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Papers authored by Hegele RA

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A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

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Hegele RA, Ban MR, Hsueh N, Kennedy BA, Cao H, Zou GY, Anand S, Yusuf S, Huff MW, and Wang J

Human molecular genetics 18(21):4189-94, 2009 Nov 1 - Who cited this? | PubMed ID: 19656773 | Fulltext

Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray.

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Lanktree MB, Hegele RA, Yusuf S, and Anand SS

Stroke; a journal of cerebral circulation 40(10):3173-9, 2009 Oct - Who cited this? | PubMed ID: 19679847 | Fulltext

Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance.

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Mulvihill EE, Allister EM, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Markle JM, Hegele RA, and Huff MW

Diabetes 58(10):2198-210, 2009 Oct - Who cited this? | PubMed ID: 19592617 | Fulltext

2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations.

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Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, Couture P, Dufour R, Fodor G, Francis GA, Grover S, Gupta M, Hegele RA, Lau DC, Leiter L, Lewis GF,

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The Canadian journal of cardiology 25(10):567-79, 2009 Oct - Who cited this? | PubMed ID: 19812802 | Fulltext

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?.

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Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC,

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PLoS genetics 5(10):e1000694, 2009 Oct - Who cited this? | PubMed ID: 19851442 | Fulltext

Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.

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Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, and Rutt BK

Circulation 120(7):592-9, 2009 Aug 18 - Who cited this? | PubMed ID: 19652086 | Fulltext

Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies.

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Kraus JP, Hasek J, Kozich V, Collard R, Venezia S, Janosíková B, Wang J, Stabler SP, Allen RH, Jakobs C, Finn CT, Chien YH, Hwu WL, Hegele RA, and Mudd SH

Molecular genetics and metabolism 97(4):250-9, 2009 Aug - Who cited this? | PubMed ID: 19428278 | Fulltext

Alternate day dosing of rosuvastatin: potential usefulness in statin-intolerant patients.

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Joy T and Hegele RA

The Canadian journal of cardiology 25(8):453, 2009 Aug - Who cited this? | PubMed ID: 19678415 | Fulltext

The end of the road for CETP inhibitors after torcetrapib?.

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Joy T and Hegele RA

Current opinion in cardiology 24(4):364-71, 2009 Jul - Who cited this? | PubMed ID: 19522058 | Fulltext

Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.

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Lanktree MB, Anand SS, Yusuf S, Hegele RA, and SHARE Investigators

Journal of lipid research 50(7):1487-96, 2009 Jul - Who cited this? | PubMed ID: 19299407 | Fulltext

Narrative review: statin-related myopathy.

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Joy TR and Hegele RA

Annals of internal medicine 150(12):858-68, 2009 Jun 16 - Who cited this? | PubMed ID: 19528564 | Fulltext

Hypertriglyceridemia: phenomics and genomics.

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Hegele RA and Pollex RL

Molecular and cellular biochemistry 326(1-2):35-43, 2009 Jun - Who cited this? | PubMed ID: 19130180 | Fulltext

Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes.

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Connelly PW, Zinman B, Maguire GF, Mamakeesick M, Harris SB, Hegele RA, Retnakaran R, and Hanley AJ

Journal of lipid research 50(6):1216-22, 2009 Jun - Who cited this? | PubMed ID: 19151417 | Fulltext

Carnitine palmitoyltransferase IA polymorphism P479L is common in Greenland Inuit and is associated with elevated plasma apolipoprotein A-I.

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Rajakumar C, Ban MR, Cao H, Young TK, Bjerregaard P, and Hegele RA

Journal of lipid research 50(6):1223-8, 2009 Jun - Who cited this? | PubMed ID: 19181627 | Fulltext

Predicting abdominal adipose tissue among women with familial partial lipodystrophy.

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Joy T, Kennedy BA, Al-Attar S, Rutt BK, and Hegele RA

Metabolism: clinical and experimental 58(6):828-34, 2009 Jun - Who cited this? | PubMed ID: 19375764 | Fulltext

Update on the genetics of stroke and cerebrovascular disease 2008.

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Dichgans M and Hegele RA

Stroke; a journal of cerebral circulation 40(5):e289-91, 2009 May - Who cited this? | PubMed ID: 19359634 | Fulltext

The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy.

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Khan NA, Hemmelgarn B, Herman RJ, Bell CM, Mahon JL, Leiter LA, Rabkin SW, Hill MD, Padwal R, Touyz RM, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Moe G, Prasad R,

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The Canadian journal of cardiology 25(5):287-98, 2009 May - Who cited this? | PubMed ID: 19417859 | Fulltext

Clinical field-strength MRI of amyloid plaques induced by low-level cholesterol feeding in rabbits.

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Ronald JA, Chen Y, Bernas L, Kitzler HH, Rogers KA, Hegele RA, and Rutt BK

Brain : a journal of neurology 132(Pt 5):1346-54, 2009 May - Who cited this? | PubMed ID: 19293239 | Fulltext

Comparison of gadofluorine-M and Gd-DTPA for noninvasive staging of atherosclerotic plaque stability using MRI.

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Ronald JA, Chen Y, Belisle AJ, Hamilton AM, Rogers KA, Hegele RA, Misselwitz B, and Rutt BK

Circulation. Cardiovascular imaging 2(3):226-34, 2009 May - Who cited this? | PubMed ID: 19808597 | Fulltext

Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR.

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Lanktree MB, Rajakumar C, Brunt JH, Koschinsky ML, Connelly PW, and Hegele RA

Journal of lipid research 50(4):768-72, 2009 Apr - Who cited this? | PubMed ID: 19060253 | Fulltext

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.

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Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, Jensen MK, Rimm EB, Wang J, Rodrigues A, Bamba V, Khetarpal SA, Wolfe ML, Derohannessian S, Li M, Reilly MP,

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The Journal of clinical investigation 119(4):1042-50, 2009 Apr - Who cited this? | PubMed ID: 19287092 | Fulltext

Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community.

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Ley SH, Harris SB, Mamakeesick M, Noon T, Fiddler E, Gittelsohn J, Wolever TM, Connelly PW, Hegele RA, Zinman B, and Hanley AJ

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 180(6):617-24, 2009 Mar 17 - Who cited this? | PubMed ID: 19289805 | Fulltext

Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada.

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Burman D, Mente A, Hegele RA, Islam S, Yusuf S, and Anand SS

Atherosclerosis 203(1):192-200, 2009 Mar - Who cited this? | PubMed ID: 18656198 | Fulltext

Novel LPL mutations associated with lipoprotein lipase deficiency: two case reports and a literature review.

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Rahalkar AR, Giffen F, Har B, Ho J, Morrison KM, Hill J, Wang J, Hegele RA, and Joy T

Canadian journal of physiology and pharmacology 87(3):151-60, 2009 Mar - Who cited this? | PubMed ID: 19295657 | Fulltext

Plasma lipoproteins: genetic influences and clinical implications.

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Hegele RA

Nature reviews. Genetics 10(2):109-21, 2009 Feb - Who cited this? | PubMed ID: 19139765 | Fulltext

A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems.

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Lahiry P, Wang J, Robinson JF, Turowec JP, Litchfield DW, Lanktree MB, Gloor GB, Puffenberger EG, Strauss KA, Martens MB, Ramsay DA, Rupar CA, Siu V, and Hegele RA

American journal of human genetics 84(2):134-47, 2009 Feb - Who cited this? | PubMed ID: 19185282 | Fulltext

Hoofbeats, zebras, and insights into insulin resistance.

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Hegele RA and Reue K

The Journal of clinical investigation 119(2):249-51, 2009 Feb - Who cited this? | PubMed ID: 19244606 | Fulltext

Triple X syndrome in a patient with partial lipodystrophy discovered using a high-density oligonucleotide microarray: a case report.

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Lanktree MB, Fantus IG, and Hegele RA

Journal of medical case reports 3:8867, 2009 - Who cited this? | PubMed ID: 19830242 | Fulltext

Predictors of mammographic density: insights gained from a novel regression analysis of a twin study.

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Dite GS, Gurrin LC, Byrnes GB, Stone J, Gunasekara A, McCredie MR, English DR, Giles GG, Cawson J, Hegele RA, Chiarelli AM, Yaffe MJ, Boyd NF, and Hopper JL

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 17(12):3474-81, 2008 Dec - Who cited this? | PubMed ID: 19064564 | Fulltext

Prevalence of reproductive abnormalities among women with familial partial lipodystrophy.

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Joy TR and Hegele RA

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 14(9):1126-32, 2008 Dec - Who cited this? | PubMed ID: 19158052 | Fulltext

Genetic testing for atherosclerosis risk: inevitability or pipe dream?.

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Lanktree M, Oh J, and Hegele RA

The Canadian journal of cardiology 24(11):851-4, 2008 Nov - Who cited this? | PubMed ID: 18987759 | Fulltext

Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area.

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Klein JH, Hegele RA, Hackam DG, Koschinsky ML, Huff MW, and Spence JD

Arteriosclerosis, thrombosis, and vascular biology 28(10):1851-6, 2008 Oct - Who cited this? | PubMed ID: 18599799 | Fulltext

Association of the FABP2 T54 variant with plasma triglycerides and insulin resistance in a multiethnic population.

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de Koning L, Merchant AT, Hegele RA, Xie C, Vuksan V, Teo K, Yusuf S, Anand SS, and Study of Health Assessment and Risk in Ethnic Groups investigators

Clinical chemistry 54(10):1742-4, 2008 Oct - Who cited this? | PubMed ID: 18824579 | Fulltext

Polygenic determinants of severe hypertriglyceridemia.

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Wang J, Ban MR, Zou GY, Cao H, Lin T, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, and Hegele RA

Human molecular genetics 17(18):2894-9, 2008 Sep 15 - Who cited this? | PubMed ID: 18596051 | Fulltext

APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia.

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Wang J, Ban MR, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, and Hegele RA

Nature clinical practice. Cardiovascular medicine, 2008 Sep 9 - Who cited this? | PubMed ID: 18779834 | Fulltext

Microsomal triglyceride transfer protein inhibition-friend or foe?.

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Joy TR and Hegele RA

Nature clinical practice. Cardiovascular medicine 5(8):506-8, 2008 Aug - Who cited this? | PubMed ID: 18506153 | Fulltext

Adipokines and incident type 2 diabetes in a canadian aborigine population: the sandy lake health and diabetes project.

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Ley SH, Harris SB, Connelly PW, Mamakeesick M, Gittelsohn J, Hegele RA, Retnakaran R, Zinman B, and Hanley AJ

Diabetes care 31(7):1410, 2008 Jul - Who cited this? | PubMed ID: 18339973 | Fulltext

The failure of torcetrapib: what have we learned?.

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Joy TR and Hegele RA

British journal of pharmacology, 2008 Jun 9 - Who cited this? | PubMed ID: 18536741 | Fulltext

Genetics of metabolic syndrome: is there a role for phenomics?.

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Joy T and Hegele RA

Current atherosclerosis reports 10(3):201, 2008 Jun - Who cited this? | PubMed ID: 18489847 | Fulltext

The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy.

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Khan NA, Hemmelgarn B, Herman RJ, Rabkin SW, McAlister FA, Bell CM, Touyz RM, Padwal R, Leiter LA, Mahon JL, Hill MD, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Arnold MO,

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The Canadian journal of cardiology 24(6):465, 2008 Jun - Who cited this? | PubMed ID: 18548143 | Fulltext

Emerging antidyslipidemic drugs.

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Pollex RL, Joy TR, and Hegele RA

Expert opinion on emerging drugs 13(2):363-81, 2008 Jun - Who cited this? | PubMed ID: 18537526 | Fulltext

Genetics of metabolic syndrome.

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Joy T, Lahiry P, Pollex RL, and Hegele RA

Current diabetes reports 8(2):141, 2008 Apr - Who cited this? | PubMed ID: 18445357 | Fulltext

Vascular calcifications in homozygote familial hypercholesterolemia.

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Awan Z, Alrasadi K, Francis GA, Hegele RA, McPherson R, Frohlich J, Valenti D, de Varennes B, Marcil M, Gagne C, Genest J, and Couture P

Arteriosclerosis, thrombosis, and vascular biology 28(4):777-85, 2008 Apr - Who cited this? | PubMed ID: 18239150 | Fulltext

Clinical and public health assessment of benefits and risks of statins in primary prevention of coronary events: resolved and unresolved issues.

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Moride Y, Hegele RA, Langer A, McPherson R, Miller DB, and Rinfret S

The Canadian journal of cardiology 24(4):293-300, 2008 Apr - Who cited this? | PubMed ID: 18401470 | Fulltext

An unusual case of severe hypertriglyceridemia and splenomegaly.

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Rahalkar AR, Wang J, Sirrs S, Dimmick J, Holmes D, Urquhart N, Hegele RA, and Mattman A

Clinical chemistry 54(3):606, 2008 Mar - Who cited this? | PubMed ID: 18310149 | Fulltext

Monogenic pediatric dyslipidemias: Classification, genetics and clinical spectrum.

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Rahalkar AR and Hegele RA

Molecular genetics and metabolism 93(3):282-94, 2008 Mar - Who cited this? | PubMed ID: 18023224 | Fulltext

Is raising HDL a futile strategy for atheroprotection?.

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Joy T and Hegele RA

Nature reviews. Drug discovery 7(2):143, 2008 Feb - Who cited this? | PubMed ID: 18239670 | Fulltext

Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency.

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Santos RD, Schaefer EJ, Asztalos BF, Polisecki E, Wang J, Hegele RA, Martinez LR, Miname MH, Rochitte CE, Da Luz PL, and Maranhão RC

Journal of lipid research 49(2):349-57, 2008 Feb - Who cited this? | PubMed ID: 17991756 | Fulltext

Update on the genetics of stroke and cerebrovascular disease 2007.

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Hegele RA and Dichgans M

Stroke; a journal of cerebral circulation 39(2):252-4, 2008 Feb - Who cited this? | PubMed ID: 18187682 | Fulltext

Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.

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Al-Attar SA, Pollex RL, Ban MR, Young TK, Bjerregaard P, Anand SS, Yusuf S, Zinman B, Harris SB, Hanley AJ, Connelly PW, Huff MW, and Hegele RA

Cardiovascular diabetology 7:5, 2008 - Who cited this? | PubMed ID: 18339204 | Fulltext

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