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Papers authored by Hirotsu K

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Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions.

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Kitamura Y, Ebihara A, Agari Y, Shinkai A, Hirotsu K, and Kuramitsu S

Acta crystallographica. Section D, Biological crystallography 65(Pt 10):1098-106, 2009 Oct - Who cited this? | PubMed ID: 19770507 | Fulltext

Crystal Structure of a Homolog of Mammalian Serine Racemase from Schizosaccharomyces pombe.

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Goto M, Yamauchi T, Kamiya N, Miyahara I, Yoshimura T, Mihara H, Kurihara T, Hirotsu K, and Esaki N

The Journal of biological chemistry 284(38):25944-52, 2009 Sep 18 - Who cited this? | PubMed ID: 19640845 | Fulltext

X-Ray crystallographic and mutational studies of fluoroacetate dehalogenase from Burkholderia sp. strain FA1.

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Jitsumori K, Omi R, Kurihara T, Kurata A, Mihara H, Miyahara I, Hirotsu K, and Esaki N

Journal of bacteriology 191(8):2630-7, 2009 Apr - Who cited this? | PubMed ID: 19218394 | Fulltext

Serine racemase with catalytically active lysinoalanyl residue.

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Yamauchi T, Goto M, Wu HY, Uo T, Yoshimura T, Mihara H, Kurihara T, Miyahara I, Hirotsu K, and Esaki N

Journal of biochemistry 145(4):421-4, 2009 Apr - Who cited this? | PubMed ID: 19155267 | Fulltext

Crystallization screening test for the whole-cell project on Thermus thermophilus HB8.

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Iino H, Naitow H, Nakamura Y, Nakagawa N, Agari Y, Kanagawa M, Ebihara A, Shinkai A, Sugahara M, Miyano M, Kamiya N, Yokoyama S, Hirotsu K, and Kuramitsu S

Acta crystallographica. Section F, Structural biology and crystallization communications 64(Pt 6):487-91, 2008 Jun 1 - Who cited this? | PubMed ID: 18540056 | Fulltext

Crystal structure of monofunctional histidinol phosphate phosphatase from Thermus thermophilus HB8.

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Omi R, Goto M, Miyahara I, Manzoku M, Ebihara A, and Hirotsu K

Biochemistry 46(44):12618-27, 2007 Nov 6 - Who cited this? | PubMed ID: 17929834 | Fulltext

Expression, purification and preliminary X-ray characterization of DL-2-haloacid dehalogenase from Methylobacterium sp. CPA1.

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Omi R, Jitsumori K, Yamauchi T, Ichiyama S, Kurihara T, Esaki N, Kamiya N, Hirotsu K, and Miyahara I

Acta crystallographica. Section F, Structural biology and crystallization communications 63(Pt 7):586-9, 2007 Jul 1 - Who cited this? | PubMed ID: 17620717 | Fulltext

Crystal structures of nonoxidative zinc-dependent 2,6-dihydroxybenzoate (gamma-resorcylate) decarboxylase from Rhizobium sp. strain MTP-10005.

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Goto M, Hayashi H, Miyahara I, Hirotsu K, Yoshida M, and Oikawa T

The Journal of biological chemistry 281(45):34365-73, 2006 Nov 10 - Who cited this? | PubMed ID: 16963440 | Fulltext

Engineering the substrate specificity of porcine kidney D-amino acid oxidase by mutagenesis of the "active-site lid".

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Setoyama C, Nishina Y, Mizutani H, Miyahara I, Hirotsu K, Kamiya N, Shiga K, and Miura R

Journal of biochemistry 139(5):873-9, 2006 May - Who cited this? | PubMed ID: 16751595 | Fulltext

Three-dimensional structure of rat-liver acyl-CoA oxidase in complex with a fatty acid: insights into substrate-recognition and reactivity toward molecular oxygen.

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Tokuoka K, Nakajima Y, Hirotsu K, Miyahara I, Nishina Y, Shiga K, Tamaoki H, Setoyama C, Tojo H, and Miura R

Journal of biochemistry 139(4):789-95, 2006 Apr - Who cited this? | PubMed ID: 16672280 | Fulltext

Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction.

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Goto M, Muramatsu H, Mihara H, Kurihara T, Esaki N, Omi R, Miyahara I, and Hirotsu K

The Journal of biological chemistry 280(49):40875-84, 2005 Dec 9 - Who cited this? | PubMed ID: 16192274 | Fulltext

Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin.

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Goto M, Miyahara I, Hirotsu K, Conway M, Yennawar N, Islam MM, and Hutson SM

The Journal of biological chemistry 280(44):37246-56, 2005 Nov 4 - Who cited this? | PubMed ID: 16141215 | Fulltext

Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step.

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Islam MM, Goto M, Miyahara I, Ikushiro H, Hirotsu K, and Hayashi H

Biochemistry 44(23):8218-29, 2005 Jun 14 - Who cited this? | PubMed ID: 15938611 | Fulltext

A new family of NAD(P)H-dependent oxidoreductases distinct from conventional Rossmann-fold proteins.

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Muramatsu H, Mihara H, Goto M, Miyahara I, Hirotsu K, Kurihara T, and Esaki N

Journal of bioscience and bioengineering 99(6):541-7, 2005 Jun - Who cited this? | PubMed ID: 16233829 | Fulltext

Dual substrate recognition of aminotransferases.

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Hirotsu K, Goto M, Okamoto A, and Miyahara I

Chemical record (New York, N.Y.) 5(3):160-72, 2005 - Who cited this? | PubMed ID: 15889412 | Fulltext

Remarkable structure deformation in phenothiazine trimer radical cation.

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Okamoto T, Kuratsu M, Kozaki M, Hirotsu K, Ichimura A, Matsushita T, and Okada K

Organic letters 6(20):3493-6, 2004 Sep 30 - Who cited this? | PubMed ID: 15387531 | Fulltext

Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites.

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Goto M, Omi R, Nakagawa N, Miyahara I, and Hirotsu K

Structure (London, England : 1993) 12(8):1413, 2004 Aug - Who cited this? | PubMed ID: 15296735 | Fulltext

Crystal structures of glutamine:phenylpyruvate aminotransferase from Thermus thermophilus HB8: induced fit and substrate recognition.

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Goto M, Omi R, Miyahara I, Hosono A, Mizuguchi H, Hayashi H, Kagamiyama H, and Hirotsu K

The Journal of biological chemistry 279(16):16518-25, 2004 Apr 16 - Who cited this? | PubMed ID: 14761974 | Fulltext

Expression, purification and preliminary X-ray characterization of histidinol phosphate phosphatase.

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Omi R, Goto M, Nakagawa N, Miyahara I, and Hirotsu K

Acta crystallographica. Section D, Biological crystallography 60(Pt 3):574-6, 2004 Mar - Who cited this? | PubMed ID: 14993698 | Fulltext

Glutamine:phenylpyruvate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus HB8.

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Hosono A, Mizuguchi H, Hayashi H, Goto M, Miyahara I, Hirotsu K, and Kagamiyama H

Journal of biochemistry 134(6):843-51, 2003 Dec - Who cited this? | PubMed ID: 14769873 | Fulltext

Crystal structures of threonine synthase from Thermus thermophilus HB8: conformational change, substrate recognition, and mechanism.

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Omi R, Goto M, Miyahara I, Mizuguchi H, Hayashi H, Kagamiyama H, and Hirotsu K

The Journal of biological chemistry 278(46):46035-45, 2003 Nov 14 - Who cited this? | PubMed ID: 12952961 | Fulltext

Structure of the transition state analog of medium-chain acyl-CoA dehydrogenase. Crystallographic and molecular orbital studies on the charge-transfer complex of medium-chain acyl-CoA dehydrogenase with 3-thiaoctanoyl-CoA.

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Satoh A, Nakajima Y, Miyahara I, Hirotsu K, Tanaka T, Nishina Y, Shiga K, Tamaoki H, Setoyama C, and Miura R

Journal of biochemistry 134(2):297-304, 2003 Aug - Who cited this? | PubMed ID: 12966080 | Fulltext

Structures of argininosuccinate synthetase in enzyme-ATP substrates and enzyme-AMP product forms: stereochemistry of the catalytic reaction.

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Goto M, Omi R, Miyahara I, Sugahara M, and Hirotsu K

The Journal of biological chemistry 278(25):22964-71, 2003 Jun 20 - Who cited this? | PubMed ID: 12684518 | Fulltext

Strain and catalysis in aspartate aminotransferase.

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Hayashi H, Mizuguchi H, Miyahara I, Islam MM, Ikushiro H, Nakajima Y, Hirotsu K, and Kagamiyama H

Biochimica et biophysica acta 1647(1-2):103-9, 2003 Apr 11 - Who cited this? | PubMed ID: 12686117 | Fulltext

The active site structure of quinohemoprotein amine dehydrogenase inhibited by p-nitrophenylhydrazine.

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Satoh A, Adachi O, Tanizawa K, and Hirotsu K

Biochimica et biophysica acta 1647(1-2):272-7, 2003 Apr 11 - Who cited this? | PubMed ID: 12686145 | Fulltext

Characterization of histidinol phosphate aminotransferase from Escherichia coli.

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Mizuguchi H, Hayashi H, Miyahara I, Hirotsu K, and Kagamiyama H

Biochimica et biophysica acta 1647(1-2):321-4, 2003 Apr 11 - Who cited this? | PubMed ID: 12686152 | Fulltext

Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: true reaction intermediate and double substrate recognition of the enzyme.

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Goto M, Miyahara I, Hayashi H, Kagamiyama H, and Hirotsu K

Biochemistry 42(13):3725-33, 2003 Apr 8 - Who cited this? | PubMed ID: 12667063 | Fulltext

Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis.

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Hayashi H, Mizuguchi H, Miyahara I, Nakajima Y, Hirotsu K, and Kagamiyama H

The Journal of biological chemistry 278(11):9481-8, 2003 Mar 14 - Who cited this? | PubMed ID: 12488449 | Fulltext

Expression, purification and preliminary X-ray characterization of CTP synthetase from Thermus thermophilus HB8.

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Goto M, Omi R, Hoseki J, Nakagawa N, Miyahara I, and Hirotsu K

Acta crystallographica. Section D, Biological crystallography 59(Pt 3):551-3, 2003 Mar - Who cited this? | PubMed ID: 12595723 | Fulltext

Expression, purification and preliminary X-ray characterization of N-acetyl-gamma-glutamyl-phosphate reductase from Thermus thermophilus HB8.

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Goto M, Agari Y, Omi R, Miyahara I, and Hirotsu K

Acta crystallographica. Section D, Biological crystallography 59(Pt 2):356-8, 2003 Feb - Who cited this? | PubMed ID: 12554952 | Fulltext

Mechanism of preferential enrichment, an unusual enantiomeric resolution phenomenon caused by polymorphic transition during crystallization of mixed crystals composed of two enantiomers.

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Tamura R, Fujimoto D, Lepp Z, Misaki K, Miura H, Takahashi H, Ushio T, Nakai T, and Hirotsu K

Journal of the American Chemical Society 124(44):13139-53, 2002 Nov 6 - Who cited this? | PubMed ID: 12405843 | Fulltext

Structure of imidazole glycerol phosphate synthase from Thermus thermophilus HB8: open-closed conformational change and ammonia tunneling.

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Omi R, Mizuguchi H, Goto M, Miyahara I, Hayashi H, Kagamiyama H, and Hirotsu K

Journal of biochemistry 132(5):759-65, 2002 Nov - Who cited this? | PubMed ID: 12417026 | Fulltext

Crystal structure of argininosuccinate synthetase from Thermus thermophilus HB8. Structural basis for the catalytic action.

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Goto M, Nakajima Y, and Hirotsu K

The Journal of biological chemistry 277(18):15890-6, 2002 May 3 - Who cited this? | PubMed ID: 11844799 | Fulltext

Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase.

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Nakajima Y, Miyahara I, Hirotsu K, Nishina Y, Shiga K, Setoyama C, Tamaoki H, and Miura R

Journal of biochemistry 131(3):365-74, 2002 Mar - Who cited this? | PubMed ID: 11872165 | Fulltext

Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges.

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Satoh A, Kim JK, Miyahara I, Devreese B, Vandenberghe I, Hacisalihoglu A, Okajima T, Kuroda S, Adachi O, Duine JA, Van Beeumen J, Tanizawa K, and Hirotsu K

The Journal of biological chemistry 277(4):2830-4, 2002 Jan 25 - Who cited this? | PubMed ID: 11704672 | Fulltext

A CMOS feedforward neural-network chip with on-chip parallel learning for oscillation cancellation.

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Liu J, Brooke MA, and Hirotsu K

IEEE transactions on neural networks / a publication of the IEEE Neural Networks Council 13(5):1178-86, 2002 - Who cited this? | PubMed ID: 18244513 | Fulltext

Effects of hydrogen bonds in association with flavin and substrate in flavoenzyme d-amino acid oxidase. The catalytic and structural roles of Gly313 and Thr317.

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Setoyama C, Nishina Y, Tamaoki H, Mizutani H, Miyahara I, Hirotsu K, Shiga K, and Miura R

Journal of biochemistry 131(1):59-69, 2002 Jan - Who cited this? | PubMed ID: 11754736 | Fulltext

Crystallization and preliminary X-ray characterization of rat liver acyl-CoA oxidase.

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Nakajima Y, Miyahara I, Hirotsu K, Nishina Y, Shiga K, Setoyama C, Tamaoki H, and Miura R

Acta crystallographica. Section D, Biological crystallography 57(Pt 11):1680-1, 2001 Nov - Who cited this? | PubMed ID: 11679743 | Fulltext

Substrate recognition mechanism of thermophilic dual-substrate enzyme.

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Ura H, Nakai T, Kawaguchi SI, Miyahara I, Hirotsu K, and Kuramitsu S

Journal of biochemistry 130(1):89-98, 2001 Jul - Who cited this? | PubMed ID: 11432784 | Fulltext

Structures of Escherichia coli branched-chain amino acid aminotransferase and its complexes with 4-methylvalerate and 2-methylleucine: induced fit and substrate recognition of the enzyme.

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Okada K, Hirotsu K, Hayashi H, and Kagamiyama H

Biochemistry 40(25):7453-63, 2001 Jun 26 - Who cited this? | PubMed ID: 11412098 | Fulltext

Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme.

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Haruyama K, Nakai T, Miyahara I, Hirotsu K, Mizuguchi H, Hayashi H, and Kagamiyama H

Biochemistry 40(15):4633-44, 2001 Apr 17 - Who cited this? | PubMed ID: 11294630 | Fulltext

Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase.

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Mizuguchi H, Hayashi H, Okada K, Miyahara I, Hirotsu K, and Kagamiyama H

Biochemistry 40(2):353-60, 2001 Jan 16 - Who cited this? | PubMed ID: 11148029 | Fulltext

Stereochemistry of the transamination reaction catalyzed by aminodeoxychorismate lyase from Escherichia coli: close relationship between fold type and stereochemistry.

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Jhee KH, Yoshimura T, Miles EW, Takeda S, Miyahara I, Hirotsu K, Soda K, Kawata Y, and Esaki N

Journal of biochemistry 128(4):679-86, 2000 Oct - Who cited this? | PubMed ID: 11011151 | Fulltext

Three-dimensional structure of 4-amino-4-deoxychorismate lyase from Escherichia coli.

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Nakai T, Mizutani H, Miyahara I, Hirotsu K, Takeda S, Jhee KH, Yoshimura T, and Esaki N

Journal of biochemistry 128(1):29-38, 2000 Jul - Who cited this? | PubMed ID: 10876155 | Fulltext

Three-dimensional structure of the purple intermediate of porcine kidney D-amino acid oxidase. Optimization of the oxidative half-reaction through alignment of the product with reduced flavin.

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Mizutani H, Miyahara I, Hirotsu K, Nishina Y, Shiga K, Setoyama C, and Miura R

Journal of biochemistry 128(1):73-81, 2000 Jul - Who cited this? | PubMed ID: 10876160 | Fulltext

Influenza in three patients with human immunodeficiency virus infection.

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Nabeshima S, Ariyama I, Chong Y, Hirotsu K, Kakuda K, Hayashi J, and Kashiwagi S

Internal medicine (Tokyo, Japan) 39(7):592-7, 2000 Jul - Who cited this? | PubMed ID: 10888219 | Fulltext

Free energy requirement for domain movement of an enzyme.

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Ishijima J, Nakai T, Kawaguchi S, Hirotsu K, and Kuramitsu S

The Journal of biological chemistry 275(25):18939-45, 2000 Jun 23 - Who cited this? | PubMed ID: 10858450 | Fulltext

The crystal structure of pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals a new structure for a cysteine protease.

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Odagaki Y, Hayashi A, Okada K, Hirotsu K, Kabashima T, Ito K, Yoshimoto T, Tsuru D, Sato M, and Clardy J

Structure (London, England : 1993) 7(4):399-411, 1999 Apr 15 - Who cited this? | PubMed ID: 10196127 | Fulltext

Structure of Thermus thermophilus HB8 aspartate aminotransferase and its complex with maleate.

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Nakai T, Okada K, Akutsu S, Miyahara I, Kawaguchi S, Kato R, Kuramitsu S, and Hirotsu K

Biochemistry 38(8):2413-24, 1999 Feb 23 - Who cited this? | PubMed ID: 10029535 | Fulltext

The active site of Paracoccus denitrificans aromatic amino acid aminotransferase has contrary properties: flexibility and rigidity.

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Okamoto A, Ishii S, Hirotsu K, and Kagamiyama H

Biochemistry 38(4):1176-84, 1999 Jan 26 - Who cited this? | PubMed ID: 9930977 | Fulltext

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