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Papers authored by Ishihara A

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Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.

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Ito M, Ishihara A, Gomori A, Egashira S, Matsushita H, Mashiko S, Ito J, Ito M, Nakase K, Haga Y, Iwaasa H, Suzuki T, Ohtake N, Moriya M, Sato N, Macneil DJ,

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European journal of pharmacology 624(1-3):77-83, 2009 Dec 10 - Who cited this? | PubMed ID: 19836369 | Fulltext

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.

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Haga Y, Sakamoto T, Shibata T, Nonoshita K, Ishikawa M, Suga T, Takahashi H, Takahashi T, Takahashi H, Ando M, Murai T, Gomori A, Oda Z, Kitazawa H, Mitobe Y, Kanesaka M,

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Bioorganic & medicinal chemistry 17(19):6971-82, 2009 Oct 1 - Who cited this? | PubMed ID: 19720539 | Fulltext

Evolutionary changes to transthyretin: developmentally regulated and tissue-specific gene expression.

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Yamauchi K and Ishihara A

The FEBS journal 276(19):5357-66, 2009 Oct - Who cited this? | PubMed ID: 19725881 | Fulltext

Skeletal muscle characteristics of rats with obesity, diabetes, hypertension, and hyperlipidemia.

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Nagatomo F, Gu N, Fujino H, Takeda I, Tsuda K, and Ishihara A

Journal of atherosclerosis and thrombosis 16(5):576-85, 2009 Oct - Who cited this? | PubMed ID: 19763017 | Fulltext

Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.

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Takahashi H, Haga Y, Shibata T, Nonoshita K, Sakamoto T, Moriya M, Ohe T, Chiba M, Mitobe Y, Kitazawa H, Iwaasa H, Ishihara A, Ishii Y, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 19(18):5436-9, 2009 Sep 15 - Who cited this? | PubMed ID: 19679469 | Fulltext

Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.

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Suzuki T, Kameda M, Ando M, Miyazoe H, Sekino E, Ito S, Masutani K, Kamijo K, Takezawa A, Moriya M, Ito M, Ito J, Nakase K, Matsushita H, Ishihara A, Takenaga N,

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Bioorganic & medicinal chemistry letters 19(18):5339-45, 2009 Sep 15 - Who cited this? | PubMed ID: 19683441 | Fulltext

Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.

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Ando M, Sekino E, Haga Y, Moriya M, Ito M, Ito J, Iwaasa H, Ishihara A, Kanatani A, and Ohtake N

Bioorganic & medicinal chemistry letters 19(17):5186-90, 2009 Sep 1 - Who cited this? | PubMed ID: 19632840 | Fulltext

Protective effects of exercise preconditioning on hindlimb unloading-induced atrophy of rat soleus muscle.

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Fujino H, Ishihara A, Murakami S, Yasuhara T, Kondo H, Mohri S, Takeda I, and Roy RR

Acta physiologica (Oxford, England) 197(1):65-74, 2009 Sep - Who cited this? | PubMed ID: 19302410 | Fulltext

Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists.

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Kishino H, Moriya M, Sakuraba S, Sakamoto T, Takahashi H, Suzuki T, Moriya R, Ito M, Iwaasa H, Takenaga N, Ishihara A, Kanatani A, Sato N, and Fukami T

Bioorganic & medicinal chemistry letters 19(16):4589-93, 2009 Aug 15 - Who cited this? | PubMed ID: 19615899 | Fulltext

Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.

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Ando M, Sato N, Nagase T, Nagai K, Ishikawa S, Takahashi H, Ohtake N, Ito J, Hirayama M, Mitobe Y, Iwaasa H, Gomori A, Matsushita H, Tadano K, Fujino N, Tanaka S,

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Bioorganic & medicinal chemistry 17(16):6106-22, 2009 Aug 15 - Who cited this? | PubMed ID: 19616955 | Fulltext

A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo.

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Yagi N, Manabe I, Tottori T, Ishihara A, Ogata F, Kim JH, Nishimura S, Fujiu K, Oishi Y, Itaka K, Kato Y, Yamauchi M, and Nagai R

Cancer research 69(16):6531-8, 2009 Aug 15 - Who cited this? | PubMed ID: 19654315 | Fulltext

Synergistic interaction between neuropeptide Y(1) and Y(5) receptor pathways in regulation of energy homeostasis.

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Mashiko S, Moriya R, Ishihara A, Gomori A, Matsushita H, Egashira S, Iwaasa H, Takahashi T, Haga Y, Fukami T, and Kanatani A

European journal of pharmacology 615(1-3):113-7, 2009 Aug 1 - Who cited this? | PubMed ID: 19482021 | Fulltext

Accumulation of hydroxycinnamic acid amides induced by pathogen infection and identification of agmatine coumaroyltransferase in Arabidopsis thaliana.

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Muroi A, Ishihara A, Tanaka C, Ishizuka A, Takabayashi J, Miyoshi H, and Nishioka T

Planta 230(3):517-27, 2009 Aug - Who cited this? | PubMed ID: 19521717 | Fulltext

[Dysfunction of multiple cranial nerves in cephalic tetanus--case report].

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Fujii M, Hokari M, Yokoyama A, Miyashita H, Ishihara A, and Fujikawa T

Brain and nerve = Shinkei kenkyu no shinpo 61(8):983-7, 2009 Aug - Who cited this? | PubMed ID: 19697889 | Fulltext

Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.

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Sakamoto T, Moriya M, Tsuge H, Takahashi T, Haga Y, Nonoshita K, Okamoto O, Takahashi H, Sakuraba A, Hirohashi T, Shibata T, Kanno T, Ito J, Iwaasa H, Gomori A, Ishihara A,

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Bioorganic & medicinal chemistry 17(14):5015-26, 2009 Jul 15 - Who cited this? | PubMed ID: 19525116 | Fulltext

Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

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Moriya M, Kishino H, Sakuraba S, Sakamoto T, Suga T, Takahashi H, Suzuki T, Ito M, Ito J, Moriya R, Takenaga N, Iwaasa H, Ishihara A, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 19(13):3568-72, 2009 Jul 1 - Who cited this? | PubMed ID: 19457661 | Fulltext

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.

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Takahashi T, Haga Y, Sakamoto T, Moriya M, Okamoto O, Nonoshita K, Shibata T, Suga T, Takahashi H, Hirohashi T, Sakuraba A, Gomori A, Iwaasa H, Ohe T, Ishihara A, Ishii Y,

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Bioorganic & medicinal chemistry letters 19(13):3511-6, 2009 Jul 1 - Who cited this? | PubMed ID: 19464889 | Fulltext

Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice.

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Moriya R, Mashiko S, Ishihara A, Takahashi T, Murai T, Ito J, Mitobe Y, Oda Z, Iwaasa H, Takehiro F, and Kanatani A

Peptides 30(7):1318-22, 2009 Jul - Who cited this? | PubMed ID: 19394383 | Fulltext

Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.

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Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N,

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Bioorganic & medicinal chemistry letters 19(11):3072-7, 2009 Jun 1 - Who cited this? | PubMed ID: 19403308 | Fulltext

Chronic intracerebroventricular infusion of nociceptin/orphanin FQ produces body weight gain by affecting both feeding and energy metabolism in mice.

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Matsushita H, Ishihara A, Mashiko S, Tanaka T, Kanno T, Iwaasa H, Ohta H, and Kanatani A

Endocrinology 150(6):2668-73, 2009 Jun - Who cited this? | PubMed ID: 19196798 | Fulltext

Species-specific glucosylation of DIMBOA in larvae of the rice Armyworm.

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Sasai H, Ishida M, Murakami K, Tadokoro N, Ishihara A, Nishida R, and Mori N

Bioscience, biotechnology, and biochemistry 73(6):1333-8, 2009 Jun - Who cited this? | PubMed ID: 19502734 | Fulltext

Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.

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Sato N, Ando M, Ishikawa S, Jitsuoka M, Nagai K, Takahashi H, Sakuraba A, Tsuge H, Kitazawa H, Iwaasa H, Mashiko S, Gomori A, Moriya R, Fujino N, Ohe T, Ishihara A,

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Journal of medicinal chemistry 52(10):3385-96, 2009 May 28 - Who cited this? | PubMed ID: 19459652 | Fulltext

Limits on a muon flux from neutralino annihilations in the sun with the IceCube 22-string detector.

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Abbasi R, Abdou Y, Ackermann M, Adams J, Ahlers M, Andeen K, Auffenberg J, Bai X, Baker M, Barwick SW, Bay R, Bazo Alba JL, Beattie K, Beatty JJ, Bechet S, Becker JK,

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Physical review letters 102(20):201302, 2009 May 22 - Who cited this? | PubMed ID: 19519015 | Fulltext

Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).

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Ito M, Sakamoto T, Suzuki T, Egashira S, Moriya M, Ishihara A, Iwaasa H, Matsushita H, Nakase K, Wallace MA, Dean D, Sato N, Tokita S, and Kanatani A

Bioorganic & medicinal chemistry letters 19(10):2835-9, 2009 May 15 - Who cited this? | PubMed ID: 19361985 | Fulltext

Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.

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Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Simizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, and Saito N

Nano letters 9(4):1406-13, 2009 Apr - Who cited this? | PubMed ID: 19284728 | Fulltext

Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists.

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Sato N, Jitsuoka M, Ishikawa S, Nagai K, Tsuge H, Ando M, Okamoto O, Iwaasa H, Gomori A, Ishihara A, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 19(6):1670-4, 2009 Mar 15 - Who cited this? | PubMed ID: 19233647 | Fulltext

Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.

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Sakamoto T, Moriya M, Haga Y, Takahashi T, Shibata T, Okamoto O, Nonoshita K, Kitazawa H, Hidaka M, Gomori A, Iwaasa H, Ishihara A, Kanatani A, Fukami T, Gao YD, Macneil DJ,

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Bioorganic & medicinal chemistry letters 19(6):1564-8, 2009 Mar 15 - Who cited this? | PubMed ID: 19243937 | Fulltext

High-resolution spatial and temporal analysis of phytoalexin production in oats.

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Izumi Y, Kajiyama S, Nakamura R, Ishihara A, Okazawa A, Fukusaki E, Kanematsu Y, and Kobayashi A

Planta 229(4):931-43, 2009 Mar - Who cited this? | PubMed ID: 19148672 | Fulltext

Use of kinetic gait analysis for detection, quantification, and differentiation of hind limb lameness and spinal ataxia in horses.

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Ishihara A, Reed SM, Rajala-Schultz PJ, Robertson JT, and Bertone AL

Journal of the American Veterinary Medical Association 234(5):644-51, 2009 Mar 1 - Who cited this? | PubMed ID: 19250044 | Fulltext

In vitro thyroid hormone-disrupting activity in effluents and surface waters in Thailand.

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Ishihara A, Rahman FB, Leelawatwattana L, Prapunpoj P, and Yamauchi K

Environmental toxicology and chemistry / SETAC 28(3):586-94, 2009 Mar - Who cited this? | PubMed ID: 18937531 | Fulltext

Effects of hindlimb unloading at early postnatal growth on cell body size in spinal motoneurons innervating soleus muscle of rats.

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Nagatomo F, Ishihara A, and Ohira Y

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 27(1):21-6, 2009 Feb - Who cited this? | PubMed ID: 19041389 | Fulltext

Morphological characteristics of basal-like subtype of breast carcinoma with special reference to cytopathological features.

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Ishihara A, Tsuda H, Kitagawa K, Yoneda M, and Shiraishi T

Breast cancer (Tokyo, Japan) 16(3):179-85, 2009 - Who cited this? | PubMed ID: 19466513 | Fulltext

A new reporting form for breast cytology.

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Tsuchiya S, Akiyama F, Moriya T, Tsuda H, Umemura S, Katayama Y, Ishihara A, Inai Y, Itoh H, and Kitamura T

Breast cancer (Tokyo, Japan) 16(3):202-6, 2009 - Who cited this? | PubMed ID: 19484337 | Fulltext

Thermal preconditioning prevents fiber type transformation of the unloading induced-atrophied muscle in rats.

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Takeda I, Fujino H, Murakami S, Kondo H, Nagatomo F, and Ishihara A

Journal of muscle research and cell motility 30(3-4):145-52, 2009 - Who cited this? | PubMed ID: 19551479 | Fulltext

Anti-inflammatory and analgesic effects of intra-articular injection of triamcinolone acetonide, mepivacaine hydrochloride, or both on lipopolysaccharide-induced lameness in horses.

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Kay AT, Bolt DM, Ishihara A, Rajala-Schultz PJ, and Bertone AL

American journal of veterinary research 69(12):1646-54, 2008 Dec - Who cited this? | PubMed ID: 19046013 | Fulltext

Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine h3 receptor inverse agonists.

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Nagase T, Mizutani T, Sekino E, Ishikawa S, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, and Sato N

Journal of medicinal chemistry 51(21):6889-901, 2008 Nov 13 - Who cited this? | PubMed ID: 18841880 | Fulltext

Gene Expression Levels of Heat Shock Proteins in the Soleus and Plantaris Muscles of Rats after Hindlimb Suspension or Spaceflight.

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Ishihara A, Fujino H, Nagatomo F, Takeda I, and Ohira Y

The journal of physiological sciences : JPS, 2008 Oct 11 - Who cited this? | PubMed ID: 18845059 | Fulltext

Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I).

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Ichimaru N, Murai M, Kakutani N, Kako J, Ishihara A, Nakagawa Y, Nishioka T, Yagi T, and Miyoshi H

Biochemistry 47(40):10816-26, 2008 Oct 7 - Who cited this? | PubMed ID: 18781777 | Fulltext

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.

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Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 18(18):5010-4, 2008 Sep 15 - Who cited this? | PubMed ID: 18723347 | Fulltext

Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.

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Ogino Y, Ohtake N, Nagae Y, Matsuda K, Ishikawa M, Moriya M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, and Fukami T

Bioorganic & medicinal chemistry letters 18(18):4997-5001, 2008 Sep 15 - Who cited this? | PubMed ID: 18752943 | Fulltext

[A case of advanced accessory breast cancer effectively treated with trastuzumab and Paclitaxel.].

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Suzuki S, Ohchi T, Doi K, Ogata K, Maeda T, Kudo K, and Ishihara A

Gan to kagaku ryoho. Cancer & chemotherapy 35(9):1615-7, 2008 Sep - Who cited this? | PubMed ID: 18799924 | Fulltext

Induction of serotonin accumulation by feeding of rice striped stem borer in rice leaves.

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Ishihara A, Hashimoto Y, Miyagawa H, and Wakasa K

Plant signaling & behavior 3(9):714-6, 2008 Sep - Who cited this? | PubMed ID: 19704837 | Fulltext

Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine h3 receptor inverse agonists.

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Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, and Sato N

Journal of medicinal chemistry 51(15):4780-9, 2008 Aug 14 - Who cited this? | PubMed ID: 18598020 | Fulltext

Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.

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Ito M, Gomori A, Suzuki J, Tsujioka S, Sasaki M, Matsuda M, Bednarek MA, Ito M, Ishihara A, Iwaasa H, MacNeil DJ, and Kanatani A

The Journal of endocrinology 198(2):309, 2008 Aug - Who cited this? | PubMed ID: 18523032 | Fulltext

Bone Density of the Femur and Fiber Cross-Sectional Area and Oxidative Enzyme Activity of the Tibialis Anterior Muscle in Type II Collagen-Induced Arthritic Mice.

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Okiura T, Nagatomo F, Gu N, Taguchi Y, Morimatsu F, and Ishihara A

The journal of physiological sciences : JPS 58(4):221-7, 2008 Aug - Who cited this? | PubMed ID: 18534044 | Fulltext

GLUCOSE REGULATION OF DIPEPTIDYL PEPTIDASE IV GENE EXPRESSION IS MEDIATED BY HEPATOCYTE NUCLEAR FACTOR-1alpha IN EPITHELIAL INTESTINAL CELLS.

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Gu N, Tsuda M, Matsunaga T, Adachi T, Yasuda K, Ishihara A, and Tsuda K

Clinical and experimental pharmacology & physiology, 2008 Jul 29 - Who cited this? | PubMed ID: 18671716 | Fulltext

(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a Selective and Orally Active Neuropeptide Y Y5 Receptor Antagonist.

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Sato N, Jitsuoka M, Shibata T, Hirohashi T, Nonoshita K, Moriya M, Haga Y, Sakuraba A, Ando M, Ohe T, Iwaasa H, Gomori A, Ishihara A, Kanatani A, and Fukami T

Journal of medicinal chemistry, 2008 Jul 19 - Who cited this? | PubMed ID: 18637668 | Fulltext

Effects of a novel y5 antagonist in obese mice: combination with food restriction or sibutramine.

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Mashiko S, Ishihara A, Iwaasa H, Moriya R, Kitazawa H, Mitobe Y, Ito J, Gomori A, Matsushita H, Takahashi T, Macneil DJ, Van der Ploeg LH, Fukami T, and Kanatani A

Obesity (Silver Spring, Md.) 16(7):1510-5, 2008 Jul - Who cited this? | PubMed ID: 18421274 | Fulltext

Effects of triamcinolone acetonide, sodium hyaluronate, amikacin sulfate, and mepivacaine hydrochloride, alone and in combination, on morphology and matrix composition of lipopolysaccharide-challenged and unchallenged equine articular cartilage explants.

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Bolt DM, Ishihara A, Weisbrode SE, and Bertone AL

American journal of veterinary research 69(7):861-7, 2008 Jul - Who cited this? | PubMed ID: 18593234 | Fulltext

Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models.

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Ishihara A, Shields KM, Litsky AS, Mattoon JS, Weisbrode SE, Bartlett JS, and Bertone AL

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 26(6):764-71, 2008 Jun - Who cited this? | PubMed ID: 18241059 | Fulltext

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