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Papers authored by Hotamisligil GS

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Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.

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Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, and Shi GP

Nature medicine 15(8):940-5, 2009 Aug - Who cited this? | PubMed ID: 19633655 | Fulltext

CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance.

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Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E,

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Cell metabolism 9(4):339-49, 2009 Apr - Who cited this? | PubMed ID: 19356715 | Fulltext

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.

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Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, and Klein S

Diabetes 58(3):693-700, 2009 Mar - Who cited this? | PubMed ID: 19066313 | Fulltext

Erratum.

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Vallerie SN, Furuhashi M, Fucho R, and Hotamisligil GS

PLoS ONE 4(1), 2009 - Who cited this? | PubMed ID: 19238227 | Fulltext

Nutrient sensing and inflammation in metabolic diseases.

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Hotamisligil GS and Erbay E

Nature reviews. Immunology 8(12):923-34, 2008 Dec - Who cited this? | PubMed ID: 19029988 | Fulltext

Inflammation and endoplasmic reticulum stress in obesity and diabetes.

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Hotamisligil GS

International journal of obesity (2005) 32 Suppl 7:S52-4, 2008 Dec - Who cited this? | PubMed ID: 19136991 | Fulltext

Stressing the brain, fattening the body.

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Yang L and Hotamisligil GS

Cell 135(1):20-2, 2008 Oct 3 - Who cited this? | PubMed ID: 18854151 | Fulltext

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

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Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, and Hotamisligil GS

Cell 134(6):933, 2008 Sep 19 - Who cited this? | PubMed ID: 18805087 | Fulltext

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

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Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, and Hotamisligil GS

The Journal of clinical investigation, 2008 Jun 12 - Who cited this? | PubMed ID: 18551191 | Fulltext

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.

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Furuhashi M and Hotamisligil GS

Nature reviews. Drug discovery 7(6):489, 2008 Jun - Who cited this? | PubMed ID: 18511927 | Fulltext

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

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Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, and Hotamisligil GS

Molecular cell 29(5):541, 2008 Mar 14 - Who cited this? | PubMed ID: 18342602 | Fulltext

A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity.

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Vallerie SN, Furuhashi M, Fucho R, and Hotamisligil GS

PLoS ONE 3(9), 2008 - Who cited this? | PubMed ID: 18773087 | Fulltext

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.

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Gregor MF and Hotamisligil GS

Journal of lipid research 48(9):1905, 2007 Sep - Who cited this? | PubMed ID: 17699733 | Fulltext

Adipocyte/Macrophage Fatty Acid binding proteins in metabolic syndrome.

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Erbay E, Cao H, and Hotamisligil GS

Current atherosclerosis reports 9(3):222-9, 2007 Sep - Who cited this? | PubMed ID: 18241617 | Fulltext

Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis.

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Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ, Hotamisligil GS, Stout RD, and Suttles J

Journal of immunology (Baltimore, Md. : 1950) 179(1):313-21, 2007 Jul 1 - Who cited this? | PubMed ID: 17579051 | Fulltext

Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.

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Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, and Liu S

Diabetes 56(7):1898-904, 2007 Jul - Who cited this? | PubMed ID: 17389327 | Fulltext

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

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Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, and Hotamisligil GS

Nature 447(7147):959-65, 2007 Jun 21 - Who cited this? | PubMed ID: 17554340 | Fulltext

Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.

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Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, and Hotamisligil GS

Cell 129(3):537-48, 2007 May 4 - Who cited this? | PubMed ID: 17482547 | Fulltext

Developmental biology: cell fate in the mammary gland.

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Tong Q and Hotamisligil GS

Nature 445(7129):724-6, 2007 Feb 15 - Who cited this? | PubMed ID: 17301782 | Fulltext

A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women.

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Liu S, Tinker L, Song Y, Rifai N, Bonds DE, Cook NR, Heiss G, Howard BV, Hotamisligil GS, Hu FB, Kuller LH, and Manson JE

Archives of internal medicine 167(15):1676-85, 2007 - Who cited this? | PubMed ID: 17698692 | Fulltext

Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes.

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Hotamisligil GS

Novartis Foundation symposium 286:86-94; discussion 94-8, 162-3, 196-203, 2007 - Who cited this? | PubMed ID: 18269176 | Fulltext

Inflammation and metabolic disorders.

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Hotamisligil GS

Nature 444(7121):860, 2006 Dec 14 - Who cited this? | PubMed ID: 17167474 | Fulltext

Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.

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Rolph MS, Young TR, Shum BO, Gorgun CZ, Schmitz-Peiffer C, Ramshaw IA, Hotamisligil GS, and Mackay CR

Journal of immunology (Baltimore, Md. : 1950) 177(11):7794, 2006 Dec 1 - Who cited this? | PubMed ID: 17114450 | Fulltext

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

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Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, and Kemp BE

Cell metabolism 4(6):465, 2006 Dec - Who cited this? | PubMed ID: 17141630 | Fulltext

JNK1 deficiency does not enhance muscle glucose metabolism in lean mice.

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Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, and Goodyear LJ

Biochemical and biophysical research communications 350(4):1063-8, 2006 Dec 1 - Who cited this? | PubMed ID: 17045576 | Fulltext

Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance.

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Tilg H and Hotamisligil GS

Gastroenterology 131(3):934-45, 2006 Sep - Who cited this? | PubMed ID: 16952562 | Fulltext

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

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Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, and Hotamisligil GS

Science (New York, N.Y.) 313(5790):1137-40, 2006 Aug 25 - Who cited this? | PubMed ID: 16931765 | Fulltext

Neuronal PTP1B regulates body weight, adiposity and leptin action.

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Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, and Kahn BB

Nature medicine 12(8):917-24, 2006 Aug - Who cited this? | PubMed ID: 16845389 | Fulltext

The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation.

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Shum BO, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, and Rolph MS

The Journal of clinical investigation 116(8):2183-2192, 2006 Aug - Who cited this? | PubMed ID: 16841093 | Fulltext

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

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Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, and Hotamisligil GS

Proceedings of the National Academy of Sciences of the United States of America 103(28):10741-6, 2006 Jul 11 - Who cited this? | PubMed ID: 16818881 | Fulltext

Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.

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Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, and Hotamisligil GS

Diabetes 55(7):1915, 2006 Jul - Who cited this? | PubMed ID: 16804058 | Fulltext

A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.

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Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, and Hotamisligil GS

Proceedings of the National Academy of Sciences of the United States of America 103(18):6970-5, 2006 May 2 - Who cited this? | PubMed ID: 16641093 | Fulltext

Regulation of adiponectin in adipocytes upon exposure to HIV-1.

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Sankalé JL, Tong Q, Hadigan CM, Tan G, Grinspoon SK, Kanki PJ, and Hotamisligil GS

HIV medicine 7(4):268-74, 2006 May - Who cited this? | PubMed ID: 16630040 | Fulltext

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

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Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, and Brüning JC

Cell metabolism 3(4):247, 2006 Apr - Who cited this? | PubMed ID: 16581002 | Fulltext

Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice.

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Neels JG, Pandey M, Hotamisligil GS, and Samad F

The American journal of pathology 168(2):435-44, 2006 Feb - Who cited this? | PubMed ID: 16436658 | Fulltext

Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes.

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Hotamisligil GS

Diabetes 54 Suppl 2:S73-8, 2005 Dec - Who cited this? | PubMed ID: 16306344 | Fulltext

The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis.

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Makowski L and Hotamisligil GS

Current opinion in lipidology 16(5):543-8, 2005 Oct - Who cited this? | PubMed ID: 16148539 | Fulltext

The transcription factor GATA2 regulates differentiation of brown adipocytes.

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Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, and Hotamisligil GS

EMBO reports 6(9):879-84, 2005 Sep - Who cited this? | PubMed ID: 16082385 | Fulltext

Inflammation, stress, and diabetes.

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Wellen KE and Hotamisligil GS

The Journal of clinical investigation 115(5):1111-9, 2005 May - Who cited this? | PubMed ID: 15864338 | Fulltext

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.

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Makowski L, Brittingham KC, Reynolds JM, Suttles J, and Hotamisligil GS

The Journal of biological chemistry 280(13):12888-95, 2005 Apr 1 - Who cited this? | PubMed ID: 15684432 | Fulltext

Association between dietary factors and plasma adiponectin concentrations in men.

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Pischon T, Girman CJ, Rifai N, Hotamisligil GS, and Rimm EB

The American journal of clinical nutrition 81(4):780-6, 2005 Apr - Who cited this? | PubMed ID: 15817852 | Fulltext

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

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Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, and Hotamisligil GS

Cell metabolism 1(2):107, 2005 Feb - Who cited this? | PubMed ID: 16054052 | Fulltext

Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.

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Tong Q, Tsai J, Tan G, Dalgin G, and Hotamisligil GS

Molecular and cellular biology 25(2):706-15, 2005 Jan - Who cited this? | PubMed ID: 15632071 | Fulltext

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

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Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, and Hotamisligil GS

Science (New York, N.Y.) 306(5695):457-61, 2004 Oct 15 - Who cited this? | PubMed ID: 15486293 | Fulltext

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

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Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, and Hotamisligil GS

Circulation 110(11):1492-8, 2004 Sep 14 - Who cited this? | PubMed ID: 15353487 | Fulltext

Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.

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Makowski L and Hotamisligil GS

The Journal of nutrition 134(9):2464S-2468S, 2004 Sep - Who cited this? | PubMed ID: 15333743 | Fulltext

Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity.

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Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, and Hotamisligil GS

Endocrinology 145(5):2214, 2004 May - Who cited this? | PubMed ID: 14764635 | Fulltext

Plasma adiponectin levels and risk of myocardial infarction in men.

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Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, and Rimm EB

JAMA : the journal of the American Medical Association 291(14):1730, 2004 Apr 14 - Who cited this? | PubMed ID: 15082700 | Fulltext

Obesity-induced inflammatory changes in adipose tissue.

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Wellen KE and Hotamisligil GS

The Journal of clinical investigation 112(12):1785-8, 2003 Dec - Who cited this? | PubMed ID: 14679172 | Fulltext

Inflammatory pathways and insulin action.

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Hotamisligil GS

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 27 Suppl 3:S53-5, 2003 Dec - Who cited this? | PubMed ID: 14704746 | Fulltext

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