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Papers authored by Keegan AD

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Complex Regulation of Tartrate-resistant Acid Phosphatase (TRAP) Expression by Interleukin 4 (IL-4): IL-4 INDIRECTLY SUPPRESSES RECEPTOR ACTIVATOR OF NF-{kappa}B LIGAND (RANKL)-MEDIATED TRAP EXPRESSION BUT MODESTLY INDUCES ITS EXPRESSION DIRECTLY.

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Yu M, Moreno JL, Stains JP, and Keegan AD

The Journal of biological chemistry 284(47):32968-79, 2009 Nov 20 - Who cited this? | PubMed ID: 19801646 | Fulltext

Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.

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Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, and Elias JA

Clinical immunology (Orlando, Fla.) 132(3):371-84, 2009 Sep - Who cited this? | PubMed ID: 19553159 | Fulltext

An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation.

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Ford AQ, Heller NM, Stephenson L, Boothby MR, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 183(3):1607-16, 2009 Aug 1 - Who cited this? | PubMed ID: 19592641 | Fulltext

Francisella tularensis Live Vaccine Strain Induces Macrophage Alternative Activation as a Survival Mechanism.

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Shirey KA, Cole LE, Keegan AD, and Vogel SN

Journal of immunology (Baltimore, Md. : 1950) 181(6):4159, 2008 Sep 15 - Who cited this? | PubMed ID: 18768873 | Fulltext

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

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LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, and Garcia KC

Cell 132(2):259-72, 2008 Jan 25 - Who cited this? | PubMed ID: 18243101 | Fulltext

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages.

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Heller NM, Qi X, Junttila IS, Shirey KA, Vogel SN, Paul WE, and Keegan AD

Science signaling 1(51):ra17, 2008 - Who cited this? | PubMed ID: 19109239 | Fulltext

IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin.

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Moreno JL, Mikhailenko I, Tondravi MM, and Keegan AD

Journal of leukocyte biology 82(6):1542, 2007 Dec - Who cited this? | PubMed ID: 17855502 | Fulltext

IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway.

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Carey GB, Semenova E, Qi X, and Keegan AD

Cell research 17(11):942-55, 2007 Nov - Who cited this? | PubMed ID: 17968425 | Fulltext

Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention.

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Gwinn WM, Damsker JM, Falahati R, Okwumabua I, Kelly-Welch A, Keegan AD, Vanpouille C, Lee JJ, Dent LA, Leitenberg D, Bukrinsky MI, and Constant SL

Journal of immunology (Baltimore, Md. : 1950) 177(7):4870-9, 2006 Oct 1 - Who cited this? | PubMed ID: 16982929 | Fulltext

Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13.

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Yamada A, Sheikh F, Niimi T, DeMayo FJ, Keegan AD, Donnelly RP, and Kimura S

Journal of immunology (Baltimore, Md. : 1950) 175(9):5708-15, 2005 Nov 1 - Who cited this? | PubMed ID: 16237061 | Fulltext

Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism.

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Greeneltch KM, Kelly-Welch AE, Shi Y, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 175(8):4999-5005, 2005 Oct 15 - Who cited this? | PubMed ID: 16210602 | Fulltext

Interleukin-13 (IL-13) pathway.

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Kelly-Welch A, Hanson EM, and Keegan AD

Science's STKE : signal transduction knowledge environment 2005(293):cm8, 2005 Jul 19 - Who cited this? | PubMed ID: 16030286 | Fulltext

Interleukin-4 (IL-4) pathway.

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Kelly-Welch A, Hanson EM, and Keegan AD

Science's STKE : signal transduction knowledge environment 2005(293):cm9, 2005 Jul 19 - Who cited this? | PubMed ID: 16030287 | Fulltext

Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1.

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Yu WM, Wang S, Keegan AD, Williams MS, and Qu CK

Journal of immunology (Baltimore, Md. : 1950) 174(2):1013-9, 2005 Jan 15 - Who cited this? | PubMed ID: 15634925 | Fulltext

The opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis factor-alpha production.

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Greeneltch KM, Haudenschild CC, Keegan AD, and Shi Y

Brain, behavior, and immunity 18(5):476-84, 2004 Sep - Who cited this? | PubMed ID: 15265541 | Fulltext

Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression.

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Bunting KD, Yu WM, Bradley HL, Haviernikova E, Kelly-Welch AE, Keegan AD, and Qu CK

Journal of leukocyte biology 76(2):484-90, 2004 Aug - Who cited this? | PubMed ID: 15123777 | Fulltext

Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation.

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Kelly-Welch AE, Melo ME, Smith E, Ford AQ, Haudenschild C, Noben-Trauth N, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 172(7):4545-55, 2004 Apr 1 - Who cited this? | PubMed ID: 15034072 | Fulltext

Transgenic expression of insulin receptor substrate 2 in murine B cells alters the cell density-dependence of IgE production in vitro and enhances IgE production in vivo.

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Kelly-Welch AE, Wang HY, Wang LM, Pierce JH, Jay G, Finkelman F, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 172(5):2803-10, 2004 Mar 1 - Who cited this? | PubMed ID: 14978080 | Fulltext

Phosphatidylcholine-specific phospholipase C activity is necessary for the activation of STAT6.

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Zamorano J, Rivas MD, Garcia-Trinidad A, Qu CK, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 171(8):4203-9, 2003 Oct 15 - Who cited this? | PubMed ID: 14530343 | Fulltext

New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines.

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Mora AL, Stephenson LM, Enerson B, Youn J, Keegan AD, and Boothby M

Journal of immunology (Baltimore, Md. : 1950) 171(4):1891-900, 2003 Aug 15 - Who cited this? | PubMed ID: 12902491 | Fulltext

IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL.

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Moreno JL, Kaczmarek M, Keegan AD, and Tondravi M

Blood 102(3):1078-86, 2003 Aug 1 - Who cited this? | PubMed ID: 12689929 | Fulltext

Interleukin-4 and interleukin-13 signaling connections maps.

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Kelly-Welch AE, Hanson EM, Boothby MR, and Keegan AD

Science (New York, N.Y.) 300(5625):1527-8, 2003 Jun 6 - Who cited this? | PubMed ID: 12791978 | Fulltext

Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome.

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Hanson EM, Dickensheets H, Qu CK, Donnelly RP, and Keegan AD

The Journal of biological chemistry 278(6):3903-11, 2003 Feb 7 - Who cited this? | PubMed ID: 12459556 | Fulltext

Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation.

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Zhang XR, Zhang LY, Devadas S, Li L, Keegan AD, and Shi YF

Cell death and differentiation 10(2):203-10, 2003 Feb - Who cited this? | PubMed ID: 12700648 | Fulltext

Plasminogen promotes sarcoma growth and suppresses the accumulation of tumor-infiltrating macrophages.

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Curino A, Mitola DJ, Aaronson H, McMahon GA, Raja K, Keegan AD, Lawrence DA, and Bugge TH

Oncogene 21(57):8830-42, 2002 Dec 12 - Who cited this? | PubMed ID: 12483535 | Fulltext

Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death.

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Li L, Qi X, Williams M, Shi Y, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 168(12):6215-23, 2002 Jun 15 - Who cited this? | PubMed ID: 12055235 | Fulltext

Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6.

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Perez-G M, Melo M, Keegan AD, and Zamorano J

Journal of immunology (Baltimore, Md. : 1950) 168(3):1428-34, 2002 Feb 1 - Who cited this? | PubMed ID: 11801685 | Fulltext

NF-kappa B activation plays an important role in the IL-4-induced protection from apoptosis.

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Zamorano J, Mora AL, Boothby M, and Keegan AD

International immunology 13(12):1479-87, 2001 Dec - Who cited this? | PubMed ID: 11717189 | Fulltext

Efficient transduction of murine B lymphocytes and B lymphoma lines by modified adenoviral vectors: enhancement via targeting to FcR and heparan-containing proteins.

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Li L, Wickham TJ, and Keegan AD

Gene therapy 8(12):938-45, 2001 Jun - Who cited this? | PubMed ID: 11426334 | Fulltext

Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation.

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Zamorano J, Kelly AE, Austrian J, Wang HY, and Keegan AD

Cell research 11(1):44-54, 2001 Mar - Who cited this? | PubMed ID: 11305324 | Fulltext

Cutting edge: effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction.

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Wang HY, Shelburne CP, Zamorano J, Kelly AE, Ryan JJ, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 162(8):4385-9, 1999 Apr 15 - Who cited this? | PubMed ID: 10201973 | Fulltext

The IL-4 receptor: signaling mechanisms and biologic functions.

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Nelms K, Keegan AD, Zamorano J, Ryan JJ, and Paul WE

Annual review of immunology 17:701, 1999 - Who cited this? | PubMed ID: 10358772 | Fulltext

Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis.

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Zamorano J and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 161(2):859-67, 1998 Jul 15 - Who cited this? | PubMed ID: 9670964 | Fulltext

A role for the insulin-interleukin (IL)-4 receptor motif of the IL-4 receptor alpha-chain in regulating activation of the insulin receptor substrate 2 and signal transducer and activator of transcription 6 pathways. Analysis by mutagenesis.

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Wang HY, Zamorano J, and Keegan AD

The Journal of biological chemistry 273(16):9898-905, 1998 Apr 17 - Who cited this? | PubMed ID: 9545332 | Fulltext

Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression.

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Zamorano J, Wang HY, Wang R, Shi Y, Longmore GD, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 160(7):3502-12, 1998 Apr 1 - Who cited this? | PubMed ID: 9531312 | Fulltext

Regulation of gene expression, growth, and cell survival by IL-4: contribution of multiple signaling pathways.

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Keegan AD and Zamorano J

Cell research 8(1):1-13, 1998 Mar - Who cited this? | PubMed ID: 9570012 | Fulltext

HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor.

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Wang D, Zamorano J, Keegan AD, and Boothby M

The Journal of biological chemistry 272(40):25083-90, 1997 Oct 3 - Who cited this? | PubMed ID: 9312117 | Fulltext

The IL-4-induced tyrosine phosphorylation of the insulin receptor substrate is dependent on JAK1 expression in human fibrosarcoma cells.

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Wang HY, Zamorano J, Yoerkie JL, Paul WE, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 158(3):1037-40, 1997 Feb 1 - Who cited this? | PubMed ID: 9013940 | Fulltext

IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway.

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Zamorano J, Wang HY, Wang LM, Pierce JH, and Keegan AD

Journal of immunology (Baltimore, Md. : 1950) 157(11):4926-34, 1996 Dec 1 - Who cited this? | PubMed ID: 8943397 | Fulltext

IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain.

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Wang HY, Paul WE, and Keegan AD

Immunity 4(2):113-21, 1996 Feb - Who cited this? | PubMed ID: 8624802 | Fulltext

Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.

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Keegan AD, Johnston JA, Tortolani PJ, McReynolds LJ, Kinzer C, O'Shea JJ, and Paul WE

Proceedings of the National Academy of Sciences of the United States of America 92(17):7681-5, 1995 Aug 15 - Who cited this? | PubMed ID: 7544000 | Fulltext

Interleukin 4 signals through two related pathways.

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Pernis A, Witthuhn B, Keegan AD, Nelms K, Garfein E, Ihle JN, Paul WE, Pierce JH, and Rothman P

Proceedings of the National Academy of Sciences of the United States of America 92(17):7971-5, 1995 Aug 15 - Who cited this? | PubMed ID: 7544011 | Fulltext

Identification of Fc epsilon RIneg mast cells in mouse bone marrow cell cultures. Use of a monoclonal anti-p161 antibody.

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Kinzer CA, Keegan AD, and Paul WE

The Journal of experimental medicine 182(2):575-9, 1995 Aug 1 - Who cited this? | PubMed ID: 7629514 | Fulltext

Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis.

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Quelle FW, Shimoda K, Thierfelder W, Fischer C, Kim A, Ruben SM, Cleveland JL, Pierce JH, Keegan AD, and Nelms K

Molecular and cellular biology 15(6):3336-43, 1995 Jun - Who cited this? | PubMed ID: 7760829 | Fulltext

Interleukin 4 receptor: signaling mechanisms.

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Keegan AD, Nelms K, Wang LM, Pierce JH, and Paul WE

Immunology today 15(9):423-32, 1994 Sep - Who cited this? | PubMed ID: 7945783 | Fulltext

Hepatic infarction and nodular regenerative hyperplasia of the liver with associated anticardiolipin antibodies in a young woman.

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Keegan AD, Brooks LT, and Painter DM

Journal of clinical gastroenterology 18(4):309-13, 1994 Jun - Who cited this? | PubMed ID: 8071516 | Fulltext

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth.

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Keegan AD, Nelms K, White M, Wang LM, Pierce JH, and Paul WE

Cell 76(5):811-20, 1994 Mar 11 - Who cited this? | PubMed ID: 8124718 | Fulltext

The interleukin-4 receptor: signal transduction by a hematopoietin receptor.

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Keegan AD and Pierce JH

Journal of leukocyte biology 55(2):272-9, 1994 Feb - Who cited this? | PubMed ID: 7507973 | Fulltext

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor.

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Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, and Paul WE

Science (New York, N.Y.) 262(5141):1880-3, 1993 Dec 17 - Who cited this? | PubMed ID: 8266078 | Fulltext

Doxepin-induced recurrent acute hepatitis.

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Keegan AD

Australian and New Zealand journal of medicine 23(5):523, 1993 Oct - Who cited this? | PubMed ID: 8297287 | Fulltext

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