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Papers authored by Hickson I

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Yeast as a model system to study RecQ helicase function.

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Ashton TM and Hickson ID

DNA repair 9(3):303-14, 2010 Mar 2 - Who cited this? | PubMed ID: 20071248 | Fulltext

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.

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Chresta CM, Davies BR, Hickson I, Harding T, Cosulich S, Critchlow SE, Vincent JP, Ellston R, Jones D, Sini P, James D, Howard Z, Dudley P, Hughes G, Smith L, Maguire S,

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Cancer research 70(1):288-98, 2010 Jan 1 - Who cited this? | PubMed ID: 20028854 | Fulltext

JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity.

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Arts J, King P, Mariën A, Floren W, Beliën A, Janssen L, Pilatte I, Roux B, Decrane L, Gilissen R, Hickson I, Vreys V, Cox E, Bol K, Talloen W, Goris I,

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Clinical cancer research : an official journal of the American Association for Cancer Research 15(22):6841-51, 2009 Nov 15 - Who cited this? | PubMed ID: 19861438 | Fulltext

Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR.

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Menear KA, Gomez S, Malagu K, Bailey C, Blackburn K, Cockcroft XL, Ewen S, Fundo A, Le Gall A, Hermann G, Sebastian L, Sunose M, Presnot T, Torode E, Hickson I, Martin NM,

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Bioorganic & medicinal chemistry letters 19(20):5898-901, 2009 Oct 15 - Who cited this? | PubMed ID: 19733066 | Fulltext

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.

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Malagu K, Duggan H, Menear K, Hummersone M, Gomez S, Bailey C, Edwards P, Drzewiecki J, Leroux F, Quesada MJ, Hermann G, Maine S, Molyneaux CA, Le Gall A, Pullen J, Hickson I,

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Bioorganic & medicinal chemistry letters 19(20):5950-3, 2009 Oct 15 - Who cited this? | PubMed ID: 19762236 | Fulltext

On the origins of ultra-fine anaphase bridges.

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Chan KL and Hickson ID

Cell cycle (Georgetown, Tex.) 8(19):3065-6, 2009 Oct 1 - Who cited this? | PubMed ID: 19755843 | Fulltext

RecQ helicases: multifunctional genome caretakers.

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Chu WK and Hickson ID

Nature reviews. Cancer 9(9):644-54, 2009 Sep - Who cited this? | PubMed ID: 19657341 | Fulltext

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.

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Payne M and Hickson ID

Biochemical Society transactions 37(Pt 3):553-9, 2009 Jun - Who cited this? | PubMed ID: 19442250 | Fulltext

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

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Chan KL, Palmai-Pallag T, Ying S, and Hickson ID

Nature cell biology 11(6):753-60, 2009 Jun - Who cited this? | PubMed ID: 19465922 | Fulltext

RecQ helicases: multiple structures for multiple functions?.

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Vindigni A and Hickson ID

HFSP Journal 3(3):153-64, 2009 Jun - Who cited this? | PubMed ID: 19949442 | Fulltext

Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.

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Mankouri HW, Ngo HP, and Hickson ID

Molecular biology of the cell 20(6):1683-94, 2009 Mar - Who cited this? | PubMed ID: 19158388 | Fulltext

Topo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents.

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Hemphill AW, Akkari Y, Newell AH, Schultz RA, Grompe M, North PS, Hickson ID, Jakobs PM, Rennie S, Pauw D, Hejna J, Olson SB, and Moses RE

Cytogenetic and genome research 125(3):165-75, 2009 - Who cited this? | PubMed ID: 19738377 | Fulltext

Dissolution of Double Holliday Junctions by the Concerted Action of BLM and Topoisomerase IIIalpha.

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Bachrati CZ and Hickson ID

Methods in molecular biology (Clifton, N.J.) 582:91-102, 2009 - Who cited this? | PubMed ID: 19763944 | Fulltext

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts.

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London TB, Barber LJ, Mosedale G, Kelly GP, Balasubramanian S, Hickson ID, Boulton SJ, and Hiom K

The Journal of biological chemistry 283(52):36132-9, 2008 Dec 26 - Who cited this? | PubMed ID: 18978354 | Fulltext

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.

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Xu D, Guo R, Sobeck A, Bachrati CZ, Yang J, Enomoto T, Brown GW, Hoatlin ME, Hickson ID, and Wang W

Genes & development 22(20):2843-55, 2008 Oct 15 - Who cited this? | PubMed ID: 18923082 | Fulltext

The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase {delta}.

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Selak N, Bachrati CZ, Shevelev I, Dietschy T, van Loon B, Jacob A, Hübscher U, Hoheisel JD, Hickson ID, and Stagljar I

Nucleic acids research, 2008 Aug 5 - Who cited this? | PubMed ID: 18682526 | Fulltext

RecQ helicases: guardian angels of the DNA replication fork.

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Bachrati CZ and Hickson ID

Chromosoma 117(3):219, 2008 Jun - Who cited this? | PubMed ID: 18188578 | Fulltext

The human recq helicases, blm and recq1, display distinct DNA substrate specificities.

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Popuri V, Bachrati CZ, Muzzolini L, Mosedale G, Costantini S, Giacomini E, Hickson ID, and Vindigni A

The Journal of biological chemistry, 2008 Apr 30 - Who cited this? | PubMed ID: 18448429 | Fulltext

The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'?.

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Mankouri HW and Hickson ID

Trends in biochemical sciences 32(12):538-46, 2007 Dec - Who cited this? | PubMed ID: 17980605 | Fulltext

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.

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Hanada K, Budzowska M, Davies SL, van Drunen E, Onizawa H, Beverloo HB, Maas A, Essers J, Hickson ID, and Kanaar R

Nature structural & molecular biology 14(11):1096, 2007 Nov - Who cited this? | PubMed ID: 17934473 | Fulltext

Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3.

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Mankouri HW, Ngo HP, and Hickson ID

Molecular biology of the cell 18(10):4062-73, 2007 Oct - Who cited this? | PubMed ID: 17671161 | Fulltext

Molecular genetics of RecQ helicase disorders.

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Hanada K and Hickson ID

Cellular and molecular life sciences : CMLS 64(17):2306-22, 2007 Sep - Who cited this? | PubMed ID: 17571213 | Fulltext

BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.

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Chan KL, North PS, and Hickson ID

The EMBO journal 26(14):3397, 2007 Jul 25 - Who cited this? | PubMed ID: 17599064 | Fulltext

Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.

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Rao VA, Conti C, Guirouilh-Barbat J, Nakamura A, Miao ZH, Davies SL, Saccá B, Hickson ID, Bensimon A, and Pommier Y

Molecular cancer research : MCR 5(7):713, 2007 Jul - Who cited this? | PubMed ID: 17634426 | Fulltext

Role for BLM in replication-fork restart and suppression of origin firing after replicative stress.

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Davies SL, North PS, and Hickson ID

Nature structural & molecular biology 14(7):677-9, 2007 Jul - Who cited this? | PubMed ID: 17603497 | Fulltext

Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.

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Chan K, Houlbrook S, Zhang QM, Harrison M, Hickson ID, and Dianov GL

Mutagenesis 22(3):183-8, 2007 May - Who cited this? | PubMed ID: 17267816 | Fulltext

Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.

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Hollick JJ, Rigoreau LJ, Cano-Soumillac C, Cockcroft X, Curtin NJ, Frigerio M, Golding BT, Guiard S, Hardcastle IR, Hickson I, Hummersone MG, Menear KA, Martin NM, Matthews I, Newell DR, Ord R,

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Journal of medicinal chemistry 50(8):1958-72, 2007 Apr 19 - Who cited this? | PubMed ID: 17371003 | Fulltext

Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.

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Mankouri HW and Hickson ID

Molecular biology of the cell 17(10):4473-83, 2006 Oct - Who cited this? | PubMed ID: 16899506 | Fulltext

The Bloom's syndrome helicase can promote the regression of a model replication fork.

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Ralf C, Hickson ID, and Wu L

The Journal of biological chemistry 281(32):22839-46, 2006 Aug 11 - Who cited this? | PubMed ID: 16766518 | Fulltext

Redundancy of DNA helicases in p53-mediated apoptosis.

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Spillare EA, Wang XW, von Kobbe C, Bohr VA, Hickson ID, and Harris CC

Oncogene 25(14):2119-23, 2006 Mar 30 - Who cited this? | PubMed ID: 16288211 | Fulltext

BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.

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Wu L, Bachrati CZ, Ou J, Xu C, Yin J, Chang M, Wang W, Li L, Brown GW, and Hickson ID

Proceedings of the National Academy of Sciences of the United States of America 103(11):4068, 2006 Mar 14 - Who cited this? | PubMed ID: 16537486 | Fulltext

Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.

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Bachrati CZ, Borts RH, and Hickson ID

Nucleic acids research 34(8):2269, 2006 - Who cited this? | PubMed ID: 16670433 | Fulltext

Analysis of the DNA unwinding activity of RecQ family helicases.

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Bachrati CZ and Hickson ID

Methods in enzymology 409:86-100, 2006 - Who cited this? | PubMed ID: 16793396 | Fulltext

DNA helicases required for homologous recombination and repair of damaged replication forks.

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Wu L and Hickson ID

Annual review of genetics 40:279-306, 2006 - Who cited this? | PubMed ID: 16856806 | Fulltext

A role for the fission yeast Rqh1 helicase in chromosome segregation.

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Win TZ, Mankouri HW, Hickson ID, and Wang SW

Journal of cell science 118(Pt 24):5777-84, 2005 Dec 15 - Who cited this? | PubMed ID: 16303848 | Fulltext

Roles of the Bloom's syndrome helicase in the maintenance of genome stability.

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Cheok CF, Bachrati CZ, Chan KL, Ralf C, Wu L, and Hickson ID

Biochemical Society transactions 33(Pt 6):1456, 2005 Dec - Who cited this? | PubMed ID: 16246145 | Fulltext

DNA repair inhibition: a selective tumour targeting strategy.

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Madhusudan S and Hickson ID

Trends in molecular medicine 11(11):503-11, 2005 Nov - Who cited this? | PubMed ID: 16214418 | Fulltext

Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.

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Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, and Pommier Y

Molecular and cellular biology 25(20):8925, 2005 Oct - Who cited this? | PubMed ID: 16199871 | Fulltext

A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair.

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Matsushita N, Kitao H, Ishiai M, Nagashima N, Hirano S, Okawa K, Ohta T, Yu DS, McHugh PJ, Hickson ID, Venkitaraman AR, Kurumizaka H, and Takata M

Molecular cell 19(6):841, 2005 Sep 16 - Who cited this? | PubMed ID: 16168378 | Fulltext

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.

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Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, and Bohr VA

The Journal of biological chemistry 280(37):32069, 2005 Sep 16 - Who cited this? | PubMed ID: 16030011 | Fulltext

The HRDC domain of BLM is required for the dissolution of double Holliday junctions.

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Wu L, Chan KL, Ralf C, Bernstein DA, Garcia PL, Bohr VA, Vindigni A, Janscak P, Keck JL, and Hickson ID

The EMBO journal 24(14):2679, 2005 Jul 20 - Who cited this? | PubMed ID: 15990871 | Fulltext

Pharmacokinetically guided phase I trial of topotecan and etoposide phosphate in recurrent ovarian cancer.

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Levitt NC, Propper DJ, Madhusudan S, Braybrooke JP, Echeta C, Te Poele R, Davies SL, Flanagan E, Hickson ID, Joel S, and Ganesan TS

British journal of cancer 93(1):60-9, 2005 Jul 11 - Who cited this? | PubMed ID: 15956976 | Fulltext

Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

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Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, and Curtin NJ

Clinical cancer research : an official journal of the American Association for Cancer Research 11(9):3402-9, 2005 May 1 - Who cited this? | PubMed ID: 15867241 | Fulltext

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.

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Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, and Ashworth A

Nature 434(7035):917, 2005 Apr 14 - Who cited this? | PubMed ID: 15829967 | Fulltext

The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA.

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Cheok CF, Wu L, Garcia PL, Janscak P, and Hickson ID

Nucleic acids research 33(12):3932-41, 2005 - Who cited this? | PubMed ID: 16024743 | Fulltext

Isolation of a small molecule inhibitor of DNA base excision repair.

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Madhusudan S, Smart F, Shrimpton P, Parsons JL, Gardiner L, Houlbrook S, Talbot DC, Hammonds T, Freemont PA, Sternberg MJ, Dianov GL, and Hickson ID

Nucleic acids research 33(15):4711-24, 2005 - Who cited this? | PubMed ID: 16113242 | Fulltext

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.

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Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, and Smith GC

Cancer research 64(24):9152, 2004 Dec 15 - Who cited this? | PubMed ID: 15604286 | Fulltext

Understanding the roles of RecQ helicases in the maintenance of genome integrity and suppression of tumorigenesis.

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Mankouri HW and Hickson ID

Biochemical Society transactions 32(Pt 6):957, 2004 Dec - Who cited this? | PubMed ID: 15506934 | Fulltext

Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.

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Win TZ, Goodwin A, Hickson ID, Norbury CJ, and Wang SW

Journal of cell science 117(Pt 20):4769-78, 2004 Sep 15 - Who cited this? | PubMed ID: 15340008 | Fulltext

Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1.

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Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL, Egli D, Hickson ID, and Stagljar I

Molecular and cellular biology 24(11):4710-9, 2004 Jun - Who cited this? | PubMed ID: 15143166 | Fulltext

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