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Papers authored by Hoffmann JA

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The N-terminal Domain of Drosophila Gram-negative Binding Protein 3 (GNBP3) Defines a Novel Family of Fungal Pattern Recognition Receptors.

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Mishima Y, Quintin J, Aimanianda V, Kellenberger C, Coste F, Clavaud C, Hetru C, Hoffmann JA, Latgé JP, Ferrandon D, and Roussel A

The Journal of biological chemistry 284(42):28687-97, 2009 Oct 16 - Who cited this? | PubMed ID: 19692333 | Fulltext

Two Mosquito LRR Proteins Function as Complement Control Factors in the TEP1-Mediated Killing of Plasmodium.

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Fraiture M, Baxter RH, Steinert S, Chelliah Y, Frolet C, Quispe-Tintaya W, Hoffmann JA, Blandin SA, and Levashina EA

Cell host & microbe 5(3):273-84, 2009 Mar 19 - Who cited this? | PubMed ID: 19286136 | Fulltext

To explant or not to explant: an invasive and noninvasive monitoring protocol to determine the need of continued ventricular assist device support.

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Osaki S, Sweitzer NK, Rahko PS, Murray MA, Hoffmann JA, Johnson MR, Edwards NM, and Kohmoto T

Congestive heart failure (Greenwich, Conn.) 15(2):58-62, 2009 - Who cited this? | PubMed ID: 19385118 | Fulltext

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.

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Deddouche S, Matt N, Budd A, Mueller S, Kemp C, Galiana-Arnoux D, Dostert C, Antoniewski C, Hoffmann JA, and Imler JL

Nature immunology 9(12):1425-32, 2008 Dec - Who cited this? | PubMed ID: 18953338 | Fulltext

Improved survival in patients with ventricular assist device therapy: the University of Wisconsin experience.

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Osaki S, Edwards NM, Velez M, Johnson MR, Murray MA, Hoffmann JA, and Kohmoto T

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 34(2):281-8, 2008 Aug - Who cited this? | PubMed ID: 18513988 | Fulltext

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.

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Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, and Reichhart JM

Nature immunology 9(1):97, 2008 Jan - Who cited this? | PubMed ID: 18066067 | Fulltext

A model of bacterial intestinal infections in Drosophila melanogaster.

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Nehme NT, Liégeois S, Kele B, Giammarinaro P, Pradel E, Hoffmann JA, Ewbank JJ, and Ferrandon D

PLoS pathogens 3(11), 2007 Nov - Who cited this? | PubMed ID: 18039029 | Fulltext

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections.

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Ferrandon D, Imler JL, Hetru C, and Hoffmann JA

Nature reviews. Immunology 7(11):862-74, 2007 Nov - Who cited this? | PubMed ID: 17948019 | Fulltext

Genetic analysis of resistance to viral infection.

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Beutler B, Eidenschenk C, Crozat K, Imler JL, Takeuchi O, Hoffmann JA, and Akira S

Nature reviews. Immunology 7(10):753-66, 2007 Oct - Who cited this? | PubMed ID: 17893693 | Fulltext

Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors.

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Gottar M, Gobert V, Matskevich AA, Reichhart JM, Wang C, Butt TM, Belvin M, Hoffmann JA, and Ferrandon D

Cell 127(7):1425-37, 2006 Dec 29 - Who cited this? | PubMed ID: 17190605 | Fulltext

Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut.

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Shiao SH, Whitten MM, Zachary D, Hoffmann JA, and Levashina EA

PLoS pathogens 2(12):e133, 2006 Dec - Who cited this? | PubMed ID: 17196037 | Fulltext

Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei.

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Frolet C, Thoma M, Blandin S, Hoffmann JA, and Levashina EA

Immunity 25(4):677, 2006 Oct - Who cited this? | PubMed ID: 17045818 | Fulltext

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila.

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Galiana-Arnoux D, Dostert C, Schneemann A, Hoffmann JA, and Imler JL

Nature immunology 7(6):590-7, 2006 Jun - Who cited this? | PubMed ID: 16554838 | Fulltext

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2.

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Bischoff V, Vignal C, Duvic B, Boneca IG, Hoffmann JA, and Royet J

PLoS pathogens 2(2), 2006 Feb - Who cited this? | PubMed ID: 16518472 | Fulltext

Prophenoloxidase activation is not required for survival to microbial infections in Drosophila.

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Leclerc V, Pelte N, El Chamy L, Martinelli C, Ligoxygakis P, Hoffmann JA, and Reichhart JM

EMBO reports 7(2):231-5, 2006 Feb - Who cited this? | PubMed ID: 16322759 | Fulltext

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.

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Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, and Ezekowitz RA

Cell 123(2):335, 2005 Oct 21 - Who cited this? | PubMed ID: 16239149 | Fulltext

The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.

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Dostert C, Jouanguy E, Irving P, Troxler L, Galiana-Arnoux D, Hetru C, Hoffmann JA, and Imler JL

Nature immunology 6(9):946, 2005 Sep - Who cited this? | PubMed ID: 16086017 | Fulltext

New insights into Drosophila larval haemocyte functions through genome-wide analysis.

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Irving P, Ubeda JM, Doucet D, Troxler L, Lagueux M, Zachary D, Hoffmann JA, Hetru C, and Meister M

Cellular microbiology 7(3):335, 2005 Mar - Who cited this? | PubMed ID: 15679837 | Fulltext

Sensing and signaling during infection in Drosophila.

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Royet J, Reichhart JM, and Hoffmann JA

Current opinion in immunology 17(1):11-7, 2005 Feb - Who cited this? | PubMed ID: 15653304 | Fulltext

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.

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Bischoff V, Vignal C, Boneca IG, Michel T, Hoffmann JA, and Royet J

Nature immunology 5(11):1175-80, 2004 Nov - Who cited this? | PubMed ID: 15448690 | Fulltext

Sensing infection in Drosophila: Toll and beyond.

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Ferrandon D, Imler JL, and Hoffmann JA

Seminars in immunology 16(1):43-53, 2004 Feb - Who cited this? | PubMed ID: 14751763 | Fulltext

A descriptive study of the relationship between mood disorders and hepatitis C treatment compliance: does nursing play a role?.

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Strinko JM, Di Bisceglie AM, and Hoffmann JA

Issues in mental health nursing 25(7):715-22, 2004 - Who cited this? | PubMed ID: 15371138 | Fulltext

Toll-dependent and Toll-independent immune responses in Drosophila.

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Imler JL, Ferrandon D, Royet J, Reichhart JM, Hetru C, and Hoffmann JA

Journal of endotoxin research 10(4):241-6, 2004 - Who cited this? | PubMed ID: 15373968 | Fulltext

Peptidomic and proteomic analyses of the systemic immune response of Drosophila.

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Levy F, Rabel D, Charlet M, Bulet P, Hoffmann JA, and Ehret-Sabatier L

Biochimie 86(9-10):607-16, 2004 - Who cited this? | PubMed ID: 15556270 | Fulltext

Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus.

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Thouzeau C, Le Maho Y, Froget G, Sabatier L, Le Bohec C, Hoffmann JA, and Bulet P

The Journal of biological chemistry 278(51):51053-8, 2003 Dec 19 - Who cited this? | PubMed ID: 14525994 | Fulltext

Dual activation of the Drosophila toll pathway by two pattern recognition receptors.

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Gobert V, Gottar M, Matskevich AA, Rutschmann S, Royet J, Belvin M, Hoffmann JA, and Ferrandon D

Science (New York, N.Y.) 302(5653):2126-30, 2003 Dec 19 - Who cited this? | PubMed ID: 14684822 | Fulltext

The immune response of Drosophila.

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Hoffmann JA

Nature 426(6962):33, 2003 Nov 6 - Who cited this? | PubMed ID: 14603309 | Fulltext

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling.

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Weber AN, Tauszig-Delamasure S, Hoffmann JA, Lelièvre E, Gascan H, Ray KP, Morse MA, Imler JL, and Gay NJ

Nature immunology 4(8):794-800, 2003 Aug - Who cited this? | PubMed ID: 12872120 | Fulltext

Drosophila melanogaster antimicrobial defense.

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Hetru C, Troxler L, and Hoffmann JA

The Journal of infectious diseases 187 Suppl 2:S327-34, 2003 Jun 15 - Who cited this? | PubMed ID: 12792847 | Fulltext

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening.

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Kurz CL, Chauvet S, Andrès E, Aurouze M, Vallet I, Michel GP, Uh M, Celli J, Filloux A, de Bentzmann S, Steinmetz I, Hoffmann JA, Finlay BB, Gorvel JP, Ferrandon D, and Ewbank JJ

The EMBO journal 22(7):1451, 2003 Apr 1 - Who cited this? | PubMed ID: 12660152 | Fulltext

Toll signaling: the TIReless quest for specificity.

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Imler JL and Hoffmann JA

Nature immunology 4(2):105-6, 2003 Feb - Who cited this? | PubMed ID: 12555093 | Fulltext

A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

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Ligoxygakis P, Pelte N, Ji C, Leclerc V, Duvic B, Belvin M, Jiang H, Hoffmann JA, and Reichhart JM

The EMBO journal 21(23):6330-7, 2002 Dec 2 - Who cited this? | PubMed ID: 12456640 | Fulltext

PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae.

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Munier AI, Doucet D, Perrodou E, Zachary D, Meister M, Hoffmann JA, Janeway CA, and Lagueux M

EMBO reports 3(12):1195, 2002 Dec - Who cited this? | PubMed ID: 12446570 | Fulltext

Tissue and stage-specific expression of the Tolls in Drosophila embryos.

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Kambris Z, Hoffmann JA, Imler JL, and Capovilla M

Gene expression patterns : GEP 2(3-4):311-7, 2002 Dec - Who cited this? | PubMed ID: 12617819 | Fulltext

Notch signaling controls lineage specification during Drosophila larval hematopoiesis.

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Duvic B, Hoffmann JA, Meister M, and Royet J

Current biology : CB 12(22):1923, 2002 Nov 19 - Who cited this? | PubMed ID: 12445385 | Fulltext

The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

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Naitza S, Rossé C, Kappler C, Georgel P, Belvin M, Gubb D, Camonis J, Hoffmann JA, and Reichhart JM

Immunity 17(5):575-81, 2002 Nov - Who cited this? | PubMed ID: 12433364 | Fulltext

Immunity-related genes and gene families in Anopheles gambiae.

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Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA,

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Science (New York, N.Y.) 298(5591):159-65, 2002 Oct 4 - Who cited this? | PubMed ID: 12364793 | Fulltext

Activation of Drosophila Toll during fungal infection by a blood serine protease.

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Ligoxygakis P, Pelte N, Hoffmann JA, and Reichhart JM

Science (New York, N.Y.) 297(5578):114-6, 2002 Jul 5 - Who cited this? | PubMed ID: 12098703 | Fulltext

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein.

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Gottar M, Gobert V, Michel T, Belvin M, Duyk G, Hoffmann JA, Ferrandon D, and Royet J

Nature 416(6881):640, 2002 Apr 11 - Who cited this? | PubMed ID: 11912488 | Fulltext

Prevalence and physician awareness of symptoms of urinary bladder dysfunction.

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Goepel M, Hoffmann JA, Piro M, Rübben H, and Michel MC

European urology 41(3):234-9, 2002 Mar - Who cited this? | PubMed ID: 12180221 | Fulltext

Drosophila innate immunity: an evolutionary perspective.

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Hoffmann JA and Reichhart JM

Nature immunology 3(2):121-6, 2002 Feb - Who cited this? | PubMed ID: 11812988 | Fulltext

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections.

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Tauszig-Delamasure S, Bilak H, Capovilla M, Hoffmann JA, and Imler JL

Nature immunology 3(1):91-7, 2002 Jan - Who cited this? | PubMed ID: 11743586 | Fulltext

Toll receptors in Drosophila: a family of molecules regulating development and immunity.

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Imler JL and Hoffmann JA

Current topics in microbiology and immunology 270:63-79, 2002 - Who cited this? | PubMed ID: 12467244 | Fulltext

A genome-wide analysis of immune responses in Drosophila.

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Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, and Hetru C

Proceedings of the National Academy of Sciences of the United States of America 98(26):15119-24, 2001 Dec 18 - Who cited this? | PubMed ID: 11742098 | Fulltext

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein.

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Michel T, Reichhart JM, Hoffmann JA, and Royet J

Nature 414(6865):756, 2001 Dec 13 - Who cited this? | PubMed ID: 11742401 | Fulltext

Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae.

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Vizioli J, Bulet P, Hoffmann JA, Kafatos FC, Müller HM, and Dimopoulos G

Proceedings of the National Academy of Sciences of the United States of America 98(22):12630, 2001 Oct 23 - Who cited this? | PubMed ID: 11606751 | Fulltext

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis.

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Georgel P, Naitza S, Kappler C, Ferrandon D, Zachary D, Swimmer C, Kopczynski C, Duyk G, Reichhart JM, and Hoffmann JA

Developmental cell 1(4):503-14, 2001 Oct - Who cited this? | PubMed ID: 11703941 | Fulltext

Toll receptors in innate immunity.

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Imler JL and Hoffmann JA

Trends in cell biology 11(7):304-11, 2001 Jul - Who cited this? | PubMed ID: 11413042 | Fulltext

Microfluorometer assay to measure the expression of beta-galactosidase and green fluorescent protein reporter genes in single Drosophila flies.

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Jung AC, Criqui MC, Rutschmann S, Hoffmann JA, and Ferrandon D

BioTechniques 30(3):594-8, 600-1, 2001 Mar - Who cited this? | PubMed ID: 11252795 | Fulltext

Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect.

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Lamberty M, Zachary D, Lanot R, Bordereau C, Robert A, Hoffmann JA, and Bulet P

The Journal of biological chemistry 276(6):4085-92, 2001 Feb 9 - Who cited this? | PubMed ID: 11053427 | Fulltext

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