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Papers authored by Kahn BB

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Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

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Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, and Elmquist JK

Endocrinology 150(11):4874-82, 2009 Nov - Who cited this? | PubMed ID: 19819947 | Fulltext

Retinol-binding protein 4 (RBP4): a biomarker for subclinical atherosclerosis?.

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Stuck BJ and Kahn BB

American journal of hypertension : journal of the American Society of Hypertension 22(9):948-9, 2009 Sep - Who cited this? | PubMed ID: 19701163 | Fulltext

Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.

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Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, and Kahn BB

Molecular and cellular biology 29(16):4563-73, 2009 Aug - Who cited this? | PubMed ID: 19528236 | Fulltext

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.

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Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, and Shi GP

Nature medicine 15(8):940-5, 2009 Aug - Who cited this? | PubMed ID: 19633655 | Fulltext

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress.

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Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, and Bence KK

Diabetes 58(3):590-9, 2009 Mar - Who cited this? | PubMed ID: 19074988 | Fulltext

The Relationship of Retinol Binding Protein 4 to Changes in Insulin Resistance and Cardiometabolic Risk in Overweight Black Adolescents.

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Goodman E, Graham TE, Dolan LM, Daniels SR, Goodman ER, and Kahn BB

The Journal of pediatrics, 2008 Sep 9 - Who cited this? | PubMed ID: 18783798 | Fulltext

Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes.

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Krzyzanowska K, Zemany L, Krugluger W, Schernthaner GH, Mittermayer F, Schnack C, Rahman R, Brix J, Kahn BB, and Schernthaner G

Diabetologia 51(7):1115-22, 2008 Jul - Who cited this? | PubMed ID: 18437353 | Fulltext

Deletion of Cd39/Entpd1 results in hepatic insulin resistance.

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Enjyoji K, Ko K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, and Robson SC

Diabetes, 2008 Jun 20 - Who cited this? | PubMed ID: 18567823 | Fulltext

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo.

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Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, and Kahn BB

The Journal of biological chemistry 283(21):14230-41, 2008 May 23 - Who cited this? | PubMed ID: 18281274 | Fulltext

High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects.

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Hammarstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, and Smith U

Journal of internal medicine 263(4):440, 2008 Apr - Who cited this? | PubMed ID: 18324929 | Fulltext

Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice.

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Mody N, Graham TE, Tsuji Y, Yang Q, and Kahn BB

American journal of physiology. Endocrinology and metabolism 294(4):E785-93, 2008 Apr - Who cited this? | PubMed ID: 18285525 | Fulltext

Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression.

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Kovacs P, Geyer M, Berndt J, Klöting N, Graham TE, Böttcher Y, Enigk B, Tönjes A, Schleinitz D, Schön MR, Kahn BB, Blüher M, and Stumvoll M

Diabetes 56(12):3095-100, 2007 Dec - Who cited this? | PubMed ID: 17728376 | Fulltext

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

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Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, and Neel BG

Molecular and cellular biology 27(21):7727-34, 2007 Nov - Who cited this? | PubMed ID: 17724080 | Fulltext

The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance.

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Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, and Rosen ED

Diabetes 56(10):2533-40, 2007 Oct - Who cited this? | PubMed ID: 17639021 | Fulltext

Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes.

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Graham TE and Kahn BB

Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme 39(10):717-21, 2007 Oct - Who cited this? | PubMed ID: 17952832 | Fulltext

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

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Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, and Kahn BB

The Journal of biological chemistry 282(33):23829-40, 2007 Aug 17 - Who cited this? | PubMed ID: 17545163 | Fulltext

Cathepsin L activity controls adipogenesis and glucose tolerance.

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Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, and Shi GP

Nature cell biology 9(8):970-7, 2007 Aug - Who cited this? | PubMed ID: 17643114 | Fulltext

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.

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Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, and Shulman GI

Proceedings of the National Academy of Sciences of the United States of America 104(31):12587-94, 2007 Jul 31 - Who cited this? | PubMed ID: 17640906 | Fulltext

Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass.

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Klöting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schön MR, Stumvoll M, Blüher M, and Kahn BB

Cell metabolism 6(1):79-87, 2007 Jul - Who cited this? | PubMed ID: 17618858 | Fulltext

A high-fat, ketogenic diet induces a unique metabolic state in mice.

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Kennedy AR, Pissios P, Otu H, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, and Maratos-Flier E

American journal of physiology. Endocrinology and metabolism 292(6):E1724-39, 2007 Jun - Who cited this? | PubMed ID: 17299079 | Fulltext

Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation.

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Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, and George D

The Journal of clinical endocrinology and metabolism 92(5):1971-4, 2007 May - Who cited this? | PubMed ID: 17341558 | Fulltext

Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects.

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Graham TE, Wason CJ, Blüher M, and Kahn BB

Diabetologia 50(4):814-23, 2007 Apr - Who cited this? | PubMed ID: 17294166 | Fulltext

Regulation of gluconeogenesis by Krüppel-like factor 15.

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Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, and Jain MK

Cell metabolism 5(4):305-12, 2007 Apr - Who cited this? | PubMed ID: 17403374 | Fulltext

Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia.

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Alquier T, Kawashima J, Tsuji Y, and Kahn BB

Endocrinology 148(3):1367-75, 2007 Mar - Who cited this? | PubMed ID: 17185376 | Fulltext

Neuronal PTP1B regulates body weight, adiposity and leptin action.

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Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, and Kahn BB

Nature medicine 12(8):917-24, 2006 Aug - Who cited this? | PubMed ID: 16845389 | Fulltext

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.

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Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, and Kahn BB

The Journal of biological chemistry 281(28):18933, 2006 Jul 14 - Who cited this? | PubMed ID: 16687413 | Fulltext

AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues.

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Xue B and Kahn BB

The Journal of physiology 574(Pt 1):73-83, 2006 Jul 1 - Who cited this? | PubMed ID: 16709629 | Fulltext

Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.

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Herman MA and Kahn BB

The Journal of clinical investigation 116(7):1767-75, 2006 Jul - Who cited this? | PubMed ID: 16823474 | Fulltext

Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.

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Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, and Kahn BB

The New England journal of medicine 354(24):2552-63, 2006 Jun 15 - Who cited this? | PubMed ID: 16775236 | Fulltext

mTOR tells the brain that the body is hungry.

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Kahn BB and Myers MG

Nature medicine 12(6):615-7, 2006 Jun - Who cited this? | PubMed ID: 16761005 | Fulltext

Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.

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Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, and Kahn BB

Molecular and cellular biology 25(21):9713-23, 2005 Nov - Who cited this? | PubMed ID: 16227617 | Fulltext

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.

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Carvalho E, Kotani K, Peroni OD, and Kahn BB

American journal of physiology. Endocrinology and metabolism 289(4):E551-61, 2005 Oct - Who cited this? | PubMed ID: 15928024 | Fulltext

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

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Furukawa N, Ongusaha P, Jahng WJ, Araki K, Choi CS, Kim HJ, Lee YH, Kaibuchi K, Kahn BB, Masuzaki H, Kim JK, Lee SW, and Kim YB

Cell metabolism 2(2):119, 2005 Aug - Who cited this? | PubMed ID: 16098829 | Fulltext

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.

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Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, and Kahn BB

Nature 436(7049):356-62, 2005 Jul 21 - Who cited this? | PubMed ID: 16034410 | Fulltext

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.

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Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, and Dunaif A

American journal of physiology. Endocrinology and metabolism 288(5):E1047-54, 2005 May - Who cited this? | PubMed ID: 15613682 | Fulltext

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.

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Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, and Magnuson MA

Proceedings of the National Academy of Sciences of the United States of America 102(17):6207-12, 2005 Apr 26 - Who cited this? | PubMed ID: 15833818 | Fulltext

Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.

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Haj FG, Zabolotny JM, Kim YB, Kahn BB, and Neel BG

The Journal of biological chemistry 280(15):15038-46, 2005 Apr 15 - Who cited this? | PubMed ID: 15699041 | Fulltext

Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.

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Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, and Wu H

Molecular and cellular biology 25(6):2498-510, 2005 Mar - Who cited this? | PubMed ID: 15743841 | Fulltext

Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency.

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Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB, Kahn BB, and Mantzoros CS

The Journal of clinical endocrinology and metabolism 90(3):1625-31, 2005 Mar - Who cited this? | PubMed ID: 15613409 | Fulltext

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

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Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, and Hotamisligil GS

Cell metabolism 1(2):107, 2005 Feb - Who cited this? | PubMed ID: 16054052 | Fulltext

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

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Kahn BB, Alquier T, Carling D, and Hardie DG

Cell metabolism 1(1):15, 2005 Jan - Who cited this? | PubMed ID: 16054041 | Fulltext

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.

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Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, and Tiganis T

Molecular and cellular biology 25(2):819-29, 2005 Jan - Who cited this? | PubMed ID: 15632081 | Fulltext

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.

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Kotani K, Peroni OD, Minokoshi Y, Boss O, and Kahn BB

The Journal of clinical investigation 114(11):1666-75, 2004 Dec - Who cited this? | PubMed ID: 15578099 | Fulltext

Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland.

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Morroni M, Giordano A, Zingaretti MC, Boiani R, De Matteis R, Kahn BB, Nisoli E, Tonello C, Pisoschi C, Luchetti MM, Marelli M, and Cinti S

Proceedings of the National Academy of Sciences of the United States of America 101(48):16801, 2004 Nov 30 - Who cited this? | PubMed ID: 15556998 | Fulltext

Nutrient sensor links obesity with diabetes risk.

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Patti ME and Kahn BB

Nature medicine 10(10):1049-50, 2004 Oct - Who cited this? | PubMed ID: 15459705 | Fulltext

Peripheral signals set the tone for central regulation of metabolism.

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Alquier T and Kahn BB

Endocrinology 145(9):4022-4, 2004 Sep - Who cited this? | PubMed ID: 15321948 | Fulltext

Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.

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Blüher M, Patti ME, Gesta S, Kahn BB, and Kahn CR

The Journal of biological chemistry 279(30):31891-901, 2004 Jul 23 - Who cited this? | PubMed ID: 15131119 | Fulltext

Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.

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Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, and Kahn BB

The Journal of biological chemistry 279(23):24844-51, 2004 Jun 4 - Who cited this? | PubMed ID: 15031294 | Fulltext

Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.

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Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, and Cantley LC

Molecular and cellular biology 24(11):5080-7, 2004 Jun - Who cited this? | PubMed ID: 15143198 | Fulltext

GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase.

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Carvalho E, Schellhorn SE, Zabolotny JM, Martin S, Tozzo E, Peroni OD, Houseknecht KL, Mundt A, James DE, and Kahn BB

The Journal of biological chemistry 279(20):21598-605, 2004 May 14 - Who cited this? | PubMed ID: 14985357 | Fulltext

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