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Papers authored by Kain KC

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CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria.

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Erdman LK, Cosio G, Helmers AJ, Gowda DC, Grinstein S, and Kain KC

Journal of immunology (Baltimore, Md. : 1950) 183(10):6452-9, 2009 Nov 15 - Who cited this? | PubMed ID: 19864601 | Fulltext

Adenosine Triphosphate Depletion of Erythrocytes Simulates the Phenotype Associated with Pyruvate Kinase Deficiency and Confers Protection against Plasmodium falciparum In Vitro.

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Ayi K, Liles WC, Gros P, and Kain KC

The Journal of infectious diseases 200(8):1289-99, 2009 Oct 15 - Who cited this? | PubMed ID: 19743919 | Fulltext

Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages.

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Helmers AJ, Gowda DC, Kain KC, and Liles WC

The American journal of tropical medicine and hygiene 81(4):631-7, 2009 Oct - Who cited this? | PubMed ID: 19815878 | Fulltext

Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial.

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Boggild AK, Krudsood S, Patel SN, Serghides L, Tangpukdee N, Katz K, Wilairatana P, Liles WC, Looareesuwan S, and Kain KC

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 49(6):841-9, 2009 Sep 15 - Who cited this? | PubMed ID: 19673614 | Fulltext

Rosiglitazone modulates the innate immune response to plasmodium falciparum infection and improves outcome in experimental cerebral malaria.

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Serghides L, Patel SN, Ayi K, Lu Z, Gowda DC, Liles WC, and Kain KC

The Journal of infectious diseases 199(10):1536-45, 2009 May 15 - Who cited this? | PubMed ID: 19392627 | Fulltext

Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria.

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Finney CA, Lu Z, LeBourhis L, Philpott DJ, and Kain KC

The American journal of tropical medicine and hygiene 80(5):718-22, 2009 May - Who cited this? | PubMed ID: 19407112 | Fulltext

Human immunodeficiency virus co-infection increases placental parasite density and transplacental malaria transmission in Western kenya.

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Perrault SD, Hajek J, Zhong K, Owino SO, Sichangi M, Smith G, Shi YP, Moore JM, and Kain KC

The American journal of tropical medicine and hygiene 80(1):119-25, 2009 Jan - Who cited this? | PubMed ID: 19141849 | Fulltext

Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in african children.

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Lovegrove FE, Tangpukdee N, Opoka RO, Lafferty EI, Rajwans N, Hawkes M, Krudsood S, Looareesuwan S, John CC, Liles WC, and Kain KC

PLoS ONE 4(3):e4912, 2009 - Who cited this? | PubMed ID: 19300530 | Fulltext

C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.

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Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, and Kain KC

PLoS ONE 4(3):e4953, 2009 - Who cited this? | PubMed ID: 19308263 | Fulltext

Inflammatory pathways in malaria infection: TLRs share the stage with other components of innate immunity.

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Erdman LK, Finney CA, Liles WC, and Kain KC

Molecular and biochemical parasitology 162(2):105-11, 2008 Dec - Who cited this? | PubMed ID: 18804125 | Fulltext

Failure of two distinct anti-apoptotic approaches to reduce mortality in experimental cerebral malaria.

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Helmers AJ, Lovegrove FE, Harlan JM, Kain KC, and Liles WC

The American journal of tropical medicine and hygiene 79(6):823-5, 2008 Dec - Who cited this? | PubMed ID: 19052286 | Fulltext

Clinical problem-solving. A gut feeling.

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Fan E, Soong C, Kain KC, and Detsky AS

The New England journal of medicine 359(1):75, 2008 Jul 3 - Who cited this? | PubMed ID: 18596276 | Fulltext

Seasonality, Annual Trends, and Characteristics of Dengue among Ill Returned Travelers, 1997-2006.

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Schwartz E, Weld LH, Wilder-Smith A, von Sonnenburg F, Keystone JS, Kain KC, Torresi J, Freedman DO, and

Emerging infectious diseases 14(7):1081, 2008 Jul - Who cited this? | PubMed ID: 18598629 | Fulltext

Plasmodium falciparum shows transcriptional versatility within the human host.

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Lovegrove FE, Peña-Castillo L, Liles WC, Hughes TR, and Kain KC

Trends in parasitology 24(7):288-91, 2008 Jul - Who cited this? | PubMed ID: 18538633 | Fulltext

Atovaquone-proguanil resistance in imported falciparum malaria in a young child.

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Rose GW, Suh KN, Kain KC, Le Saux N, and McCarthy AE

The Pediatric infectious disease journal 27(6):567-9, 2008 Jun - Who cited this? | PubMed ID: 18434932 | Fulltext

C5 deficiency and C5a or C5aR blockade protects against cerebral malaria.

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Patel SN, Berghout J, Lovegrove FE, Ayi K, Conroy A, Serghides L, Min-Oo G, Gowda DC, Sarma JV, Rittirsch D, Ward PA, Liles WC, Gros P, and Kain KC

The Journal of experimental medicine 205(5):1133-43, 2008 May 12 - Who cited this? | PubMed ID: 18426986 | Fulltext

Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.

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Lovegrove FE, Gharib SA, Peña-Castillo L, Patel SN, Ruzinski JT, Hughes TR, Liles WC, and Kain KC

PLoS pathogens 4(5):e1000068, 2008 May - Who cited this? | PubMed ID: 18483551 | Fulltext

Pyruvate kinase deficiency and malaria.

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Ayi K, Min-Oo G, Serghides L, Crockett M, Kirby-Allen M, Quirt I, Gros P, and Kain KC

The New England journal of medicine 358(17):1805-10, 2008 Apr 24 - Who cited this? | PubMed ID: 18420493 | Fulltext

Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase.

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Bello AM, Poduch E, Liu Y, Wei L, Crandall I, Wang X, Dyanand C, Kain KC, Pai EF, and Kotra LP

Journal of medicinal chemistry 51(3):439-48, 2008 Feb 14 - Who cited this? | PubMed ID: 18189347 | Fulltext

Molecular diagnostic and surveillance tools for global malaria control.

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Erdman LK and Kain KC

Travel medicine and infectious disease 6(1-2):82-99, 2008 - Who cited this? | PubMed ID: 18342279 | Fulltext

Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria.

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Lovegrove FE, Gharib SA, Patel SN, Hawkes CA, Kain KC, and Liles WC

The American journal of pathology 171(6):1894-903, 2007 Dec - Who cited this? | PubMed ID: 17991715 | Fulltext

Real-time PCR assay for rapid detection and analysis of PfCRT haplotypes of chloroquine-resistant Plasmodium falciparum isolates from India.

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Keen J, Farcas GA, Zhong K, Yohanna S, Dunne MW, and Kain KC

Journal of clinical microbiology 45(9):2889-93, 2007 Sep - Who cited this? | PubMed ID: 17609321 | Fulltext

Convergence of quantum dot barcodes with microfluidics and signal processing for multiplexed high-throughput infectious disease diagnostics.

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Klostranec JM, Xiang Q, Farcas GA, Lee JA, Rhee A, Lafferty EI, Perrault SD, Kain KC, and Chan WC

Nano letters 7(9):2812-8, 2007 Sep - Who cited this? | PubMed ID: 17705551 | Fulltext

A randomized, placebo-controlled trial of rosiglitazone for HIV-related lipoatrophy.

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Cavalcanti RB, Raboud J, Shen S, Kain KC, Cheung A, and Walmsley S

The Journal of infectious diseases 195(12):1754-61, 2007 Jun 15 - Who cited this? | PubMed ID: 17492590 | Fulltext

Fever in returned travelers: results from the GeoSentinel Surveillance Network.

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Wilson ME, Weld LH, Boggild A, Keystone JS, Kain KC, von Sonnenburg F, Schwartz E, and GeoSentinel Surveillance Network

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 44(12):1560-8, 2007 Jun 15 - Who cited this? | PubMed ID: 17516399 | Fulltext

Advances in malaria diagnosis.

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Hawkes M and Kain KC

Expert review of anti-infective therapy 5(3):485-95, 2007 Jun - Who cited this? | PubMed ID: 17547512 | Fulltext

HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites.

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Keen J, Serghides L, Ayi K, Patel SN, Ayisi J, van Eijk A, Steketee R, Udhayakumar V, and Kain KC

PLoS medicine 4(5), 2007 May - Who cited this? | PubMed ID: 17535103 | Fulltext

Tafenoquine: a promising new antimalarial agent.

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Crockett M and Kain KC

Expert opinion on investigational drugs 16(5):705-15, 2007 May - Who cited this? | PubMed ID: 17461742 | Fulltext

Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand.

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Krudsood S, Patel SN, Tangpukdee N, Thanachartwet W, Leowattana W, Pornpininworakij K, Boggild AK, Looareesuwan S, and Kain KC

The American journal of tropical medicine and hygiene 76(4):655-8, 2007 Apr - Who cited this? | PubMed ID: 17426165 | Fulltext

Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo.

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Patel SN, Lu Z, Ayi K, Serghides L, Gowda DC, and Kain KC

Journal of immunology (Baltimore, Md. : 1950) 178(6):3954-61, 2007 Mar 15 - Who cited this? | PubMed ID: 17339496 | Fulltext

A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.

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Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, and Kotra LP

Journal of medicinal chemistry 50(5):915-21, 2007 Mar 8 - Who cited this? | PubMed ID: 17290979 | Fulltext

Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II).

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Boggild AK, Parise ME, Lewis LS, and Kain KC

The American journal of tropical medicine and hygiene 76(2):208-23, 2007 Feb - Who cited this? | PubMed ID: 17297027 | Fulltext

Environmental hazards in Nepal: altitude illness, environmental exposures, injuries, and bites in travelers and expatriates.

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Boggild AK, Costiniuk C, Kain KC, and Pandey P

Journal of travel medicine : official publication of the International Society of Travel Medicine and the Asia Pacific Travel Health Association 14(6):361-8, 2007 - Who cited this? | PubMed ID: 17995530 | Fulltext

HIV immunosuppression and antimalarial efficacy: sulfadoxine-pyrimethamine for the treatment of uncomplicated malaria in HIV-infected adults in Siaya, Kenya.

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Shah SN, Smith EE, Obonyo CO, Kain KC, Bloland PB, Slutsker L, and Hamel MJ

The Journal of infectious diseases 194(11):1519-28, 2006 Dec 1 - Who cited this? | PubMed ID: 17083036 | Fulltext

Illness in travelers visiting friends and relatives: a review of the GeoSentinel Surveillance Network.

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Leder K, Tong S, Weld L, Kain KC, Wilder-Smith A, von Sonnenburg F, Black J, Brown GV, Torresi J, and GeoSentinel Surveillance Network

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 43(9):1185-93, 2006 Nov 1 - Who cited this? | PubMed ID: 17029140 | Fulltext

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model.

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Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, and Kain KC

Journal of immunology (Baltimore, Md. : 1950) 177(9):6344-52, 2006 Nov 1 - Who cited this? | PubMed ID: 17056565 | Fulltext

Placental chondroitin sulfate A-binding malarial isolates evade innate phagocytic clearance.

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Serghides L, Patel SN, Ayi K, and Kain KC

The Journal of infectious diseases 194(1):133-9, 2006 Jul 1 - Who cited this? | PubMed ID: 16741892 | Fulltext

Parasitic central nervous system infections in immunocompromised hosts: clarification of malaria diagnosis.

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Stauffer WM, Magill A, and Kain KC

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 43(1):114-5; author reply 115-6, 2006 Jul 1 - Who cited this? | PubMed ID: 16758433 | Fulltext

Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers.

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Farcas GA, Soeller R, Zhong K, Zahirieh A, and Kain KC

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 42(5):622-7, 2006 Mar 1 - Who cited this? | PubMed ID: 16447106 | Fulltext

Prospective analysis of parasitic infections in Canadian travelers and immigrants.

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Boggild AK, Yohanna S, Keystone JS, and Kain KC

Journal of travel medicine : official publication of the International Society of Travel Medicine and the Asia Pacific Travel Health Association 13(3):138-44, 2006 - Who cited this? | PubMed ID: 16706944 | Fulltext

Simultaneous host and parasite expression profiling identifies tissue-specific transcriptional programs associated with susceptibility or resistance to experimental cerebral malaria.

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Lovegrove FE, Peña-Castillo L, Mohammad N, Liles WC, Hughes TR, and Kain KC

BMC genomics 7:295, 2006 - Who cited this? | PubMed ID: 17118208 | Fulltext

Atovaquone/proguanil for the prophylaxis and treatment of malaria.

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Patel SN and Kain KC

Expert review of anti-infective therapy 3(6):849-61, 2005 Dec - Who cited this? | PubMed ID: 16307498 | Fulltext

Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum.

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Ayi K, Patel SN, Serghides L, Smith TG, and Kain KC

Infection and immunity 73(4):2559-63, 2005 Apr - Who cited this? | PubMed ID: 15784606 | Fulltext

Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa.

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Kuhn S, Gill MJ, and Kain KC

The American journal of tropical medicine and hygiene 72(4):407-9, 2005 Apr - Who cited this? | PubMed ID: 15827276 | Fulltext

Travel patterns and risk behaviour of HIV-positive people travelling internationally.

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Salit IE, Sano M, Boggild AK, and Kain KC

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 172(7):884-8, 2005 Mar 29 - Who cited this? | PubMed ID: 15795409 | Fulltext

Entamoeba histolytica: identification of a distinct beta2 integrin-like molecule with a potential role in cellular adherence.

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Pillai DR and Kain KC

Experimental parasitology 109(3):135-42, 2005 Mar - Who cited this? | PubMed ID: 15713444 | Fulltext

Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocytes.

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Serghides L and Kain KC

Infection and immunity 73(2):1209-13, 2005 Feb - Who cited this? | PubMed ID: 15664966 | Fulltext

Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus.

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Farcas GA, Poutanen SM, Mazzulli T, Willey BM, Butany J, Asa SL, Faure P, Akhavan P, Low DE, and Kain KC

The Journal of infectious diseases 191(2):193-7, 2005 Jan 15 - Who cited this? | PubMed ID: 15609228 | Fulltext

Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.

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Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L,

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Antiviral therapy 10(2):263-75, 2005 - Who cited this? | PubMed ID: 15865221 | Fulltext

Imported Plasmodium vivax malaria: demographic and clinical features in nonimmune travelers.

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Elliott JH, O'Brien D, Leder K, Kitchener S, Schwartz E, Weld L, Brown GV, Kain KC, Torresi J, and

Journal of travel medicine : official publication of the International Society of Travel Medicine and the Asia Pacific Travel Health Association 11(4):213 - Who cited this? | PubMed ID: 15541223 | Fulltext

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