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Papers authored by Harkema J

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Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans.

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Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, Morishita M, Marsik FJ, Kamal AS, Kaciroti N, Harkema J, Corey P, Silverman F, Gold DR, Wellenius G, Mittleman MA,

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Hypertension 54(3):659-67, 2009 Sep - Who cited this? | PubMed ID: 19620518 | Fulltext

The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential.

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Li N, Wang M, Bramble LA, Schmitz DA, Schauer JJ, Sioutas C, Harkema JR, and Nel AE

Environmental health perspectives 117(7):1116-23, 2009 Jul - Who cited this? | PubMed ID: 19654922 | Fulltext

Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains.

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Yang C, Tan YS, Harkema JR, and Haslam SZ

Reproductive toxicology (Elmsford, N.Y.) 27(3-4):299-306, 2009 Jun - Who cited this? | PubMed ID: 19013232 | Fulltext

The role of parity status on cigarette smoke-induced modulation of anti-tumor immune mechanisms.

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Vancza EM, Ng SP, Harkema JR, and Zelikoff JT

Journal of immunotoxicology 6(2):94-103, 2009 Jun - Who cited this? | PubMed ID: 19589096 | Fulltext

Magnetic resonance imaging and computational fluid dynamics (CFD) simulations of rabbit nasal airflows for the development of hybrid CFD/PBPK models.

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Corley RA, Minard KR, Kabilan S, Einstein DR, Kuprat AP, Harkema JR, Kimbell JS, Gargas ML, and Kinzell JH

Inhalation toxicology 21(6):512-8, 2009 May - Who cited this? | PubMed ID: 19519151 | Fulltext

Comparative microarray analysis and pulmonary changes in brown norway rats exposed to ovalbumin and concentrated air particulates.

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Heidenfelder BL, Reif DM, Harkema JR, Cohen Hubal EA, Hudgens EE, Bramble LA, Wagner JG, Morishita M, Keeler GJ, Edwards SW, and Gallagher JE

Toxicological sciences : an official journal of the Society of Toxicology 108(1):207-21, 2009 Mar - Who cited this? | PubMed ID: 19176365 | Fulltext

Society of toxicologic pathology's 27th annual symposium presentations.

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Lin TY, Foley K, Ying W, Barsoum J, London C, Matsumoto I, Kouchi M, Okimoto K, Ueda T, Yamada T, Inoue T, Seki T, Hino O, Radi ZA, Metz A, Bruner R,

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Toxicologic pathology 37(1):123-54, 2009 - Who cited this? | PubMed ID: 19234236 | Fulltext

Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats.

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Wagner JG, Harkema JR, Jiang Q, Illek B, Ames BN, and Peden DB

Toxicologic pathology 37(4):481-91, 2009 - Who cited this? | PubMed ID: 19389874 | Fulltext

HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice.

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Saini Y, Harkema JR, and Lapres JJ

The Journal of biological chemistry, 2008 Sep 18 - Who cited this? | PubMed ID: 18801745 | Fulltext

Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma.

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Pestka JJ, Yike I, Dearborn DG, Ward MD, and Harkema JR

Toxicological sciences : an official journal of the Society of Toxicology 104(1):4-26, 2008 Jul - Who cited this? | PubMed ID: 18007011 | Fulltext

Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure.

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Amuzie CJ, Harkema JR, and Pestka JJ

Toxicology 248(1):39, 2008 Jun 3 - Who cited this? | PubMed ID: 18433975 | Fulltext

Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice.

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Mall MA, Harkema JR, Trojanek JB, Treis D, Livraghi A, Schubert S, Zhou Z, Kreda SM, Tilley SL, Hudson EJ, O'Neal WK, and Boucher RC

American journal of respiratory and critical care medicine 177(7):730-42, 2008 Apr 1 - Who cited this? | PubMed ID: 18079494 | Fulltext

Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress.

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Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, and Nel AE

Circulation research 102(5):589, 2008 Mar 14 - Who cited this? | PubMed ID: 18202315 | Fulltext

Comparative Toxicogenomic Examination of the Hepatic Effects of PCB126 and TCDD in Immature, Ovariectomized C57BL/6 Mice.

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Kopec AK, Boverhof DR, Burgoon LD, Ibrahim-Aibo D, Harkema JR, Tashiro C, Chittim B, and Zacharewski TR

Toxicological sciences : an official journal of the Society of Toxicology 102(1):61-75, 2008 Mar - Who cited this? | PubMed ID: 18042819 | Fulltext

Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma.

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Wagner JG, Jiang Q, Harkema JR, Ames BN, Illek B, Roubey RA, and Peden DB

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 38(3):501-11, 2008 Mar - Who cited this? | PubMed ID: 17970781 | Fulltext

Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of {Delta}9-tetrahydrocannabinol.

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Buchweitz JP, Karmaus PW, Williams KJ, Harkema JR, and Kaminski NE

Journal of leukocyte biology 83(3):785-96, 2008 Mar - Who cited this? | PubMed ID: 18073275 | Fulltext

Role of neutrophils in preventing and resolving acute fungal sinusitis.

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Rodriguez TE, Falkowski NR, Harkema JR, and Huffnagle GB

Infection and immunity 75(12):5663-8, 2007 Dec - Who cited this? | PubMed ID: 17875637 | Fulltext

Modulation of airway responses to influenza A/PR/8/34 by Delta9-tetrahydrocannabinol in C57BL/6 mice.

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Buchweitz JP, Karmaus PW, Harkema JR, Williams KJ, and Kaminski NE

The Journal of pharmacology and experimental therapeutics 323(2):675-83, 2007 Nov - Who cited this? | PubMed ID: 17726158 | Fulltext

Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol.

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Wagner JG, Jiang Q, Harkema JR, Illek B, Patel DD, Ames BN, and Peden DB

Free radical biology & medicine 43(8):1176-88, 2007 Oct 15 - Who cited this? | PubMed ID: 17854713 | Fulltext

Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure.

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Islam Z, Amuzie CJ, Harkema JR, and Pestka JJ

Toxicological sciences : an official journal of the Society of Toxicology 98(2):526, 2007 Aug - Who cited this? | PubMed ID: 17483119 | Fulltext

Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice.

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Rockx B, Sheahan T, Donaldson E, Harkema J, Sims A, Heise M, Pickles R, Cameron M, Kelvin D, and Baric R

Journal of virology 81(14):7410, 2007 Jul - Who cited this? | PubMed ID: 17507479 | Fulltext

Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene.

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Pottenger LH, Malley LA, Bogdanffy MS, Donner EM, Upton PB, Li Y, Walker VE, Harkema JR, Banton MI, and Swenberg JA

Toxicological sciences : an official journal of the Society of Toxicology 97(2):336-47, 2007 Jun - Who cited this? | PubMed ID: 17341482 | Fulltext

Rodent models of allergic rhinitis: relevance to human pathophysiology.

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Wagner JG and Harkema JR

Current allergy and asthma reports 7(2):134-40, 2007 May - Who cited this? | PubMed ID: 17437684 | Fulltext

Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection.

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Li M, Harkema JR, Cuff CF, and Pestka JJ

Toxicological sciences : an official journal of the Society of Toxicology 95(2):412, 2007 Feb - Who cited this? | PubMed ID: 17090620 | Fulltext

Characterization of urban atmospheres during inhalation exposure studies in Detroit and Grand Rapids, Michigan.

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Keeler GJ, Morishita M, Wagner JG, and Harkema JR

Toxicologic pathology 35(1):15-22, 2007 - Who cited this? | PubMed ID: 17325968 | Fulltext

Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques.

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Carey SA, Minard KR, Trease LL, Wagner JG, Garcia GJ, Ballinger CA, Kimbell JS, Plopper CG, Corley RA, Postlethwait EM, Harkema JR, and Einstein DR

Toxicologic pathology 35(1):27-40, 2007 - Who cited this? | PubMed ID: 17325970 | Fulltext

Use of pre-operative Tc99m-Sestamibi scintigraphy and intraoperative parathyroid hormone monitoring to eliminate neck exploration in mediastinal parathyroid adenocarcinoma.

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Damadi A, Harkema J, Kareti R, and Saxe A

Journal of surgical education 64(2):108-12, 2007 - Who cited this? | PubMed ID: 17462212 | Fulltext

Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice.

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Buchweitz JP, Harkema JR, and Kaminski NE

Toxicologic pathology 35(3):424-35, 2007 - Who cited this? | PubMed ID: 17487773 | Fulltext

An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut.

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Birmingham NP, Parvataneni S, Hassan HM, Harkema J, Samineni S, Navuluri L, Kelly CJ, and Gangur V

International archives of allergy and immunology 144(3):203-10, 2007 - Who cited this? | PubMed ID: 17570928 | Fulltext

Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants.

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Deming D, Sheahan T, Heise M, Yount B, Davis N, Sims A, Suthar M, Harkema J, Whitmore A, Pickles R, West A, Donaldson E, Curtis K, Johnston R, and Baric R

PLoS medicine 3(12), 2006 Dec - Who cited this? | PubMed ID: 17194199 | Fulltext

Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice.

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Boverhof DR, Burgoon LD, Tashiro C, Sharratt B, Chittim B, Harkema JR, Mendrick DL, and Zacharewski TR

Toxicological sciences : an official journal of the Society of Toxicology 94(2):398, 2006 Dec - Who cited this? | PubMed ID: 16960034 | Fulltext

A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black.

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Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, and Oberdorster G

Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 48(12):1265-78, 2006 Dec - Who cited this? | PubMed ID: 17159643 | Fulltext

T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis.

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Li M, Harkema JR, Islam Z, Cuff CF, and Pestka JJ

Toxicology and applied pharmacology 217(1):76-85, 2006 Nov 15 - Who cited this? | PubMed ID: 17005225 | Fulltext

Airway inflammation is associated with mucous cell metaplasia and increased intraepithelial stored mucosubstances in horses.

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Lugo J, Harkema JR, deFeijter-Rupp H, Bartner L, Boruta D, and Robinson NE

Veterinary journal (London, England : 1997) 172(2):293-301, 2006 Sep - Who cited this? | PubMed ID: 15925524 | Fulltext

Topical application versus intranasal instillation: a qualitative comparison of the effect of the route of sensitization on trimellitic anhydride-induced allergic rhinitis in A/J mice.

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Farraj AK, Harkema JR, and Kaminski NE

Toxicological sciences : an official journal of the Society of Toxicology 92(1):321, 2006 Jul - Who cited this? | PubMed ID: 16611626 | Fulltext

Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain.

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Islam Z, Harkema JR, and Pestka JJ

Environmental health perspectives 114(7):1099-107, 2006 Jul - Who cited this? | PubMed ID: 16835065 | Fulltext

Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease.

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Sirivelu MP, MohanKumar SM, Wagner JG, Harkema JR, and MohanKumar PS

Environmental health perspectives 114(6):870-4, 2006 Jun - Who cited this? | PubMed ID: 16759987 | Fulltext

The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium.

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Harkema JR, Carey SA, and Wagner JG

Toxicologic pathology 34(3):252-69, 2006 - Who cited this? | PubMed ID: 16698724 | Fulltext

Design-based sampling and quantitation of the respiratory airways.

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Hyde DM, Harkema JR, Tyler NK, and Plopper CG

Toxicologic pathology 34(3):286-95, 2006 - Who cited this? | PubMed ID: 16698728 | Fulltext

Protection of early phase hepatic ischemia-reperfusion injury by cholinergic agonists.

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Crockett ET, Galligan JJ, Uhal BD, Harkema J, Roth R, and Pandya K

BMC clinical pathology 6:3, 2006 - Who cited this? | PubMed ID: 16480493 | Fulltext

Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology.

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Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, and Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology 88(2):614-29, 2005 Dec - Who cited this? | PubMed ID: 16177241 | Fulltext

A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling.

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Kwekel JC, Burgoon LD, Burt JW, Harkema JR, and Zacharewski TR

Physiological genomics 23(3):327-42, 2005 Nov 17 - Who cited this? | PubMed ID: 16174780 | Fulltext

Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and biogenic substances: enhancement of toxicant-induced airway injury.

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Harkema JR and Wagner JG

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 57 Suppl 1:129-41, 2005 Jul - Who cited this? | PubMed ID: 16092720 | Fulltext

Experimental Assessment of the Toxicological Effects of Inhaled Complex Mixtures on the Respiratory System, 23-25 April 2005, Barcelona, Spain. Summary and conclusions of the review committee.

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Aufderheide M, Costa DL, Devlin R, Feron V, Harkema JR, Hayashi Y, Pauluhn J, and Spielmann H

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 57 Suppl 1:239-43, 2005 Jul - Who cited this? | PubMed ID: 16092732 | Fulltext

Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity.

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Boverhof DR, Burgoon LD, Tashiro C, Chittim B, Harkema JR, Jump DB, and Zacharewski TR

Toxicological sciences : an official journal of the Society of Toxicology 85(2):1048-63, 2005 Jun - Who cited this? | PubMed ID: 15800033 | Fulltext

Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium.

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Harris JF, Fischer MJ, Hotchkiss JR, Monia BP, Randell SH, Harkema JR, and Tesfaigzi Y

American journal of respiratory and critical care medicine 171(7):764, 2005 Apr 1 - Who cited this? | PubMed ID: 15618464 | Fulltext

Assessing the competencies in general surgery residency training.

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Anderson CI, Jentz AB, Harkema JM, Kareti LR, Apelgren KN, and Slomski CA

American journal of surgery 189(3):288-92, 2005 Mar - Who cited this? | PubMed ID: 15792752 | Fulltext

Assessing the competencies in general surgery residency training.

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Anderson CI, Jentz AB, Kareti LR, Harkema JM, Apelgren KN, and Slomski CA

Current surgery 62(1):111-6, 2005 - Who cited this? | PubMed ID: 15708161 | Fulltext

Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.

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Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, and Basbaum C

The Journal of biological chemistry 279(37):39085-93, 2004 Sep 10 - Who cited this? | PubMed ID: 15262961 | Fulltext

Pulmonary retention of particulate matter is associated with airway inflammation in allergic rats exposed to air pollution in urban Detroit.

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Morishita M, Keeler G, Wagner J, Marsik F, Timm E, Dvonch J, and Harkema J

Inhalation toxicology 16(10):663-74, 2004 Sep - Who cited this? | PubMed ID: 15371055 | Fulltext

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