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Papers authored by Inohara N

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A putative role for human BFK in DNA damage-induced apoptosis.

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Ozören N, Inohara N, and Núñez G

Biotechnology journal 4(7):1046-54, 2009 Jul - Who cited this? | PubMed ID: 19557800 | Fulltext

Significant Association of ANKK1 and Detection of a Functional Polymorphism with Nicotine Dependence in an African-American Sample.

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Huang W, Payne TJ, Ma JZ, Beuten J, Dupont RT, Inohara N, and Li MD

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008 Mar 19 - Who cited this? | PubMed ID: 18354387 | Fulltext

The NLR gene family: a standard nomenclature.

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Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, MacKenzie A, Maltais LJ, Nunez G,

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Immunity 28(3):285, 2008 Mar - Who cited this? | PubMed ID: 18341998 | Fulltext

Monomer/dimer transition of the caspase-recruitment domain of human Nod1.

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Srimathi T, Robbins SL, Dubas RL, Hasegawa M, Inohara N, and Park YC

Biochemistry 47(5):1319-25, 2008 Feb 5 - Who cited this? | PubMed ID: 18186648 | Fulltext

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands.

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Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, and Núñez G

Immunity 28(2):246-57, 2008 Feb - Who cited this? | PubMed ID: 18261938 | Fulltext

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

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Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Núñez G, and Inohara N

The EMBO journal 27(2):373-83, 2008 Jan 23 - Who cited this? | PubMed ID: 18079694 | Fulltext

Synthesis of Diaminopimelic Acid Containing Peptidoglycan Fragments and Tracheal Cytotoxin (TCT) and Investigation of Their Biological Functions.

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Kawasaki A, Karasudani Y, Otsuka Y, Hasegawa M, Inohara N, Fujimoto Y, and Fukase K

Chemistry (Weinheim an der Bergstrasse, Germany) 14(33):10318-30, 2008 - Who cited this? | PubMed ID: 18830984 | Fulltext

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.

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Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, and Nuñez G

PLoS pathogens 3(8):e111, 2007 Aug 10 - Who cited this? | PubMed ID: 17696608 | Fulltext

Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells.

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Park JH, Kim YG, Shaw M, Kanneganti TD, Fujimoto Y, Fukase K, Inohara N, and Núñez G

Journal of immunology (Baltimore, Md. : 1950) 179(1):514-21, 2007 Jul 1 - Who cited this? | PubMed ID: 17579072 | Fulltext

Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells.

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Zhao L, Kwon MJ, Huang S, Lee JY, Fukase K, Inohara N, and Hwang DH

The Journal of biological chemistry 282(16):11618-28, 2007 Apr 20 - Who cited this? | PubMed ID: 17303577 | Fulltext

A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses.

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Hasegawa M, Kawasaki A, Yang K, Fujimoto Y, Masumoto J, Breukink E, Nuñez G, Fukase K, and Inohara N

The Journal of biological chemistry 282(16):11757-64, 2007 Apr 20 - Who cited this? | PubMed ID: 17322292 | Fulltext

[The molecular mechanism of autoinflammatory disease--lessons from the function of NOD protein families].

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Masumoto J, Hasegawa M, and Inohara N

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 30(2):68-77, 2007 Apr - Who cited this? | PubMed ID: 17473508 | Fulltext

Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells.

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Hasegawa M, Kawase K, Inohara N, Imamura R, Yeh WC, Kinoshita T, and Suda T

Oncogene 26(12):1748-56, 2007 Mar 15 - Who cited this? | PubMed ID: 16964285 | Fulltext

RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs.

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Park JH, Kim YG, McDonald C, Kanneganti TD, Hasegawa M, Body-Malapel M, Inohara N, and Núñez G

Journal of immunology (Baltimore, Md. : 1950) 178(4):2380-6, 2007 Feb 15 - Who cited this? | PubMed ID: 17277144 | Fulltext

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.

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Kanneganti TD, Body-Malapel M, Amer A, Park JH, Whitfield J, Franchi L, Taraporewala ZF, Miller D, Patton JT, Inohara N, and Núñez G

The Journal of biological chemistry 281(48):36560, 2006 Dec 1 - Who cited this? | PubMed ID: 17008311 | Fulltext

Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.

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Hasegawa M, Yang K, Hashimoto M, Park JH, Kim YG, Fujimoto Y, Nuñez G, Fukase K, and Inohara N

The Journal of biological chemistry 281(39):29054-63, 2006 Sep 29 - Who cited this? | PubMed ID: 16870615 | Fulltext

Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnes.

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Tanabe T, Ishige I, Suzuki Y, Aita Y, Furukawa A, Ishige Y, Uchida K, Suzuki T, Takemura T, Ikushima S, Oritsu M, Yokoyama T, Fujimoto Y, Fukase K, Inohara N, Nunez G,

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Biochimica et biophysica acta 1762(9):794-801, 2006 Sep - Who cited this? | PubMed ID: 16935475 | Fulltext

Regulation of the ASC expression in response to LPS stimulation is related to IL-8 secretion in the human intestinal mucosa.

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Masumoto J, Kobayashi H, Nakamura T, Kaneko Y, Ota H, Hasegawa M, Kobayashi Y, Suzuki T, Matsuda K, Sano K, Katsuyama T, and Inohara N

Biochemical and biophysical research communications 346(3):968-73, 2006 Aug 4 - Who cited this? | PubMed ID: 16777061 | Fulltext

MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis.

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Nishito Y, Hasegawa M, Inohara N, and Núñez G

The Biochemical journal 396(3):411-7, 2006 Jun 15 - Who cited this? | PubMed ID: 16522193 | Fulltext

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.

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Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozören N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, and Núñez G

Nature immunology 7(6):576-82, 2006 Jun - Who cited this? | PubMed ID: 16648852 | Fulltext

Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection.

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Boughan PK, Argent RH, Body-Malapel M, Park JH, Ewings KE, Bowie AG, Ong SJ, Cook SJ, Sorensen OE, Manzo BA, Inohara N, Klein NJ, Nuñez G, Atherton JC, and Bajaj-Elliott M

The Journal of biological chemistry 281(17):11637, 2006 Apr 28 - Who cited this? | PubMed ID: 16513653 | Fulltext

Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes.

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Ozören N, Masumoto J, Franchi L, Kanneganti TD, Body-Malapel M, Ertürk I, Jagirdar R, Zhu L, Inohara N, Bertin J, Coyle A, Grant EP, and Núñez G

Journal of immunology (Baltimore, Md. : 1950) 176(7):4337-42, 2006 Apr 1 - Who cited this? | PubMed ID: 16547271 | Fulltext

Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo.

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Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, Fujimoto Y, Kawasaki A, Foster SJ, Horie Y, Mak TW, Núñez G, Chinnaiyan AM, Fukase K, and Inohara N

The Journal of experimental medicine 203(1):203-13, 2006 Jan 23 - Who cited this? | PubMed ID: 16418393 | Fulltext

Synthesis of peptidoglycan fragments and evaluation of their biological activity.

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Inamura S, Fujimoto Y, Kawasaki A, Shiokawa Z, Woelk E, Heine H, Lindner B, Inohara N, Kusumoto S, and Fukase K

Organic & biomolecular chemistry 4(2):232-42, 2006 Jan 21 - Who cited this? | PubMed ID: 16391765 | Fulltext

Peptidoglycan signaling in innate immunity and inflammatory disease.

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McDonald C, Inohara N, and Nuñez G

The Journal of biological chemistry 280(21):20177-80, 2005 May 27 - Who cited this? | PubMed ID: 15802263 | Fulltext

ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP.

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Hasegawa M, Imamura R, Kinoshita T, Matsumoto N, Masumoto J, Inohara N, and Suda T

The Journal of biological chemistry 280(15):15122-30, 2005 Apr 15 - Who cited this? | PubMed ID: 15701651 | Fulltext

A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages.

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Suzuki T, Nakanishi K, Tsutsui H, Iwai H, Akira S, Inohara N, Chamaillard M, Nuñez G, and Sasakawa C

The Journal of biological chemistry 280(14):14042-50, 2005 Apr 8 - Who cited this? | PubMed ID: 15695506 | Fulltext

NOD1 variation, immunoglobulin E and asthma.

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Hysi P, Kabesch M, Moffatt MF, Schedel M, Carr D, Zhang Y, Boardman B, von Mutius E, Weiland SK, Leupold W, Fritzsch C, Klopp N, Musk AW, James A, Nunez G, Inohara N,

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Human molecular genetics 14(7):935, 2005 Apr 1 - Who cited this? | PubMed ID: 15718249 | Fulltext

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.

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Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G, and Flavell RA

Science (New York, N.Y.) 307(5710):731-4, 2005 Feb 4 - Who cited this? | PubMed ID: 15692051 | Fulltext

Battling enteroinvasive bacteria: Nod1 comes to the rescue.

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Chamaillard M, Inohara N, and Nuñez G

Trends in microbiology 12(12):529-32, 2004 Dec - Who cited this? | PubMed ID: 15539110 | Fulltext

[Bacteria/host interaction mediated by Nod proteins].

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Inohara N

Nippon saikingaku zasshi. Japanese journal of bacteriology 59(3):483-96, 2004 Aug - Who cited this? | PubMed ID: 15484813 | Fulltext

Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.

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Dowds TA, Masumoto J, Zhu L, Inohara N, and Núñez G

The Journal of biological chemistry 279(21):21924-8, 2004 May 21 - Who cited this? | PubMed ID: 15020601 | Fulltext

Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.

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Imaizumi K, Benito A, Kiryu-Seo S, Gonzalez V, Inohara N, Lieberman AP, Kiyama H, and Nuñez G

The Journal of neuroscience : the official journal of the Society for Neuroscience 24(15):3721-5, 2004 Apr 14 - Who cited this? | PubMed ID: 15084651 | Fulltext

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.

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Tanabe T, Chamaillard M, Ogura Y, Zhu L, Qiu S, Masumoto J, Ghosh P, Moran A, Predergast MM, Tromp G, Williams CJ, Inohara N, and Núñez G

The EMBO journal 23(7):1587-97, 2004 Apr 7 - Who cited this? | PubMed ID: 15044951 | Fulltext

Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected].

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Tang ED, Inohara N, Wang CY, Nuñez G, and Guan KL

The Journal of biological chemistry 278(40):38566, 2003 Oct 3 - Who cited this? | PubMed ID: 12890679 | Fulltext

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.

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Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y, Kawasaki A, Fukase K, Kusumoto S, Valvano MA, Foster SJ, Mak TW, Nuñez G, and Inohara N

Nature immunology 4(7):702-7, 2003 Jul - Who cited this? | PubMed ID: 12796777 | Fulltext

NODs: intracellular proteins involved in inflammation and apoptosis.

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Inohara N and Nuñez G

Nature reviews. Immunology 3(5):371-82, 2003 May - Who cited this? | PubMed ID: 12766759 | Fulltext

Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease.

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Ogura Y, Saab L, Chen FF, Benito A, Inohara N, and Nuñez G

Genomics 81(4):369-77, 2003 Apr - Who cited this? | PubMed ID: 12676561 | Fulltext

ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.

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Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Núñez G, and Inohara N

Biochemical and biophysical research communications 303(1):69-73, 2003 Mar 28 - Who cited this? | PubMed ID: 12646168 | Fulltext

Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product.

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Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, and Núñez G

Biochemical and biophysical research communications 302(3):575-80, 2003 Mar 14 - Who cited this? | PubMed ID: 12615073 | Fulltext

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.

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Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, and Nuñez G

The Journal of biological chemistry 278(8):5509-12, 2003 Feb 21 - Who cited this? | PubMed ID: 12514169 | Fulltext

ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.

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Jimbo A, Fujita E, Kouroku Y, Ohnishi J, Inohara N, Kuida K, Sakamaki K, Yonehara S, and Momoi T

Experimental cell research 283(2):156-66, 2003 Feb 15 - Who cited this? | PubMed ID: 12581736 | Fulltext

Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development.

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Masumoto J, Zhou W, Chen FF, Su F, Kuwada JY, Hidaka E, Katsuyama T, Sagara J, Taniguchi S, Ngo-Hazelett P, Postlethwait JH, Núñez G, and Inohara N

The Journal of biological chemistry 278(6):4268-76, 2003 Feb 7 - Who cited this? | PubMed ID: 12464617 | Fulltext

Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.

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Bonen DK, Ogura Y, Nicolae DL, Inohara N, Saab L, Tanabe T, Chen FF, Foster SJ, Duerr RH, Brant SR, Cho JH, and Nuñez G

Gastroenterology 124(1):140-6, 2003 Jan - Who cited this? | PubMed ID: 12512038 | Fulltext

Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation.

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Gutierrez O, Pipaon C, Inohara N, Fontalba A, Ogura Y, Prosper F, Nunez G, and Fernandez-Luna JL

The Journal of biological chemistry 277(44):41701-5, 2002 Nov 1 - Who cited this? | PubMed ID: 12194982 | Fulltext

CARD15 mutations in familial granulomatosis syndromes: a study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy.

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Wang X, Kuivaniemi H, Bonavita G, Mutkus L, Mau U, Blau E, Inohara N, Nunez G, Tromp G, and Williams CJ

Arthritis and rheumatism 46(11):3041-5, 2002 Nov - Who cited this? | PubMed ID: 12428248 | Fulltext

Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester.

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Muto A, Ruland J, McAllister-Lucas LM, Lucas PC, Yamaoka S, Chen FF, Lin A, Mak TW, Núñez G, and Inohara N

The Journal of biological chemistry 277(35):31871-6, 2002 Aug 30 - Who cited this? | PubMed ID: 12091384 | Fulltext

Lack of common NOD2 variants in Japanese patients with Crohn's disease.

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Inoue N, Tamura K, Kinouchi Y, Fukuda Y, Takahashi S, Ogura Y, Inohara N, Núñez G, Kishi Y, Koike Y, Shimosegawa T, Shimoyama T, and Hibi T

Gastroenterology 123(1):86-91, 2002 Jul - Who cited this? | PubMed ID: 12105836 | Fulltext

ML -- a conserved domain involved in innate immunity and lipid metabolism.

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Inohara N and Nuñez G

Trends in biochemical sciences 27(5):219-21, 2002 May - Who cited this? | PubMed ID: 12076526 | Fulltext

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.

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Kobayashi K, Inohara N, Hernandez LD, Galán JE, Núñez G, Janeway CA, Medzhitov R, and Flavell RA

Nature 416(6877):194, 2002 Mar 14 - Who cited this? | PubMed ID: 11894098 | Fulltext

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