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Papers authored by Kay TW

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Beta cell apoptosis in diabetes.

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Thomas HE, McKenzie MD, Angstetra E, Campbell PD, and Kay TW

Apoptosis : an international journal on programmed cell death 14(12):1389-404, 2009 Dec - Who cited this? | PubMed ID: 19322660 | Fulltext

Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli.

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Carrington EM, McKenzie MD, Jansen E, Myers M, Fynch S, Kos C, Strasser A, Kay TW, Scott CL, and Allison J

Diabetes 58(10):2316-23, 2009 Oct - Who cited this? | PubMed ID: 19581414 | Fulltext

Insulin teaches a new lesson in tolerance.

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Kay TW, Krishnamurthy B, Brodnicki TC, and Mannering SI

The EMBO journal 28(18):2687-8, 2009 Sep 16 - Who cited this? | PubMed ID: 19759522 | Fulltext

In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes.

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Angstetra E, Graham KL, Emmett S, Dudek NL, Darwiche R, Ayala-Perez R, Allison J, Santamaria P, Kay TW, and Thomas HE

Immunology and cell biology 87(2):178-85, 2009 Feb - Who cited this? | PubMed ID: 19015667 | Fulltext

Interferon signalling in pancreatic beta cells.

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Thomas HE, Graham KL, Angstetra E, McKenzie MD, Dudek NL, and Kay TW

Frontiers in bioscience : a journal and virtual library 14:644-56, 2009 - Who cited this? | PubMed ID: 19273092 | Fulltext

SOCS1 negatively regulates the production of Foxp3(+) CD4(+) T cells in the thymus.

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Zhan Y, Davey GM, Graham KL, Kiu H, Dudek NL, Kay TW, and Lew AM

Immunology and cell biology 87(6):473-80, 2009 - Who cited this? | PubMed ID: 19381159 | Fulltext

Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro.

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Campbell PD, Estella E, Dudek NL, Jhala G, Thomas HE, Kay TW, and Mannering SI

Human immunology 69(9):543, 2008 Sep - Who cited this? | PubMed ID: 18639598 | Fulltext

Rotavirus infection accelerates type 1 diabetes in mice with established insulitis.

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Graham KL, Sanders N, Tan Y, Allison J, Kay TW, and Coulson BS

Journal of virology 82(13):6139-49, 2008 Jul - Who cited this? | PubMed ID: 18417562 | Fulltext

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.

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Croom HA, Izon DJ, Chong MM, Curtis DJ, Roberts AW, Kay TW, Hilton DJ, Alexander WS, and Starr R

Molecular immunology 45(10):2888, 2008 May - Who cited this? | PubMed ID: 18321577 | Fulltext

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

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McKenzie MD, Carrington EM, Kaufmann T, Strasser A, Huang DC, Kay TW, Allison J, and Thomas HE

Diabetes 57(5):1284-92, 2008 May - Who cited this? | PubMed ID: 18252892 | Fulltext

Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice.

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Krishnamurthy B, Mariana L, Gellert SA, Colman PG, Harrison LC, Lew AM, Santamaria P, Thomas HE, and Kay TW

Journal of immunology (Baltimore, Md. : 1950) 180(7):4458-64, 2008 Apr 1 - Who cited this? | PubMed ID: 18354167 | Fulltext

Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice.

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Kay TW, Dudek NL, Graham K, Estella E, Angstetra E, McKenzie MD, Allison J, and Thomas HE

Novartis Foundation symposium 292:68-78; discussion 78-84, 122-9, 202-3, 2008 - Who cited this? | PubMed ID: 19203093 | Fulltext

Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets.

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Londrigan SL, Brady JL, Sutherland RM, Hawthorne WJ, Thomas HE, Jhala G, Cowan PJ, Kay TW, O'Connell PJ, and Lew AM

Xenotransplantation 14(2):119-25, 2007 Mar - Who cited this? | PubMed ID: 17381686 | Fulltext

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

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Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, and Kemp BE

Cell metabolism 4(6):465, 2006 Dec - Who cited this? | PubMed ID: 17141630 | Fulltext

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

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Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, and Kay TW

The Journal of clinical investigation 116(12):3258, 2006 Dec - Who cited this? | PubMed ID: 17143333 | Fulltext

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

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Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, and von Herrath MG

Journal of autoimmunity 27(3):166-73, 2006 Nov - Who cited this? | PubMed ID: 17045460 | Fulltext

Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.

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Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, and Kay TW

Diabetes 55(9):2412, 2006 Sep - Who cited this? | PubMed ID: 16936188 | Fulltext

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

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Estella E, McKenzie MD, Catterall T, Sutton VR, Bird PI, Trapani JA, Kay TW, and Thomas HE

Diabetes 55(8):2212, 2006 Aug - Who cited this? | PubMed ID: 16873683 | Fulltext

IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

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O'Sullivan BJ, Thomas HE, Pai S, Santamaria P, Iwakura Y, Steptoe RJ, Kay TW, and Thomas R

Journal of immunology (Baltimore, Md. : 1950) 176(12):7278, 2006 Jun 15 - Who cited this? | PubMed ID: 16751371 | Fulltext

Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL.

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McKenzie MD, Dudek NL, Mariana L, Chong MM, Trapani JA, Kay TW, and Thomas HE

International immunology 18(6):837-46, 2006 Jun - Who cited this? | PubMed ID: 16574667 | Fulltext

Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death.

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Thomas HE, Angstetra E, Fernandes RV, Mariana L, Irawaty W, Jamieson EL, Dudek NL, and Kay TW

Immunology and cell biology 84(1):20-7, 2006 Feb - Who cited this? | PubMed ID: 16277639 | Fulltext

A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.

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Sutton VR, Estella E, Li C, Chen M, Thomas HE, Kay TW, and Trapani JA

Transplantation 81(2):146-54, 2006 Jan 27 - Who cited this? | PubMed ID: 16436955 | Fulltext

Prolonged local expression of anti-CD4 antibody by adenovirally transduced allografts can promote long-term graft survival.

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Londrigan SL, Sutherland RM, Brady JL, Zhan Y, Li R, Estella E, Kay TW, and Lew AM

The journal of gene medicine 8(1):42-52, 2006 Jan - Who cited this? | PubMed ID: 16075436 | Fulltext

The insulin A-chain epitope recognized by human T cells is posttranslationally modified.

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Mannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, and Purcell AW

The Journal of experimental medicine 202(9):1191-7, 2005 Nov 7 - Who cited this? | PubMed ID: 16260488 | Fulltext

Socs1 deficiency enhances hepatic insulin signaling.

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Jamieson E, Chong MM, Steinberg GR, Jovanovska V, Fam BC, Bullen DV, Chen Y, Kemp BE, Proietto J, Kay TW, and Andrikopoulos S

The Journal of biological chemistry 280(36):31516-21, 2005 Sep 9 - Who cited this? | PubMed ID: 15983045 | Fulltext

Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation.

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Chong MM, Metcalf D, Jamieson E, Alexander WS, and Kay TW

Blood 106(5):1668-75, 2005 Sep 1 - Who cited this? | PubMed ID: 15899915 | Fulltext

Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

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Allison J, Thomas HE, Catterall T, Kay TW, and Strasser A

Journal of immunology (Baltimore, Md. : 1950) 175(1):293, 2005 Jul 1 - Who cited this? | PubMed ID: 15972661 | Fulltext

Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency.

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Chen Y, Chong MM, Darwiche R, Thomas HE, and Kay TW

The American journal of pathology 165(3):913-21, 2004 Sep - Who cited this? | PubMed ID: 15331415 | Fulltext

Bcl-2 protection of islet allografts is unmasked by costimulation blockade.

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Sutherland RM, Allison J, Thomas HE, Brady JL, Kay TW, and Lew AM

Transplantation 77(10):1610-3, 2004 May 27 - Who cited this? | PubMed ID: 15239630 | Fulltext

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

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Chong MM, Chen Y, Darwiche R, Dudek NL, Irawaty W, Santamaria P, Allison J, Kay TW, and Thomas HE

Journal of immunology (Baltimore, Md. : 1950) 172(9):5714-21, 2004 May 1 - Who cited this? | PubMed ID: 15100317 | Fulltext

IL-1 receptor deficiency slows progression to diabetes in the NOD mouse.

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Thomas HE, Irawaty W, Darwiche R, Brodnicki TC, Santamaria P, Allison J, and Kay TW

Diabetes 53(1):113-21, 2004 Jan - Who cited this? | PubMed ID: 14693705 | Fulltext

Activated macrophages require T cells for xenograft rejection under the kidney capsule.

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Zhan Y, Brady JL, Irawaty W, Thomas HE, Kay TW, and Lew AM

Immunology and cell biology 81(6):451-8, 2003 Dec - Who cited this? | PubMed ID: 14636242 | Fulltext

Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.

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Cornish AL, Chong MM, Davey GM, Darwiche R, Nicola NA, Hilton DJ, Kay TW, Starr R, and Alexander WS

The Journal of biological chemistry 278(25):22755-61, 2003 Jun 20 - Who cited this? | PubMed ID: 12665516 | Fulltext

Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice.

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Darwiche R, Chong MM, Santamaria P, Thomas HE, and Kay TW

Journal of immunology (Baltimore, Md. : 1950) 170(12):6292, 2003 Jun 15 - Who cited this? | PubMed ID: 12794162 | Fulltext

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

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Chong MM, Cornish AL, Darwiche R, Stanley EG, Purton JF, Godfrey DI, Hilton DJ, Starr R, Alexander WS, and Kay TW

Immunity 18(4):475-87, 2003 Apr - Who cited this? | PubMed ID: 12705851 | Fulltext

The role of cytokines as effectors of tissue destruction in autoimmunity.

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Kay TW, Darwiche R, Irawaty W, Chong MM, Pennington HL, and Thomas HE

Advances in experimental medicine and biology 520:73-86, 2003 - Who cited this? | PubMed ID: 12613573 | Fulltext

Transmembrane TNF and IFNgamma induce caspase-independent death of primary mouse pancreatic beta cells.

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Irawaty W, Kay TW, and Thomas HE

Autoimmunity 35(6):369-75, 2002 Sep - Who cited this? | PubMed ID: 12568116 | Fulltext

Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor.

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Chong MM, Thomas HE, and Kay TW

The Journal of biological chemistry 277(31):27945-52, 2002 Aug 2 - Who cited this? | PubMed ID: 12032139 | Fulltext

Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure.

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Kooptiwut S, Zraika S, Thorburn AW, Dunlop ME, Darwiche R, Kay TW, Proietto J, and Andrikopoulos S

Endocrinology 143(6):2085-92, 2002 Jun - Who cited this? | PubMed ID: 12021173 | Fulltext

International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.

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Bonifacio E, Atkinson M, Eisenbarth G, Serreze D, Kay TW, Lee-Chan E, and Singh B

Annals of the New York Academy of Sciences 958:1-2, 2002 Apr - Who cited this? | PubMed ID: 12021078 | Fulltext

Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production.

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Thomas HE, Darwiche R, Corbett JA, and Kay TW

Diabetes 51(2):311-6, 2002 Feb - Who cited this? | PubMed ID: 11812737 | Fulltext

gamma-Interferon signaling in pancreatic beta-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1.

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Chong MM, Thomas HE, and Kay TW

Diabetes 50(12):2744-51, 2001 Dec - Who cited this? | PubMed ID: 11723057 | Fulltext

Behçet's disease with cerebral vasculitis.

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Scardamaglia L, Desmond PM, Gonzales MF, Bendrups A, Brodtmann A, and Kay TW

Internal medicine journal 31(9):560-1, 2001 Dec - Who cited this? | PubMed ID: 11767874 | Fulltext

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.

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Bonifacio E, Atkinson M, Eisenbarth G, Serreze D, Kay TW, Lee-Chan E, and Singh B

Diabetes 50(11):2451-8, 2001 Nov - Who cited this? | PubMed ID: 11679421 | Fulltext

Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.

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McQualter JL, Darwiche R, Ewing C, Onuki M, Kay TW, Hamilton JA, Reid HH, and Bernard CC

The Journal of experimental medicine 194(7):873-82, 2001 Oct 1 - Who cited this? | PubMed ID: 11581310 | Fulltext

Lack of expression of Gp-130 makes pancreatic beta cell lines unresponsive to the IL-6 family of cytokines.

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Naselli G, Deaizpurua HJ, Thomas HE, Johnston AM, and Kay TW

International journal of experimental diabetes research 1(4):239-48, 2001 - Who cited this? | PubMed ID: 11467415 | Fulltext

How beta cells die in type 1 diabetes.

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Thomas HE and Kay TW

Current directions in autoimmunity 4:144-70, 2001 - Who cited this? | PubMed ID: 11569401 | Fulltext

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

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Seewaldt S, Thomas HE, Ejrnaes M, Christen U, Wolfe T, Rodrigo E, Coon B, Michelsen B, Kay TW, and von Herrath MG

Diabetes 49(11):1801-9, 2000 Nov - Who cited this? | PubMed ID: 11078446 | Fulltext

Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction.

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Allison J, Thomas H, Beck D, Brady JL, Lew AM, Elefanty A, Kosaka H, Kay TW, Huang DC, and Strasser A

International immunology 12(1):9-17, 2000 Jan - Who cited this? | PubMed ID: 10607745 | Fulltext

Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse.

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Thomas HE and Kay TW

Diabetes/metabolism research and reviews 16(4):251-61, 2000 - Who cited this? | PubMed ID: 10934453 | Fulltext

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