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Papers authored by Hirshman MF

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Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats.

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Gollisch KS, Brandauer J, Jessen N, Toyoda T, Nayer A, Hirshman MF, and Goodyear LJ

American journal of physiology. Endocrinology and metabolism 297(2):E495-504, 2009 Aug - Who cited this? | PubMed ID: 19491293 | Fulltext

Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus.

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Rogers NH, Witczak CA, Hirshman MF, Goodyear LJ, and Greenberg AS

Biochemical and biophysical research communications 382(4):646-50, 2009 May 15 - Who cited this? | PubMed ID: 19265681 | Fulltext

Response: skeletal muscle precursor grafts in dystrophic mice.

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Cerletti M, Stevenson K, Neuberg D, Jurga S, Witczak CA, Hirshman MF, Shadrach JL, Goodyear LJ, and Wagers AJ

Cell 135(6):998-9, 2008 Dec 12 - Who cited this? | PubMed ID: 19070566 | Fulltext

Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.

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Fujii N, Ho RC, Manabe Y, Jessen N, Toyoda T, Holland WL, Summers SA, Hirshman MF, and Goodyear LJ

Diabetes 57(11):2958-66, 2008 Nov - Who cited this? | PubMed ID: 18728234 | Fulltext

Endogenous Peroxisome Proliferator-Activated Receptor {gamma} Augments Fatty Acid Uptake in Oxidative Muscle.

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Norris AW, Hirshman MF, Yao J, Jessen N, Musi N, Chen L, Sivitz WI, Goodyear LJ, and Kahn CR

Endocrinology, 2008 Jul 24 - Who cited this? | PubMed ID: 18653710 | Fulltext

Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles.

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Cerletti M, Jurga S, Witczak CA, Hirshman MF, Shadrach JL, Goodyear LJ, and Wagers AJ

Cell 134(1):37, 2008 Jul 11 - Who cited this? | PubMed ID: 18614009 | Fulltext

Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway.

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Higaki Y, Mikami T, Fujii N, Hirshman MF, Koyama K, Seino T, Tanaka K, and Goodyear LJ

American journal of physiology. Endocrinology and metabolism 294(5):E889-97, 2008 May - Who cited this? | PubMed ID: 18303121 | Fulltext

Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.

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Taylor EB, An D, Kramer HF, Yu H, Fujii NL, Roeckl KS, Bowles N, Hirshman MF, Xie J, Feener EP, and Goodyear LJ

The Journal of biological chemistry 283(15):9787, 2008 Apr 11 - Who cited this? | PubMed ID: 18276596 | Fulltext

Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle.

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Bouskila M, Hirshman MF, Jensen J, Goodyear LJ, and Sakamoto K

American journal of physiology. Endocrinology and metabolism 294(1):E28-35, 2008 Jan - Who cited this? | PubMed ID: 18003720 | Fulltext

Calmodulin-binding domain of AS160 regulates contraction- but not insulin-stimulated glucose uptake in skeletal muscle.

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Kramer HF, Taylor EB, Witczak CA, Fujii N, Hirshman MF, and Goodyear LJ

Diabetes 56(12):2854-62, 2007 Dec - Who cited this? | PubMed ID: 17717281 | Fulltext

Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle.

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Ho RC, Fujii N, Witters LA, Hirshman MF, and Goodyear LJ

Biochemical and biophysical research communications 362(2):354-9, 2007 Oct 19 - Who cited this? | PubMed ID: 17709097 | Fulltext

Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model-.

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Fujii N, Seifert MM, Kane EM, Peter LE, Ho RC, Winstead S, Hirshman MF, and Goodyear LJ

Diabetes research and clinical practice 77 Suppl 1:S92-8, 2007 Sep - Who cited this? | PubMed ID: 17452058 | Fulltext

Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift.

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Röckl KS, Hirshman MF, Brandauer J, Fujii N, Witters LA, and Goodyear LJ

Diabetes 56(8):2062-9, 2007 Aug - Who cited this? | PubMed ID: 17513699 | Fulltext

Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes.

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Koh HJ, Hirshman MF, He H, Li Y, Manabe Y, Balschi JA, and Goodyear LJ

The Biochemical journal 403(3):473-81, 2007 May 1 - Who cited this? | PubMed ID: 17253964 | Fulltext

Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation.

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Witczak CA, Fujii N, Hirshman MF, and Goodyear LJ

Diabetes 56(5):1403-9, 2007 May - Who cited this? | PubMed ID: 17287469 | Fulltext

Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage.

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Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M, Seidman CE, Seidman JG, Ingwall JS, Balschi JA, and Tian R

The Journal of clinical investigation 117(5):1432-9, 2007 May - Who cited this? | PubMed ID: 17431505 | Fulltext

Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation.

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Barré L, Richardson C, Hirshman MF, Brozinick J, Fiering S, Kemp BE, Goodyear LJ, and Witters LA

American journal of physiology. Endocrinology and metabolism 292(3):E802-11, 2007 Mar - Who cited this? | PubMed ID: 17106064 | Fulltext

JNK1 deficiency does not enhance muscle glucose metabolism in lean mice.

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Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, and Goodyear LJ

Biochemical and biophysical research communications 350(4):1063-8, 2006 Dec 1 - Who cited this? | PubMed ID: 17045576 | Fulltext

Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle.

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Sakamoto K, Arnolds DE, Fujii N, Kramer HF, Hirshman MF, and Goodyear LJ

American journal of physiology. Endocrinology and metabolism 291(5):E1031-7, 2006 Nov - Who cited this? | PubMed ID: 16803855 | Fulltext

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.

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Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, and Goodyear LJ

Molecular and cellular biology 26(22):8217-27, 2006 Nov - Who cited this? | PubMed ID: 16966378 | Fulltext

AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.

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Kramer HF, Witczak CA, Taylor EB, Fujii N, Hirshman MF, and Goodyear LJ

The Journal of biological chemistry 281(42):31478-85, 2006 Oct 20 - Who cited this? | PubMed ID: 16935857 | Fulltext

Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation.

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Yu H, Hirshman MF, Fujii N, Pomerleau JM, Peter LE, and Goodyear LJ

American journal of physiology. Endocrinology and metabolism 291(3), 2006 Sep - Who cited this? | PubMed ID: 16638825 | Fulltext

Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway.

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Aschenbach WG, Ho RC, Sakamoto K, Fujii N, Li Y, Kim YB, Hirshman MF, and Goodyear LJ

American journal of physiology. Endocrinology and metabolism 291(1), 2006 Jul - Who cited this? | PubMed ID: 16478782 | Fulltext

Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle.

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Kramer HF, Witczak CA, Fujii N, Jessen N, Taylor EB, Arnolds DE, Sakamoto K, Hirshman MF, and Goodyear LJ

Diabetes 55(7):2067, 2006 Jul - Who cited this? | PubMed ID: 16804077 | Fulltext

Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.

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Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, and Cantley LC

Cell metabolism 3(5):355, 2006 May - Who cited this? | PubMed ID: 16679293 | Fulltext

AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle.

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Fujii N, Hirshman MF, Kane EM, Ho RC, Peter LE, Seifert MM, and Goodyear LJ

The Journal of biological chemistry 280(47):39033-41, 2005 Nov 25 - Who cited this? | PubMed ID: 16186119 | Fulltext

Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle.

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Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, and Goodyear LJ

American journal of physiology. Cell physiology 289(4), 2005 Oct - Who cited this? | PubMed ID: 15888549 | Fulltext

Functional role of AMP-activated protein kinase in the heart during exercise.

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Musi N, Hirshman MF, Arad M, Xing Y, Fujii N, Pomerleau J, Ahmad F, Berul CI, Seidman JG, Tian R, and Goodyear LJ

FEBS letters 579(10):2045-50, 2005 Apr 11 - Who cited this? | PubMed ID: 15811316 | Fulltext

Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity.

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Fujii N, Boppart MD, Dufresne SD, Crowley PF, Jozsi AC, Sakamoto K, Yu H, Aschenbach WG, Kim S, Miyazaki H, Rui L, White MF, Hirshman MF, and Goodyear LJ

American journal of physiology. Cell physiology 287(1), 2004 Jul - Who cited this? | PubMed ID: 15013949 | Fulltext

Regulation of glucose transport by the AMP-activated protein kinase.

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Fujii N, Aschenbach WG, Musi N, Hirshman MF, and Goodyear LJ

The Proceedings of the Nutrition Society 63(2):205-10, 2004 May - Who cited this? | PubMed ID: 15294031 | Fulltext

Cloning and characterization of mouse 5'-AMP-activated protein kinase gamma3 subunit.

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Yu H, Fujii N, Hirshman MF, Pomerleau JM, and Goodyear LJ

American journal of physiology. Cell physiology 286(2):C283-92, 2004 Feb - Who cited this? | PubMed ID: 14512293 | Fulltext

p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle.

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Ho RC, Alcazar O, Fujii N, Hirshman MF, and Goodyear LJ

American journal of physiology. Regulatory, integrative and comparative physiology 286(2):R342-9, 2004 Feb - Who cited this? | PubMed ID: 14592936 | Fulltext

Akt signaling in skeletal muscle: regulation by exercise and passive stretch.

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Sakamoto K, Aschenbach WG, Hirshman MF, and Goodyear LJ

American journal of physiology. Endocrinology and metabolism 285(5), 2003 Nov - Who cited this? | PubMed ID: 12837666 | Fulltext

Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase.

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Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman MF, Goodyear LJ, and Tian R

The Journal of biological chemistry 278(31):28372-7, 2003 Aug 1 - Who cited this? | PubMed ID: 12766162 | Fulltext

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.

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Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, and Kahn CR

The Journal of clinical investigation 112(4):608-18, 2003 Aug - Who cited this? | PubMed ID: 12925701 | Fulltext

Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.

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El-Haschimi K, Dufresne SD, Hirshman MF, Flier JS, Goodyear LJ, and Bjørbaek C

Diabetes 52(6):1340-6, 2003 Jun - Who cited this? | PubMed ID: 12765942 | Fulltext

Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.

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Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, Zhou G, Williamson JM, Ljunqvist O, Efendic S, Moller DE, Thorell A, and Goodyear LJ

Diabetes 51(7):2074-81, 2002 Jul - Who cited this? | PubMed ID: 12086935 | Fulltext

Contraction regulation of Akt in rat skeletal muscle.

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Sakamoto K, Hirshman MF, Aschenbach WG, and Goodyear LJ

The Journal of biological chemistry 277(14):11910, 2002 Apr 5 - Who cited this? | PubMed ID: 11809761 | Fulltext

Effect of AICAR treatment on glycogen metabolism in skeletal muscle.

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Aschenbach WG, Hirshman MF, Fujii N, Sakamoto K, Howlett KF, and Goodyear LJ

Diabetes 51(3):567, 2002 Mar - Who cited this? | PubMed ID: 11872652 | Fulltext

Insulin signaling after exercise in insulin receptor substrate-2-deficient mice.

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Howlett KF, Sakamoto K, Hirshman MF, Aschenbach WG, Dow M, White MF, and Goodyear LJ

Diabetes 51(2):479, 2002 Feb - Who cited this? | PubMed ID: 11812758 | Fulltext

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.

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Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, and Kahn CR

The Journal of clinical investigation 109(1):141-9, 2002 Jan - Who cited this? | PubMed ID: 11781359 | Fulltext

The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise.

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Aschenbach WG, Suzuki Y, Breeden K, Prats C, Hirshman MF, Dufresne SD, Sakamoto K, Vilardo PG, Steele M, Kim JH, Jing SL, Goodyear LJ, and DePaoli-Roach AA

The Journal of biological chemistry 276(43):39959, 2001 Oct 26 - Who cited this? | PubMed ID: 11522787 | Fulltext

Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy.

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Tian R, Musi N, D'Agostino J, Hirshman MF, and Goodyear LJ

Circulation 104(14):1664-9, 2001 Oct 2 - Who cited this? | PubMed ID: 11581146 | Fulltext

Role of AMP-activated protein kinase in mechanism of metformin action.

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Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, and Moller DE

The Journal of clinical investigation 108(8):1167-74, 2001 Oct - Who cited this? | PubMed ID: 11602624 | Fulltext

AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle.

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Musi N, Hayashi T, Fujii N, Hirshman MF, Witters LA, and Goodyear LJ

American journal of physiology. Endocrinology and metabolism 280(5), 2001 May - Who cited this? | PubMed ID: 11287349 | Fulltext

AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise.

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Musi N, Fujii N, Hirshman MF, Ekberg I, Fröberg S, Ljungqvist O, Thorell A, and Goodyear LJ

Diabetes 50(5):921-7, 2001 May - Who cited this? | PubMed ID: 11334434 | Fulltext

Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle.

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Higaki Y, Hirshman MF, Fujii N, and Goodyear LJ

Diabetes 50(2):241-7, 2001 Feb - Who cited this? | PubMed ID: 11272132 | Fulltext

Static stretch increases c-Jun NH2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle.

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Boppart MD, Hirshman MF, Sakamoto K, Fielding RA, and Goodyear LJ

American journal of physiology. Cell physiology 280(2):C352-8, 2001 Feb - Who cited this? | PubMed ID: 11208531 | Fulltext

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

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Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, and Kahn BB

Nature medicine 6(8):924-8, 2000 Aug - Who cited this? | PubMed ID: 10932232 | Fulltext

Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.

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Fujii N, Hayashi T, Hirshman MF, Smith JT, Habinowski SA, Kaijser L, Mu J, Ljungqvist O, Birnbaum MJ, Witters LA, Thorell A, and Goodyear LJ

Biochemical and biophysical research communications 273(3):1150-5, 2000 Jul 14 - Who cited this? | PubMed ID: 10891387 | Fulltext

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