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Papers authored by Jakob C

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Synergistic interaction of proteasome and topoisomerase II inhibition in multiple myeloma.

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von Metzler I, Heider U, Mieth M, Lamottke B, Kaiser M, Jakob C, and Sezer O

Experimental cell research 315(14):2471-8, 2009 Aug 15 - Who cited this? | PubMed ID: 19410573 | Fulltext

Novel renal replacement strategies for the elimination of serum free light chains in patients with kappa light chain nephropathy.

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Kleeberg L, Morgera S, Jakob C, Hocher B, Schneider M, Peters H, Rötzer S, Müller C, Kaiser M, Fleissner C, Heider U, Neumayer HH, and Sezer O

European journal of medical research 14(2):47-54, 2009 Feb 18 - Who cited this? | PubMed ID: 19258212 | Fulltext

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum.

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Clerc S, Hirsch C, Oggier DM, Deprez P, Jakob C, Sommer T, and Aebi M

The Journal of cell biology 184(1):159-72, 2009 Jan 12 - Who cited this? | PubMed ID: 19124653 | Fulltext

Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment.

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Heider U, Kaiser M, Mieth M, Lamottke B, Rademacher J, Jakob C, Braendle E, Stover D, and Sezer O

European journal of haematology 82(1):31-8, 2009 Jan - Who cited this? | PubMed ID: 19067746 | Fulltext

Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation.

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Stoehlmacher J, Goekkurt E, Mogck U, Aust DE, Kramer M, Baretton GB, Liersch T, Ehninger G, and Jakob C

Cancer letters 272(2):221-5, 2008 Dec 18 - Who cited this? | PubMed ID: 18722050 | Fulltext

Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated IkappaB kinase.

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von Metzler I, Krebbel H, Kuckelkorn U, Heider U, Jakob C, Kaiser M, Fleissner C, Terpos E, and Sezer O

Journal of cancer research and clinical oncology, 2008 Sep 3 - Who cited this? | PubMed ID: 18766375 | Fulltext

Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma.

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Jakob C, Sterz J, Liebisch P, Mieth M, Rademacher J, Goerke A, Heider U, Fleissner C, Kaiser M, von Metzler I, Müller C, and Sezer O

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 22(9):1812, 2008 Sep - Who cited this? | PubMed ID: 18781159 | Fulltext

Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma.

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Jakob C, Sterz J, Liebisch P, Mieth M, Rademacher J, Goerke A, Heider U, Fleissner C, Kaiser M, von Metzler I, Müller C, and Sezer O

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2008 Jun 26 - Who cited this? | PubMed ID: 18580957 | Fulltext

Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma.

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Kaiser M, Mieth M, Liebisch P, Oberländer R, Rademacher J, Jakob C, Kleeberg L, Fleissner C, Braendle E, Peters M, Stover D, Sezer O, and Heider U

European journal of haematology 80(6):490-4, 2008 Jun - Who cited this? | PubMed ID: 18331598 | Fulltext

Predictive value of Ki67 and p53 in locally advanced rectal cancer: Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy.

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Jakob C, Liersch T, Meyer W, Becker H, Baretton GB, and Aust DE

World journal of gastroenterology : WJG 14(7):1060-6, 2008 Feb 21 - Who cited this? | PubMed ID: 18286688 | Fulltext

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma.

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Heider U, von Metzler I, Kaiser M, Rosche M, Sterz J, Rötzer S, Rademacher J, Jakob C, Fleissner C, Kuckelkorn U, Kloetzel PM, and Sezer O

European journal of haematology 80(2):133, 2008 Feb - Who cited this? | PubMed ID: 18005386 | Fulltext

Transport of Na(+) and K (+) by an antiporter-related subunit from the Escherichia coli NADH dehydrogenase I produced in Saccharomyces cerevisiae.

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Gemperli AC, Schaffitzel C, Jakob C, and Steuber J

Archives of microbiology 188(5):509-21, 2007 Nov - Who cited this? | PubMed ID: 17583799 | Fulltext

A potent erythropoietin-mimicking human antibody interacts through a novel binding site.

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Liu Z, Stoll VS, Devries PJ, Jakob CG, Xie N, Simmer RL, Lacy SE, Egan DA, Harlan JE, Lesniewski RR, and Reilly EB

Blood 110(7):2408-13, 2007 Oct 1 - Who cited this? | PubMed ID: 17620453 | Fulltext

Bortezomib inhibits human osteoclastogenesis.

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von Metzler I, Krebbel H, Hecht M, Manz RA, Fleissner C, Mieth M, Kaiser M, Jakob C, Sterz J, Kleeberg L, Heider U, and Sezer O

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 21(9):2025-34, 2007 Sep - Who cited this? | PubMed ID: 17581612 | Fulltext

Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma.

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Jakob C, Egerer K, Liebisch P, Türkmen S, Zavrski I, Kuckelkorn U, Heider U, Kaiser M, Fleissner C, Sterz J, Kleeberg L, Feist E, Burmester GR, Kloetzel PM, and Sezer O

Blood 109(5):2100-5, 2007 Mar 1 - Who cited this? | PubMed ID: 17095627 | Fulltext

4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.

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Matulenko MA, Paight ES, Frey RR, Gomtsyan A, DiDomenico S, Jiang M, Lee CH, Stewart AO, Yu H, Kohlhaas KL, Alexander KM, McGaraughty S, Mikusa J, Marsh KC, Muchmore SW, Jakob CL,

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Bioorganic & medicinal chemistry 15(4):1586-605, 2007 Feb 15 - Who cited this? | PubMed ID: 17197188 | Fulltext

Proteasome as an emerging therapeutic target in cancer.

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Zavrski I, Kleeberg L, Kaiser M, Fleissner C, Heider U, Sterz J, Jakob C, and Sezer O

Current pharmaceutical design 13(5):471-85, 2007 - Who cited this? | PubMed ID: 17348844 | Fulltext

Molecular and clinical aspects of proteasome inhibition in the treatment of cancer.

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Zavrski I, Jakob C, Kaiser M, Fleissner C, Heider U, and Sezer O

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 176:165-76, 2007 - Who cited this? | PubMed ID: 17607924 | Fulltext

Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.

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Muchmore SW, Smith RA, Stewart AO, Cowart MD, Gomtsyan A, Matulenko MA, Yu H, Severin JM, Bhagwat SS, Lee CH, Kowaluk EA, Jarvis MF, and Jakob CL

Journal of medicinal chemistry 49(23):6726-31, 2006 Nov 16 - Who cited this? | PubMed ID: 17154503 | Fulltext

Bortezomib-induced tumor lysis syndrome in multiple myeloma.

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Sezer O, Vesole DH, Singhal S, Richardson P, Stadtmauer E, Jakob C, Boral AL, Esseltine DL, and Mehta J

Clinical lymphoma & myeloma 7(3):233-5, 2006 Nov - Who cited this? | PubMed ID: 17229340 | Fulltext

Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy.

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Liersch T, Langer C, Ghadimi BM, Kulle B, Aust DE, Baretton GB, Schwabe W, Häusler P, Becker H, and Jakob C

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24(25):4062, 2006 Sep 1 - Who cited this? | PubMed ID: 16943523 | Fulltext

Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment.

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Heider U, Kaiser M, Müller C, Jakob C, Zavrski I, Schulz CO, Fleissner C, Hecht M, and Sezer O

European journal of haematology 77(3):233-8, 2006 Sep - Who cited this? | PubMed ID: 16923110 | Fulltext

Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy.

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Jakob C, Liersch T, Meyer W, Baretton GB, Schwabe W, Häusler P, Kulle B, Becker H, and Aust DE

The American journal of surgical pathology 30(9):1169-74, 2006 Sep - Who cited this? | PubMed ID: 16931962 | Fulltext

Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma.

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Eucker J, Sterz J, Krebbel H, Zavrski I, Kaiser M, Zang C, Heider U, Jakob C, Elstner E, and Sezer O

Anti-cancer drugs 17(7):763, 2006 Aug - Who cited this? | PubMed ID: 16926626 | Fulltext

Bone markers in multiple myeloma.

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Heider U, Fleissner C, Zavrski I, Kaiser M, Hecht M, Jakob C, and Sezer O

European journal of cancer (Oxford, England : 1990) 42(11):1544-53, 2006 Jul - Who cited this? | PubMed ID: 16765040 | Fulltext

Angiogenesis in multiple myeloma.

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Jakob C, Sterz J, Zavrski I, Heider U, Kleeberg L, Fleissner C, Kaiser M, and Sezer O

European journal of cancer (Oxford, England : 1990) 42(11):1581-90, 2006 Jul - Who cited this? | PubMed ID: 16797965 | Fulltext

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

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Longenecker KL, Stewart KD, Madar DJ, Jakob CG, Fry EH, Wilk S, Lin CW, Ballaron SJ, Stashko MA, Lubben TH, Yong H, Pireh D, Pei Z, Basha F, Wiedeman PE, von Geldern TW,

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Biochemistry 45(24):7474, 2006 Jun 20 - Who cited this? | PubMed ID: 16768443 | Fulltext

Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.

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Li Q, Woods KW, Thomas S, Zhu GD, Packard G, Fisher J, Li T, Gong J, Dinges J, Song X, Abrams J, Luo Y, Johnson EF, Shi Y, Liu X, Klinghofer V,

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Bioorganic & medicinal chemistry letters 16(7):2000-7, 2006 Apr 1 - Who cited this? | PubMed ID: 16413780 | Fulltext

Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.

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Li Q, Li T, Zhu GD, Gong J, Claibone A, Dalton C, Luo Y, Johnson EF, Shi Y, Liu X, Klinghofer V, Bauch JL, Marsh KC, Bouska JJ, Arries S, De Jong R,

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Bioorganic & medicinal chemistry letters 16(6):1679-85, 2006 Mar 15 - Who cited this? | PubMed ID: 16403626 | Fulltext

Volume-reduced platelet concentrates.

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Schoenfeld H, Spies C, and Jakob C

Current hematology reports 5(1):82-8, 2006 Mar - Who cited this? | PubMed ID: 16537051 | Fulltext

The effects of the histone deacetylase inhibitor valproic acid on cell cycle, growth suppression and apoptosis in multiple myeloma.

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Kaiser M, Zavrski I, Sterz J, Jakob C, Fleissner C, Kloetzel PM, Sezer O, and Heider U

Haematologica 91(2):248-51, 2006 Feb - Who cited this? | PubMed ID: 16461312 | Fulltext

Structure-based optimization of MurF inhibitors.

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Stamper GF, Longenecker KL, Fry EH, Jakob CG, Florjancic AS, Gu YG, Anderson DD, Cooper CS, Zhang T, Clark RF, Cia Y, Black-Schaefer CL, Owen McCall J, Lerner CG, Hajduk PJ, Beutel BA,

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Chemical biology & drug design 67(1):58, 2006 Jan - Who cited this? | PubMed ID: 16492149 | Fulltext

Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma.

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Heider U, Kaiser M, Sterz J, Zavrski I, Jakob C, Fleissner C, Eucker J, Possinger K, and Sezer O

European journal of haematology 76(1):42-50, 2006 Jan - Who cited this? | PubMed ID: 16343270 | Fulltext

Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolism.

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Freimoser FM, Hürlimann HC, Jakob CA, Werner TP, and Amrhein N

Genome biology 7(11):R109, 2006 - Who cited this? | PubMed ID: 17107617 | Fulltext

Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease.

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Heider U, Hofbauer LC, Zavrski I, Kaiser M, Jakob C, and Sezer O

Biochemical and biophysical research communications 338(2):687-93, 2005 Dec 16 - Who cited this? | PubMed ID: 16216218 | Fulltext

Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.

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Longenecker KL, Stamper GF, Hajduk PJ, Fry EH, Jakob CG, Harlan JE, Edalji R, Bartley DM, Walter KA, Solomon LR, Holzman TF, Gu YG, Lerner CG, Beutel BA, and Stoll VS

Protein science : a publication of the Protein Society 14(12):3039-47, 2005 Dec - Who cited this? | PubMed ID: 16322581 | Fulltext

A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies.

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Gu WZ, Joseph I, Wang YC, Frost D, Sullivan GM, Wang L, Lin NH, Cohen J, Stoll VS, Jakob CG, Muchmore SW, Harlan JE, Holzman T, Walten KA, Ladror US, Anderson MG,

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Anti-cancer drugs 16(10):1059-69, 2005 Nov - Who cited this? | PubMed ID: 16222147 | Fulltext

Biosynthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc(2)-PP-dolichol.

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Bickel T, Lehle L, Schwarz M, Aebi M, and Jakob CA

The Journal of biological chemistry 280(41):34500-6, 2005 Oct 14 - Who cited this? | PubMed ID: 16100113 | Fulltext

Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemoradiotherapy.

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Jakob C, Liersch T, Meyer W, Baretton GB, Häusler P, Schwabe W, Becker H, and Aust DE

The American journal of surgical pathology 29(10):1304-9, 2005 Oct - Who cited this? | PubMed ID: 16160472 | Fulltext

Prevention of aspiration under general anesthesia by use of the size 2 1/2 ProSeal laryngeal mask airway in a 6-year-old boy: a case report.

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Goldmann K and Jakob C

Paediatric anaesthesia 15(10):886-9, 2005 Oct - Who cited this? | PubMed ID: 16176318 | Fulltext

Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.

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Szathmary R, Bielmann R, Nita-Lazar M, Burda P, and Jakob CA

Molecular cell 19(6):765, 2005 Sep 16 - Who cited this? | PubMed ID: 16168372 | Fulltext

Proteasome: an emerging target for cancer therapy.

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Zavrski I, Jakob C, Schmid P, Krebbel H, Kaiser M, Fleissner C, Rosche M, Possinger K, and Sezer O

Anti-cancer drugs 16(5):475-81, 2005 Jun - Who cited this? | PubMed ID: 15846112 | Fulltext

A randomized crossover comparison of the size 2 1/2 laryngeal mask airway ProSeal versus laryngeal mask airway-Classic in pediatric patients.

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Goldmann K and Jakob C

Anesthesia and analgesia 100(6):1605-10, 2005 Jun - Who cited this? | PubMed ID: 15920181 | Fulltext

Size 2 ProSeal laryngeal mask airway: a randomized, crossover investigation with the standard laryngeal mask airway in paediatric patients.

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Goldmann K and Jakob C

British journal of anaesthesia 94(3):385-9, 2005 Mar - Who cited this? | PubMed ID: 15591332 | Fulltext

Determination of pseudophakic accommodation with translation lenses using Purkinje image analysis.

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Langenbucher A, Jakob C, Reese S, and Seitz B

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 25(2):87-96, 2005 Mar - Who cited this? | PubMed ID: 15713200 | Fulltext

Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer.

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Jakob C, Aust DE, Meyer W, Baretton GB, Schwabe W, Häusler P, Becker H, and Liersch T

The Journal of pathology 204(5):562-8, 2004 Dec - Who cited this? | PubMed ID: 15538739 | Fulltext

Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma.

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Eucker J, Bängeroth K, Zavrski I, Krebbel H, Zang C, Heider U, Jakob C, Elstner E, Possinger K, and Sezer O

Anti-cancer drugs 15(10):955, 2004 Nov - Who cited this? | PubMed ID: 15514564 | Fulltext

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.

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Li Q, Claiborne A, Li T, Hasvold L, Stoll VS, Muchmore S, Jakob CG, Gu W, Cohen J, Hutchins C, Frost D, Rosenberg SH, and Sham HL

Bioorganic & medicinal chemistry letters 14(21):5367-70, 2004 Nov 1 - Who cited this? | PubMed ID: 15454228 | Fulltext

Pseudophakic accommodation with translation lenses--dual optic vs mono optic.

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Langenbucher A, Reese S, Jakob C, and Seitz B

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 24(5):450-7, 2004 Sep - Who cited this? | PubMed ID: 15315660 | Fulltext

Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.

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von Geldern TW, Tu N, Kym PR, Link JT, Jae HS, Lai C, Apelqvist T, Rhonnstad P, Hagberg L, Koehler K, Grynfarb M, Goos-Nilsson A, Sandberg J, Osterlund M, Barkhem T, Höglund M,

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Journal of medicinal chemistry 47(17):4213-30, 2004 Aug 12 - Who cited this? | PubMed ID: 15293993 | Fulltext

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