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Papers authored by Hardeman EC

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Negative Autoregulation of GTF2IRD1 in Williams-Beuren Syndrome via a Novel DNA Binding Mechanism.

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Palmer SJ, Santucci N, Widagdo J, Bontempo SJ, Taylor KM, Tay ES, Hook J, Lemckert F, Gunning PW, and Hardeman EC

The Journal of biological chemistry 285(7):4715-24, 2010 Feb 12 - Who cited this? | PubMed ID: 20007321 | Fulltext

A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle.

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Kee AJ, Gunning PW, and Hardeman EC

Cell motility and the cytoskeleton 66(9):710-20, 2009 Sep - Who cited this? | PubMed ID: 19530183 | Fulltext

Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.

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Lee AS, Kahatapitiya P, Kramer B, Joya JE, Hook J, Liu R, Schevzov G, Alexander IE, McCowage G, Montarras D, Gunning PW, and Hardeman EC

Stem cells (Dayton, Ohio) 27(5):1098-108, 2009 May - Who cited this? | PubMed ID: 19415780 | Fulltext

Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle.

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Vlahovich N, Kee AJ, Van der Poel C, Kettle E, Hernandez-Deviez D, Lucas C, Lynch GS, Parton RG, Gunning PW, and Hardeman EC

Molecular biology of the cell 20(1):400-9, 2009 Jan - Who cited this? | PubMed ID: 19005216 | Fulltext

Diverse roles of the actin cytoskeleton in striated muscle.

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Kee AJ, Gunning PW, and Hardeman EC

Journal of muscle research and cell motility 30(5-6):187-97, 2009 - Who cited this? | PubMed ID: 19997772 | Fulltext

Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.

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Cowling BS, McGrath MJ, Nguyen MA, Cottle DL, Kee AJ, Brown S, Schessl J, Zou Y, Joya J, Bönnemann CG, Hardeman EC, and Mitchell CA

The Journal of cell biology 183(6):1033-48, 2008 Dec 15 - Who cited this? | PubMed ID: 19075112 | Fulltext

The murine stanniocalcin 2 gene is a negative regulator of postnatal growth.

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Chang AC, Hook J, Lemckert FA, McDonald MM, Nguyen MA, Hardeman EC, Little DG, Gunning PW, and Reddel RR

Endocrinology 149(5):2403-10, 2008 May - Who cited this? | PubMed ID: 18258678 | Fulltext

An Actn3 knockout mouse provides mechanistic insights into the association between {alpha}-actinin-3 deficiency and human athletic performance.

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Macarthur DG, Seto JT, Chan S, Quinlan KG, Raftery JM, Turner N, Nicholson MD, Kee AJ, Hardeman EC, Gunning PW, Cooney GJ, Head SI, Yang N, and North KN

Human molecular genetics 17(8):1076-86, 2008 Apr 15 - Who cited this? | PubMed ID: 18178581 | Fulltext

Divergent regulation of the sarcomere and the cytoskeleton.

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Schevzov G, Fath T, Vrhovski B, Vlahovich N, Rajan S, Hook J, Joya JE, Lemckert F, Puttur F, Lin JJ, Hardeman EC, Wieczorek DF, O'Neill GM, and Gunning PW

The Journal of biological chemistry 283(1):275-83, 2008 Jan 4 - Who cited this? | PubMed ID: 17951248 | Fulltext

Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle.

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Vlahovich N, Schevzov G, Nair-Shaliker V, Ilkovski B, Artap ST, Joya JE, Kee AJ, North KN, Gunning PW, and Hardeman EC

Cell motility and the cytoskeleton 65(1):73-85, 2008 Jan - Who cited this? | PubMed ID: 17968984 | Fulltext

Mouse models for thin filament disease.

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Nguyen MA and Hardeman EC

Advances in experimental medicine and biology 642:66-77, 2008 - Who cited this? | PubMed ID: 19181094 | Fulltext

Tropomyosins in skeletal muscle diseases.

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Kee AJ and Hardeman EC

Advances in experimental medicine and biology 644:143-57, 2008 - Who cited this? | PubMed ID: 19209820 | Fulltext

Mechanisms underlying intranuclear rod formation.

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Domazetovska A, Ilkovski B, Cooper ST, Ghoddusi M, Hardeman EC, Minamide LS, Gunning PW, Bamburg JR, and North KN

Brain : a journal of neurology 130(Pt 12):3275-84, 2007 Dec - Who cited this? | PubMed ID: 17928315 | Fulltext

Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans.

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MacArthur DG, Seto JT, Raftery JM, Quinlan KG, Huttley GA, Hook JW, Lemckert FA, Kee AJ, Edwards MR, Berman Y, Hardeman EC, Gunning PW, Easteal S, Yang N, and North KN

Nature genetics 39(10):1261-5, 2007 Oct - Who cited this? | PubMed ID: 17828264 | Fulltext

Ultrastructural changes and sarcoplasmic reticulum Ca2+ regulation in red vastus muscle following eccentric exercise in the rat.

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Chen W, Ruell PA, Ghoddusi M, Kee A, Hardeman EC, Hoffman KM, and Thompson MW

Experimental physiology 92(2):437-47, 2007 Mar - Who cited this? | PubMed ID: 17138618 | Fulltext

Expression of Gtf2ird1, the Williams syndrome-associated gene, during mouse development.

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Palmer SJ, Tay ES, Santucci N, Cuc Bach TT, Hook J, Lemckert FA, Jamieson RV, Gunnning PW, and Hardeman EC

Gene expression patterns : GEP 7(4):396-404, 2007 Feb - Who cited this? | PubMed ID: 17239664 | Fulltext

Skeletal muscle repair in a mouse model of nemaline myopathy.

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Sanoudou D, Corbett MA, Han M, Ghoddusi M, Nguyen MA, Vlahovich N, Hardeman EC, and Beggs AH

Human molecular genetics 15(17):2603, 2006 Sep 1 - Who cited this? | PubMed ID: 16877500 | Fulltext

Cardiac aquaporin expression in humans, rats, and mice.

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Butler TL, Au CG, Yang B, Egan JR, Tan YM, Hardeman EC, North KN, Verkman AS, and Winlaw DS

American journal of physiology. Heart and circulatory physiology 291(2):H705-13, 2006 Aug - Who cited this? | PubMed ID: 16582023 | Fulltext

MusTRD can regulate postnatal fiber-specific expression.

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Issa LL, Palmer SJ, Guven KL, Santucci N, Hodgson VR, Popovic K, Joya JE, and Hardeman EC

Developmental biology 293(1):104, 2006 May 1 - Who cited this? | PubMed ID: 16494860 | Fulltext

Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.

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McGrath MJ, Cottle DL, Nguyen MA, Dyson JM, Coghill ID, Robinson PA, Holdsworth M, Cowling BS, Hardeman EC, Mitchell CA, and Brown S

The Journal of biological chemistry 281(11):7666-83, 2006 Mar 17 - Who cited this? | PubMed ID: 16407297 | Fulltext

Tropomyosin isoforms: divining rods for actin cytoskeleton function.

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Gunning PW, Schevzov G, Kee AJ, and Hardeman EC

Trends in cell biology 15(6):333-41, 2005 Jun - Who cited this? | PubMed ID: 15953552 | Fulltext

An alphaTropomyosin mutation alters dimer preference in nemaline myopathy.

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Corbett MA, Akkari PA, Domazetovska A, Cooper ST, North KN, Laing NG, Gunning PW, and Hardeman EC

Annals of neurology 57(1):42-9, 2005 Jan - Who cited this? | PubMed ID: 15562513 | Fulltext

Muscle weakness in a mouse model of nemaline myopathy can be reversed with exercise and reveals a novel myofiber repair mechanism.

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Joya JE, Kee AJ, Nair-Shalliker V, Ghoddusi M, Nguyen MA, Luther P, and Hardeman EC

Human molecular genetics 13(21):2633-45, 2004 Nov 1 - Who cited this? | PubMed ID: 15367485 | Fulltext

Myofiber adaptational response to exercise in a mouse model of nemaline myopathy.

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Nair-Shalliker V, Kee AJ, Joya JE, Lucas CA, Hoh JF, and Hardeman EC

Muscle & nerve 30(4):470-80, 2004 Oct - Who cited this? | PubMed ID: 15372535 | Fulltext

Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.

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Kee AJ, Schevzov G, Nair-Shalliker V, Robinson CS, Vrhovski B, Ghoddusi M, Qiu MR, Lin JJ, Weinberger R, Gunning PW, and Hardeman EC

The Journal of cell biology 166(5):685-96, 2004 Aug 30 - Who cited this? | PubMed ID: 15337777 | Fulltext

C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression.

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Cooper ST, Maxwell AL, Kizana E, Ghoddusi M, Hardeman EC, Alexander IE, Allen DG, and North KN

Cell motility and the cytoskeleton 58(3):200-11, 2004 Jul - Who cited this? | PubMed ID: 15146538 | Fulltext

hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer.

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Polly P, Haddadi LM, Issa LL, Subramaniam N, Palmer SJ, Tay ES, and Hardeman EC

The Journal of biological chemistry 278(38):36603-10, 2003 Sep 19 - Who cited this? | PubMed ID: 12857748 | Fulltext

Regulation of alternative splicing of Gtf2ird1 and its impact on slow muscle promoter activity.

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Tay ES, Guven KL, Subramaniam N, Polly P, Issa LL, Gunning PW, and Hardeman EC

The Biochemical journal 374(Pt 2):359-67, 2003 Sep 1 - Who cited this? | PubMed ID: 12780350 | Fulltext

Specification of actin filament function and molecular composition by tropomyosin isoforms.

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Bryce NS, Schevzov G, Ferguson V, Percival JM, Lin JJ, Matsumura F, Bamburg JR, Jeffrey PL, Hardeman EC, Gunning P, and Weinberger RP

Molecular biology of the cell 14(3):1002-16, 2003 Mar - Who cited this? | PubMed ID: 12631719 | Fulltext

Skeletal muscle of mice with a mutation in slow alpha-tropomyosin is weaker at lower lengths.

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de Haan A, van der Vliet MR, Gommans IM, Hardeman EC, and van Engelen BG

Neuromuscular disorders : NMD 12(10):952-7, 2002 Dec - Who cited this? | PubMed ID: 12467751 | Fulltext

Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene.

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Ilkovski B, Cooper ST, Nowak K, Ryan MM, Yang N, Schnell C, Durling HJ, Roddick LG, Wilkinson I, Kornberg AJ, Collins KJ, Wallace G, Gunning P, Hardeman EC, Laing NG, and North KN

American journal of human genetics 68(6):1333-43, 2001 Jun - Who cited this? | PubMed ID: 11333380 | Fulltext

A mutation in alpha-tropomyosin(slow) affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy.

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Corbett MA, Robinson CS, Dunglison GF, Yang N, Joya JE, Stewart AW, Schnell C, Gunning PW, North KN, and Hardeman EC

Human molecular genetics 10(4):317-28, 2001 Feb 15 - Who cited this? | PubMed ID: 11157795 | Fulltext

Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.

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Gunning PW, Ferguson V, Brennan KJ, and Hardeman EC

Journal of cell science 114(Pt 3):513, 2001 Feb - Who cited this? | PubMed ID: 11171321 | Fulltext

Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53.

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Wadhwa R, Sugihara T, Yoshida A, Duncan EL, Hardeman EC, Nomura H, Reddel RR, and Kaul SC

The Journal of biological chemistry 274(21):14948-55, 1999 May 21 - Who cited this? | PubMed ID: 10329696 | Fulltext

Identification of a novel slow-muscle-fiber enhancer binding protein, MusTRD1.

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O'Mahoney JV, Guven KL, Lin J, Joya JE, Robinson CS, Wade RP, and Hardeman EC

Molecular and cellular biology 18(11):6641-52, 1998 Nov - Who cited this? | PubMed ID: 9774679 | Fulltext

Transcription occurs in pulses in muscle fibers.

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Newlands S, Levitt LK, Robinson CS, Karpf AB, Hodgson VR, Wade RP, and Hardeman EC

Genes & development 12(17):2748-58, 1998 Sep 1 - Who cited this? | PubMed ID: 9732272 | Fulltext

Nerve-responsive troponin I slow promoter does not respond to unloading.

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Criswell DS, Hodgson VR, Hardeman EC, and Booth FW

Journal of applied physiology (Bethesda, Md. : 1985) 84(3):1083-7, 1998 Mar - Who cited this? | PubMed ID: 9480972 | Fulltext

Reappearance of the minor alpha-sarcomeric actins in postnatal muscle.

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Collins T, Joya JE, Arkell RM, Ferguson V, and Hardeman EC

The American journal of physiology 273(6 Pt 1):C1801-10, 1997 Dec - Who cited this? | PubMed ID: 9435483 | Fulltext

The human troponin I slow promoter directs slow fiber-specific expression in transgenic mice.

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Levitt LK, O'Mahoney JV, Brennan KJ, Joya JE, Zhu L, Wade RP, and Hardeman EC

DNA and cell biology 14(7):599-607, 1995 Jul - Who cited this? | PubMed ID: 7626219 | Fulltext

Delineation of a slow-twitch-myofiber-specific transcriptional element by using in vivo somatic gene transfer.

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Corin SJ, Levitt LK, O'Mahoney JV, Joya JE, Hardeman EC, and Wade R

Proceedings of the National Academy of Sciences of the United States of America 92(13):6185-9, 1995 Jun 20 - Who cited this? | PubMed ID: 7597099 | Fulltext

Developmental regulation of troponin I isoform genes in striated muscles of transgenic mice.

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Zhu L, Lyons GE, Juhasz O, Joya JE, Hardeman EC, and Wade R

Developmental biology 169(2):487-503, 1995 Jun - Who cited this? | PubMed ID: 7781893 | Fulltext

Changes in contractile protein mRNA accumulation in response to spaceflight.

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Esser KA and Hardeman EC

The American journal of physiology 268(2 Pt 1):C466-71, 1995 Feb - Who cited this? | PubMed ID: 7864086 | Fulltext

Multiple regions of the human cardiac actin gene are necessary for maturation-based expression in striated muscle.

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Dunwoodie SL, Joya JE, Arkell RM, and Hardeman EC

The Journal of biological chemistry 269(16):12212-9, 1994 Apr 22 - Who cited this? | PubMed ID: 8163527 | Fulltext

Quantitative analysis of the human alpha-skeletal actin gene in transgenic mice.

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Brennan KJ and Hardeman EC

The Journal of biological chemistry 268(1):719-25, 1993 Jan 5 - Who cited this? | PubMed ID: 7678010 | Fulltext

Identification of a program of contractile protein gene expression initiated upon skeletal muscle differentiation.

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Sutherland CJ, Esser KA, Elsom VL, Gordon ML, and Hardeman EC

Developmental dynamics : an official publication of the American Association of Anatomists 196(1):25-36, 1993 Jan - Who cited this? | PubMed ID: 8334297 | Fulltext

Coordination of skeletal muscle gene expression occurs late in mammalian development.

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Sutherland CJ, Elsom VL, Gordon ML, Dunwoodie SL, and Hardeman EC

Developmental biology 146(1):167-78, 1991 Jul - Who cited this? | PubMed ID: 2060700 | Fulltext

In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function.

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Hardeman EC, Minty A, Benton-Vosman P, Kedes L, and Blau HM

The Journal of cell biology 106(4):1027-34, 1988 Apr - Who cited this? | PubMed ID: 3162914 | Fulltext

The pattern of actin expression in human fibroblast x mouse muscle heterokaryons suggests that human muscle regulatory factors are produced.

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Hardeman EC, Chiu CP, Minty A, and Blau HM

Cell 47(1):123-30, 1986 Oct 10 - Who cited this? | PubMed ID: 3757033 | Fulltext

Plasticity of the differentiated state.

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Blau HM, Pavlath GK, Hardeman EC, Chiu CP, Silberstein L, Webster SG, Miller SC, and Webster C

Science (New York, N.Y.) 230(4727):758-66, 1985 Nov 15 - Who cited this? | PubMed ID: 2414846 | Fulltext

Mechanisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase overaccumulation in three compactin-resistant cell lines.

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Skalnik DG, Brown DA, Brown PC, Friedman RL, Hardeman EC, Schimke RT, and Simoni RD

The Journal of biological chemistry 260(4):1991-4, 1985 Feb 25 - Who cited this? | PubMed ID: 3838302 | Fulltext

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