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Papers authored by Iwaasa H

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Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.

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Ito M, Ishihara A, Gomori A, Egashira S, Matsushita H, Mashiko S, Ito J, Ito M, Nakase K, Haga Y, Iwaasa H, Suzuki T, Ohtake N, Moriya M, Sato N, Macneil DJ,

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European journal of pharmacology 624(1-3):77-83, 2009 Dec 10 - Who cited this? | PubMed ID: 19836369 | Fulltext

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.

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Haga Y, Sakamoto T, Shibata T, Nonoshita K, Ishikawa M, Suga T, Takahashi H, Takahashi T, Takahashi H, Ando M, Murai T, Gomori A, Oda Z, Kitazawa H, Mitobe Y, Kanesaka M,

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Bioorganic & medicinal chemistry 17(19):6971-82, 2009 Oct 1 - Who cited this? | PubMed ID: 19720539 | Fulltext

Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.

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Takahashi H, Haga Y, Shibata T, Nonoshita K, Sakamoto T, Moriya M, Ohe T, Chiba M, Mitobe Y, Kitazawa H, Iwaasa H, Ishihara A, Ishii Y, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 19(18):5436-9, 2009 Sep 15 - Who cited this? | PubMed ID: 19679469 | Fulltext

Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.

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Ando M, Sekino E, Haga Y, Moriya M, Ito M, Ito J, Iwaasa H, Ishihara A, Kanatani A, and Ohtake N

Bioorganic & medicinal chemistry letters 19(17):5186-90, 2009 Sep 1 - Who cited this? | PubMed ID: 19632840 | Fulltext

Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists.

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Kishino H, Moriya M, Sakuraba S, Sakamoto T, Takahashi H, Suzuki T, Moriya R, Ito M, Iwaasa H, Takenaga N, Ishihara A, Kanatani A, Sato N, and Fukami T

Bioorganic & medicinal chemistry letters 19(16):4589-93, 2009 Aug 15 - Who cited this? | PubMed ID: 19615899 | Fulltext

Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.

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Ando M, Sato N, Nagase T, Nagai K, Ishikawa S, Takahashi H, Ohtake N, Ito J, Hirayama M, Mitobe Y, Iwaasa H, Gomori A, Matsushita H, Tadano K, Fujino N, Tanaka S,

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Bioorganic & medicinal chemistry 17(16):6106-22, 2009 Aug 15 - Who cited this? | PubMed ID: 19616955 | Fulltext

Synergistic interaction between neuropeptide Y(1) and Y(5) receptor pathways in regulation of energy homeostasis.

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Mashiko S, Moriya R, Ishihara A, Gomori A, Matsushita H, Egashira S, Iwaasa H, Takahashi T, Haga Y, Fukami T, and Kanatani A

European journal of pharmacology 615(1-3):113-7, 2009 Aug 1 - Who cited this? | PubMed ID: 19482021 | Fulltext

Cloning and characterization of rabbit neuropeptide Y receptor subtypes.

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Umeda T, Kanatani A, and Iwaasa H

Peptides 30(8):1441-7, 2009 Aug - Who cited this? | PubMed ID: 19481128 | Fulltext

Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.

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Sakamoto T, Moriya M, Tsuge H, Takahashi T, Haga Y, Nonoshita K, Okamoto O, Takahashi H, Sakuraba A, Hirohashi T, Shibata T, Kanno T, Ito J, Iwaasa H, Gomori A, Ishihara A,

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Bioorganic & medicinal chemistry 17(14):5015-26, 2009 Jul 15 - Who cited this? | PubMed ID: 19525116 | Fulltext

Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

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Moriya M, Kishino H, Sakuraba S, Sakamoto T, Suga T, Takahashi H, Suzuki T, Ito M, Ito J, Moriya R, Takenaga N, Iwaasa H, Ishihara A, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 19(13):3568-72, 2009 Jul 1 - Who cited this? | PubMed ID: 19457661 | Fulltext

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.

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Takahashi T, Haga Y, Sakamoto T, Moriya M, Okamoto O, Nonoshita K, Shibata T, Suga T, Takahashi H, Hirohashi T, Sakuraba A, Gomori A, Iwaasa H, Ohe T, Ishihara A, Ishii Y,

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Bioorganic & medicinal chemistry letters 19(13):3511-6, 2009 Jul 1 - Who cited this? | PubMed ID: 19464889 | Fulltext

Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice.

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Moriya R, Mashiko S, Ishihara A, Takahashi T, Murai T, Ito J, Mitobe Y, Oda Z, Iwaasa H, Takehiro F, and Kanatani A

Peptides 30(7):1318-22, 2009 Jul - Who cited this? | PubMed ID: 19394383 | Fulltext

Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.

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Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N,

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Bioorganic & medicinal chemistry letters 19(11):3072-7, 2009 Jun 1 - Who cited this? | PubMed ID: 19403308 | Fulltext

Chronic intracerebroventricular infusion of nociceptin/orphanin FQ produces body weight gain by affecting both feeding and energy metabolism in mice.

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Matsushita H, Ishihara A, Mashiko S, Tanaka T, Kanno T, Iwaasa H, Ohta H, and Kanatani A

Endocrinology 150(6):2668-73, 2009 Jun - Who cited this? | PubMed ID: 19196798 | Fulltext

Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.

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Sato N, Ando M, Ishikawa S, Jitsuoka M, Nagai K, Takahashi H, Sakuraba A, Tsuge H, Kitazawa H, Iwaasa H, Mashiko S, Gomori A, Moriya R, Fujino N, Ohe T, Ishihara A,

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Journal of medicinal chemistry 52(10):3385-96, 2009 May 28 - Who cited this? | PubMed ID: 19459652 | Fulltext

Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).

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Ito M, Sakamoto T, Suzuki T, Egashira S, Moriya M, Ishihara A, Iwaasa H, Matsushita H, Nakase K, Wallace MA, Dean D, Sato N, Tokita S, and Kanatani A

Bioorganic & medicinal chemistry letters 19(10):2835-9, 2009 May 15 - Who cited this? | PubMed ID: 19361985 | Fulltext

Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists.

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Sato N, Jitsuoka M, Ishikawa S, Nagai K, Tsuge H, Ando M, Okamoto O, Iwaasa H, Gomori A, Ishihara A, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 19(6):1670-4, 2009 Mar 15 - Who cited this? | PubMed ID: 19233647 | Fulltext

Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.

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Sakamoto T, Moriya M, Haga Y, Takahashi T, Shibata T, Okamoto O, Nonoshita K, Kitazawa H, Hidaka M, Gomori A, Iwaasa H, Ishihara A, Kanatani A, Fukami T, Gao YD, Macneil DJ,

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Bioorganic & medicinal chemistry letters 19(6):1564-8, 2009 Mar 15 - Who cited this? | PubMed ID: 19243937 | Fulltext

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.

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Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 18(18):5010-4, 2008 Sep 15 - Who cited this? | PubMed ID: 18723347 | Fulltext

Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.

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Ogino Y, Ohtake N, Nagae Y, Matsuda K, Ishikawa M, Moriya M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 18(18):4997-5001, 2008 Sep 15 - Who cited this? | PubMed ID: 18752943 | Fulltext

Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.

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Ito M, Gomori A, Suzuki J, Tsujioka S, Sasaki M, Matsuda M, Bednarek MA, Ito M, Ishihara A, Iwaasa H, MacNeil DJ, and Kanatani A

The Journal of endocrinology 198(2):309, 2008 Aug - Who cited this? | PubMed ID: 18523032 | Fulltext

(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a Selective and Orally Active Neuropeptide Y Y5 Receptor Antagonist.

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Sato N, Jitsuoka M, Shibata T, Hirohashi T, Nonoshita K, Moriya M, Haga Y, Sakuraba A, Ando M, Ohe T, Iwaasa H, Gomori A, Ishihara A, Kanatani A, and Fukami T

Journal of medicinal chemistry, 2008 Jul 19 - Who cited this? | PubMed ID: 18637668 | Fulltext

Effects of a novel y5 antagonist in obese mice: combination with food restriction or sibutramine.

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Mashiko S, Ishihara A, Iwaasa H, Moriya R, Kitazawa H, Mitobe Y, Ito J, Gomori A, Matsushita H, Takahashi T, Macneil DJ, Van der Ploeg LH, Fukami T, and Kanatani A

Obesity (Silver Spring, Md.) 16(7):1510-5, 2008 Jul - Who cited this? | PubMed ID: 18421274 | Fulltext

Blockade of MCH1 receptor signalling ameliorates obesity and related hepatic steatosis in ovariectomized mice.

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Gomori A, Ishihara A, Ito M, Matsushita H, Ito M, Mashiko S, Iwaasa H, Matsuda M, Bednarek MA, Qian S, Macneil DJ, and Kanatani A

British journal of pharmacology 151(6):900-8, 2007 Jul - Who cited this? | PubMed ID: 17519948 | Fulltext

A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.

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Mashiko S, Ishihara A, Iwaasa H, Sano H, Ito J, Gomori A, Oda Z, Moriya R, Matsushita H, Jitsuoka M, Okamoto O, MacNeil DJ, Van der Ploeg LH, Fukami T, and Kanatani A

Molecular pharmacology 71(2):602-8, 2007 Feb - Who cited this? | PubMed ID: 17105869 | Fulltext

Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet.

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Ito M, Suzuki J, Tsujioka S, Sasaki M, Gomori A, Shirakura T, Hirose H, Ito M, Ishihara A, Iwaasa H, and Kanatani A

Hepatology research : the official journal of the Japan Society of Hepatology 37(1):50-7, 2007 Jan - Who cited this? | PubMed ID: 17300698 | Fulltext

Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives.

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Takahashi T, Sakuraba A, Hirohashi T, Shibata T, Hirose M, Haga Y, Nonoshita K, Kanno T, Ito J, Iwaasa H, Kanatani A, Fukami T, and Sato N

Bioorganic & medicinal chemistry 14(22):7501-11, 2006 Nov 15 - Who cited this? | PubMed ID: 16919461 | Fulltext

RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice.

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Moriya R, Sano H, Umeda T, Ito M, Takahashi Y, Matsuda M, Ishihara A, Kanatani A, and Iwaasa H

Endocrinology 147(6):2916, 2006 Jun - Who cited this? | PubMed ID: 16543370 | Fulltext

A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.

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Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T,

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Proceedings of the National Academy of Sciences of the United States of America 103(18):7154-8, 2006 May 2 - Who cited this? | PubMed ID: 16636293 | Fulltext

[Development of anorectic NPY antagonists: possible roles of Y1 and Y5 receptors in feeding regulation].

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Kanatani A, Ishihara A, Iwaasa H, MacNeil DJ, and Fukami T

Nippon yakurigaku zasshi. Folia pharmacologica Japonica 127(2):88-91, 2006 Feb - Who cited this? | PubMed ID: 16595978 | Fulltext

Development of nonalcoholic steatohepatitis model through combination of high-fat diet and tetracycline with morbid obesity in mice.

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Ito M, Suzuki J, Sasaki M, Watanabe K, Tsujioka S, Takahashi Y, Gomori A, Hirose H, Ishihara A, Iwaasa H, and Kanatani A

Hepatology research : the official journal of the Japan Society of Hepatology 34(2):92-8, 2006 Feb - Who cited this? | PubMed ID: 16423558 | Fulltext

Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice.

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Mashiko S, Ishihara A, Gomori A, Moriya R, Ito M, Iwaasa H, Matsuda M, Feng Y, Shen Z, Marsh DJ, Bednarek MA, MacNeil DJ, and Kanatani A

Endocrinology 146(7):3080-6, 2005 Jul - Who cited this? | PubMed ID: 15817671 | Fulltext

Characterization of the bombesin-like peptide receptor family in primates.

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Sano H, Feighner SD, Hreniuk DL, Iwaasa H, Sailer AW, Pan J, Reitman ML, Kanatani A, Howard AD, and Tan CP

Genomics 84(1):139-46, 2004 Jul - Who cited this? | PubMed ID: 15203211 | Fulltext

Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists.

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Sato N, Shibata T, Jitsuoka M, Ohno T, Takahashi T, Hirohashi T, Kanno T, Iwaasa H, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 14(7):1761-4, 2004 Apr 5 - Who cited this? | PubMed ID: 15026066 | Fulltext

N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.

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Hirose M, Egashira S, Goto Y, Hashihayata T, Ohtake N, Iwaasa H, Hata M, Fukami T, Kanatani A, and Yamada K

Bioorganic & medicinal chemistry letters 13(24):4497-9, 2003 Dec 15 - Who cited this? | PubMed ID: 14643355 | Fulltext

Characterization of MCH-mediated obesity in mice.

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Ito M, Gomori A, Ishihara A, Oda Z, Mashiko S, Matsushita H, Yumoto M, Ito M, Sano H, Tokita S, Moriya M, Iwaasa H, and Kanatani A

American journal of physiology. Endocrinology and metabolism 284(5):E940-5, 2003 May - Who cited this? | PubMed ID: 12554598 | Fulltext

Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34)NPY.

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Mashiko S, Ishihara A, Iwaasa H, Sano H, Oda Z, Ito J, Yumoto M, Okawa M, Suzuki J, Fukuroda T, Jitsuoka M, Morin NR, MacNeil DJ, Van der Ploeg LH, Ihara M, Fukami T,

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Endocrinology 144(5):1793-801, 2003 May - Who cited this? | PubMed ID: 12697685 | Fulltext

Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone.

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Gomori A, Ishihara A, Ito M, Mashiko S, Matsushita H, Yumoto M, Ito M, Tanaka T, Tokita S, Moriya M, Iwaasa H, and Kanatani A

American journal of physiology. Endocrinology and metabolism 284(3), 2003 Mar - Who cited this? | PubMed ID: 12453827 | Fulltext

Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B.

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Asahi S, Egashira S, Matsuda M, Iwaasa H, Kanatani A, Ohkubo M, Ihara M, and Morishima H

Bioorganic & medicinal chemistry letters 13(1):111-3, 2003 Jan 6 - Who cited this? | PubMed ID: 12467628 | Fulltext

Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression.

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Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, Ito M,

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Genomics 79(6):785-92, 2002 Jun - Who cited this? | PubMed ID: 12036292 | Fulltext

Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.

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Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H, Hreniuk DL, Morin NR, Sadowski SJ, Ito M, Ito M, Bansal A,

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Proceedings of the National Academy of Sciences of the United States of America 98(13):7564-9, 2001 Jun 19 - Who cited this? | PubMed ID: 11404457 | Fulltext

Different binding sites for the neuropeptide Y Y1 antagonists 1229U91 and J-104870 on human Y1 receptors.

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Kannoa T, Kanatani A, Keen SL, Arai-Otsuki S, Haga Y, Iwama T, Ishihara A, Sakuraba A, Iwaasa H, Hirose M, Morishima H, Fukami T, and Ihara M

Peptides 22(3):405-13, 2001 Mar - Who cited this? | PubMed ID: 11287095 | Fulltext

L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.

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Kanatani A, Ishihara A, Iwaasa H, Nakamura K, Okamoto O, Hidaka M, Ito J, Fukuroda T, MacNeil DJ, Van der Ploeg LH, Ishii Y, Okabe T, Fukami T, and Ihara M

Biochemical and biophysical research communications 272(1):169-73, 2000 May 27 - Who cited this? | PubMed ID: 10872822 | Fulltext

Structure, tissue distribution, and pharmacological characterization of Xenopus orexins.

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Shibahara M, Sakurai T, Nambu T, Takenouchi T, Iwaasa H, Egashira SI, Ihara M, and Goto K

Peptides 20(10):1169-76, 1999 - Who cited this? | PubMed ID: 10573288 | Fulltext

NPY-induced feeding involves the action of a Y1-like receptor in rodents.

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Kanatani A, Ito J, Ishihara A, Iwaasa H, Fukuroda T, Fukami T, MacNeil DJ, Van der Ploeg LH, and Ihara M

Regulatory peptides 75-76:409-15, 1998 Sep 25 - Who cited this? | PubMed ID: 9802437 | Fulltext

Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptors.

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Itadani H, Nakamura T, Itoh J, Iwaasa H, Kanatani A, Borkowski J, Ihara M, and Ohta M

Biochemical and biophysical research communications 250(1):68-71, 1998 Sep 8 - Who cited this? | PubMed ID: 9735333 | Fulltext

The unique structures of protozoan myoglobin and yeast hemoglobin: an evolutionary diversity.

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Shikama K, Matsuoka A, and Iwaasa H

The international journal of biochemistry & cell biology 27(11):1107-15, 1995 Nov - Who cited this? | PubMed ID: 7584595 | Fulltext

Primary structure of Tetrahymena hemoglobins.

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Takagi T, Iwaasa H, Yuasa H, Shikama K, Takemasa T, and Watanabe Y

Biochimica et biophysica acta 1173(1):75-8, 1993 Apr 29 - Who cited this? | PubMed ID: 8485156 | Fulltext

Amino acid sequence of yeast hemoglobin. A two-domain structure.

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Iwaasa H, Takagi T, and Shikama K

Journal of molecular biology 227(3):948-54, 1992 Oct 5 - Who cited this? | PubMed ID: 1404399 | Fulltext

Protozoan hemoglobin from Tetrahymena pyriformis. Isolation, characterization, and amino acid sequence.

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Iwaasa H, Takagi T, and Shikama K

The Journal of biological chemistry 265(15):8603-9, 1990 May 25 - Who cited this? | PubMed ID: 2111321 | Fulltext

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