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Papers authored by Kakuta H

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Peculiar rashba splitting originating from the two-dimensional symmetry of the surface.

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Sakamoto K, Kakuta H, Sugawara K, Miyamoto K, Kimura A, Kuzumaki T, Ueno N, Annese E, Fujii J, Kodama A, Shishidou T, Namatame H, Taniguchi M, Sato T, Takahashi T, and Oguchi T

Physical review letters 103(15):156801, 2009 Oct 9 - Who cited this? | PubMed ID: 19905655 | Fulltext

Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.

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Morishita K, Yakushiji N, Ohsawa F, Takamatsu K, Matsuura N, Makishima M, Kawahata M, Yamaguchi K, Tai A, Sasaki K, and Kakuta H

Bioorganic & medicinal chemistry letters 19(3):1001-3, 2009 Feb 1 - Who cited this? | PubMed ID: 19095448 | Fulltext

Necessity is the mother of invention: an ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation.

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Kakuta H

ChemMedChem 3(7):1024-5, 2008 Jul - Who cited this? | PubMed ID: 18465763 | Fulltext

Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.

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Namba K, Zheng X, Motoshima K, Kobayashi H, Tai A, Takahashi E, Sasaki K, Okamoto K, and Kakuta H

Bioorganic & medicinal chemistry 16(11):6131, 2008 Jun 1 - Who cited this? | PubMed ID: 18468909 | Fulltext

Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum.

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Yoshikawa M, Motoshima K, Fujimoto K, Tai A, Kakuta H, and Sasaki K

Bioorganic & medicinal chemistry 16(11):6027-33, 2008 Jun 1 - Who cited this? | PubMed ID: 18479926 | Fulltext

Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation.

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Zheng X, Oda H, Harada S, Sugimoto Y, Tai A, Sasaki K, and Kakuta H

Journal of pharmaceutical sciences, 2008 May 1 - Who cited this? | PubMed ID: 18452178 | Fulltext

The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist).

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Takamatsu K, Takano A, Yakushiji N, Morohashi K, Morishita K, Matsuura N, Makishima M, Tai A, Sasaki K, and Kakuta H

ChemMedChem 3(5):780, 2008 May - Who cited this? | PubMed ID: 18297677 | Fulltext

Cyclooxygenase-1-Selective Inhibitors Are Attractive Candidates for Analgesics That Do Not Cause Gastric Damage. Design and in Vitro/in Vivo Evaluation of a Benzamide-Type Cyclooxygenase-1 Selective Inhibitor.

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Kakuta H, Zheng X, Oda H, Harada S, Sugimoto Y, Sasaki K, and Tai A

Journal of medicinal chemistry 51(8):2400-11, 2008 Apr 24 - Who cited this? | PubMed ID: 18363350 | Fulltext

Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moiety.

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Takamatsu K, Takano A, Yakushiji N, Morishita K, Matsuura N, Makishima M, Ali HI, Akaho E, Tai A, Sasaki K, and Kakuta H

ChemMedChem 3(3):454, 2008 Mar - Who cited this? | PubMed ID: 18157857 | Fulltext

Antimalarial cation-dimers synthesized in two steps from an inexpensive starting material, isonicotinic acid.

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Motoshima K, Hiwasa Y, Yoshikawa M, Fujimoto K, Tai A, Kakuta H, and Sasaki K

ChemMedChem 2(10):1527-32, 2007 Oct - Who cited this? | PubMed ID: 17607684 | Fulltext

Electronic structures of the highest occupied molecular orbital bands of a pentacene ultrathin film.

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Kakuta H, Hirahara T, Matsuda I, Nagao T, Hasegawa S, Ueno N, and Sakamoto K

Physical review letters 98(24):247601, 2007 Jun 15 - Who cited this? | PubMed ID: 17677992 | Fulltext

Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.

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Zheng X, Oda H, Takamatsu K, Sugimoto Y, Tai A, Akaho E, Ali HI, Oshiki T, Kakuta H, and Sasaki K

Bioorganic & medicinal chemistry 15(2):1014-21, 2007 Jan 15 - Who cited this? | PubMed ID: 17079150 | Fulltext

Favorable changes in lipid metabolism and cardiovascular parameters after icodextrin use in peritoneal dialysis patients.

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Hiramatsu T, Furuta S, and Kakuta H

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 23:58-61, 2007 - Who cited this? | PubMed ID: 17886604 | Fulltext

Longitudinal changes in parameters of cardiovascular function in patients treated for 8 years with hemodialysis or peritoneal dialysis.

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Hiramatsu T, Furuta S, and Kakuta H

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 23:62-5, 2007 - Who cited this? | PubMed ID: 17886605 | Fulltext

Impact of dialysis modality on ultrasonographic cardiovascular parameters in elderly patients.

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Hiramatsu T, Furuta S, and Kakuta H

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 23:94-7, 2007 - Who cited this? | PubMed ID: 17886611 | Fulltext

Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide).

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Fujimoto K, Morisaki D, Yoshida M, Namba T, Hye-Sook K, Wataya Y, Kourai H, Kakuta H, and Sasaki K

Bioorganic & medicinal chemistry letters 16(10):2758-60, 2006 May 15 - Who cited this? | PubMed ID: 16524728 | Fulltext

Relationship between health-related quality of life domains and bone status in postmenopausal Japanese women.

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Tashiro A, Kakuta H, Tanaka N, and Takeuchi Y

Menopause (New York, N.Y.) 13(5):846-9, 2006 - Who cited this? | PubMed ID: 16894337 | Fulltext

Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers.

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Kakuta H, Sudoh K, Sasamata M, and Yamagishi S

International journal of clinical pharmacology research 25(1):41-6, 2005 - Who cited this? | PubMed ID: 15864875 | Fulltext

Effects of atorvastatin on glucose metabolism and insulin resistance in KK/Ay mice.

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Suzuki M, Kakuta H, Takahashi A, Shimano H, Tada-Iida K, Yokoo T, Kihara R, and Yamada N

Journal of atherosclerosis and thrombosis 12(2):77-84, 2005 - Who cited this? | PubMed ID: 15942117 | Fulltext

Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenequinones.

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Nishishiro M, Arikawa S, Wakabayashi H, Hashimoto K, Satoh K, Yokoyama K, Unten S, Kakuta H, Kurihara T, Motohashi N, and Sakagami H

Anticancer research 25(6B):4157-63, 2005 - Who cited this? | PubMed ID: 16309211 | Fulltext

Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors.

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Ishihara T, Kakuta H, Moritani H, Ugawa T, and Yanagisawa I

Bioorganic & medicinal chemistry 12(22):5899-908, 2004 Nov 15 - Who cited this? | PubMed ID: 15498666 | Fulltext

Membrane permeabilization by non-steroidal anti-inflammatory drugs.

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Tomisato W, Tanaka K, Katsu T, Kakuta H, Sasaki K, Tsutsumi S, Hoshino T, Aburaya M, Li D, Tsuchiya T, Suzuki K, Yokomizo K, and Mizushima T

Biochemical and biophysical research communications 323(3):1032-9, 2004 Oct 22 - Who cited this? | PubMed ID: 15381103 | Fulltext

Synthesis and biological evaluation of quinuclidine derivatives incorporating phenothiazine moieties as squalene synthase inhibitors.

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Ishihara T, Kakuta H, Moritani H, Ugawa T, and Yanagisawa I

Chemical & pharmaceutical bulletin 52(10):1204-9, 2004 Oct - Who cited this? | PubMed ID: 15467236 | Fulltext

Effective extracellular trehalose production by Cellulosimicrobium cellulans.

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Seto A, Yoshijima H, Toyomasu K, Ogawa HO, Kakuta H, Hosono K, Ueda K, and Beppu T

Applied microbiology and biotechnology 64(6):794-9, 2004 Jun - Who cited this? | PubMed ID: 14685787 | Fulltext

Effects of a Novel Aldose Reductase Inhibitor, Fidarestat (SNK-860), on Vibration Perception Threshold and Subjective Symptoms in Patients with Diabetic Polyneuropathy : An Open-Label Pilot Study.

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Hotta N, Yasuda K, Sumita Y, Sano T, Kakuta H, Nagashima M, Hayashi Y, Yamamoto M, Wakao T, Okuyama M, Kobayashi M, and Mori K

Clinical drug investigation 24(11):671-80, 2004 - Who cited this? | PubMed ID: 17523730 | Fulltext

Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.

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Kakuta H, Tanatani A, Nagasawa K, and Hashimoto Y

Chemical & pharmaceutical bulletin 51(11):1273-82, 2003 Nov - Who cited this? | PubMed ID: 14600372 | Fulltext

Cyclooxygenase inhibitors derived from thalidomide.

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Suizu M, Muroya Y, Kakuta H, Kagechika H, Tanatani A, Nagasawa K, and Hashimoto Y

Chemical & pharmaceutical bulletin 51(9):1098-102, 2003 Sep - Who cited this? | PubMed ID: 12951457 | Fulltext

Syntheses of 3-ethylidenequinuclidine derivatives as squalene synthase inhibitors. Part 2: enzyme inhibition and effects on plasma lipid levels.

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Ishihara T, Kakuta H, Moritani H, Ugawa T, Sakamoto S, Tsukamoto S, and Yanagisawa I

Bioorganic & medicinal chemistry 11(17):3735-45, 2003 Aug 15 - Who cited this? | PubMed ID: 12901918 | Fulltext

Phytotoxicity and fate of 1,1,2-trichloroethylene: a laboratory study.

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Inderjit, Asakawa C, and Kakuta H

Journal of chemical ecology 29(6):1329-35, 2003 Jun - Who cited this? | PubMed ID: 12918919 | Fulltext

Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors.

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Ishihara T, Kakuta H, Moritani H, Ugawa T, Sakamoto S, Tsukamoto S, and Yanagisawa I

Bioorganic & medicinal chemistry 11(11):2403-14, 2003 May 29 - Who cited this? | PubMed ID: 12735986 | Fulltext

YM-53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents.

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Ugawa T, Kakuta H, Moritani H, Inagaki O, and Shikama H

British journal of pharmacology 139(1):140-6, 2003 May - Who cited this? | PubMed ID: 12746232 | Fulltext

Experimental model of postprandial hypertriglyceridemia in sucrose-fed rats and the effectiveness of atorvastatin in the model.

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Funatsu T, Kakuta H, Takasu T, Noguchi M, Suzuki M, and Miyata K

Metabolism: clinical and experimental 52(5):609-15, 2003 May - Who cited this? | PubMed ID: 12759892 | Fulltext

Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells.

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Kakuta H, Koiso Y, Nagasawa K, and Hashimoto Y

Bioorganic & medicinal chemistry letters 13(1):83-6, 2003 Jan 6 - Who cited this? | PubMed ID: 12467622 | Fulltext

Xylitol inhibition of acid production and growth of mutans Streptococci in the presence of various dietary sugars under strictly anaerobic conditions.

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Kakuta H, Iwami Y, Mayanagi H, and Takahashi N

Caries research 37(6):404-9, 2003 - Who cited this? | PubMed ID: 14571117 | Fulltext

Atorvastatin increases hepatic fatty acid beta-oxidation in sucrose-fed rats: comparison with an MTP inhibitor.

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Funatsu T, Kakuta H, Takasu T, and Miyata K

European journal of pharmacology 455(2-3):161-7, 2002 Nov 29 - Who cited this? | PubMed ID: 12445582 | Fulltext

Effect of YM-53601, a novel squalene synthase inhibitor, on the clearance rate of plasma LDL and VLDL in hamsters.

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Ugawa T, Kakuta H, Moritani H, and Inagaki O

British journal of pharmacology 137(4):561-9, 2002 Oct - Who cited this? | PubMed ID: 12359639 | Fulltext

Intracellular and extracellular pHs of Streptococcus mutans after addition of acids: loading and efflux of a fluorescent pH indicator in streptococcal cells.

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Iwami Y, Kawarada K, Kojima I, Miyasawa H, Kakuta H, Mayanagi H, and Takahashi N

Oral microbiology and immunology 17(4):239-44, 2002 Aug - Who cited this? | PubMed ID: 12121474 | Fulltext

Experimental model of escape phenomenon in hamsters and the effectiveness of YM-53601 in the model.

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Ugawa T, Kakuta H, Moritani H, and Shikama H

British journal of pharmacology 135(6):1572-8, 2002 Mar - Who cited this? | PubMed ID: 11906972 | Fulltext

Reduction in hepatic non-esterified fatty acid concentration after long-term treatment with atorvastatin lowers hepatic triglyceride synthesis and its secretion in sucrose-fed rats.

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Funatsu T, Goto M, Kakuta H, Suzuki M, Ida M, Nishijima S, Tanaka H, Yasuda S, and Miyata K

Biochimica et biophysica acta 1580(2-3):161-70, 2002 Feb 28 - Who cited this? | PubMed ID: 11880241 | Fulltext

Diverse biological activities of fermented pine seed shell extract.

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Mihara S, Unten S, Kakuta H, Satoh K, Negoro T, Nakashima H, Komatsu N, Fujimaki M, Kikuchi H, Nishikawa H, Minagawa K, Suzuki F, Satoh T, and Sakagami H

Anticancer research 22(3):1569-74, 2002 - Who cited this? | PubMed ID: 12168838 | Fulltext

Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats.

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Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Seki J, Yamagata K, Nara Y, Hara H, Kakuta H, and Yamori Y

Hypertension research : official journal of the Japanese Society of Hypertension 24(6):735-42, 2001 Nov - Who cited this? | PubMed ID: 11768736 | Fulltext

Prolonged inhibition of cholesterol synthesis by atorvastatin inhibits apo B-100 and triglyceride secretion from HepG2 cells.

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Funatsu T, Suzuki K, Goto M, Arai Y, Kakuta H, Tanaka H, Yasuda S, Ida M, Nishijima S, and Miyata K

Atherosclerosis 157(1):107-15, 2001 Jul - Who cited this? | PubMed ID: 11427209 | Fulltext

Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study.

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Komoda M, Kakuta H, Takahashi H, Fujimoto Y, Kadoya S, Kato F, and Hashimoto Y

Bioorganic & medicinal chemistry 9(1):121-31, 2001 Jan - Who cited this? | PubMed ID: 11197332 | Fulltext

[Atorvastatin (Lipitor): a review of its pharmacological and clinical profile].

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Funatsu T, Kakuta H, Tanaka H, Arai Y, Suzuki K, and Miyata K

Nippon yakurigaku zasshi. Folia pharmacologica Japonica 117(1):65-76, 2001 Jan - Who cited this? | PubMed ID: 11233299 | Fulltext

Diverse biological activities of healthy foods.

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Kobayashi N, Unten S, Kakuta H, Komatsu N, Fujimaki M, Satoh K, Aratsu C, Nakashima H, Kikuchi H, Ochiai K, and Sakagami H

In vivo (Athens, Greece) 15(1):17-23, 2001 - Who cited this? | PubMed ID: 11286123 | Fulltext

Combination effect of lignin F and natural products.

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Jiang Y, Satoh K, Aratsu C, Kobayashi N, Unten S, Kakuta H, Kikuchi H, Nishikawa H, Ochiai K, and Sakagami H

Anticancer research 21(2A):965-70, 2001 - Who cited this? | PubMed ID: 11396189 | Fulltext

[Preparation of novel specific aminopeptidase inhibitors with a cyclic imide skeleton].

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Takahashi H, Komoda M, Kakuta H, and Hashimoto Y

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 120(10):909-21, 2000 Oct - Who cited this? | PubMed ID: 11082703 | Fulltext

YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species.

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Ugawa T, Kakuta H, Moritani H, Matsuda K, Ishihara T, Yamaguchi M, Naganuma S, Iizumi Y, and Shikama H

British journal of pharmacology 131(1):63-70, 2000 Sep - Who cited this? | PubMed ID: 10960070 | Fulltext

Hematopoietic stem cell transplantation (HSCT) for Langerhans cell histiocytosis (LCH) in Japan.

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Kinugawa N, Imashuku S, Hirota Y, Yamada K, Yamamoto A, Akazai A, Oda M, Miura N, Kakuta H, Sato T, Endo M, and Takano T

Bone marrow transplantation 24(8):935-8, 1999 Oct - Who cited this? | PubMed ID: 10516710 | Fulltext

Assembly of lipoprotein (a) in transgenic rabbits expressing human apolipoprotein (a).

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Fan J, Araki M, Wu L, Challah M, Shimoyamada H, Lawn RM, Kakuta H, Shikama H, and Watanabe T

Biochemical and biophysical research communications 255(3):639-44, 1999 Feb 24 - Who cited this? | PubMed ID: 10049763 | Fulltext

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