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Papers authored by Heikinheimo P

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Directed evolution on the cold adapted properties of TAB5 alkaline phosphatase.

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Koutsioulis D, Wang E, Tzanodaskalaki M, Nikiforaki D, Deli A, Feller G, Heikinheimo P, and Bouriotis V

Protein engineering, design & selection : PEDS 21(5):319-27, 2008 May - Who cited this? | PubMed ID: 18411226 | Fulltext

Characterization and subcellular localization of human neutral class II alpha-mannosidase cytosolic enzymes/free oligosaccharides/glycosidehydrolase family 38/M2C1/N-glycosylation.

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Kuokkanen E, Smith W, Mäkinen M, Tuominen H, Puhka M, Jokitalo E, Duvet S, Berg T, and Heikinheimo P

Glycobiology 17(10):1084-93, 2007 Oct - Who cited this? | PubMed ID: 17681998 | Fulltext

Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5.

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Wang E, Koutsioulis D, Leiros HK, Andersen OA, Bouriotis V, Hough E, and Heikinheimo P

Journal of molecular biology 366(4):1318-31, 2007 Mar 2 - Who cited this? | PubMed ID: 17198711 | Fulltext

Comparative expression study to increase the solubility of cold adapted Vibrio proteins in Escherichia coli.

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Niiranen L, Espelid S, Karlsen CR, Mustonen M, Paulsen SM, Heikinheimo P, and Willassen NP

Protein expression and purification 52(1):210-8, 2007 Mar - Who cited this? | PubMed ID: 17064934 | Fulltext

A complete structural description of the catalytic cycle of yeast pyrophosphatase.

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Oksanen E, Ahonen AK, Tuominen H, Tuominen V, Lahti R, Goldman A, and Heikinheimo P

Biochemistry 46(5):1228-39, 2007 Feb 6 - Who cited this? | PubMed ID: 17260952 | Fulltext

Funtional characterization of four novel MAN2B1 mutations causing juvenile onset alpha-mannosidosis.

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Pittis MG, Montalvo AL, Heikinheimo P, Sbaragli M, Balducci C, Persichetti E, Van Maldergem L, Filocamo M, Bembi B, and Beccari T

Clinica chimica acta; international journal of clinical chemistry 375(1-2):136-9, 2007 Jan - Who cited this? | PubMed ID: 16919251 | Fulltext

The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX).

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Leiros I, Wang E, Rasmussen T, Oksanen E, Repo H, Petersen SB, Heikinheimo P, and Hough E

Acta crystallographica. Section F, Structural biology and crystallization communications 62(Pt 12):1185-90, 2006 Dec 1 - Who cited this? | PubMed ID: 17142893 | Fulltext

Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosis.

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Sbaragli M, Bibi L, Pittis MG, Balducci C, Heikinheimo P, Ricci R, Antuzzi D, Parini R, Spaccini L, Bembi B, and Beccari T

Human mutation 25(3):320, 2005 Mar - Who cited this? | PubMed ID: 15712269 | Fulltext

Intracellular transport of human lysosomal alpha-mannosidase and alpha-mannosidosis-related mutants.

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Hansen G, Berg T, Riise Stensland HM, Heikinheimo P, Klenow H, Evjen G, Nilssen Ø, and Tollersrud OK

The Biochemical journal 381(Pt 2):537-46, 2004 Jul 15 - Who cited this? | PubMed ID: 15035660 | Fulltext

Production and preliminary analysis of perdeuterated yeast inorganic pyrophosphatase crystals suitable for neutron diffraction.

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Tuominen VU, Myles DA, Dauvergne MT, Lahti R, Heikinheimo P, and Goldman A

Acta crystallographica. Section D, Biological crystallography 60(Pt 3):606-9, 2004 Mar - Who cited this? | PubMed ID: 14993708 | Fulltext

The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation.

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Heikinheimo P, Helland R, Leiros HK, Leiros I, Karlsen S, Evjen G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud OK, McSweeney S, and Hough E

Journal of molecular biology 327(3):631-44, 2003 Mar 28 - Who cited this? | PubMed ID: 12634058 | Fulltext

Downstream coding region determinants of bacterio-opsin, muscarinic acetylcholine receptor and adrenergic receptor expression in Halobacterium salinarum.

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Bartus CL, Jaakola VP, Reusch R, Valentine HH, Heikinheimo P, Levay A, Potter LT, Heimo H, Goldman A, and Turner GJ

Biochimica et biophysica acta 1610(1):109-23, 2003 Feb 17 - Who cited this? | PubMed ID: 12586385 | Fulltext

Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase.

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Heikinheimo P, Tuominen V, Ahonen AK, Teplyakov A, Cooperman BS, Baykov AA, Lahti R, and Goldman A

Proceedings of the National Academy of Sciences of the United States of America 98(6):3121-6, 2001 Mar 13 - Who cited this? | PubMed ID: 11248042 | Fulltext

Expression and glycosylation studies of human FGF receptor 4.

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Tuominen H, Heikinheimo P, Loo BM, Kataja K, Oker-Blom C, Uutela M, Jalkanen M, and Goldman A

Protein expression and purification 21(2):275-85, 2001 Mar - Who cited this? | PubMed ID: 11237689 | Fulltext

Production and purification of recombinant human alpha 2C2 adrenergic receptor using Saccharomyces cerevisiae.

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Kapat A, Jaakola VP, Heimo H, Liitti S, Heikinheimo P, Glumoff T, and Goldman A

Bioseparation 9(3):167-72, 2000 - Who cited this? | PubMed ID: 11105246 | Fulltext

Of barn owls and bankers: a lush variety of alpha/beta hydrolases.

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Heikinheimo P, Goldman A, Jeffries C, and Ollis DL

Structure (London, England : 1993) 7(6):R141-6, 1999 Jun 15 - Who cited this? | PubMed ID: 10404588 | Fulltext

The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.

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Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytiä T, Käpylä J, Lahti R, Cooperman BS, and Goldman A

Journal of molecular biology 284(5):1565-80, 1998 Dec 18 - Who cited this? | PubMed ID: 9878371 | Fulltext

Structural and functional consequences of substitutions at the tyrosine 55-lysine 104 hydrogen bond in Escherichia coli inorganic pyrophosphatase.

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Fabrichniy IP, Kasho VN, Hyytiä T, Salminen T, Halonen P, Dudarenkov VY, Heikinheimo P, Chernyak VY, Goldman A, Lahti R, Cooperman BS, and Baykov AA

Biochemistry 36(25):7746-53, 1997 Jun 24 - Who cited this? | PubMed ID: 9201916 | Fulltext

The structural basis for pyrophosphatase catalysis.

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Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, and Goldman A

Structure (London, England : 1993) 4(12):1491-508, 1996 Dec 15 - Who cited this? | PubMed ID: 8994974 | Fulltext

A site-directed mutagenesis study of Saccharomyces cerevisiae pyrophosphatase. Functional conservation of the active site of soluble inorganic pyrophosphatases.

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Heikinheimo P, Pohjanjoki P, Helminen A, Tasanen M, Cooperman BS, Goldman A, Baykov A, and Lahti R

European journal of biochemistry / FEBS 239(1):138-43, 1996 Jul 1 - Who cited this? | PubMed ID: 8706698 | Fulltext

New crystal forms of Escherichia coli and Saccharomyces cerevisiae soluble inorganic pyrophosphatases.

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Heikinheimo P, Salminen T, Lahti R, Cooperman B, and Goldman A

Acta crystallographica. Section D, Biological crystallography 51(Pt 3):399-401, 1995 May 1 - Who cited this? | PubMed ID: 15299310 | Fulltext

Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis?.

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Salminen T, Käpylä J, Heikinheimo P, Kankare J, Goldman A, Heinonen J, Baykov AA, Cooperman BS, and Lahti R

Biochemistry 34(3):782-91, 1995 Jan 24 - Who cited this? | PubMed ID: 7827037 | Fulltext

Characterization of the 5' flanking region of the Escherichia coli ppa gene encoding inorganic pyrophosphatase: mutations in the ribosome-binding site decrease the level of ppa mRNA.

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Lahti R, Perälä M, Heikinheimo P, Pitkäranta T, Kukko-Kalske E, and Heinonen J

Journal of general microbiology 137(11):2517-23, 1991 Nov - Who cited this? | PubMed ID: 1664458 | Fulltext

Genetic engineering of Escherichia coli inorganic pyrophosphatase. Tyr55 and Tyr141 are important for the structural integrity.

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Lahti R, Salminen T, Latonen S, Heikinheimo P, Pohjanoksa K, and Heinonen J

European journal of biochemistry / FEBS 198(2):293-7, 1991 Jun 1 - Who cited this? | PubMed ID: 1645654 | Fulltext

A site-directed mutagenesis study on Escherichia coli inorganic pyrophosphatase. Glutamic acid-98 and lysine-104 are important for structural integrity, whereas aspartic acids-97 and -102 are essential for catalytic activity.

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Lahti R, Pohjanoksa K, Pitkäranta T, Heikinheimo P, Salminen T, Meyer P, and Heinonen J

Biochemistry 29(24):5761-6, 1990 Jun 19 - Who cited this? | PubMed ID: 1974462 | Fulltext

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