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Papers authored by Hylemon PB

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Bile acids as regulatory molecules.

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Hylemon PB, Zhou H, Pandak WM, Ren S, Gil G, and Dent P

Journal of lipid research 50(8):1509-20, 2009 Aug - Who cited this? | PubMed ID: 19346331 | Fulltext

HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages.

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Chen L, Jarujaron S, Wu X, Sun L, Zha W, Liang G, Wang X, Gurley EC, Studer EJ, Hylemon PB, Pandak WM, Zhang L, Wang G, Li X, Dent P, and Zhou H

Biochemical pharmacology 78(1):70-7, 2009 Jul 1 - Who cited this? | PubMed ID: 19447225 | Fulltext

The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy: Cellular Mechanisms and Clinical Implications.

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Flint OP, Noor MA, Hruz PW, Hylemon PB, Yarasheski K, Kotler DP, Parker RA, and Bellamine A

Toxicologic pathology 37(1):65-77, 2009 - Who cited this? | PubMed ID: 19171928 | Fulltext

25-Hydroxycholesterol-3-Sulfate (25HC3S) regulates macrophage lipid metabolism via the LXR/SREBP-1 Signaling Pathway.

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Ma Y, Xu L, Rodriguez-Agudo D, Li X, Heuman DM, Hylemon PB, Pandak WM, and Ren S

American journal of physiology. Endocrinology and metabolism, 2008 Oct 14 - Who cited this? | PubMed ID: 18854425 | Fulltext

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.

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Park MA, Zhang G, Martin AP, Hamed H, Mitchell C, Hylemon PB, Graf M, Rahmani M, Ryan K, Liu X, Spiegel S, Norris J, Fisher PB, Grant S, and Dent P

Cancer biology & therapy 7(10), 2008 Oct 12 - Who cited this? | PubMed ID: 18787411 | Fulltext

Regulation of autophagy by ceramide-CD95-PERK signaling.

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Park MA, Zhang G, Norris J, Hylemon PB, Fisher PB, Grant S, and Dent P

Autophagy 4(7), 2008 Oct 5 - Who cited this? | PubMed ID: 18719356 | Fulltext

Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.

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Zhang G, Park MA, Mitchell C, Walker T, Hamed H, Studer E, Graf M, Rahmani M, Gupta S, Hylemon PB, Fisher PB, Grant S, and Dent P

The Journal of biological chemistry 283(36):24343, 2008 Sep 5 - Who cited this? | PubMed ID: 18614532 | Fulltext

Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.

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Wu X, Zhang L, Gurley E, Studer E, Shang J, Wang T, Wang C, Yan M, Jiang Z, Hylemon PB, Sanyal AJ, Pandak WM, and Zhou H

Hepatology (Baltimore, Md.) 47(6):1905, 2008 Jun - Who cited this? | PubMed ID: 18452148 | Fulltext

Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin.

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Liang G, Li X, Chen L, Yang S, Wu X, Studer E, Gurley E, Hylemon PB, Ye F, Li Y, and Zhou H

Bioorganic & medicinal chemistry letters 18(4):1525-9, 2008 Feb 15 - Who cited this? | PubMed ID: 18234497 | Fulltext

Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases.

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Kang DJ, Ridlon JM, Moore DR, Barnes S, and Hylemon PB

Biochimica et biophysica acta 1781(1-2):16 - Who cited this? | PubMed ID: 18047844 | Fulltext

HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR.

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Zhou H, Jarujaron S, Gurley EC, Chen L, Ding H, Studer E, Pandak WM, Hu W, Zou T, Wang JY, and Hylemon PB

Atherosclerosis 195(1):e134-43, 2007 Nov - Who cited this? | PubMed ID: 17531241 | Fulltext

Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression.

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Xu Z, Tavares-Sanchez OL, Li Q, Fernando J, Rodriguez CM, Studer EJ, Pandak WM, Hylemon PB, and Gil G

The Journal of biological chemistry 282(34):24607-14, 2007 Aug 24 - Who cited this? | PubMed ID: 17603092 | Fulltext

Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.

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Fang Y, Studer E, Mitchell C, Grant S, Pandak WM, Hylemon PB, and Dent P

Molecular pharmacology 71(4):1122-8, 2007 Apr - Who cited this? | PubMed ID: 17200418 | Fulltext

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.

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Mitchell C, Park MA, Zhang G, Han SI, Harada H, Franklin RA, Yacoub A, Li PL, Hylemon PB, Grant S, and Dent P

Molecular cancer therapeutics 6(2):618, 2007 Feb - Who cited this? | PubMed ID: 17308059 | Fulltext

Approaches for monitoring signal transduction changes in normal and cancer cells.

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Dent P, Hylemon PB, Grant S, and Fisher PB

Methods in molecular biology (Clifton, N.J.) 383:259-76, 2007 - Who cited this? | PubMed ID: 18217691 | Fulltext

HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes.

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Zhou H, Gurley EC, Jarujaron S, Ding H, Fang Y, Xu Z, Pandak WM, and Hylemon PB

American journal of physiology. Gastrointestinal and liver physiology 291(6), 2006 Dec - Who cited this? | PubMed ID: 16861219 | Fulltext

Localization of StarD5 cholesterol binding protein.

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Rodriguez-Agudo D, Ren S, Hylemon PB, Montañez R, Redford K, Natarajan R, Medina MA, Gil G, and Pandak WM

Journal of lipid research 47(6):1168, 2006 Jun - Who cited this? | PubMed ID: 16534142 | Fulltext

A potential role for resistant starch fermentation in modulating colonic bacterial metabolism and colon cancer risk.

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Ridlon JM and Hylemon PB

Cancer biology & therapy 5(3):273-4, 2006 Mar - Who cited this? | PubMed ID: 16627972 | Fulltext

Bile salt biotransformations by human intestinal bacteria.

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Ridlon JM, Kang DJ, and Hylemon PB

Journal of lipid research 47(2):241-59, 2006 Feb - Who cited this? | PubMed ID: 16299351 | Fulltext

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.

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Dent P, Fang Y, Gupta S, Studer E, Mitchell C, Spiegel S, and Hylemon PB

Hepatology (Baltimore, Md.) 42(6):1291-9, 2005 Dec - Who cited this? | PubMed ID: 16317705 | Fulltext

Mitochondrial cholesterol transport: a possible target in the management of hyperlipidemia.

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Hall EA, Ren S, Hylemon PB, Redford K, del Castillo A, Gil G, and Pandak WM

Lipids 40(12):1237-44, 2005 Dec - Who cited this? | PubMed ID: 16477808 | Fulltext

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.

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Dent P, Han SI, Mitchell C, Studer E, Yacoub A, Grandis J, Grant S, Krystal GW, and Hylemon PB

Biochemical pharmacology 70(11):1685-96, 2005 Nov 25 - Who cited this? | PubMed ID: 16207485 | Fulltext

HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular disease.

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Zhou H, Pandak WM, Lyall V, Natarajan R, and Hylemon PB

Molecular pharmacology 68(3):690, 2005 Sep - Who cited this? | PubMed ID: 15976036 | Fulltext

Human StarD5, a cytosolic StAR-related lipid binding protein.

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Rodriguez-Agudo D, Ren S, Hylemon PB, Redford K, Natarajan R, Del Castillo A, Gil G, and Pandak WM

Journal of lipid research 46(8):1615-23, 2005 Aug - Who cited this? | PubMed ID: 15897605 | Fulltext

Development of methods for the detection and quantification of 7alpha-dehydroxylating clostridia, Desulfovibrio vulgaris, Methanobrevibacter smithii, and Lactobacillus plantarum in human feces.

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Ridlon JM, McGarr SE, and Hylemon PB

Clinica chimica acta; international journal of clinical chemistry 357(1):55-64, 2005 Jul 1 - Who cited this? | PubMed ID: 15963794 | Fulltext

Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells.

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Hall EA, Ren S, Hylemon PB, Rodriguez-Agudo D, Redford K, Marques D, Kang D, Gil G, and Pandak WM

Biochimica et biophysica acta 1733(2-3):111-9, 2005 Apr 15 - Who cited this? | PubMed ID: 15863358 | Fulltext

Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature.

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McGarr SE, Ridlon JM, and Hylemon PB

Journal of clinical gastroenterology 39(2):98-109, 2005 Feb - Who cited this? | PubMed ID: 15681903 | Fulltext

Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1.

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Langston TB, Hylemon PB, and Grogan WM

Lipids 40(1):31-8, 2005 Jan - Who cited this? | PubMed ID: 15825828 | Fulltext

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes.

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Fang Y, Han SI, Mitchell C, Gupta S, Studer E, Grant S, Hylemon PB, and Dent P

Hepatology (Baltimore, Md.) 40(4):961-71, 2004 Oct - Who cited this? | PubMed ID: 15382121 | Fulltext

Overexpression of cholesterol transporter StAR increases in vivo rates of bile acid synthesis in the rat and mouse.

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Ren S, Hylemon PB, Marques D, Gurley E, Bodhan P, Hall E, Redford K, Gil G, and Pandak WM

Hepatology (Baltimore, Md.) 40(4):910-7, 2004 Oct - Who cited this? | PubMed ID: 15382124 | Fulltext

Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.

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Gupta S, Natarajan R, Payne SG, Studer EJ, Spiegel S, Dent P, and Hylemon PB

The Journal of biological chemistry 279(7):5821-8, 2004 Feb 13 - Who cited this? | PubMed ID: 14660582 | Fulltext

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes.

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Han SI, Studer E, Gupta S, Fang Y, Qiao L, Li W, Grant S, Hylemon PB, and Dent P

Hepatology (Baltimore, Md.) 39(2):456-63, 2004 Feb - Who cited this? | PubMed ID: 14767998 | Fulltext

Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7alpha-hydroxylase mRNA levels.

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Williams K, Rao YP, Natarajan R, Pandak WM, and Hylemon PB

Biochemical pharmacology 67(2):255-67, 2004 Jan 15 - Who cited this? | PubMed ID: 14698038 | Fulltext

Fas Ligand-dependent and -independent mechanisms of toxicity induced by T cell lymphomas in lymphoid organs and in the liver.

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Lombard C, McKallip RJ, Hylemon PB, Nagarkatti PS, and Nagarkatti M

Clinical immunology (Orlando, Fla.) 109(2):144-53, 2003 Nov - Who cited this? | PubMed ID: 14597213 | Fulltext

Development and application of a polymerase chain reaction assay for the detection and enumeration of bile acid 7alpha-dehydroxylating bacteria in human feces.

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Wells JE, Williams KB, Whitehead TR, Heuman DM, and Hylemon PB

Clinica chimica acta; international journal of clinical chemistry 331(1-2):127-34, 2003 May - Who cited this? | PubMed ID: 12691873 | Fulltext

Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.

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Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, and Dent P

Molecular and cellular biology 23(9):3052-66, 2003 May - Who cited this? | PubMed ID: 12697808 | Fulltext

Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat.

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Ren S, Marques D, Redford K, Hylemon PB, Gil G, Vlahcevic ZR, and Pandak WM

Metabolism: clinical and experimental 52(5):636-42, 2003 May - Who cited this? | PubMed ID: 12759897 | Fulltext

Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3.

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Leach JK, Qiao L, Fang Y, Han SL, Gilfor D, Fisher PB, Grant S, Hylemon PB, Peterson D, and Dent P

Journal of gastroenterology and hepatology 18(4):376-85, 2003 Apr - Who cited this? | PubMed ID: 12653885 | Fulltext

Suppression of cholesterol 7alpha-hydroxylase transcription and bile acid synthesis by an alpha1-antitrypsin peptide via interaction with alpha1-fetoprotein transcription factor.

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Gerbod-Giannone MC, Del Castillo-Olivares A, Janciauskiene S, Gil G, and Hylemon PB

The Journal of biological chemistry 277(45):42973-80, 2002 Nov 8 - Who cited this? | PubMed ID: 12223476 | Fulltext

Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53.

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Qiao L, McKinstry R, Gupta S, Gilfor D, Windle JJ, Hylemon PB, Grant S, Fisher PB, and Dent P

Hepatology (Baltimore, Md.) 36(1):39-48, 2002 Jul - Who cited this? | PubMed ID: 12085347 | Fulltext

Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes.

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Pandak WM, Hylemon PB, Ren S, Marques D, Gil G, Redford K, Mallonee D, and Vlahcevic ZR

Hepatology (Baltimore, Md.) 35(6):1400-8, 2002 Jun - Who cited this? | PubMed ID: 12029625 | Fulltext

LXR alpha is the dominant regulator of CYP7A1 transcription.

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Gupta S, Pandak WM, and Hylemon PB

Biochemical and biophysical research communications 293(1):338-43, 2002 Apr 26 - Who cited this? | PubMed ID: 12054605 | Fulltext

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes.

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Qiao L, Yacoub A, Studer E, Gupta S, Pei XY, Grant S, Hylemon PB, and Dent P

Hepatology (Baltimore, Md.) 35(4):779-89, 2002 Apr - Who cited this? | PubMed ID: 11915023 | Fulltext

Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes.

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Rao YP, Studer EJ, Stravitz RT, Gupta S, Qiao L, Dent P, and Hylemon PB

Hepatology (Baltimore, Md.) 35(2):307-14, 2002 Feb - Who cited this? | PubMed ID: 11826403 | Fulltext

Bile acid metabolism by fresh human colonic contents: a comparison of caecal versus faecal samples.

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Thomas LA, Veysey MJ, French G, Hylemon PB, Murphy GM, and Dowling RH

Gut 49(6):835-42, 2001 Dec - Who cited this? | PubMed ID: 11709519 | Fulltext

Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression.

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Qiao L, Leach K, McKinstry R, Gilfor D, Yacoub A, Park JS, Grant S, Hylemon PB, Fisher PB, and Dent P

Hepatology (Baltimore, Md.) 34(5):906-17, 2001 Nov - Who cited this? | PubMed ID: 11679961 | Fulltext

Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis.

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Pandak WM, Schwarz C, Hylemon PB, Mallonee D, Valerie K, Heuman DM, Fisher RA, Redford K, and Vlahcevic ZR

American journal of physiology. Gastrointestinal and liver physiology 281(4):G878-89, 2001 Oct - Who cited this? | PubMed ID: 11557507 | Fulltext

Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

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Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, and Dent P

Molecular biology of the cell 12(9):2629-45, 2001 Sep - Who cited this? | PubMed ID: 11553704 | Fulltext

Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.

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Pandak WM, Bohdan P, Franklund C, Mallonee DH, Eggertsen G, Björkhem I, Gil G, Vlahcevic ZR, and Hylemon PB

Gastroenterology 120(7):1801-9, 2001 Jun - Who cited this? | PubMed ID: 11375960 | Fulltext

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway.

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Gupta S, Stravitz RT, Dent P, and Hylemon PB

The Journal of biological chemistry 276(19):15816-22, 2001 May 11 - Who cited this? | PubMed ID: 11278771 | Fulltext

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