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Papers authored by Huff MW

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A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

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Hegele RA, Ban MR, Hsueh N, Kennedy BA, Cao H, Zou GY, Anand S, Yusuf S, Huff MW, and Wang J

Human molecular genetics 18(21):4189-94, 2009 Nov 1 - Who cited this? | PubMed ID: 19656773 | Fulltext

Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice.

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Johnson CL, Weston JY, Chadi SA, Fazio EN, Huff MW, Kharitonenkov A, Köester A, and Pin CL

Gastroenterology 137(5):1795-804, 2009 Nov - Who cited this? | PubMed ID: 19664632 | Fulltext

Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance.

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Mulvihill EE, Allister EM, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Markle JM, Hegele RA, and Huff MW

Diabetes 58(10):2198-210, 2009 Oct - Who cited this? | PubMed ID: 19592617 | Fulltext

Lipid incorporation inhibits Src-dependent assembly of fibronectin and type I collagen by vascular smooth muscle cells.

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Frontini MJ, O'Neil C, Sawyez C, Chan BM, Huff MW, and Pickering JG

Circulation research 104(7):832-41, 2009 Apr 10 - Who cited this? | PubMed ID: 19229059 | Fulltext

Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area.

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Klein JH, Hegele RA, Hackam DG, Koschinsky ML, Huff MW, and Spence JD

Arteriosclerosis, thrombosis, and vascular biology 28(10):1851-6, 2008 Oct - Who cited this? | PubMed ID: 18599799 | Fulltext

Polygenic determinants of severe hypertriglyceridemia.

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Wang J, Ban MR, Zou GY, Cao H, Lin T, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, and Hegele RA

Human molecular genetics 17(18):2894-9, 2008 Sep 15 - Who cited this? | PubMed ID: 18596051 | Fulltext

APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia.

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Wang J, Ban MR, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, and Hegele RA

Nature clinical practice. Cardiovascular medicine, 2008 Sep 9 - Who cited this? | PubMed ID: 18779834 | Fulltext

Insulin-like effects of naringenin on inhibition of apolipoprotein B secretion from HepG2 cells occur via MAPK/ERK signaling and are independent of insulin receptor activation.

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Allister EM, Mulvihill EE, Barrett PH, Edwards JY, Carter LP, and Huff MW

Journal of lipid research, 2008 Jun 27 - Who cited this? | PubMed ID: 18587069 | Fulltext

Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.

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Al-Attar SA, Pollex RL, Ban MR, Young TK, Bjerregaard P, Anand SS, Yusuf S, Zinman B, Harris SB, Hanley AJ, Connelly PW, Huff MW, and Hegele RA

Cardiovascular diabetology 7:5, 2008 - Who cited this? | PubMed ID: 18339204 | Fulltext

Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders.

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Lahiry P, Ban MR, Pollex RL, Feldman RD, Sawyez CG, Huff MW, Young TK, Bjerregaard P, and Hegele RA

International journal of circumpolar health 66(5):390-400, 2007 Dec - Who cited this? | PubMed ID: 18274205 | Fulltext

The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin.

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Telford DE, Sutherland BG, Edwards JY, Andrews JD, Barrett PH, and Huff MW

Journal of lipid research 48(3):699, 2007 Mar - Who cited this? | PubMed ID: 17130282 | Fulltext

Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol.

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Beyea MM, Heslop CL, Sawyez CG, Edwards JY, Markle JG, Hegele RA, and Huff MW

The Journal of biological chemistry 282(8):5207, 2007 Feb 23 - Who cited this? | PubMed ID: 17186944 | Fulltext

Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample.

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Pollex RL, Ban MR, Young TK, Bjerregaard P, Anand SS, Yusuf S, Zinman B, Harris SB, Hanley AJ, Connelly PW, Huff MW, and Hegele RA

BMC medical genetics 8:80, 2007 - Who cited this? | PubMed ID: 18096054 | Fulltext

Cholesterol absorption inhibitors as a therapeutic option for hypercholesterolaemia.

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Burnett JR and Huff MW

Expert opinion on investigational drugs 15(11):1337-51, 2006 Nov - Who cited this? | PubMed ID: 17040195 | Fulltext

NPC1L1: evolution from pharmacological target to physiological sterol transporter.

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Huff MW, Pollex RL, and Hegele RA

Arteriosclerosis, thrombosis, and vascular biology 26(11):2433-8, 2006 Nov - Who cited this? | PubMed ID: 16973966 | Fulltext

Ankyrin G overexpression in Hutchinson-Gilford progeria syndrome fibroblasts identified through biological filtering of expression profiles.

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Wang J, Robinson JF, O'Neil CH, Edwards JY, Williams CM, Huff MW, Pickering JG, and Hegele RA

Journal of human genetics 51(11):934-42, 2006 - Who cited this? | PubMed ID: 17033732 | Fulltext

The ACAT inhibitor avasimibe increases the fractional clearance rate of postprandial triglyceride-rich lipoproteins in miniature pigs.

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Burnett JR, Telford DE, Barrett PH, and Huff MW

Biochimica et biophysica acta 1738(1-3):10-8, 2005 Dec 30 - Who cited this? | PubMed ID: 16427354 | Fulltext

A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content.

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Telford DE, Lipson SM, Barrett PH, Sutherland BG, Edwards JY, Aebi JD, Dehmlow H, Morand OH, and Huff MW

Arteriosclerosis, thrombosis, and vascular biology 25(12):2608-14, 2005 Dec - Who cited this? | PubMed ID: 16210564 | Fulltext

Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear.

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Huff MW and Telford DE

Trends in pharmacological sciences 26(7):335, 2005 Jul - Who cited this? | PubMed ID: 15951028 | Fulltext

Quality assessment of microarray experiments.

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Carter DE, Robinson JF, Allister EM, Huff MW, and Hegele RA

Clinical biochemistry 38(7):639-42, 2005 Jul - Who cited this? | PubMed ID: 15923000 | Fulltext

Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

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Argmann CA, Edwards JY, Sawyez CG, O'Neil CH, Hegele RA, Pickering JG, and Huff MW

The Journal of biological chemistry 280(23):22212-21, 2005 Jun 10 - Who cited this? | PubMed ID: 15817453 | Fulltext

Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes.

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Allister EM, Borradaile NM, Edwards JY, and Huff MW

Diabetes 54(6):1676-83, 2005 Jun - Who cited this? | PubMed ID: 15919788 | Fulltext

Human smooth muscle cell subpopulations differentially accumulate cholesteryl ester when exposed to native and oxidized lipoproteins.

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Argmann CA, Sawyez CG, Li S, Nong Z, Hegele RA, Pickering JG, and Huff MW

Arteriosclerosis, thrombosis, and vascular biology 24(7):1290-6, 2004 Jul - Who cited this? | PubMed ID: 15130914 | Fulltext

Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation.

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Rowe AH, Argmann CA, Edwards JY, Sawyez CG, Morand OH, Hegele RA, and Huff MW

Circulation research 93(8):717, 2003 Oct 17 - Who cited this? | PubMed ID: 14512442 | Fulltext

Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation.

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Borradaile NM, de Dreu LE, and Huff MW

Diabetes 52(10):2554-61, 2003 Oct - Who cited this? | PubMed ID: 14514640 | Fulltext

Inhibition of both the apical sodium-dependent bile acid transporter and HMG-CoA reductase markedly enhances the clearance of LDL apoB.

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Telford DE, Edwards JY, Lipson SM, Sutherland B, Barrett PH, Burnett JR, Krul ES, Keller BT, and Huff MW

Journal of lipid research 44(5):943-52, 2003 May - Who cited this? | PubMed ID: 12562847 | Fulltext

Activation of peroxisome proliferator-activated receptor gamma and retinoid X receptor results in net depletion of cellular cholesteryl esters in macrophages exposed to oxidized lipoproteins.

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Argmann CA, Sawyez CG, McNeil CJ, Hegele RA, and Huff MW

Arteriosclerosis, thrombosis, and vascular biology 23(3):475-82, 2003 Mar 1 - Who cited this? | PubMed ID: 12615696 | Fulltext

Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation.

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Borradaile NM, de Dreu LE, Barrett PH, Behrsin CD, and Huff MW

Biochemistry 42(5):1283-91, 2003 Feb 11 - Who cited this? | PubMed ID: 12564931 | Fulltext

Dietary cholesterol, cholesterol absorption, postprandial lipemia and atherosclerosis.

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Huff MW

The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 10 Suppl A:26A-32A, 2003 - Who cited this? | PubMed ID: 14571303 | Fulltext

Elevated serum C-reactive protein and free fatty acids among nondiabetic carriers of missense mutations in the gene encoding lamin A/C (LMNA) with partial lipodystrophy.

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Hegele RA, Kraw ME, Ban MR, Miskie BA, Huff MW, and Cao H

Arteriosclerosis, thrombosis, and vascular biology 23(1):111-6, 2003 Jan 1 - Who cited this? | PubMed ID: 12524233 | Fulltext

Inhibition of the apical sodium-dependent bile acid transporter reduces LDL cholesterol and apoB by enhanced plasma clearance of LDL apoB.

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Huff MW, Telford DE, Edwards JY, Burnett JR, Barrett PH, Rapp SR, Napawan N, and Keller BT

Arteriosclerosis, thrombosis, and vascular biology 22(11):1884-91, 2002 Nov 1 - Who cited this? | PubMed ID: 12426220 | Fulltext

Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms.

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Borradaile NM, de Dreu LE, Wilcox LJ, Edwards JY, and Huff MW

The Biochemical journal 366(Pt 2):531-9, 2002 Sep 1 - Who cited this? | PubMed ID: 12030847 | Fulltext

Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.

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Borradaile NM, de Dreu LE, Barrett PH, and Huff MW

Journal of lipid research 43(9):1544-54, 2002 Sep - Who cited this? | PubMed ID: 12235187 | Fulltext

Avasimibe Pfizer.

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Burnett JR and Huff MW

Current opinion in investigational drugs (London, England : 2000) 3(9):1328-33, 2002 Sep - Who cited this? | PubMed ID: 12498009 | Fulltext

Successful pregnancy outcome in a patient with severe chylomicronemia due to compound heterozygosity for mutant lipoprotein lipase.

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Al-Shali K, Wang J, Fellows F, Huff MW, Wolfe BM, and Hegele RA

Clinical biochemistry 35(2):125-30, 2002 Mar - Who cited this? | PubMed ID: 11983347 | Fulltext

Transforming growth factor-beta1 inhibits macrophage cholesteryl ester accumulation induced by native and oxidized VLDL remnants.

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Argmann CA, Van Den Diepstraten CH, Sawyez CG, Edwards JY, Hegele RA, Wolfe BM, and Huff MW

Arteriosclerosis, thrombosis, and vascular biology 21(12):2011-8, 2001 Dec - Who cited this? | PubMed ID: 11742878 | Fulltext

Common genomic variation in LMNA modulates indexes of obesity in Inuit.

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Hegele RA, Huff MW, and Young TK

The Journal of clinical endocrinology and metabolism 86(6):2747-51, 2001 Jun - Who cited this? | PubMed ID: 11397881 | Fulltext

Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.

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Wilcox LJ, Borradaile NM, de Dreu LE, and Huff MW

Journal of lipid research 42(5):725-34, 2001 May - Who cited this? | PubMed ID: 11352979 | Fulltext

LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration.

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Hegele RA, Cao H, Huff MW, and Anderson CM

The Journal of clinical endocrinology and metabolism 85(9):3089-93, 2000 Sep - Who cited this? | PubMed ID: 10999791 | Fulltext

Effect of amlodipine on hemodynamic and endocrine responses to mental stress.

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Spence JD, Munoz C, Huff MW, and Tokmakjian S

American journal of hypertension : journal of the American Society of Hypertension 13(5 Pt 1):518-22, 2000 May - Who cited this? | PubMed ID: 10826403 | Fulltext

Effects of continuous conjugated estrogen and micronized progesterone therapy upon lipoprotein metabolism in postmenopausal women.

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Wolfe BM, Barrett PH, Laurier L, and Huff MW

Journal of lipid research 41(3):368-75, 2000 Mar - Who cited this? | PubMed ID: 10706584 | Fulltext

The effect of valsartan and captopril on lipid parameters in patients with type II diabetes mellitus and nephropathy.

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Cheung R, Lewanczuk RZ, Rodger NW, Huff MW, Oddou-Stock P, Botteri F, Pecher E, and Muirhead N

International journal of clinical practice 53(8):584-92, 1999 Dec - Who cited this? | PubMed ID: 10692751 | Fulltext

The magnitude of decrease in hepatic very low density lipoprotein apolipoprotein B secretion is determined by the extent of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition in miniature pigs.

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Burnett JR, Wilcox LJ, Telford DE, Kleinstiver SJ, Barrett PH, Newton RS, and Huff MW

Endocrinology 140(11):5293-302, 1999 Nov - Who cited this? | PubMed ID: 10537160 | Fulltext

Acyl coenzyme A: cholesterol acyltransferase inhibition and hepatic apolipoprotein B secretion.

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Burnett JR, Wilcox LJ, and Huff MW

Clinica chimica acta; international journal of clinical chemistry 286(1-2):231-42, 1999 Aug - Who cited this? | PubMed ID: 10511295 | Fulltext

Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs.

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Burnett JR, Wilcox LJ, Telford DE, Kleinstiver SJ, Barrett PH, Newton RS, and Huff MW

Journal of lipid research 40(7):1317-27, 1999 Jul - Who cited this? | PubMed ID: 10393217 | Fulltext

Uptake of type IV hypertriglyceridemic VLDL by cultured macrophages is enhanced by interferon-gamma.

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Whitman SC, Argmann CA, Sawyez CG, Miller DB, Hegele RA, and Huff MW

Journal of lipid research 40(6):1017-28, 1999 Jun - Who cited this? | PubMed ID: 10357833 | Fulltext

Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin.

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Wilcox LJ, Barrett PH, and Huff MW

Journal of lipid research 40(6):1078-89, 1999 Jun - Who cited this? | PubMed ID: 10357840 | Fulltext

Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages.

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Whitman SC, Hazen SL, Miller DB, Hegele RA, Heinecke JW, and Huff MW

Arteriosclerosis, thrombosis, and vascular biology 19(5):1238-49, 1999 May - Who cited this? | PubMed ID: 10323775 | Fulltext

ApoB100 secretion from HepG2 cells is decreased by the ACAT inhibitor CI-1011: an effect associated with enhanced intracellular degradation of ApoB.

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Wilcox LJ, Barrett PH, Newton RS, and Huff MW

Arteriosclerosis, thrombosis, and vascular biology 19(4):939-49, 1999 Apr - Who cited this? | PubMed ID: 10195921 | Fulltext

The HMG-CoA reductase inhibitor atorvastatin increases the fractional clearance rate of postprandial triglyceride-rich lipoproteins in miniature pigs.

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Burnett JR, Barrett PH, Vicini P, Miller DB, Telford DE, Kleinstiver SJ, and Huff MW

Arteriosclerosis, thrombosis, and vascular biology 18(12):1906-14, 1998 Dec - Who cited this? | PubMed ID: 9848883 | Fulltext

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