Please enable Javascript

Labmeeting uses lots of Javascript - basically you can't use the site without it. So please enable Javascript in your browser. If your browser does not support Javascript, we recommend Firefox.

Papers authored by Heldin CH

Collect these papers and discover other ones on Labmeeting. Learn more.

The regulation of TGF{beta} signal transduction.

+ cite this

+ View Abstract

Moustakas A and Heldin CH

Development (Cambridge, England) 136(22):3699-714, 2009 Nov - Who cited this? | PubMed ID: 19855013 | Fulltext

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.

+ cite this

+ View Abstract

Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin CH, Bergh J, Brennan DJ, Jirström K, and Ostman A

The American journal of pathology 175(1):334-41, 2009 Jul - Who cited this? | PubMed ID: 19498003 | Fulltext

Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling.

+ cite this

+ View Abstract

Hellberg C, Schmees C, Karlsson S, Ahgren A, and Heldin CH

Molecular biology of the cell 20(12):2856-63, 2009 Jun - Who cited this? | PubMed ID: 19369415 | Fulltext

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.

+ cite this

+ View Abstract

Heldin CH, Landström M, and Moustakas A

Current opinion in cell biology 21(2):166-76, 2009 Apr - Who cited this? | PubMed ID: 19237272 | Fulltext

Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation.

+ cite this

+ View Abstract

Jurek A, Amagasaki K, Gembarska A, Heldin CH, and Lennartsson J

The Journal of biological chemistry 284(7):4626-34, 2009 Feb 13 - Who cited this? | PubMed ID: 19106095 | Fulltext

TGF-beta uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells.

+ cite this

Thakur N, Sorrentino A, Heldin CH, and Landström M

Future oncology (London, England) 5(1):1-3, 2009 Feb - Who cited this? | PubMed ID: 19243289 | Fulltext

Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom.

+ cite this

+ View Abstract

Huminiecki L, Goldovsky L, Freilich S, Moustakas A, Ouzounis C, and Heldin CH

BMC evolutionary biology 9:28, 2009 - Who cited this? | PubMed ID: 19192293 | Fulltext

HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition.

+ cite this

+ View Abstract

Thuault S, Tan EJ, Peinado H, Cano A, Heldin CH, and Moustakas A

The Journal of biological chemistry 283(48):33437-46, 2008 Nov 28 - Who cited this? | PubMed ID: 18832382 | Fulltext

Nck Adapters Are Involved in the Formation of Dorsal Ruffles, Cell Migration, and Rho Signaling Downstream of the Platelet-derived Growth Factor {beta} Receptor.

+ cite this

+ View Abstract

Ruusala A, Pawson T, Heldin CH, and Aspenström P

The Journal of biological chemistry 283(44):30034-44, 2008 Oct 31 - Who cited this? | PubMed ID: 18765673 | Fulltext

A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin.

+ cite this

+ View Abstract

Krampert M, Heldin CH, and Heuchel RL

Laboratory investigation; a journal of technical methods and pathology, 2008 Sep 1 - Who cited this? | PubMed ID: 18762776 | Fulltext

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.

+ cite this

+ View Abstract

Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, Zhang S, Heldin CH, and Landström M

Nature cell biology, 2008 Aug 31 - Who cited this? | PubMed ID: 18758450 | Fulltext

TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.

+ cite this

+ View Abstract

Kowanetz M, Lönn P, Vanlandewijck M, Kowanetz K, Heldin CH, and Moustakas A

The Journal of cell biology 182(4):655, 2008 Aug 25 - Who cited this? | PubMed ID: 18725536 | Fulltext

A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse.

+ cite this

+ View Abstract

Rosengren Pielberg G, Golovko A, Sundström E, Curik I, Lennartsson J, Seltenhammer MH, Druml T, Binns M, Fitzsimmons C, Lindgren G, Sandberg K, Baumung R, Vetterlein M, Strömberg S, Grabherr M, Wade C,

(show remaining authors)

Nature genetics, 2008 Jul 20 - Who cited this? | PubMed ID: 18641652 | Fulltext

Feedback Control: The role of negative feedback in signal transduction control.

+ cite this

Heldin CH, Lennartsson J, and Hellberg C

European journal of human genetics : EJHG 16(7):769, 2008 Jul - Who cited this? | PubMed ID: 18398443 | Fulltext

Dynamic control of TGF-beta signaling and its links to the cytoskeleton.

+ cite this

+ View Abstract

Moustakas A and Heldin CH

FEBS letters 582(14):2051, 2008 Jun 18 - Who cited this? | PubMed ID: 18375206 | Fulltext

The European Research Council--a new opportunity for European science.

+ cite this

+ View Abstract

Heldin CH

Nature reviews. Molecular cell biology 9(5):417, 2008 May - Who cited this? | PubMed ID: 18349875 | Fulltext

VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.

+ cite this

+ View Abstract

Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG,

(show remaining authors)

The Journal of clinical investigation 118(3):913-23, 2008 Mar - Who cited this? | PubMed ID: 18259607 | Fulltext

Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling.

+ cite this

+ View Abstract

Hasumi Y, Kłosowska-Wardega A, Furuhashi M, Ostman A, Heldin CH, and Hellberg C

International journal of cancer. Journal international du cancer 121(12):2606-14, 2007 Dec 15 - Who cited this? | PubMed ID: 17691110 | Fulltext

Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression.

+ cite this

+ View Abstract

Moustakas A and Heldin CH

Cancer science 98(10):1512, 2007 Oct - Who cited this? | PubMed ID: 17645776 | Fulltext

Activation of growth factor receptors in esophageal cancer--implications for therapy.

+ cite this

+ View Abstract

Ekman S, Bergqvist M, Heldin CH, and Lennartsson J

The oncologist 12(10):1165-77, 2007 Oct - Who cited this? | PubMed ID: 17962610 | Fulltext

SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma.

+ cite this

+ View Abstract

Kallin A, Johannessen LE, Cani PD, Marbehant CY, Essaghir A, Foufelle F, Ferré P, Heldin CH, Delzenne NM, and Demoulin JB

Journal of lipid research 48(7):1628, 2007 Jul - Who cited this? | PubMed ID: 17452746 | Fulltext

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.

+ cite this

+ View Abstract

Li L, Asteriou T, Bernert B, Heldin CH, and Heldin P

The Biochemical journal 404(2):327, 2007 Jun 1 - Who cited this? | PubMed ID: 17324121 | Fulltext

In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma.

+ cite this

+ View Abstract

Micke P, Kappert K, Ohshima M, Sundquist C, Scheidl S, Lindahl P, Heldin CH, Botling J, Ponten F, and Ostman A

The Journal of investigative dermatology 127(6):1516, 2007 Jun - Who cited this? | PubMed ID: 17273163 | Fulltext

Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.

+ cite this

+ View Abstract

Valcourt U, Thuault S, Pardali K, Heldin CH, and Moustakas A

Molecular oncology 1(1):55-71, 2007 Jun - Who cited this? | PubMed ID: 19383287 | Fulltext

Notch signaling is necessary for epithelial growth arrest by TGF-beta.

+ cite this

+ View Abstract

Niimi H, Pardali K, Vanlandewijck M, Heldin CH, and Moustakas A

The Journal of cell biology 176(5):695, 2007 Feb 26 - Who cited this? | PubMed ID: 17325209 | Fulltext

Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma.

+ cite this

+ View Abstract

Suzuki S, Heldin CH, and Heuchel RL

BMC cancer 7:224, 2007 - Who cited this? | PubMed ID: 18076756 | Fulltext

An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.

+ cite this

+ View Abstract

Looman C, Sun T, Yu Y, Zieba A, Ahgren A, Feinstein R, Forsberg H, Hellberg C, Heldin CH, Zhang XQ, Forsberg-Nilsson K, Khoo N, Fundele R, and Heuchel R

The International journal of developmental biology 51(5):361-70, 2007 - Who cited this? | PubMed ID: 17616925 | Fulltext

PDGF Receptors as Targets in Tumor Treatment.

+ cite this

+ View Abstract

Ostman A and Heldin CH

Advances in cancer research 97:247-74, 2007 - Who cited this? | PubMed ID: 17419949 | Fulltext

The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.

+ cite this

+ View Abstract

Simonsson M, Kanduri M, Grönroos E, Heldin CH, and Ericsson J

The Journal of biological chemistry 281(52):39870-80, 2006 Dec 29 - Who cited this? | PubMed ID: 17074756 | Fulltext

Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation.

+ cite this

+ View Abstract

Lennartsson J, Wardega P, Engström U, Hellman U, and Heldin CH

The Journal of biological chemistry 281(51):39152-8, 2006 Dec 22 - Who cited this? | PubMed ID: 17082185 | Fulltext

Highly active antiretroviral therapy attenuates re-endothelialization and alters neointima formation in the rat carotid artery after balloon injury.

+ cite this

+ View Abstract

Kappert K, Leppänen O, Paulsson J, Furuhashi M, Carlsson MA, Heldin CH, Fätkenheuer G, Rosenkranz S, and Ostman A

Journal of acquired immune deficiency syndromes (1999) 43(4):383-92, 2006 Dec 1 - Who cited this? | PubMed ID: 16967043 | Fulltext

TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner.

+ cite this

+ View Abstract

Zhang S, Ekman M, Thakur N, Bu S, Davoodpour P, Grimsby S, Tagami S, Heldin CH, and Landström M

Cell cycle (Georgetown, Tex.) 5(23):2787-95, 2006 Dec - Who cited this? | PubMed ID: 17172861 | Fulltext

Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor.

+ cite this

+ View Abstract

Karlsson S, Kowanetz K, Sandin A, Persson C, Ostman A, Heldin CH, and Hellberg C

Molecular biology of the cell 17(11):4846-55, 2006 Nov - Who cited this? | PubMed ID: 16971512 | Fulltext

Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44.

+ cite this

+ View Abstract

Li L, Heldin CH, and Heldin P

The Journal of biological chemistry 281(36):26512-9, 2006 Sep 8 - Who cited this? | PubMed ID: 16809345 | Fulltext

The gene expression profile of PDGF-treated neural stem cells corresponds to partially differentiated neurons and glia.

+ cite this

+ View Abstract

Demoulin JB, Enarsson M, Larsson J, Essaghir A, Heldin CH, and Forsberg-Nilsson K

Growth factors (Chur, Switzerland) 24(3):184-96, 2006 Sep - Who cited this? | PubMed ID: 17079202 | Fulltext

Characterization of an imatinib-sensitive subset of high-grade human glioma cultures.

+ cite this

+ View Abstract

Hägerstrand D, Hesselager G, Achterberg S, Wickenberg Bolin U, Kowanetz M, Kastemar M, Heldin CH, Isaksson A, Nistér M, and Ostman A

Oncogene 25(35):4913-22, 2006 Aug 10 - Who cited this? | PubMed ID: 16547494 | Fulltext

c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts.

+ cite this

+ View Abstract

Amagasaki K, Kaneto H, Heldin CH, and Lennartsson J

The Journal of biological chemistry 281(31):22173-9, 2006 Aug 4 - Who cited this? | PubMed ID: 16760468 | Fulltext

Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.

+ cite this

+ View Abstract

Thuault S, Valcourt U, Petersen M, Manfioletti G, Heldin CH, and Moustakas A

The Journal of cell biology 174(2):175-83, 2006 Jul 17 - Who cited this? | PubMed ID: 16831886 | Fulltext

Deletion of exon I of SMAD7 in mice results in altered B cell responses.

+ cite this

+ View Abstract

Li R, Rosendahl A, Brodin G, Cheng AM, Ahgren A, Sundquist C, Kulkarni S, Pawson T, Heldin CH, and Heuchel RL

Journal of immunology (Baltimore, Md. : 1950) 176(11):6777-84, 2006 Jun 1 - Who cited this? | PubMed ID: 16709837 | Fulltext

A new twist in Smad signaling.

+ cite this

+ View Abstract

Heldin CH and Moustakas A

Developmental cell 10(6):685-6, 2006 Jun - Who cited this? | PubMed ID: 16740469 | Fulltext

The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.

+ cite this

+ View Abstract

Kurisaki A, Kurisaki K, Kowanetz M, Sugino H, Yoneda Y, Heldin CH, and Moustakas A

Molecular and cellular biology 26(4):1318-32, 2006 Feb - Who cited this? | PubMed ID: 16449645 | Fulltext

Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells.

+ cite this

+ View Abstract

Valdimarsdottir G, Goumans MJ, Itoh F, Itoh S, Heldin CH, and ten Dijke P

BMC cell biology 7:16, 2006 - Who cited this? | PubMed ID: 16571110 | Fulltext

Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription.

+ cite this

+ View Abstract

Stasyk T, Dubrovska A, Lomnytska M, Yakymovych I, Wernstedt C, Heldin CH, Hellman U, and Souchelnytskyi S

Molecular biology of the cell 16(10):4765-80, 2005 Oct - Who cited this? | PubMed ID: 16055503 | Fulltext

Non-Smad TGF-beta signals.

+ cite this

+ View Abstract

Moustakas A and Heldin CH

Journal of cell science 118(Pt 16):3573, 2005 Aug 15 - Who cited this? | PubMed ID: 16105881 | Fulltext

Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1).

+ cite this

+ View Abstract

Pardali K, Kowanetz M, Heldin CH, and Moustakas A

Journal of cellular physiology 204(1):260-72, 2005 Jul - Who cited this? | PubMed ID: 15690394 | Fulltext

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.

+ cite this

+ View Abstract

Morén A, Imamura T, Miyazono K, Heldin CH, and Moustakas A

The Journal of biological chemistry 280(23):22115, 2005 Jun 10 - Who cited this? | PubMed ID: 15817471 | Fulltext

The balance between acetylation and deacetylation controls Smad7 stability.

+ cite this

+ View Abstract

Simonsson M, Heldin CH, Ericsson J, and Grönroos E

The Journal of biological chemistry 280(23):21797-803, 2005 Jun 10 - Who cited this? | PubMed ID: 15831498 | Fulltext

TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition.

+ cite this

+ View Abstract

Valcourt U, Kowanetz M, Niimi H, Heldin CH, and Moustakas A

Molecular biology of the cell 16(4):1987-2002, 2005 Apr - Who cited this? | PubMed ID: 15689496 | Fulltext

TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.

+ cite this

+ View Abstract

Dubrovska A, Kanamoto T, Lomnytska M, Heldin CH, Volodko N, and Souchelnytskyi S

Oncogene 24(14):2289-97, 2005 Mar 31 - Who cited this? | PubMed ID: 15735739 | Fulltext

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis.

+ cite this

+ View Abstract

Edlund S, Lee SY, Grimsby S, Zhang S, Aspenström P, Heldin CH, and Landström M

Molecular and cellular biology 25(4):1475-88, 2005 Feb - Who cited this? | PubMed ID: 15684397 | Fulltext

Search Google Scholar for Heldin CH

Join Labmeeting

Organize and search your PDF collection
Collect papers
Search millions of papers
Keep up to date with paper alerts
Read your papers from anywhere
Recommend papers to colleagues
Manage your lab

Labmeeting is a web service for researchers. Sign up with your academic email address.

Individuals or corporations not affiliated with an academic institution can request a trial subscription.

Got a question?
The Labmeeting Network
has the answer.
Ask scientists at top universities like Harvard, Stanford, and MIT for their expert opinion!