirus in vitro and in vivo.

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Ulbrandt ND, Ji H, Patel NK, Riggs JM, Brewah YA, Ready S, Donacki NE, Folliot K, Barnes AS, Senthil K, Wilson S, Chen M, Clarke L, MacPhail M, Li J, Woods RM,

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Journal of virology 80(16):7799-806, 2006 Aug - Who cited this? | PubMed ID: 16873237 | Fulltext

Comparative effects of two neutralizing anti-respiratory syncytial virus (RSV) monoclonal antibodies in the RSV murine model: time versus potency.

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Mejías A, Chávez-Bueno S, Ríos AM, Aten MF, Raynor B, Peromingo E, Soni P, Olsen KD, Kiener PA, Gómez AM, Jafri HS, and Ramilo O

Antimicrobial agents and chemotherapy 49(11):4700-7, 2005 Nov - Who cited this? | PubMed ID: 16251314 | Fulltext

Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization.

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Wu H, Pfarr DS, Tang Y, An LL, Patel NK, Watkins JD, Huse WD, Kiener PA, and Young JF

Journal of molecular biology 350(1):126-44, 2005 Jul 1 - Who cited this? | PubMed ID: 15907931 | Fulltext

EphA2 expression is associated with aggressive features in ovarian carcinoma.

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Thaker PH, Deavers M, Celestino J, Thornton A, Fletcher MS, Landen CN, Kinch MS, Kiener PA, and Sood AK

Clinical cancer research : an official journal of the American Association for Cancer Research 10(15):5145, 2004 Aug 1 - Who cited this? | PubMed ID: 15297418 | Fulltext

Analysis of human and primate CD2 molecules by protein sequence and epitope mapping with anti-human CD2 antibodies.

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Damschroder MM, Kozhich AA, Woods RM, Cheng L, Mullikin BA, Wilson SD, Ulbrandt ND, Bachy CM, Wu H, Suzich JA, Kiener PA, Dall'Acqua WF, and White WI

Molecular immunology 41(10):985-1000, 2004 Aug - Who cited this? | PubMed ID: 15302161 | Fulltext

Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

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Pitts WJ, Vaccaro W, Huynh T, Leftheris K, Roberge JY, Barbosa J, Guo J, Brown B, Watson A, Donaldson K, Starling GC, Kiener PA, Poss MA, Dodd JH, and Barrish JC

Bioorganic & medicinal chemistry letters 14(11):2955-8, 2004 Jun 7 - Who cited this? | PubMed ID: 15125967 | Fulltext

PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma.

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Pan CX, Kinch MS, Kiener PA, Langermann S, Serrero G, Sun L, Corvera J, Sweeney CJ, Li L, Zhang S, Baldridge LA, Jones TD, Koch MO, Ulbright TM, Eble JN, and Cheng L

Clinical cancer research : an official journal of the American Association for Cancer Research 10(4):1333-7, 2004 Feb 15 - Who cited this? | PubMed ID: 14977833 | Fulltext

Serum levels of CD137 ligand and CD178 are prognostic factors for progression of myelodysplastic syndrome.

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Salih HR, Nuessler V, Denzlinger C, Starling GC, Kiener PA, and Schmetzer HM

Leukemia & lymphoma 45(2):301-8, 2004 Feb - Who cited this? | PubMed ID: 15101715 | Fulltext

Alterations in Fas (CD 95/Apo-1) and Fas ligand (CD178) expression in acute promyelocytic leukemia during treatment with ATRA.

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Salih HR and Kiener PA

Leukemia & lymphoma 45(1):55-9, 2004 Jan - Who cited this? | PubMed ID: 15061197 | Fulltext

Differential EphA2 epitope display on normal versus malignant cells.

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Coffman KT, Hu M, Carles-Kinch K, Tice D, Donacki N, Munyon K, Kifle G, Woods R, Langermann S, Kiener PA, and Kinch MS

Cancer research 63(22):7907-12, 2003 Nov 15 - Who cited this? | PubMed ID: 14633720 | Fulltext

Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages.

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Park DR, Thomsen AR, Frevert CW, Pham U, Skerrett SJ, Kiener PA, and Liles WC

Journal of immunology (Baltimore, Md. : 1950) 170(12):6209-16, 2003 Jun 15 - Who cited this? | PubMed ID: 12794152 | Fulltext

Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties.

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Wrobleski ST, Chen P, Hynes J, Lin S, Norris DJ, Pandit CR, Spergel S, Wu H, Tokarski JS, Chen X, Gillooly KM, Kiener PA, McIntyre KW, Patil-Koota V, Shuster DJ, Turk LA,

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Journal of medicinal chemistry 46(11):2110-6, 2003 May 22 - Who cited this? | PubMed ID: 12747783 | Fulltext

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

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Dall'Acqua WF, Woods RM, Ward ES, Palaszynski SR, Patel NK, Brewah YA, Wu H, Kiener PA, and Langermann S

Journal of immunology (Baltimore, Md. : 1950) 169(9):5171-80, 2002 Nov 1 - Who cited this? | PubMed ID: 12391234 | Fulltext

C-3 Amido-indole cannabinoid receptor modulators.

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Hynes J, Leftheris K, Wu H, Pandit C, Chen P, Norris DJ, Chen BC, Zhao R, Kiener PA, Chen X, Turk LA, Patil-Koota V, Gillooly KM, Shuster DJ, and McIntyre KW

Bioorganic & medicinal chemistry letters 12(17):2399-402, 2002 Sep 2 - Who cited this? | PubMed ID: 12161142 | Fulltext

In vivo administration of 15-deoxyspergulin inhibits antigen-presenting cell stimulation of T cells and NF-kappaB activation.

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Diegel ML, Nadler SG, and Kiener PA

International immunopharmacology 2(10):1451-64, 2002 Sep - Who cited this? | PubMed ID: 12400875 | Fulltext

4-1 BB ligand--just another costimulating molecule?.

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Salih HR, Kiener PA, and Nüssler V

International journal of clinical pharmacology and therapeutics 40(8):348-53, 2002 Aug - Who cited this? | PubMed ID: 12467303 | Fulltext

Differentiation of promyelocytic leukaemia: alterations in Fas (CD95/Apo-1) and Fas ligand (CD178) expression.

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Salih HR, Starling GC, Brandl SF, Pelka-Fleischer R, Haferlach T, Hiddemann W, Kiener PA, and Nuessler V

British journal of haematology 117(1):76-85, 2002 Apr - Who cited this? | PubMed ID: 11918536 | Fulltext

Retinoic acid and vitamin E modulate expression and release of CD178 in carcinoma cells: consequences for induction of apoptosis in CD95-sensitive cells.

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Salih HR, Starling GC, Knauff M, Llewellyn MB, Davis PM, Pitts WJ, Aruffo A, and Kiener PA

Experimental cell research 270(2):248-58, 2001 Nov 1 - Who cited this? | PubMed ID: 11640888 | Fulltext

Soluble CD137 (4-1BB) ligand is released following leukocyte activation and is found in sera of patients with hematological malignancies.

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Salih HR, Schmetzer HM, Burke C, Starling GC, Dunn R, Pelka-Fleischer R, Nuessler V, and Kiener PA

Journal of immunology (Baltimore, Md. : 1950) 167(7):4059-66, 2001 Oct 1 - Who cited this? | PubMed ID: 11564827 | Fulltext

Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits.

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Matute-Bello G, Liles WC, Frevert CW, Nakamura M, Ballman K, Vathanaprida C, Kiener PA, and Martin TR

American journal of physiology. Lung cellular and molecular physiology 281(2):L328-35, 2001 Aug - Who cited this? | PubMed ID: 11435207 | Fulltext

Cell cycle phase-specific survival of CD95 ligand-challenged Jurkat cells: upregulation of heat-shock response.

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Parr TB, Hofman FM, Kiener PA, and Stohl W

Cellular immunology 211(1):21-9, 2001 Jul 10 - Who cited this? | PubMed ID: 11585384 | Fulltext

Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors.

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Kiener PA, Davis PM, Murray JL, Youssef S, Rankin BM, and Kowala M

International immunopharmacology 1(1):105-18, 2001 Jan - Who cited this? | PubMed ID: 11367508 | Fulltext

Differential susceptibility to CD95 (Apo-1/Fas) and MHC class II-induced apoptosis during murine dendritic cell development.

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McLellan AD, Terbeck G, Mengling T, Starling GC, Kiener PA, Gold R, Bröcker EB, Leverkus M, and Kämpgen E

Cell death and differentiation 7(10):933-8, 2000 Oct - Who cited this? | PubMed ID: 11279539 | Fulltext

Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells.

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Salih HR, Kosowski SG, Haluska VF, Starling GC, Loo DT, Lee F, Aruffo AA, Trail PA, and Kiener PA

Journal of immunology (Baltimore, Md. : 1950) 165(5):2903-10, 2000 Sep 1 - Who cited this? | PubMed ID: 10946324 | Fulltext

Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death.

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Knapp AC, Huang J, Starling G, and Kiener PA

Atherosclerosis 152(1):217-27, 2000 Sep - Who cited this? | PubMed ID: 10996358 | Fulltext

Promotion of activated human B cell apoptosis and inhibition of Ig production by soluble CD95 ligand: CD95-based downregulation of Ig production need not culminate in activated B cell death.

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Stohl W, Xu D, Starling GC, Casali P, and Kiener PA

Cellular immunology 203(1):1-11, 2000 Jul 10 - Who cited this? | PubMed ID: 10915556 | Fulltext

Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS).

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Matute-Bello G, Liles WC, Steinberg KP, Kiener PA, Mongovin S, Chi EY, Jonas M, and Martin TR

Journal of immunology (Baltimore, Md. : 1950) 163(4):2217-25, 1999 Aug 15 - Who cited this? | PubMed ID: 10438964 | Fulltext

Superantigen-driven, CD8+ T cell-mediated down-regulation: CD95 (Fas)-dependent down-regulation of human Ig responses despite CD95-independent killing of activated B cells.

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Stohl W, Lynch DH, Starling GC, and Kiener PA

Journal of immunology (Baltimore, Md. : 1950) 161(7):3292-8, 1998 Oct 1 - Who cited this? | PubMed ID: 9759844 | Fulltext

CD95 (Fas)-based, superantigen-dependent, CD4+ T cell-mediated down-regulation of human in vitro immunoglobulin responses.

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Stohl W, Elliott JE, Lynch DH, and Kiener PA

Journal of immunology (Baltimore, Md. : 1950) 160(11):5231-8, 1998 Jun 1 - Who cited this? | PubMed ID: 9605118 | Fulltext

Analysis of the ligand binding site in Fas (CD95) by site-directed mutagenesis and comparison with TNFR and CD40.

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Starling GC, Kiener PA, Aruffo A, and Bajorath J

Biochemistry 37(11):3723-6, 1998 Mar 17 - Who cited this? | PubMed ID: 9521690 | Fulltext

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