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Papers authored by Hardy JA

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Comparing spatial maps of human population-genetic variation using procrustes analysis.

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Wang C, Szpiech ZA, Degnan JH, Jakobsson M, Pemberton TJ, Hardy JA, Singleton AB, and Rosenberg NA

Statistical applications in genetics and molecular biology 9(1):Article13, 2010 - Who cited this? | PubMed ID: 20196748 | Fulltext

Genome-wide association study reveals genetic risk underlying Parkinson's disease.

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Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M,

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Nature genetics 41(12):1308-12, 2009 Dec - Who cited this? | PubMed ID: 19915575 | Fulltext

Differential DJ-1 gene expression in Parkinson's disease.

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Kumaran R, Vandrovcova J, Luk C, Sharma S, Renton A, Wood NW, Hardy JA, Lees AJ, and Bandopadhyay R

Neurobiology of disease 36(2):393-400, 2009 Nov - Who cited this? | PubMed ID: 19716892 | Fulltext

Candidate gene polymorphisms for ischemic stroke.

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Matarin M, Brown WM, Dena H, Britton A, De Vrieze FW, Brott TG, Brown RD, Worrall BB, Case LD, Chanock SJ, Metter EJ, Ferruci L, Gamble D, Hardy JA, Rich SS, Singleton A,

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Stroke; a journal of cerebral circulation 40(11):3436-42, 2009 Nov - Who cited this? | PubMed ID: 19729601 | Fulltext

Robust production of a peptide library using methodological synchronization.

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Huber KL, Olson KD, and Hardy JA

Protein expression and purification 67(2):139-47, 2009 Oct - Who cited this? | PubMed ID: 19457455 | Fulltext

Dissecting an allosteric switch in caspase-7 using chemical and mutational probes.

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Hardy JA and Wells JA

The Journal of biological chemistry 284(38):26063-9, 2009 Sep 18 - Who cited this? | PubMed ID: 19581639 | Fulltext

L2' loop is critical for caspase-7 active site formation.

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Witkowski WA and Hardy JA

Protein science : a publication of the Protein Society 18(7):1459-68, 2009 Jul - Who cited this? | PubMed ID: 19530232 | Fulltext

SNCA variants are associated with increased risk for multiple system atrophy.

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Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S,

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Annals of neurology 65(5):610-4, 2009 May - Who cited this? | PubMed ID: 19475667 | Fulltext

Genotype-imputation accuracy across worldwide human populations.

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Huang L, Li Y, Singleton AB, Hardy JA, Abecasis G, Rosenberg NA, and Scheet P

American journal of human genetics 84(2):235-50, 2009 Feb - Who cited this? | PubMed ID: 19215730 | Fulltext

Locus homogeneity between syndactyly type 1A and craniosynostosis Philadelphia type?.

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Jain M, Wallis D, Robin NH, De Vrieze FW, Hardy JA, Ghadami M, Bosse K, Betz RC, Nöthen MM, Arcos-Burgos M, and Muenke M

American journal of medical genetics. Part A 146A(17):2308-11, 2008 Sep 1 - Who cited this? | PubMed ID: 18680190 | Fulltext

Structural genomic variation in ischemic stroke.

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Matarin M, Simon-Sanchez J, Fung HC, Scholz S, Gibbs JR, Hernandez DG, Crews C, Britton A, Wavrant De Vrieze F, Brott TG, Brown RD, Worrall BB, Silliman S, Case LD, Hardy JA, Rich SS,

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Neurogenetics 9(2):101, 2008 May - Who cited this? | PubMed ID: 18288507 | Fulltext

Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21.

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Matarin M, Brown WM, Singleton A, Hardy JA, Meschia JF, and ISGS investigators

Stroke; a journal of cerebral circulation 39(5):1586-9, 2008 May - Who cited this? | PubMed ID: 18340101 | Fulltext

Genotype, haplotype and copy-number variation in worldwide human populations.

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Jakobsson M, Scholz SW, Scheet P, Gibbs JR, VanLiere JM, Fung HC, Szpiech ZA, Degnan JH, Wang K, Guerreiro R, Bras JM, Schymick JC, Hernandez DG, Traynor BJ, Simon-Sanchez J, Matarin M,

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Nature 451(7181):998, 2008 Feb 21 - Who cited this? | PubMed ID: 18288195 | Fulltext

Association of integrin alpha2 gene variants with ischemic stroke.

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Matarin M, Brown WM, Hardy JA, Rich SS, Singleton AB, Brown RD, Brott TG, Worrall BB, and Meschia JF

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 28(1):81-9, 2008 Jan - Who cited this? | PubMed ID: 17534386 | Fulltext

A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.

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Matarín M, Brown WM, Scholz S, Simón-Sánchez J, Fung HC, Hernandez D, Gibbs JR, De Vrieze FW, Crews C, Britton A, Langefeld CD, Brott TG, Brown RD, Worrall BB, Frankel M, Silliman S,

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Lancet neurology 6(5):414-20, 2007 May - Who cited this? | PubMed ID: 17434096 | Fulltext

Lack of aggregation of ischemic stroke subtypes within affected sibling pairs.

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Wiklund PG, Brown WM, Brott TG, Stegmayr B, Brown RD, Nilsson-Ardnor S, Hardy JA, Kissela BM, Singleton A, Holmberg D, Rich SS, and Meschia JF

Neurology 68(6):427-31, 2007 Feb 6 - Who cited this? | PubMed ID: 17283317 | Fulltext

Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.

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Fung HC, Scholz S, Matarin M, Simón-Sánchez J, Hernandez D, Britton A, Gibbs JR, Langefeld C, Stiegert ML, Schymick J, Okun MS, Mandel RJ, Fernandez HH, Foote KD, Rodríguez RL, Peckham E,

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Lancet neurology 5(11):911-6, 2006 Nov - Who cited this? | PubMed ID: 17052657 | Fulltext

Support for association between ADHD and two candidate genes: NET1 and DRD1.

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Bobb AJ, Addington AM, Sidransky E, Gornick MC, Lerch JP, Greenstein DK, Clasen LS, Sharp WS, Inoff-Germain G, Wavrant-De Vrièze F, Arcos-Burgos M, Straub RE, Hardy JA, Castellanos FX, and Rapoport JL

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 134(1):67-72, 2005 Apr 5 - Who cited this? | PubMed ID: 15717291 | Fulltext

Correlation of proband and sibling stroke latency: the SWISS Study.

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Meschia JF, Brott TG, Brown RD, Kissela BM, Hardy JA, Brown WM, Rich SS, and Siblings With Ischemic Stroke Study Investigators

Neurology 64(6):1061-3, 2005 Mar 22 - Who cited this? | PubMed ID: 15781828 | Fulltext

Searching for new allosteric sites in enzymes.

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Hardy JA and Wells JA

Current opinion in structural biology 14(6):706-15, 2004 Dec - Who cited this? | PubMed ID: 15582395 | Fulltext

Dementia with Lewy bodies: no association of polymorphisms in the human synphilin gene.

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Busby J, O'Brien KK, Gibson AM, McKeith IG, Perry RH, Hardy JA, Singleton AB, and Morris CM

Neurogenetics 5(4):251-2, 2004 Dec - Who cited this? | PubMed ID: 15490287 | Fulltext

Discovery of an allosteric site in the caspases.

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Hardy JA, Lam J, Nguyen JT, O'Brien T, and Wells JA

Proceedings of the National Academy of Sciences of the United States of America 101(34):12461, 2004 Aug 24 - Who cited this? | PubMed ID: 15314233 | Fulltext

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.

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Bandopadhyay R, Kingsbury AE, Cookson MR, Reid AR, Evans IM, Hope AD, Pittman AM, Lashley T, Canet-Aviles R, Miller DW, McLendon C, Strand C, Leonard AJ, Abou-Sleiman PM, Healy DG, Ariga H,

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Brain : a journal of neurology 127(Pt 2):420-30, 2004 Feb - Who cited this? | PubMed ID: 14662519 | Fulltext

Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease.

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Morris CM, O'Brien KK, Gibson AM, Hardy JA, and Singleton AB

Neuroscience letters 352(2):151-3, 2003 Dec 4 - Who cited this? | PubMed ID: 14625045 | Fulltext

Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.

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Maraganore DM, Farrer MJ, Lesnick TG, de Andrade M, Bower JH, Hernandez D, Hardy JA, and Rocca WA

Movement disorders : official journal of the Movement Disorder Society 18(11):1233-9, 2003 Nov - Who cited this? | PubMed ID: 14639662 | Fulltext

Parkin variants in North American Parkinson's disease: cases and controls.

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Lincoln SJ, Maraganore DM, Lesnick TG, Bounds R, de Andrade M, Bower JH, Hardy JA, and Farrer MJ

Movement disorders : official journal of the Movement Disorder Society 18(11):1306-11, 2003 Nov - Who cited this? | PubMed ID: 14639672 | Fulltext

APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.

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Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, and Sambamurti K

Biochemical and biophysical research communications 305(3):502-9, 2003 Jun 6 - Who cited this? | PubMed ID: 12763021 | Fulltext

Complex interactions in Parkinson's disease: a two-phased approach.

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Maraganore DM, de Andrade M, Lesnick TG, Farrer MJ, Bower JH, Hardy JA, and Rocca WA

Movement disorders : official journal of the Movement Disorder Society 18(6):631-6, 2003 Jun - Who cited this? | PubMed ID: 12784265 | Fulltext

Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease.

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Goudreau JL, Maraganore DM, Farrer MJ, Lesnick TG, Singleton AB, Bower JH, Hardy JA, and Rocca WA

Movement disorders : official journal of the Movement Disorder Society 17(6):1305-11, 2002 Nov - Who cited this? | PubMed ID: 12465073 | Fulltext

Functional association of the parkin gene promoter with idiopathic Parkinson's disease.

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West AB, Maraganore D, Crook J, Lesnick T, Lockhart PJ, Wilkes KM, Kapatos G, Hardy JA, and Farrer MJ

Human molecular genetics 11(22):2787-92, 2002 Oct 15 - Who cited this? | PubMed ID: 12374768 | Fulltext

Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease.

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Maraganore DM, Farrer MJ, McDonnell SK, Elbaz A, Schaid DJ, Hardy JA, and Rocca WA

Movement disorders : official journal of the Movement Disorder Society 17(3):509-12, 2002 May - Who cited this? | PubMed ID: 12112198 | Fulltext

Case-Control study of the extended tau gene haplotype in Parkinson's disease.

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Maraganore DM, Hernandez DG, Singleton AB, Farrer MJ, McDonnell SK, Hutton ML, Hardy JA, and Rocca WA

Annals of neurology 50(5):658-61, 2001 Nov - Who cited this? | PubMed ID: 11706972 | Fulltext

The wing in yeast heat shock transcription factor (HSF) DNA-binding domain is required for full activity.

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Cicero MP, Hubl ST, Harrison CJ, Littlefield O, Hardy JA, and Nelson HC

Nucleic acids research 29(8):1715, 2001 Apr 15 - Who cited this? | PubMed ID: 11292844 | Fulltext

Proline in alpha-helical kink is required for folding kinetics but not for kinked structure, function, or stability of heat shock transcription factor.

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Hardy JA and Nelson HC

Protein science : a publication of the Protein Society 9(11):2128-41, 2000 Nov - Who cited this? | PubMed ID: 11305238 | Fulltext

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease.

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Maraganore DM, Farrer MJ, Hardy JA, McDonnell SK, Schaid DJ, and Rocca WA

Movement disorders : official journal of the Movement Disorder Society 15(4):714-9, 2000 Jul - Who cited this? | PubMed ID: 10928584 | Fulltext

Role of an alpha-helical bulge in the yeast heat shock transcription factor.

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Hardy JA, Walsh ST, and Nelson HC

Journal of molecular biology 295(3):393-409, 2000 Jan 21 - Who cited this? | PubMed ID: 10623534 | Fulltext

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.

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Maraganore DM, Farrer MJ, Hardy JA, Lincoln SJ, McDonnell SK, and Rocca WA

Neurology 53(8):1858-60, 1999 Nov 10 - Who cited this? | PubMed ID: 10563640 | Fulltext

The effect of iron binding on the ability of crocidolite asbestos to catalyze DNA single-strand breaks.

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Hardy JA and Aust AE

Carcinogenesis 16(2):319-25, 1995 Feb - Who cited this? | PubMed ID: 7859364 | Fulltext

A physical map of the human APP gene in YACs.

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Rooke K, Talbot C, James L, Anand R, Hardy JA, and Goate AM

Mammalian genome : official journal of the International Mammalian Genome Society 4(11):662-9, 1993 Nov - Who cited this? | PubMed ID: 8281016 | Fulltext

Alzheimer's disease: the amyloid cascade hypothesis.

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Hardy JA and Higgins GA

Science (New York, N.Y.) 256(5054):184-5, 1992 Apr 10 - Who cited this? | PubMed ID: 1566067 | Fulltext

A polymorphic microsatellite repeat sequence on chromosome 21 (D21S80).

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Owen MJ, Goate AM, and Hardy JA

Nucleic acids research 19(16):4574, 1991 Aug 25 - Who cited this? | PubMed ID: 1886795 | Fulltext

Hereditary cerebral hemorrhage with amyloidosis--Dutch type: its importance for Alzheimer research.

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Haan J, Hardy JA, and Roos RA

Trends in neurosciences 14(6):231-4, 1991 Jun - Who cited this? | PubMed ID: 1716015 | Fulltext

Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.

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van Duijn CM, Hendriks L, Cruts M, Hardy JA, Hofman A, and Van Broeckhoven C

Lancet 337(8747):978, 1991 Apr 20 - Who cited this? | PubMed ID: 1678057 | Fulltext

Evidence for allelic heterogeneity in familial early-onset Alzheimer's disease.

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van Duijn CM, van Broeckhoven C, Hardy JA, Goate AM, Rossor MN, Vandenberghe A, Martin JJ, Hofman A, and Mullan MJ

The British journal of psychiatry : the journal of mental science 158:471-4, 1991 Apr - Who cited this? | PubMed ID: 2054561 | Fulltext

The multipoint genetic mapping of mouse chromosome 16.

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Irving NG, Hardy JA, and Brown SD

Genomics 9(2):386-9, 1991 Feb - Who cited this? | PubMed ID: 1672298 | Fulltext

Clinical and pathologic features of chromosome 21-linked familial Alzheimer's disease.

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Mullan MJ, Giuffra L, Hardy JA, Ovenstone I, Haynes AR, James LA, Williamson R, Newton PJ, Owen MJ, and Roques P

Annals of the New York Academy of Sciences 640:177-80, 1991 - Who cited this? | PubMed ID: 1776736 | Fulltext

Increased tau messenger RNA in Alzheimer's disease hippocampus.

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Barton AJ, Harrison PJ, Najlerahim A, Heffernan J, McDonald B, Robinson JR, Davies DC, Harrison WJ, Mitra P, and Hardy JA

The American journal of pathology 137(3):497-502, 1990 Sep - Who cited this? | PubMed ID: 2119143 | Fulltext

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).

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Van Broeckhoven C, Haan J, Bakker E, Hardy JA, Van Hul W, Wehnert A, Vegter-Van der Vlis M, and Roos RA

Science (New York, N.Y.) 248(4959):1120-2, 1990 Jun 1 - Who cited this? | PubMed ID: 1971458 | Fulltext

Glutamatergic neurotransmission in Alzheimer's disease.

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Cowburn RF, Hardy JA, and Roberts PJ

Biochemical Society transactions 18(3):390-2, 1990 Jun - Who cited this? | PubMed ID: 2164981 | Fulltext

D21S194, a jump clone from D21S16.

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Walker AP, Collins FS, Siddique T, Yamaoka LH, Herbstreith MH, Pericak-Vance MA, Secore SL, Hung WY, Goate AM, and Hardy JA

Nucleic acids research 18(7):1931, 1990 Apr 11 - Who cited this? | PubMed ID: 1970875 | Fulltext

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