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Papers authored by Harder DR

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Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion.

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Cao S, Wang LC, Kwansa H, Roman RJ, Harder DR, and Koehler RC

American journal of physiology. Regulatory, integrative and comparative physiology 296(5):R1412-8, 2009 May - Who cited this? | PubMed ID: 19261918 | Fulltext

Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion.

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Renic M, Klaus JA, Omura T, Kawashima N, Onishi M, Miyata N, Koehler RC, Harder DR, and Roman RJ

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 29(3):629-39, 2009 Mar - Who cited this? | PubMed ID: 19107134 | Fulltext

Astrocytes and the regulation of cerebral blood flow.

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Koehler RC, Roman RJ, and Harder DR

Trends in neurosciences 32(3):160-9, 2009 Mar - Who cited this? | PubMed ID: 19162338 | Fulltext

Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats.

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Dunn KM, Renic M, Flasch AK, Harder DR, Falck J, and Roman RJ

American journal of physiology. Heart and circulatory physiology 295(6):H2455-65, 2008 Dec - Who cited this? | PubMed ID: 18952718 | Fulltext

Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism.

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Stowe DF, Camara AK, Heisner JS, Aldakkak M, and Harder DR

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 27(9):1008-15, 2008 Sep - Who cited this? | PubMed ID: 18765194 | Fulltext

Increased blood pressure in mice lacking cytochrome P450 2J5.

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Athirakul K, Bradbury Dagger JA, Graves JP, Degraff LM, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, Korach KS,

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The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008 Aug 20 - Who cited this? | PubMed ID: 18716027 | Fulltext

The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.

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Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, and Miura H

The Journal of clinical investigation, 2008 Aug 7 - Who cited this? | PubMed ID: 18688283 | Fulltext

Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex.

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Liu X, Li C, Falck JR, Roman RJ, Harder DR, and Koehler RC

American journal of physiology. Heart and circulatory physiology 295(2), 2008 Aug - Who cited this? | PubMed ID: 18502903 | Fulltext

Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme.

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Zagorac D, Jakovcevic D, Gebremedhin D, and Harder DR

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 28(8):1431-9, 2008 Aug - Who cited this? | PubMed ID: 18414496 | Fulltext

Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes.

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Prasad VV, Nithipatikom K, and Harder DR

Neurochemistry international, 2008 Jul 16 - Who cited this? | PubMed ID: 18680775 | Fulltext

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of {beta}-endorphin and Met-enkephalin in the rat ventrolateral periaqueductal gray.

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Terashvili M, Tseng LF, Wu HE, Narayanan J, Hart LM, Falck JR, Pratt PF, and Harder DR

The Journal of pharmacology and experimental therapeutics, 2008 May 20 - Who cited this? | PubMed ID: 18492947 | Fulltext

Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex.

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Shi Y, Liu X, Gebremedhin D, Falck JR, Harder DR, and Koehler RC

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 28(1):111-25, 2008 Jan - Who cited this? | PubMed ID: 17519974 | Fulltext

Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells.

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Gebremedhin D, Yamaura K, and Harder DR

American journal of physiology. Heart and circulatory physiology 294(1):H107-20, 2008 Jan - Who cited this? | PubMed ID: 17906097 | Fulltext

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat.

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Terashvili M, Wu HE, Moore RM, Harder DR, and Tseng LF

European journal of pharmacology 571(1):1-7, 2007 Sep 24 - Who cited this? | PubMed ID: 17597599 | Fulltext

Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution.

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Stowe DF, Camara AK, Heisner JS, Aldakkak M, and Harder DR

American journal of physiology. Heart and circulatory physiology 293(1):H895-901, 2007 Jul - Who cited this? | PubMed ID: 17434975 | Fulltext

Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response.

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Thomas S, Kotamraju S, Zielonka J, Harder DR, and Kalyanaraman B

Free radical biology & medicine 42(7):1049-61, 2007 Apr 1 - Who cited this? | PubMed ID: 17349932 | Fulltext

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

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Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, and Pratt PF

Prostaglandins & other lipid mediators 82(1-4):19-29, 2007 Jan - Who cited this? | PubMed ID: 17164129 | Fulltext

Role of astrocytes in matching blood flow to neuronal activity.

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Jakovcevic D and Harder DR

Current topics in developmental biology 79:75-97, 2007 - Who cited this? | PubMed ID: 17498548 | Fulltext

Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+ -activated K+ channel current in cultured rat hippocampal astrocytes.

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Yamaura K, Gebremedhin D, Zhang C, Narayanan J, Hoefert K, Jacobs ER, Koehler RC, and Harder DR

Neuroscience 143(3):703-16, 2006 Dec - Who cited this? | PubMed ID: 17027168 | Fulltext

Reactive oxygen species cerebral autoregulation in health and disease.

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Terashvili M, Pratt PF, Gebremedhin D, Narayanan J, and Harder DR

Pediatric clinics of North America 53(5):1029-37, xi, 2006 Oct - Who cited this? | PubMed ID: 17027622 | Fulltext

Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and disease.

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Iadecola C, Goldman SS, Harder DR, Heistad DD, Katusic ZS, Moskowitz MA, Simard JM, Sloan MA, Traystman RJ, and Velletri PA

Stroke; a journal of cerebral circulation 37(6):1578, 2006 Jun - Who cited this? | PubMed ID: 16627792 | Fulltext

Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury.

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Omura T, Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, Hachiuma K, Minagawa T, Susumu T, Yoshida S, Nakaike S, Okuyama S, Harder DR, and Roman RJ

Stroke; a journal of cerebral circulation 37(5):1307, 2006 May - Who cited this? | PubMed ID: 16601220 | Fulltext

Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.

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Harder DR and Roman RJ

Circulation research 98(7):866, 2006 Apr 14 - Who cited this? | PubMed ID: 16614311 | Fulltext

Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH.

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Takeuchi K, Miyata N, Renic M, Harder DR, and Roman RJ

American journal of physiology. Regulatory, integrative and comparative physiology 290(1):R84-9, 2006 Jan - Who cited this? | PubMed ID: 16166205 | Fulltext

Role of astrocytes in cerebrovascular regulation.

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Koehler RC, Gebremedhin D, and Harder DR

Journal of applied physiology (Bethesda, Md. : 1985) 100(1):307-17, 2006 Jan - Who cited this? | PubMed ID: 16357084 | Fulltext

Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage.

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Hacein-Bey L, Harder DR, Meier HT, Varelas PN, Miyata N, Lauer KK, Cusick JF, and Roman RJ

AJNR. American journal of neuroradiology 27(6):1350-4, 2006 - Who cited this? | PubMed ID: 16775295 | Fulltext

The effect of superoxide anion on autoregulation of cerebral blood flow.

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Zagorac D, Yamaura K, Zhang C, Roman RJ, and Harder DR

Stroke; a journal of cerebral circulation 36(12):2589-94, 2005 Dec - Who cited this? | PubMed ID: 16293785 | Fulltext

Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE.

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Takeuchi K, Renic M, Bohman QC, Harder DR, Miyata N, and Roman RJ

American journal of physiology. Heart and circulatory physiology 289(5):H2203-11, 2005 Nov - Who cited this? | PubMed ID: 15964920 | Fulltext

Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.

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Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani S, Sato M, Okuyama S, Cambj-Sapunar L, Harder DR, and Roman RJ

The Journal of pharmacology and experimental therapeutics 314(1):77-85, 2005 Jul - Who cited this? | PubMed ID: 15831442 | Fulltext

Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor.

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Drummond HA, Gebremedhin D, and Harder DR

Hypertension 44(5):643-8, 2004 Nov - Who cited this? | PubMed ID: 15381679 | Fulltext

Ca-induced Ca release: lessons regarding cell models.

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Harder DR

American journal of physiology. Cell physiology 287(5):C1165-6, 2004 Nov - Who cited this? | PubMed ID: 15475514 | Fulltext

Ca-induced Ca release: lessons regarding cell models.

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Harder DR

American journal of physiology. Heart and circulatory physiology 287(5):H1885-6, 2004 Nov - Who cited this? | PubMed ID: 15475522 | Fulltext

Mechanisms regulating cerebral blood flow as therapeutic targets.

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Pratt PF, Medhora M, and Harder DR

Current opinion in investigational drugs (London, England : 2000) 5(9):952-6, 2004 Sep - Who cited this? | PubMed ID: 15503650 | Fulltext

Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats.

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Peng X, Zhang C, Alkayed NJ, Harder DR, and Koehler RC

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 24(5):509-17, 2004 May - Who cited this? | PubMed ID: 15129182 | Fulltext

Effects of a 20-HETE antagonist and agonists on cerebral vascular tone.

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Yu M, Cambj-Sapunar L, Kehl F, Maier KG, Takeuchi K, Miyata N, Ishimoto T, Reddy LM, Falck JR, Gebremedhin D, Harder DR, and Roman RJ

European journal of pharmacology 486(3):297-306, 2004 Feb 23 - Who cited this? | PubMed ID: 14985052 | Fulltext

Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage.

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Cambj-Sapunar L, Yu M, Harder DR, and Roman RJ

Stroke; a journal of cerebral circulation 34(5):1269-75, 2003 May - Who cited this? | PubMed ID: 12677022 | Fulltext

Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6.

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Bylund J, Harder AG, Maier KG, Roman RJ, and Harder DR

Archives of biochemistry and biophysics 412(1):34-41, 2003 Apr 1 - Who cited this? | PubMed ID: 12646265 | Fulltext

Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes.

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Gebremedhin D, Yamaura K, Zhang C, Bylund J, Koehler RC, and Harder DR

The Journal of neuroscience : the official journal of the Society for Neuroscience 23(5):1678-87, 2003 Mar 1 - Who cited this? | PubMed ID: 12629172 | Fulltext

Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells.

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Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER, and Harder DR

American journal of physiology. Heart and circulatory physiology 284(1):H215-24, 2003 Jan - Who cited this? | PubMed ID: 12388259 | Fulltext

Interaction of myogenic mechanisms and hypoxic dilation in rat middle cerebral arteries.

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Liu Y, Harder DR, and Lombard JH

American journal of physiology. Heart and circulatory physiology 283(6):H2276-81, 2002 Dec - Who cited this? | PubMed ID: 12388266 | Fulltext

Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid.

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Zhang C and Harder DR

Stroke; a journal of cerebral circulation 33(12):2957-64, 2002 Dec - Who cited this? | PubMed ID: 12468797 | Fulltext

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors.

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Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, and Koehler RC

American journal of physiology. Heart and circulatory physiology 283(5):H2029-37, 2002 Nov - Who cited this? | PubMed ID: 12384482 | Fulltext

Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.

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Bylund J, Zhang C, and Harder DR

Biochemical and biophysical research communications 296(3):677-84, 2002 Aug 23 - Who cited this? | PubMed ID: 12176035 | Fulltext

Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack.

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Alkayed NJ, Goyagi T, Joh HD, Klaus J, Harder DR, Traystman RJ, and Hurn PD

Stroke; a journal of cerebral circulation 33(6):1677-84, 2002 Jun - Who cited this? | PubMed ID: 12053011 | Fulltext

Mechanism of cGMP contribution to the vasodilator response to NO in rat middle cerebral arteries.

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Yu M, Sun CW, Maier KG, Harder DR, and Roman RJ

American journal of physiology. Heart and circulatory physiology 282(5):H1724-31, 2002 May - Who cited this? | PubMed ID: 11959637 | Fulltext

20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat.

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Kehl F, Cambj-Sapunar L, Maier KG, Miyata N, Kametani S, Okamoto H, Hudetz AG, Schulte ML, Zagorac D, Harder DR, and Roman RJ

American journal of physiology. Heart and circulatory physiology 282(4):H1556-65, 2002 Apr - Who cited this? | PubMed ID: 11893593 | Fulltext

Astrocytes function in matching blood flow to metabolic activity.

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Harder DR, Zhang C, and Gebremedhin D

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 17:27-31, 2002 Feb - Who cited this? | PubMed ID: 11821533 | Fulltext

Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid.

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Nithipatikom K, Grall AJ, Holmes BB, Harder DR, Falck JR, and Campbell WB

Analytical biochemistry 298(2):327-36, 2001 Nov 15 - Who cited this? | PubMed ID: 11700990 | Fulltext

Prologue: EDHF--what is it?.

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Campbell WB and Harder DR

American journal of physiology. Heart and circulatory physiology 280(6):H2413-6, 2001 Jun - Who cited this? | PubMed ID: 11356592 | Fulltext

Renal and cardiovascular actions of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids.

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Roman RJ, Maier KG, Sun CW, Harder DR, and Alonso-Galicia M

Clinical and experimental pharmacology & physiology 27(11):855-65, 2000 Nov - Who cited this? | PubMed ID: 11071299 | Fulltext

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