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Papers authored by Hirosumi J

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Mechanism by which a novel non-thiazolidinedione peroxisome proliferator-activated receptor gamma agonist, FK614, ameliorates insulin resistance in Zucker fatty rats.

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Minoura H, Takeshita S, Kimura C, Hirosumi J, Takakura S, Kawamura I, Seki J, Manda T, and Mutoh S

Diabetes, obesity & metabolism 9(3):369-78, 2007 May - Who cited this? | PubMed ID: 17391165 | Fulltext

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

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Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, and Hotamisligil GS

Proceedings of the National Academy of Sciences of the United States of America 103(28):10741-6, 2006 Jul 11 - Who cited this? | PubMed ID: 16818881 | Fulltext

FR177391, a new anti-hyperlipidemic agent from Serratia. II. Pharmacological activity of FR177391.

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Inami M, Kawamura I, Tsujimoto S, Yasuno T, Lacey E, Hirosumi J, Takakura S, Nishigaki F, Naoe Y, Manda T, and Mutoh S

The Journal of antibiotics 58(10):640-7, 2005 Oct - Who cited this? | PubMed ID: 16392680 | Fulltext

Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat.

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Minoura H, Takeshita S, Yamamoto T, Mabuchi M, Hirosumi J, Takakura S, Kawamura I, Seki J, Manda T, Ita M, and Mutoh S

European journal of pharmacology 519(1-2):182-90, 2005 Sep 5 - Who cited this? | PubMed ID: 16039648 | Fulltext

Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614.

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Minoura H, Takeshita S, Ita M, Hirosumi J, Mabuchi M, Kawamura I, Nakajima S, Nakayama O, Kayakiri H, Oku T, Ohkubo-Suzuki A, Fukagawa M, Kojo H, Hanioka K, Yamasaki N, Imoto T,

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European journal of pharmacology 494(2-3):273-81, 2004 Jun 28 - Who cited this? | PubMed ID: 15212984 | Fulltext

Phosphodiesterase type 5 inhibition ameliorates nephrotoxicity induced by cyclosporin A in spontaneous hypertensive rats.

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Hosogai N, Tomita M, Hamada K, Ogawa T, Hirosumi J, Manda T, and Mutoh S

European journal of pharmacology 477(2):171-8, 2003 Sep 12 - Who cited this? | PubMed ID: 14519421 | Fulltext

Choleretic actions of insulin-like growth factor-I, prednisolone, and ursodeoxycholic acid in rats.

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Mabuchi M, Kawamura I, Fushimi M, Takeshita S, Takakura S, Hirosumi J, and Mutoh S

Digestive diseases and sciences 48(7):1398-405, 2003 Jul - Who cited this? | PubMed ID: 12870804 | Fulltext

Insulin-like growth factor-I enhances choleretic action of FK506 in rats.

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Mabuchi M, Kawamura I, Takeshita S, Fushimi M, Takakura S, Hirosumi J, and Mutoh S

Transplantation proceedings 35(4):1596-8, 2003 Jun - Who cited this? | PubMed ID: 12826230 | Fulltext

A central role for JNK in obesity and insulin resistance.

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Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, and Hotamisligil GS

Nature 420(6913):333-6, 2002 Nov 21 - Who cited this? | PubMed ID: 12447443 | Fulltext

Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance.

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Xu H, Hirosumi J, Uysal KT, Guler AD, and Hotamisligil GS

Endocrinology 143(4):1502-11, 2002 Apr - Who cited this? | PubMed ID: 11897709 | Fulltext

Alteration in expression profiles of a series of diabetes-related genes in db/db mice following treatment with thiazolidinediones.

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Suzuki A, Yasuno T, Kojo H, Hirosumi J, Mutoh S, and Notsu Y

Japanese journal of pharmacology 84(2):113-23, 2000 Oct - Who cited this? | PubMed ID: 11128033 | Fulltext

Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on different in vivo animal models of inflammation.

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Asano M, Hatori C, Inamura N, Sawai H, Hirosumi J, Fujiwara T, and Nakahara K

British journal of pharmacology 122(7):1436-40, 1997 Dec - Who cited this? | PubMed ID: 9421292 | Fulltext

Pharmacological characterization of a novel, orally active, nonpeptide bradykinin B2 receptor antagonist, FR167344.

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Inamura N, Asano M, Hatori C, Sawai H, Hirosumi J, Fujiwara T, Kayakiri H, Satoh S, Abe Y, Inoue T, Sawada Y, Oku T, and Nakahara K

European journal of pharmacology 333(1):79-86, 1997 Aug 20 - Who cited this? | PubMed ID: 9311664 | Fulltext

FR146687, a novel steroid 5 alpha-reductase inhibitor: in vitro and in vivo effects on prostates.

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Nakayama O, Hirosumi J, Chida N, Takahashi S, Sawada K, Kojo H, and Notsu Y

The Prostate 31(4):241-9, 1997 Jun 1 - Who cited this? | PubMed ID: 9180934 | Fulltext

Novel steroid 5 alpha-reductase inhibitor FK143: its dual inhibition against the two isozymes and its effect on transcription of the isozyme genes.

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Kojo H, Nakayama O, Hirosumi J, Chida N, Notsu Y, and Okuhara M

Molecular pharmacology 48(3):401-6, 1995 Sep - Who cited this? | PubMed ID: 7565619 | Fulltext

FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (1) In vitro effects on human and animal prostatic enzymes.

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Hirosumi J, Nakayama O, Fagan T, Sawada K, Chida N, Inami M, Takahashi S, Kojo H, Notsu Y, and Okuhara M

The Journal of steroid biochemistry and molecular biology 52(4):357-63, 1995 Apr - Who cited this? | PubMed ID: 7734404 | Fulltext

FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (2) In vivo effects on rat and dog prostates.

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Hirosumi J, Nakayama O, Chida N, Inami M, Fagan T, Sawada K, Shigematsu S, Kojo H, Notsu Y, and Okuhara M

The Journal of steroid biochemistry and molecular biology 52(4):365-73, 1995 Apr - Who cited this? | PubMed ID: 7734405 | Fulltext

Effect of nilvadipine on balloon catheterization-induced intimal thickening of the coronary artery in miniature pigs.

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Arakawa H, Mutoh S, Hirosumi J, and Yamaguchi I

Journal of cardiovascular pharmacology 20(5):731-4, 1992 - Who cited this? | PubMed ID: 1280734 | Fulltext

Effects of growth factors on cytosolic free calcium concentration and DNA synthesis in cultured rat aortic smooth muscle cells.

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Hirosumi J, Ouchi Y, Watanabe M, Kusunoki J, Nakamura T, and Orimo H

The Tohoku journal of experimental medicine 157(4):289-300, 1989 Apr - Who cited this? | PubMed ID: 2741168 | Fulltext

Inhibitory effect of transforming growth factor-beta on epidermal growth factor-induced proliferation of cultured rat aortic smooth muscle cells.

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Ouchi Y, Hirosumi J, Watanabe M, Hattori A, Nakamura T, and Orimo H

Biochemical and biophysical research communications 157(1):301-7, 1988 Nov 30 - Who cited this? | PubMed ID: 3264159 | Fulltext

Effect of superoxide and lipid peroxide on cytosolic free calcium concentration in cultured pig aortic endothelial cells.

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Hirosumi J, Ouchi Y, Watanabe M, Kusunoki J, Nakamura T, and Orimo H

Biochemical and biophysical research communications 152(1):301-7, 1988 Apr 15 - Who cited this? | PubMed ID: 2833890 | Fulltext

1,25(OH)2D3 increases cytosolic Ca++ concentration of osteoblastic cells, clone MC3T3-E1.

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Oshima J, Watanabe M, Hirosumi J, and Orimo H

Biochemical and biophysical research communications 145(2):956-60, 1987 Jun 15 - Who cited this? | PubMed ID: 3496096 | Fulltext

Inflammatory responses in cuff-induced atherosclerosis in rabbits.

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Hirosumi J, Nomoto A, Ohkubo Y, Sekiguchi C, Mutoh S, Yamaguchi I, and Aoki H

Atherosclerosis 64(2-3):243-54, 1987 Apr - Who cited this? | PubMed ID: 3606722 | Fulltext

Antiatherogenic activity of FR34235 (Nilvadipine), a new potent calcium antagonist. Effect on cuff-induced intimal thickening of rabbit carotid artery.

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Nomoto A, Hirosumi J, Sekiguchi C, Mutoh S, Yamaguchi I, and Aoki H

Atherosclerosis 64(2-3):255-61, 1987 Apr - Who cited this? | PubMed ID: 3606723 | Fulltext

Purification and initial characterization of a protein which facilitates assembly of nucleosome-like structure from mammalian cells.

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Ishimi Y, Hirosumi J, Sato W, Sugasawa K, Yokota S, Hanaoka F, and Yamada M

European journal of biochemistry / FEBS 142(3):431-9, 1984 Aug 1 - Who cited this? | PubMed ID: 6468372 | Fulltext

A protein which facilitates assembly of nucleosome-like structures in vitro in mammalian cells.

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Ishimi Y, Yasuda H, Hirosumi J, Hanaoka F, and Yamada M

Journal of biochemistry 94(3):735-44, 1983 Sep - Who cited this? | PubMed ID: 6643419 | Fulltext

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