Please enable Javascript

Labmeeting uses lots of Javascript - basically you can't use the site without it. So please enable Javascript in your browser. If your browser does not support Javascript, we recommend Firefox.

Papers authored by Horwich AL

Collect these papers and discover other ones on Labmeeting. Learn more.

The GroEL/GroES cis cavity as a passive anti-aggregation device.

+ cite this

+ View Abstract

Horwich AL, Apetri AC, and Fenton WA

FEBS letters 583(16):2654-62, 2009 Aug 20 - Who cited this? | PubMed ID: 19577567 | Fulltext

Chaperonin-mediated protein folding: using a central cavity to kinetically assist polypeptide chain folding.

+ cite this

+ View Abstract

Horwich AL and Fenton WA

Quarterly reviews of biophysics 42(2):83-116, 2009 May - Who cited this? | PubMed ID: 19638247 | Fulltext

A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL.

+ cite this

+ View Abstract

Chapman E, Farr GW, Furtak K, and Horwich AL

Bioorganic & medicinal chemistry letters 19(3):811-3, 2009 Feb 1 - Who cited this? | PubMed ID: 19110421 | Fulltext

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.

+ cite this

+ View Abstract

Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR, Perrin S, Feany MB, and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America, 2009 Jan 26 - Who cited this? | PubMed ID: 19171884 | Fulltext

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans.

+ cite this

+ View Abstract

Wang J, Farr GW, Hall DH, Li F, Furtak K, Dreier L, and Horwich AL

PLoS genetics 5(1):e1000350, 2009 Jan - Who cited this? | PubMed ID: 19165329 | Fulltext

Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state.

+ cite this

+ View Abstract

Chapman E, Farr GW, Fenton WA, Johnson SM, and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America 105(49):19205-10, 2008 Dec 9 - Who cited this? | PubMed ID: 19050077 | Fulltext

Chaperonin chamber accelerates protein folding through passive action of preventing aggregation.

+ cite this

+ View Abstract

Apetri AC and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America, 2008 Nov 5 - Who cited this? | PubMed ID: 18987317 | Fulltext

Multiple States of a nucleotide-bound group 2 chaperonin.

+ cite this

+ View Abstract

Clare DK, Stagg S, Quispe J, Farr GW, Horwich AL, and Saibil HR

Structure (London, England : 1993) 16(4):528, 2008 Apr - Who cited this? | PubMed ID: 18400175 | Fulltext

Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution.

+ cite this

+ View Abstract

Horst R, Fenton WA, Englander SW, Wüthrich K, and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America 104(52):20788, 2007 Dec 26 - Who cited this? | PubMed ID: 18093916 | Fulltext

Topologies of a substrate protein bound to the chaperonin GroEL.

+ cite this

+ View Abstract

Elad N, Farr GW, Clare DK, Orlova EV, Horwich AL, and Saibil HR

Molecular cell 26(3):415, 2007 May 11 - Who cited this? | PubMed ID: 17499047 | Fulltext

Perturbed ATPase activity and not "close confinement" of substrate in the cis cavity affects rates of folding by tail-multiplied GroEL.

+ cite this

+ View Abstract

Farr GW, Fenton WA, and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America 104(13):5342, 2007 Mar 27 - Who cited this? | PubMed ID: 17372195 | Fulltext

Disulfide formation as a probe of folding in GroEL-GroES reveals correct formation of long-range bonds and editing of incorrect short-range ones.

+ cite this

+ View Abstract

Park ES, Fenton WA, and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America 104(7):2145, 2007 Feb 13 - Who cited this? | PubMed ID: 17283341 | Fulltext

Two families of chaperonin: physiology and mechanism.

+ cite this

+ View Abstract

Horwich AL, Fenton WA, Chapman E, and Farr GW

Annual review of cell and developmental biology 23:115, 2007 - Who cited this? | PubMed ID: 17489689 | Fulltext

Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL.

+ cite this

+ View Abstract

Chapman E, Farr GW, Usaite R, Furtak K, Fenton WA, Chaudhuri TK, Hondorp ER, Matthews RG, Wolf SG, Yates JR, Pypaert M, and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America 103(43):15800, 2006 Oct 24 - Who cited this? | PubMed ID: 17043235 | Fulltext

Proton-proton Overhauser NMR spectroscopy with polypeptide chains in large structures.

+ cite this

+ View Abstract

Horst R, Wider G, Fiaux J, Bertelsen EB, Horwich AL, and Wüthrich K

Proceedings of the National Academy of Sciences of the United States of America 103(42):15445, 2006 Oct 17 - Who cited this? | PubMed ID: 17032756 | Fulltext

GroEL-GroES-mediated protein folding.

+ cite this

Horwich AL, Farr GW, and Fenton WA

Chemical reviews 106(5):1917, 2006 May - Who cited this? | PubMed ID: 16683761 | Fulltext

Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes.

+ cite this

+ View Abstract

Ranson NA, Clare DK, Farr GW, Houldershaw D, Horwich AL, and Saibil HR

Nature structural & molecular biology 13(2):147, 2006 Feb - Who cited this? | PubMed ID: 16429154 | Fulltext

Probing the sequence of conformationally induced polarity changes in the molecular chaperonin GroEL with fluorescence spectroscopy.

+ cite this

+ View Abstract

Kim SY, Semyonov AN, Twieg RJ, Horwich AL, Frydman J, and Moerner WE

The journal of physical chemistry. B 109(51):24517, 2005 Dec 29 - Who cited this? | PubMed ID: 16375456 | Fulltext

Roles of the N-domains of the ClpA unfoldase in binding substrate proteins and in stable complex formation with the ClpP protease.

+ cite this

+ View Abstract

Hinnerwisch J, Reid BG, Fenton WA, and Horwich AL

The Journal of biological chemistry 280(49):40838, 2005 Dec 9 - Who cited this? | PubMed ID: 16207718 | Fulltext

Direct NMR observation of a substrate protein bound to the chaperonin GroEL.

+ cite this

+ View Abstract

Horst R, Bertelsen EB, Fiaux J, Wider G, Horwich AL, and Wüthrich K

Proceedings of the National Academy of Sciences of the United States of America 102(36):12748-53, 2005 Sep 6 - Who cited this? | PubMed ID: 16116078 | Fulltext

Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation.

+ cite this

+ View Abstract

Hinnerwisch J, Fenton WA, Furtak KJ, Farr GW, and Horwich AL

Cell 121(7):1029, 2005 Jul 1 - Who cited this? | PubMed ID: 15989953 | Fulltext

No evidence for a forced-unfolding mechanism during ATP/GroES binding to substrate-bound GroEL: no observable protection of metastable Rubisco intermediate or GroEL-bound Rubisco from tritium exchange.

+ cite this

+ View Abstract

Park ES, Fenton WA, and Horwich AL

FEBS letters 579(5):1183, 2005 Feb 14 - Who cited this? | PubMed ID: 15710410 | Fulltext

Chaperoned protein disaggregation--the ClpB ring uses its central channel.

+ cite this

+ View Abstract

Horwich AL

Cell 119(5):579-81, 2004 Nov 24 - Who cited this? | PubMed ID: 15550237 | Fulltext

A mutant chaperonin with rearranged inter-ring electrostatic contacts and temperature-sensitive dissociation.

+ cite this

+ View Abstract

Sewell BT, Best RB, Chen S, Roseman AM, Farr GW, Horwich AL, and Saibil HR

Nature structural & molecular biology 11(11):1128, 2004 Nov - Who cited this? | PubMed ID: 15475965 | Fulltext

Substrate polypeptide presents a load on the apical domains of the chaperonin GroEL.

+ cite this

+ View Abstract

Motojima F, Chaudhry C, Fenton WA, Farr GW, and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America 101(42):15005, 2004 Oct 19 - Who cited this? | PubMed ID: 15479763 | Fulltext

Exploring the structural dynamics of the E.coli chaperonin GroEL using translation-libration-screw crystallographic refinement of intermediate states.

+ cite this

+ View Abstract

Chaudhry C, Horwich AL, Brunger AT, and Adams PD

Journal of molecular biology 342(1):229-45, 2004 Sep 3 - Who cited this? | PubMed ID: 15313620 | Fulltext

Uniform and residue-specific 15N-labeling of proteins on a highly deuterated background.

+ cite this

+ View Abstract

Fiaux J, Bertelsen EB, Horwich AL, and Wüthrich K

Journal of biomolecular NMR 29(3):289-97, 2004 Jul - Who cited this? | PubMed ID: 15213427 | Fulltext

Role of the gamma-phosphate of ATP in triggering protein folding by GroEL-GroES: function, structure and energetics.

+ cite this

+ View Abstract

Chaudhry C, Farr GW, Todd MJ, Rye HS, Brunger AT, Adams PD, Horwich AL, and Sigler PB

The EMBO journal 22(19):4877, 2003 Oct 1 - Who cited this? | PubMed ID: 14517228 | Fulltext

Folding with and without encapsulation by cis- and trans-only GroEL-GroES complexes.

+ cite this

+ View Abstract

Farr GW, Fenton WA, Chaudhuri TK, Clare DK, Saibil HR, and Horwich AL

The EMBO journal 22(13):3220, 2003 Jul 1 - Who cited this? | PubMed ID: 12839985 | Fulltext

Chaperonin-mediated protein folding: fate of substrate polypeptide.

+ cite this

+ View Abstract

Fenton WA and Horwich AL

Quarterly reviews of biophysics 36(2):229, 2003 May - Who cited this? | PubMed ID: 14686103 | Fulltext

Solution NMR techniques for large molecular and supramolecular structures.

+ cite this

+ View Abstract

Riek R, Fiaux J, Bertelsen EB, Horwich AL, and Wuthrich K

Journal of the American Chemical Society 124(41):12144-53, 2002 Oct 16 - Who cited this? | PubMed ID: 12371854 | Fulltext

NMR analysis of a 900K GroEL GroES complex.

+ cite this

+ View Abstract

Fiaux J, Bertelsen EB, Horwich AL, and Wüthrich K

Nature 418(6894):207-11, 2002 Jul 11 - Who cited this? | PubMed ID: 12110894 | Fulltext

ClpS, a substrate modulator of the ClpAP machine.

+ cite this

+ View Abstract

Dougan DA, Reid BG, Horwich AL, and Bukau B

Molecular cell 9(3):673, 2002 Mar - Who cited this? | PubMed ID: 11931773 | Fulltext

ATP-bound states of GroEL captured by cryo-electron microscopy.

+ cite this

+ View Abstract

Ranson NA, Farr GW, Roseman AM, Gowen B, Fenton WA, Horwich AL, and Saibil HR

Cell 107(7):869, 2001 Dec 28 - Who cited this? | PubMed ID: 11779463 | Fulltext

Protein folding taking shape. Workshop on molecular chaperones.

+ cite this

Horwich AL, Fenton WA, and Rapoport TA

EMBO reports 2(12):1068, 2001 Dec - Who cited this? | PubMed ID: 11743017 | Fulltext

GroEL/GroES-mediated folding of a protein too large to be encapsulated.

+ cite this

+ View Abstract

Chaudhuri TK, Farr GW, Fenton WA, Rospert S, and Horwich AL

Cell 107(2):235, 2001 Oct 19 - Who cited this? | PubMed ID: 11672530 | Fulltext

Folding of malate dehydrogenase inside the GroEL-GroES cavity.

+ cite this

+ View Abstract

Chen J, Walter S, Horwich AL, and Smith DL

Nature structural biology 8(8):721, 2001 Aug - Who cited this? | PubMed ID: 11473265 | Fulltext

ClpA mediates directional translocation of substrate proteins into the ClpP protease.

+ cite this

+ View Abstract

Reid BG, Fenton WA, Horwich AL, and Weber-Ban EU

Proceedings of the National Academy of Sciences of the United States of America 98(7):3768, 2001 Mar 27 - Who cited this? | PubMed ID: 11259663 | Fulltext

Mechanisms of protein folding.

+ cite this

+ View Abstract

Grantcharova V, Alm EJ, Baker D, and Horwich AL

Current opinion in structural biology 11(1):70-82, 2001 Feb - Who cited this? | PubMed ID: 11179895 | Fulltext

Allostery and protein substrate conformational change during GroEL/GroES-mediated protein folding.

+ cite this

Saibil HR, Horwich AL, and Fenton WA

Advances in protein chemistry 59:45, 2001 - Who cited this? | PubMed ID: 11868280 | Fulltext

Multivalent binding of nonnative substrate proteins by the chaperonin GroEL.

+ cite this

+ View Abstract

Farr GW, Furtak K, Rowland MB, Ranson NA, Saibil HR, Kirchhausen T, and Horwich AL

Cell 100(5):561, 2000 Mar 3 - Who cited this? | PubMed ID: 10721993 | Fulltext

Chaperone rings in protein folding and degradation.

+ cite this

+ View Abstract

Horwich AL, Weber-Ban EU, and Finley D

Proceedings of the National Academy of Sciences of the United States of America 96(20):11033-40, 1999 Sep 28 - Who cited this? | PubMed ID: 10500119 | Fulltext

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA.

+ cite this

+ View Abstract

Weber-Ban EU, Reid BG, Miranker AD, and Horwich AL

Nature 401(6748):90-3, 1999 Sep 2 - Who cited this? | PubMed ID: 10485712 | Fulltext

GroEL-GroES cycling: ATP and nonnative polypeptide direct alternation of folding-active rings.

+ cite this

+ View Abstract

Rye HS, Roseman AM, Chen S, Furtak K, Fenton WA, Saibil HR, and Horwich AL

Cell 97(3):325, 1999 Apr 30 - Who cited this? | PubMed ID: 10319813 | Fulltext

Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT.

+ cite this

+ View Abstract

Won KA, Schumacher RJ, Farr GW, Horwich AL, and Reed SI

Molecular and cellular biology 18(12):7584-9, 1998 Dec - Who cited this? | PubMed ID: 9819444 | Fulltext

Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins.

+ cite this

+ View Abstract

Kim S, Schilke B, Craig EA, and Horwich AL

Proceedings of the National Academy of Sciences of the United States of America 95(22):12860-5, 1998 Oct 27 - Who cited this? | PubMed ID: 9789005 | Fulltext

The thermosome: chaperonin with a built-in lid.

+ cite this

Horwich AL and Saibil HR

Nature structural biology 5(5):333-6, 1998 May - Who cited this? | PubMed ID: 9586988 | Fulltext

The Hsp70 and Hsp60 chaperone machines.

+ cite this

Bukau B and Horwich AL

Cell 92(3):351-66, 1998 Feb 6 - Who cited this? | PubMed ID: 9476895 | Fulltext

Structure and function in GroEL-mediated protein folding.

+ cite this

+ View Abstract

Sigler PB, Xu Z, Rye HS, Burston SG, Fenton WA, and Horwich AL

Annual review of biochemistry 67:581, 1998 - Who cited this? | PubMed ID: 9759498 | Fulltext

Construction of single-ring and two-ring hybrid versions of bacterial chaperonin GroEL.

+ cite this

Horwich AL, Burston SG, Rye HS, Weissman JS, and Fenton WA

Methods in enzymology 290:141, 1998 - Who cited this? | PubMed ID: 9534157 | Fulltext

Search Google Scholar for Horwich AL

Join Labmeeting

Organize and search your PDF collection
Collect papers
Search millions of papers
Keep up to date with paper alerts
Read your papers from anywhere
Recommend papers to colleagues
Manage your lab

Labmeeting is a web service for researchers. Sign up with your academic email address.

Individuals or corporations not affiliated with an academic institution can request a trial subscription.

Got a question?
The Labmeeting Network
has the answer.
Ask scientists at top universities like Harvard, Stanford, and MIT for their expert opinion!