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Papers authored by Higaki K

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Amino acids suppress apoptosis induced by sodium laurate, an absorption enhancer.

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Takayama C, Mukaizawa F, Fujita T, Ogawara K, Higaki K, and Kimura T

Journal of pharmaceutical sciences 98(12):4629-38, 2009 Dec - Who cited this? | PubMed ID: 19630065 | Fulltext

Inhibition of autophagosome formation restores mitochondrial function in mucolipidosis II and III skin fibroblasts.

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Otomo T, Higaki K, Nanba E, Ozono K, and Sakai N

Molecular genetics and metabolism 98(4):393-9, 2009 Dec - Who cited this? | PubMed ID: 19656701 | Fulltext

Intracerebral cell transplantation therapy for murine GM1 gangliosidosis.

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Sawada T, Tanaka A, Higaki K, Takamura A, Nanba E, Seto T, Maeda M, Yamaguchi E, Matsuda J, and Yamano T

Brain & development 31(10):717-24, 2009 Nov - Who cited this? | PubMed ID: 19118961 | Fulltext

[Catamenial pneumothorax with breast cancer treated successfully by goserelin acetate].

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Matsuura M, Fujiwara T, Kataoka K, Itoh M, Ohtani S, Higaki K, and Senoo N

Kyobu geka. The Japanese journal of thoracic surgery 62(11):1015-8, 2009 Oct - Who cited this? | PubMed ID: 19827558 | Fulltext

Uracil-tegafur and tamoxifen vs cyclophosphamide, methotrexate, fluorouracil, and tamoxifen in post-operative adjuvant therapy for stage I, II, or IIIA lymph node-positive breast cancer: a comparative study.

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Park Y, Okamura K, Mitsuyama S, Saito T, Koh J, Kyono S, Higaki K, Ogita M, Asaga T, Inaji H, Komichi H, Kohno N, Yamazaki K, Tanaka F, Ito T, Nishikawa H,

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British journal of cancer 101(4):598-604, 2009 Aug 18 - Who cited this? | PubMed ID: 19638976 | Fulltext

Structural characterization of multibranched oligosaccharides from seal milk by a combination of off-line high-performance liquid chromatography-matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and sequential exoglycosidase digestion.

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Kinoshita M, Ohta H, Higaki K, Kojima Y, Urashima T, Nakajima K, Suzuki M, Kovacs KM, Lydersen C, Hayakawa T, and Kakehi K

Analytical biochemistry 388(2):242-53, 2009 May 15 - Who cited this? | PubMed ID: 19275874 | Fulltext

A case of overwhelming postsplenectomy infection (OPSI) with chronic hepatitis type C during peginterferon/ribavirin combination therapy.

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Okamura S, Sakai T, Yoshikai H, Sumie H, Narita K, Karashima T, Maeyama Y, Higaki K, Ide T, and Sata M

Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 106(3):411-7, 2009 Mar - Who cited this? | PubMed ID: 19262056 | Fulltext

Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells.

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Kimoto T, Takanashi M, Mukai H, Ogawara K, Kimura T, and Higaki K

International journal of pharmaceutics 368(1-2):31-6, 2009 Feb 23 - Who cited this? | PubMed ID: 18977284 | Fulltext

Stabilizing effects of eicosapentaenoic acid on Kv1.5 channel protein expressed in mammalian cells.

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Koshida S, Kurata Y, Notsu T, Hirota Y, Kuang TY, Li P, Bahrudin U, Harada S, Miake J, Yamamoto Y, Hoshikawa Y, Igawa O, Higaki K, Soma M, Yoshida A, Ninomiya H,

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European journal of pharmacology 604(1-3):93-102, 2009 Feb 14 - Who cited this? | PubMed ID: 19121632 | Fulltext

Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers.

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Mukaizawa F, Taniguchi K, Miyake M, Ogawara K, Odomi M, Higaki K, and Kimura T

International journal of pharmaceutics 367(1-2):103-8, 2009 Feb 9 - Who cited this? | PubMed ID: 18929635 | Fulltext

A highly stable and nonintegrated human artificial chromosome (HAC) containing the 2.4 Mb entire human dystrophin gene.

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Hoshiya H, Kazuki Y, Abe S, Takiguchi M, Kajitani N, Watanabe Y, Yoshino T, Shirayoshi Y, Higaki K, Messina G, Cossu G, and Oshimura M

Molecular therapy : the journal of the American Society of Gene Therapy 17(2):309-17, 2009 Feb - Who cited this? | PubMed ID: 19034264 | Fulltext

In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells.

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Ogawara K, Un K, Tanaka K, Higaki K, and Kimura T

Journal of controlled release : official journal of the Controlled Release Society 133(1):4-10, 2009 Jan 5 - Who cited this? | PubMed ID: 18840484 | Fulltext

Quantitative Evaluation of PEPT1 Contribution to Oral Absorption of Cephalexin in Rats.

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Hironaka T, Itokawa S, Ogawara K, Higaki K, and Kimura T

Pharmaceutical research 26(1):40-50, 2009 Jan - Who cited this? | PubMed ID: 18784906 | Fulltext

Pathomorphologic study of undifferentiated carcinoma in seven cases: relationship between tumor and pancreatic duct epithelium.

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Naito Y, Kinoshita H, Okabe Y, Arikawa S, Higaki K, Morimitsu Y, Yamasaki F, Suda K, Yasumoto M, Kusano H, Nakashima O, and Yano H

Journal of hepato-biliary-pancreatic surgery 16(4):478-84, 2009 - Who cited this? | PubMed ID: 19367361 | Fulltext

Ubiquitin-proteasome system impairment caused by a missense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy.

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Bahrudin U, Morisaki H, Morisaki T, Ninomiya H, Higaki K, Nanba E, Igawa O, Takashima S, Mizuta E, Miake J, Yamamoto Y, Shirayoshi Y, Kitakaze M, Carrier L, and Hisatome I

Journal of molecular biology 384(4):896-907, 2008 Dec 26 - Who cited this? | PubMed ID: 18929575 | Fulltext

[Clinical effect of vinorelbine monotherapy in 18 cases of advanced or metastatic breast cancer.].

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Sasada S, Ohtani S, Kim R, and Higaki K

Gan to kagaku ryoho. Cancer & chemotherapy 35(10):1703-7, 2008 Oct - Who cited this? | PubMed ID: 18931572 | Fulltext

Mechanistic understanding of time-dependent oral absorption based on gastric motor activity in humans.

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Higaki K, Choe SY, Löbenberg R, Welage LS, and Amidon GL

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 70(1):313-25, 2008 Sep - Who cited this? | PubMed ID: 18434110 | Fulltext

[Prediction of Response to Primary Systemic Chemotherapy Involving Weekly Paclitaxel Followed by FEC 100 for Advanced Breast Cancer.].

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Higaki K, Ohtani S, Kin R, Masumura K, Harano M, Urashima M, Kagemoto M, Takada S, and Matsuura H

Gan to kagaku ryoho. Cancer & chemotherapy 35(9):1513-7, 2008 Sep - Who cited this? | PubMed ID: 18799903 | Fulltext

In vitro-in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol.

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Jinno J, Kamada N, Miyake M, Yamada K, Mukai T, Odomi M, Toguchi H, Liversidge GG, Higaki K, and Kimura T

Journal of controlled release : official journal of the Controlled Release Society 130(1):29-37, 2008 Aug 25 - Who cited this? | PubMed ID: 18582979 | Fulltext

Functional stabilization of Kv1.5 protein by Hsp70 in mammalian cell lines.

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Hirota Y, Kurata Y, Kato M, Notsu T, Koshida S, Inoue T, Kawata Y, Miake J, Bahrudin U, Li P, Hoshikawa Y, Yamamoto Y, Igawa O, Shirayoshi Y, Nakai A, Ninomiya H,

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Biochemical and biophysical research communications 372(3):469, 2008 Aug 1 - Who cited this? | PubMed ID: 18502196 | Fulltext

Changes of HCN gene expression and I(f) currents in Nkx2.5-positive cardiomyocytes derived from murine embryonic stem cells during differentiation.

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Yano S, Miake J, Mizuta E, Manabe K, Bahrudin U, Morikawa K, Arakawa K, Sasaki N, Igawa O, Shigemasa C, Yamamoto Y, Morisaki T, Hidaka K, Kurata Y, Yoshida A, Shiota G,

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Biomedical research (Tokyo, Japan) 29(4):195-203, 2008 Aug - Who cited this? | PubMed ID: 18724007 | Fulltext

Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers.

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Shehata T, Ogawara K, Higaki K, and Kimura T

International journal of pharmaceutics 359(1-2):272-9, 2008 Jul 9 - Who cited this? | PubMed ID: 18486370 | Fulltext

Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: Importance of vascular permeability within tumors.

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Ogawara K, Un K, Minato K, Tanaka K, Higaki K, and Kimura T

International journal of pharmaceutics 359(1-2):234-40, 2008 Jul 9 - Who cited this? | PubMed ID: 18448289 | Fulltext

Novel beta-galactosidase gene mutation p.W273R in a woman with mucopolysaccharidosis type IVB (Morquio B) and lack of response to in vitro chaperone treatment of her skin fibroblasts.

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Gucev ZS, Tasic V, Jancevska A, Zafirovski G, Kremensky I, Sinigerska I, Nanba E, Higaki K, Gucev F, and Suzuki Y

American journal of medical genetics. Part A 146A(13):1736-40, 2008 Jul 1 - Who cited this? | PubMed ID: 18546276 | Fulltext

[Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between april 2006 and march 2007].

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Shinagawa N, Hirata K, Katsuramaki T, Mizukuchi T, Ushijima Y, Ushida T, Aikawa N, Yo K, Mashita K, Ishikawa S, Mizuno A, Kubo S, Lee S, Fujimoto M, Higaki K, Taniguchi K,

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The Japanese journal of antibiotics 61(3):122-71, 2008 Jun - Who cited this? | PubMed ID: 18814799 | Fulltext

Effect of percutaneous endoscopic gastrostomy on gastrointestinal motility: evaluation by gastric-emptying scintigraphy.

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Wakamatsu H, Nagamachi S, Nishii R, Higaki K, Kawai K, Kamimura K, Fujita S, Futami S, and Tamura S

Nuclear medicine communications 29(6):562-7, 2008 Jun - Who cited this? | PubMed ID: 18458604 | Fulltext

An autopsy case of granulocyte-colony-stimulating-factor-producing extrahepatic bile duct carcinoma.

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Matsuyama S, Shimonishi T, Yoshimura H, Higaki K, Nasu K, Toyooka M, Aoki S, Watanabe K, and Sugihara H

World journal of gastroenterology : WJG 14(18):2924, 2008 May 14 - Who cited this? | PubMed ID: 18473424 | Fulltext

A case of galactosialidosis with a homozygous Q49R point mutation.

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Matsumoto N, Gondo K, Kukita J, Higaki K, Paragison RC, and Nanba E

Brain & development, 2008 Apr 4 - Who cited this? | PubMed ID: 18396002 | Fulltext

Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats.

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Yokoe J, Sakuragi S, Yamamoto K, Teragaki T, Ogawara K, Higaki K, Katayama N, Kai T, Sato M, and Kimura T

International journal of pharmaceutics 353(1-2):28-34, 2008 Apr 2 - Who cited this? | PubMed ID: 18082345 | Fulltext

Appearance of Double Peaks in Plasma Concentration-time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight Function.

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Metsugi Y, Miyaji Y, Ogawara K, Higaki K, and Kimura T

Pharmaceutical research 25(4):886-95, 2008 Apr - Who cited this? | PubMed ID: 17955185 | Fulltext

Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug.

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Fujioka Y, Metsugi Y, Ogawara K, Higaki K, and Kimura T

International journal of pharmaceutics 352(1-2):36-43, 2008 Mar 20 - Who cited this? | PubMed ID: 18037251 | Fulltext

Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis.

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Takamura A, Higaki K, Kajimaki K, Otsuka S, Ninomiya H, Matsuda J, Ohno K, Suzuki Y, and Nanba E

Biochemical and biophysical research communications 367(3):616, 2008 Mar 14 - Who cited this? | PubMed ID: 18190792 | Fulltext

Chemical chaperone therapy: clinical effect in murine G(M1)-gangliosidosis.

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Suzuki Y, Ichinomiya S, Kurosawa M, Ohkubo M, Watanabe H, Iwasaki H, Matsuda J, Noguchi Y, Takimoto K, Itoh M, Tabe M, Iida M, Kubo T, Ogawa S, Nanba E, Higaki K,

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Annals of neurology 62(6):671-5, 2007 Dec - Who cited this? | PubMed ID: 17994547 | Fulltext

Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics.

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Nagayama S, Ogawara K, Fukuoka Y, Higaki K, and Kimura T

International journal of pharmaceutics 342(1-2):215, 2007 Sep 5 - Who cited this? | PubMed ID: 17566676 | Fulltext

Antisense suppression of TSC1 gene product, hamartin, enhances neurite outgrowth in NGF-treated PC12h cells.

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Floricel F, Higaki K, Maki H, Nanba E, Ninomiya H, and Ohno K

Brain & development 29(8):502-9, 2007 Sep - Who cited this? | PubMed ID: 17376623 | Fulltext

Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: utilization of a more suitable medium for in-vitro dissolution study.

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Fujioka Y, Kadono K, Fujie Y, Metsugi Y, Ogawara K, Higaki K, and Kimura T

Journal of controlled release : official journal of the Controlled Release Society 119(2):222-8, 2007 Jun 4 - Who cited this? | PubMed ID: 17442444 | Fulltext

Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans.

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Takahira T, Oda Y, Tamiya S, Higaki K, Yamamoto H, Kobayashi C, Izumi T, Tateishi N, Iwamoto Y, and Tsuneyoshi M

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20(6):668-75, 2007 Jun - Who cited this? | PubMed ID: 17431412 | Fulltext

The TSC1 gene product hamartin interacts with NADE.

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Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, and Ohno K

Molecular and cellular neurosciences 35(1):100-8, 2007 May - Who cited this? | PubMed ID: 17355907 | Fulltext

[Safe improvement of drug absorption by combinatorial use of sodium laurate with amino acids: cytoprotection by amino acids and its mechanisms].

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Higaki K

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 127(4):589-99, 2007 Apr - Who cited this? | PubMed ID: 17409688 | Fulltext

[Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between april 2003 and march 2004].

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Shinagawa N, Fuchimoto S, Sueda T, Hiyama E, Takesue Y, Murakami Y, Ooge H, Uemura K, Mizuno I, Tsumura H, Hirata K, Katsuramaki T, Mizukuchi T, Ushijima Y, Ushida T, Aikawa N,

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The Japanese journal of antibiotics 60(2):59-97, 2007 Apr - Who cited this? | PubMed ID: 17612256 | Fulltext

Animal models for predicting potency of oral sustained-release adhesive microspheres in humans.

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Nagahara N, Akiyama Y, Higaki K, and Kimura T

International journal of pharmaceutics 331(1):46-53, 2007 Feb 22 - Who cited this? | PubMed ID: 17098383 | Fulltext

Enhanced autophagic cell death in expanded polyhistidine variants of HOXA1 reduces PBX1-coupled transcriptional activity and inhibits neuronal differentiation.

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Paraguison RC, Higaki K, Yamamoto K, Matsumoto H, Sasaki T, Kato N, and Nanba E

Journal of neuroscience research 85(3):479, 2007 Feb 15 - Who cited this? | PubMed ID: 17131398 | Fulltext

Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition.

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Furumoto K, Yokoe J, Ogawara K, Amano S, Takaguchi M, Higaki K, Kai T, and Kimura T

International journal of pharmaceutics 329(1-2):110-6, 2007 Feb 1 - Who cited this? | PubMed ID: 17000067 | Fulltext

Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor.

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Nagayama S, Ogawara K, Minato K, Fukuoka Y, Takakura Y, Hashida M, Higaki K, and Kimura T

International journal of pharmaceutics 329(1-2):192-8, 2007 Feb 1 - Who cited this? | PubMed ID: 17005341 | Fulltext

[A case of progressive gastric carcinoma accompanied by disseminated carcinomatosis of bone marrow due to bone metastasis with DIC recovery by joint administration of 5-FU and paclitaxel].

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Satoh D, Ninomiya M, Umeoka T, Harano M, Sasaki H, Aoki H, Onoda T, Shiozaki Y, Ohno S, Higaki K, and Takakura N

Gan to kagaku ryoho. Cancer & chemotherapy 33(13):2079-81, 2006 Dec - Who cited this? | PubMed ID: 17197758 | Fulltext

Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption.

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Miyake M, Minami T, Toguchi H, Odomi M, Ogawara K, Higaki K, and Kimura T

Journal of controlled release : official journal of the Controlled Release Society 115(2):130-3, 2006 Oct 10 - Who cited this? | PubMed ID: 16973235 | Fulltext

Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer.

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Okuda T, Kadotsuji K, Takayama C, Hanada K, Mukaizawa F, Ogawara K, Higaki K, and Kimura T

Journal of pharmaceutical sciences 95(10):2256-65, 2006 Oct - Who cited this? | PubMed ID: 16886194 | Fulltext

Fibroblast screening for chaperone therapy in beta-galactosidosis.

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Iwasaki H, Watanabe H, Iida M, Ogawa S, Tabe M, Higaki K, Nanba E, and Suzuki Y

Brain & development 28(8):482-6, 2006 Sep - Who cited this? | PubMed ID: 16617000 | Fulltext

D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells.

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Nakamura Y, Kanemura Y, Yamada T, Sugita Y, Higaki K, Yamamoto M, Takahashi M, and Yamasaki M

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 19(7):974-85, 2006 Jul - Who cited this? | PubMed ID: 16648867 | Fulltext

Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): in vivo evaluation.

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Tanaka N, Imai K, Okimoto K, Ueda S, Tokunaga Y, Ibuki R, Higaki K, and Kimura T

Journal of controlled release : official journal of the Controlled Release Society 112(1):51-6, 2006 May 1 - Who cited this? | PubMed ID: 16545477 | Fulltext

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