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Papers authored by Harrity T

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Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

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Zhang H, Ryono DE, Devasthale P, Wang W, O'Malley K, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Locke K, Zhang L, Lippy J, Kunselman L, Morgan N, Flynn N,

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Bioorganic & medicinal chemistry letters 19(5):1451-6, 2009 Mar 1 - Who cited this? | PubMed ID: 19201606 | Fulltext

(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with.

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Ahmad S, Madsen CS, Stein PD, Janovitz E, Huang C, Ngu K, Bisaha S, Kennedy LJ, Chen BC, Zhao R, Sitkoff D, Monshizadegan H, Yin X, Ryan CS, Zhang R, Giancarli M,

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Journal of medicinal chemistry 51(9):2722-33, 2008 May 8 - Who cited this? | PubMed ID: 18412317 | Fulltext

Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.

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Wang W, Devasthale P, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Kunselman L, Morgan N, Ponticiello R, Zebo R, Zhang L, Locke K, Lippy J, O'Malley K, Hosagrahara V,

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Bioorganic & medicinal chemistry letters 18(6):1939, 2008 Mar 15 - Who cited this? | PubMed ID: 18291645 | Fulltext

The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.

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Madsen CS, Janovitz E, Zhang R, Nguyen-Tran V, Ryan CS, Yin X, Monshizadegan H, Chang M, D'Arienzo C, Scheer S, Setters R, Search D, Chen X, Zhuang S, Kunselman L, Peters A,

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The Journal of pharmacology and experimental therapeutics 324(2):576-86, 2008 Feb - Who cited this? | PubMed ID: 17986646 | Fulltext

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

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Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL,

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Bioorganic & medicinal chemistry letters 17(12):3511-5, 2007 Jun 15 - Who cited this? | PubMed ID: 17502136 | Fulltext

2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.

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Li JJ, Wang H, Tino JA, Robl JA, Herpin TF, Lawrence RM, Biller S, Jamil H, Ponticiello R, Chen L, Chu CH, Flynn N, Cheng D, Zhao R, Chen B, Schnur D,

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Bioorganic & medicinal chemistry letters 17(11):3208-11, 2007 Jun 1 - Who cited this? | PubMed ID: 17383874 | Fulltext

The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.

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Tozzo E, Ponticiello R, Swartz J, Farrelly D, Zebo R, Welzel G, Egan D, Kunselman L, Peters A, Gu L, French M, Chen S, Devasthale P, Janovitz E, Staal A, Harrity T,

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The Journal of pharmacology and experimental therapeutics 321(1):107, 2007 Apr - Who cited this? | PubMed ID: 17259449 | Fulltext

Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.

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Harrity T, Farrelly D, Tieman A, Chu C, Kunselman L, Gu L, Ponticiello R, Cap M, Qu F, Shao C, Wang W, Zhang H, Fenderson W, Chen S, Devasthale P, Jeon Y,

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Diabetes 55(1):240-8, 2006 Jan - Who cited this? | PubMed ID: 16380499 | Fulltext

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

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Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R,

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Journal of medicinal chemistry 48(6):2248-50, 2005 Mar 24 - Who cited this? | PubMed ID: 15771468 | Fulltext

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

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Sulsky R, Robl JA, Biller SA, Harrity TW, Wetterau J, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 14(20):5067-70, 2004 Oct 18 - Who cited this? | PubMed ID: 15380200 | Fulltext

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.

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Magnin DR, Biller SA, Wetterau J, Robl JA, Dickson JK, Taunk P, Harrity TW, Lawrence RM, Sun CQ, Wang T, Logan J, Fryszman O, Connolly F, Jolibois K, and Kunselman L

Bioorganic & medicinal chemistry letters 13(7):1337-40, 2003 Apr 7 - Who cited this? | PubMed ID: 12657277 | Fulltext

The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity.

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Staal A, Frith JC, French MH, Swartz J, Güngör T, Harrity TW, Tamasi J, Rogers MJ, and Feyen JH

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 18(1):88-96, 2003 Jan - Who cited this? | PubMed ID: 12510809 | Fulltext

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

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Robl JA, Sulsky R, Sun CQ, Simpkins LM, Wang T, Dickson JK, Chen Y, Magnin DR, Taunk P, Slusarchyk WA, Biller SA, Lan SJ, Connolly F, Kunselman LK, Sabrah T, Jamil H,

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Journal of medicinal chemistry 44(6):851-6, 2001 Mar 15 - Who cited this? | PubMed ID: 11300866 | Fulltext

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

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Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois KG, Kunselman LK, Lan SJ, Maccagnan TJ, Ricci B, Yan M,

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Science (New York, N.Y.) 282(5389):751-4, 1998 Oct 23 - Who cited this? | PubMed ID: 9784135 | Fulltext

An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells.

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Jamil H, Gordon DA, Eustice DC, Brooks CM, Dickson JK, Chen Y, Ricci B, Chu CH, Harrity TW, Ciosek CP, Biller SA, Gregg RE, and Wetterau JR

Proceedings of the National Academy of Sciences of the United States of America 93(21):11991-5, 1996 Oct 15 - Who cited this? | PubMed ID: 8876250 | Fulltext

alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.

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Magnin DR, Biller SA, Chen Y, Dickson JK, Fryszman OM, Lawrence RM, Logan JV, Sieber-McMaster ES, Sulsky RB, Traeger SC, Hsieh DC, Lan SJ, Rinehart JK, Harrity TW, Jolibois KG, Kunselman LK,

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Journal of medicinal chemistry 39(3):657-60, 1996 Feb 2 - Who cited this? | PubMed ID: 8576905 | Fulltext

Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety.

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Dickson JK, Biller SA, Magnin DR, Petrillo EW, Hillyer JW, Hsieh DC, Lan SJ, Rinehart JK, Gregg RE, Harrity TW, Jolibois KG, Kalinowski SS, Kunselman LK, Mookhtiar KA, and Ciosek CP

Journal of medicinal chemistry 39(3):661-4, 1996 Feb 2 - Who cited this? | PubMed ID: 8576906 | Fulltext

1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate.

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Magnin DR, Biller SA, Dickson JK, Logan JV, Lawrence RM, Chen Y, Sulsky RB, Ciosek CP, Harrity TW, and Jolibois KG

Journal of medicinal chemistry 38(14):2596-605, 1995 Jul 7 - Who cited this? | PubMed ID: 7629799 | Fulltext

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo.

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Ciosek CP, Magnin DR, Harrity TW, Logan JV, Dickson JK, Gordon EM, Hamilton KA, Jolibois KG, Kunselman LK, and Lawrence RM

The Journal of biological chemistry 268(33):24832-7, 1993 Nov 25 - Who cited this? | PubMed ID: 8227045 | Fulltext

Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety.

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Robl JA, Duncan LA, Pluscec J, Karanewsky DS, Gordon EM, Ciosek CP, Rich LC, Dehmel VC, Slusarchyk DA, and Harrity TW

Journal of medicinal chemistry 34(9):2804-15, 1991 Sep - Who cited this? | PubMed ID: 1895299 | Fulltext

Isoprenyl phosphinylformates: new inhibitors of squalene synthetase.

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Biller SA, Forster C, Gordon EM, Harrity T, Rich LC, Marretta J, and Ciosek CP

Journal of medicinal chemistry 34(6):1912-4, 1991 Jun - Who cited this? | PubMed ID: 2061928 | Fulltext

Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.

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Karanewsky DS, Badia MC, Ciosek CP, Robl JA, Sofia MJ, Simpkins LM, DeLange B, Harrity TW, Biller SA, and Gordon EM

Journal of medicinal chemistry 33(11):2952-6, 1990 Nov - Who cited this? | PubMed ID: 2231594 | Fulltext

Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase.

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Biller SA, Forster C, Gordon EM, Harrity T, Scott WA, and Ciosek CP

Journal of medicinal chemistry 31(10):1869-71, 1988 Oct - Who cited this? | PubMed ID: 3172121 | Fulltext

Cartilage-associated collagenolytic activity in rabbits with antigen-induced chronic synovitis.

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Ciosek CP and Harrity TW

The Journal of laboratory and clinical medicine 96(3):460-9, 1980 Sep - Who cited this? | PubMed ID: 6249878 | Fulltext

Effects of antiinflammatory agents on the acute response of immune synovitis in rabbits.

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Goldlust MB, Rich LC, and Harrity TW

Arthritis and rheumatism 20(4):937-46, 1977 May - Who cited this? | PubMed ID: 871302 | Fulltext

Anti-complement effects of two anti-inflammatory agents. Niflumic and flufenamic acids.

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Harrity TW and Goldlust MB

Biochemical pharmacology 23(22):3107-20, 1974 Nov 15 - Who cited this? | PubMed ID: 4216354 | Fulltext

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