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Papers authored by Hancock RE

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Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-{gamma} on APCs.

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Nijnik A, Pistolic J, Wyatt A, Tam S, and Hancock RE

Journal of immunology (Baltimore, Md. : 1950) 183(9):5788-98, 2009 Nov 1 - Who cited this? | PubMed ID: 19812202 | Fulltext

Potential of immunomodulatory host defense peptides as novel anti-infectives.

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Easton DM, Nijnik A, Mayer ML, and Hancock RE

Trends in biotechnology 27(10):582-90, 2009 Oct - Who cited this? | PubMed ID: 19683819 | Fulltext

Involvement of pmrAB and phoPQ in Polymyxin B Adaptation and Inducible Resistance in Non-Cystic Fibrosis Clinical Isolates of Pseudomonas aeruginosa.

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Schurek KN, Sampaio JL, Kiffer CR, Sinto S, Mendes CM, and Hancock RE

Antimicrobial agents and chemotherapy 53(10):4345-51, 2009 Oct - Who cited this? | PubMed ID: 19635950 | Fulltext

Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR.

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Yeung AT, Torfs EC, Jamshidi F, Bains M, Wiegand I, Hancock RE, and Overhage J

Journal of bacteriology 191(18):5592-602, 2009 Sep - Who cited this? | PubMed ID: 19592586 | Fulltext

Intracellular receptor for human host defense peptide LL-37 in monocytes.

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Mookherjee N, Lippert DN, Hamill P, Falsafi R, Nijnik A, Kindrachuk J, Pistolic J, Gardy J, Miri P, Naseer M, Foster LJ, and Hancock RE

Journal of immunology (Baltimore, Md. : 1950) 183(4):2688-96, 2009 Aug 15 - Who cited this? | PubMed ID: 19605696 | Fulltext

Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to proinflammatory stimuli.

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Filewod NC, Pistolic J, and Hancock RE

FEMS immunology and medical microbiology 56(3):233-40, 2009 Aug - Who cited this? | PubMed ID: 19527294 | Fulltext

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity.

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Kindrachuk J, Jenssen H, Elliott M, Townsend R, Nijnik A, Lee SF, Gerdts V, Babiuk LA, Halperin SA, and Hancock RE

Vaccine 27(34):4662-71, 2009 Jul 23 - Who cited this? | PubMed ID: 19539585 | Fulltext

An iron-regulated LysR-type element mediates antimicrobial peptide resistance and virulence in Yersinia pseudotuberculosis.

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Arafah S, Rosso ML, Rehaume L, Hancock RE, Simonet M, and Marceau M

Microbiology (Reading, England) 155(Pt 7):2168-81, 2009 Jul - Who cited this? | PubMed ID: 19389764 | Fulltext

Enabling a systems biology approach to immunology: focus on innate immunity.

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Gardy JL, Lynn DJ, Brinkman FS, and Hancock RE

Trends in immunology 30(6):249-62, 2009 Jun - Who cited this? | PubMed ID: 19428301 | Fulltext

The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically regulated, cation-selective channel.

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McPhee JB, Tamber S, Bains M, Maier E, Gellatly S, Lo A, Benz R, and Hancock RE

FEMS microbiology letters 296(2):241-7, 2009 Jun - Who cited this? | PubMed ID: 19486157 | Fulltext

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.

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Mookherjee N, Hamill P, Gardy J, Blimkie D, Falsafi R, Chikatamarla A, Arenillas DJ, Doria S, Kollmann TR, and Hancock RE

Molecular bioSystems 5(5):483-96, 2009 May - Who cited this? | PubMed ID: 19381363 | Fulltext

The Human Host Defense Peptide LL-37 Induces Apoptosis in a Calpain- and Apoptosis-Inducing Factor-Dependent Manner Involving Bax Activity.

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Mader JS, Mookherjee N, Hancock RE, and Bleackley RC

Molecular cancer research : MCR 7(5):689-702, 2009 May - Who cited this? | PubMed ID: 19435812 | Fulltext

Identification of novel antibacterial peptides by chemoinformatics and machine learning.

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Fjell CD, Jenssen H, Hilpert K, Cheung WA, Panté N, Hancock RE, and Cherkasov A

Journal of medicinal chemistry 52(7):2006-15, 2009 Apr 9 - Who cited this? | PubMed ID: 19296598 | Fulltext

The novel adjuvant combination of CpG ODN, indolicidin and polyphosphazene induces potent antibody- and cell-mediated immune responses in mice.

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Kovacs-Nolan J, Latimer L, Landi A, Jenssen H, Hancock RE, Babiuk LA, and van Drunen Littel-van den Hurk S

Vaccine 27(14):2055-64, 2009 Mar 23 - Who cited this? | PubMed ID: 19428830 | Fulltext

Strategies to link innate and adaptive immunity when designing vaccine adjuvants.

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Garlapati S, Facci M, Polewicz M, Strom S, Babiuk LA, Mutwiri G, Hancock RE, Elliott MR, and Gerdts V

Veterinary immunology and immunopathology 128(1-3):184-91, 2009 Mar 15 - Who cited this? | PubMed ID: 19042032 | Fulltext

Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa.

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Gooderham WJ and Hancock RE

FEMS microbiology reviews 33(2):279-94, 2009 Mar - Who cited this? | PubMed ID: 19243444 | Fulltext

The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.

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Gooderham WJ, Gellatly SL, Sanschagrin F, McPhee JB, Bains M, Cosseau C, Levesque RC, and Hancock RE

Microbiology (Reading, England) 155(Pt 3):699-711, 2009 Mar - Who cited this? | PubMed ID: 19246741 | Fulltext

Screening and characterization of surface-tethered cationic peptides for antimicrobial activity.

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Hilpert K, Elliott M, Jenssen H, Kindrachuk J, Fjell CD, Körner J, Winkler DF, Weaver LL, Henklein P, Ulrich AS, Chiang SH, Farmer SW, Pante N, Volkmer R, and Hancock RE

Chemistry & biology 16(1):58-69, 2009 Jan 30 - Who cited this? | PubMed ID: 19171306 | Fulltext

Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs.

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Cherkasov A, Hilpert K, Jenssen H, Fjell CD, Waldbrook M, Mullaly SC, Volkmer R, and Hancock RE

ACS chemical biology 4(1):65-74, 2009 Jan 16 - Who cited this? | PubMed ID: 19055425 | Fulltext

The roles of cathelicidin LL-37 in immune defences and novel clinical applications.

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Nijnik A and Hancock RE

Current opinion in hematology 16(1):41-7, 2009 Jan - Who cited this? | PubMed ID: 19068548 | Fulltext

Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes.

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Winsor GL, Van Rossum T, Lo R, Khaira B, Whiteside MD, Hancock RE, and Brinkman FS

Nucleic acids research 37(Database issue):D483-8, 2009 Jan - Who cited this? | PubMed ID: 18978025 | Fulltext

Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa.

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Winstanley C, Langille MG, Fothergill JL, Kukavica-Ibrulj I, Paradis-Bleau C, Sanschagrin F, Thomson NR, Winsor GL, Quail MA, Lennard N, Bignell A, Clarke L, Seeger K, Saunders D, Harris D, Parkhill J,

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Genome research 19(1):12-23, 2009 Jan - Who cited this? | PubMed ID: 19047519 | Fulltext

Bovine lactoferrin and lactoferricin interfere with intracellular trafficking of Herpes simplex virus-1.

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Marr AK, Jenssen H, Moniri MR, Hancock RE, and Panté N

Biochimie 91(1):160-4, 2009 Jan - Who cited this? | PubMed ID: 18573311 | Fulltext

Antimicrobial properties of lactoferrin.

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Jenssen H and Hancock RE

Biochimie 91(1):19-29, 2009 Jan - Who cited this? | PubMed ID: 18573312 | Fulltext

Effect of membrane composition on antimicrobial peptides aurein 2.2 and 2.3 from Australian southern bell frogs.

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Cheng JT, Hale JD, Elliot M, Hancock RE, and Straus SK

Biophysical journal 96(2):552-65, 2009 Jan - Who cited this? | PubMed ID: 19167304 | Fulltext

Killing of Trypanosomatid Parasites by a Modified Bovine Host Defense Peptide, BMAP-18.

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Haines LR, Thomas JM, Jackson AM, Eyford BA, Razavi M, Watson CN, Gowen B, Hancock RE, and Pearson TW

PLoS neglected tropical diseases 3(2):e373, 2009 - Who cited this? | PubMed ID: 19190729 | Fulltext

Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.

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Jiang Z, Vasil AI, Hale J, Hancock RE, Vasil ML, and Hodges RS

Advances in experimental medicine and biology 611:561-2, 2009 - Who cited this? | PubMed ID: 19400313 | Fulltext

Synthesis of Peptide Arrays Using SPOT-Technology and the CelluSpots-Method.

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Winkler DF, Hilpert K, Brandt O, and Hancock RE

Methods in molecular biology (Clifton, N.J.) 570:157-74, 2009 - Who cited this? | PubMed ID: 19649591 | Fulltext

Novel Genetic Determinants of Low-Level Aminoglycoside Resistance in Pseudomonas aeruginosa.

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Schurek KN, Marr AK, Taylor PK, Wiegand I, Semenec L, Khaira BK, and Hancock RE

Antimicrobial agents and chemotherapy 52(12):4213-9, 2008 Dec - Who cited this? | PubMed ID: 18824604 | Fulltext

Complex Ciprofloxacin Resistome Revealed by Screening a Pseudomonas aeruginosa Mutant Library for Altered Susceptibility.

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Breidenstein EB, Khaira BK, Wiegand I, Overhage J, and Hancock RE

Antimicrobial agents and chemotherapy 52(12):4486-91, 2008 Dec - Who cited this? | PubMed ID: 18824609 | Fulltext

Novel anti-infectives: is host defence the answer?.

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Hamill P, Brown K, Jenssen H, and Hancock RE

Current opinion in biotechnology 19(6):628-36, 2008 Dec - Who cited this? | PubMed ID: 19000763 | Fulltext

Effects of Hydrophobicity on the Antifungal Activity of alpha-Helical Antimicrobial Peptides.

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Jiang Z, Kullberg BJ, van der Lee H, Vasil AI, Hale JD, Mant CT, Hancock RE, Vasil ML, Netea MG, and Hodges RS

Chemical biology & drug design 72(6):483-95, 2008 Dec - Who cited this? | PubMed ID: 19090916 | Fulltext

Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome.

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Fjell CD, Jenssen H, Fries P, Aich P, Griebel P, Hilpert K, Hancock RE, and Cherkasov A

Proteins 73(2):420-30, 2008 Nov 1 - Who cited this? | PubMed ID: 18442133 | Fulltext

Neutrophil elastase mediates innate host protection against Pseudomonas aeruginosa.

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Hirche TO, Benabid R, Deslee G, Gangloff S, Achilefu S, Guenounou M, Lebargy F, Hancock RE, and Belaaouaj A

Journal of immunology (Baltimore, Md. : 1950) 181(7):4945-54, 2008 Oct 1 - Who cited this? | PubMed ID: 18802098 | Fulltext

ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease.

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Brown KL, Bylund J, MacDonald KL, Song-Zhao GX, Elliott MR, Falsafi R, Hancock RE, and Speert DP

Clinical immunology (Orlando, Fla.) 129(1):90-102, 2008 Oct - Who cited this? | PubMed ID: 18676204 | Fulltext

Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa.

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Wiegand I, Marr AK, Breidenstein EB, Schurek KN, Taylor P, and Hancock RE

Antimicrobial agents and chemotherapy 52(10):3810-3, 2008 Oct - Who cited this? | PubMed ID: 18663021 | Fulltext

Human host defense peptide LL-37 prevents bacterial biofilm formation.

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Overhage J, Campisano A, Bains M, Torfs EC, Rehm BH, and Hancock RE

Infection and immunity 76(9):4176, 2008 Sep - Who cited this? | PubMed ID: 18591225 | Fulltext

Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin.

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Jenssen H, Sandvik K, Andersen JH, Hancock RE, and Gutteberg TJ

Antiviral research 79(3):192-8, 2008 Sep - Who cited this? | PubMed ID: 18456345 | Fulltext

The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world.

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Wasan KM, Thornton SJ, Bell I, Goulding RE, Gretes M, Gray AP, Hancock RE, and Campbell B

Journal of pharmaceutical sciences, 2008 Aug 7 - Who cited this? | PubMed ID: 18688820 | Fulltext

The commensal Streptococcus salivarius K12 down-regulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis.

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Cosseau C, Devine DA, Dullaghan E, Gardy JL, Chikatamarla A, Gellatly S, Yu LL, Pistolic J, Falsafi R, Tagg J, and Hancock RE

Infection and immunity, 2008 Jul 14 - Who cited this? | PubMed ID: 18625732 | Fulltext

Induction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation and swarming motility of psrA in Pseudomonas aeruginosa.

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Gooderham WJ, Bains M, McPhee JB, Wiegand I, and Hancock RE

Journal of bacteriology, 2008 Jun 13 - Who cited this? | PubMed ID: 18556795 | Fulltext

Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease.

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Blohmke CJ, Victor RE, Hirschfeld AF, Elias IM, Hancock DG, Lane CR, Davidson AG, Wilcox PG, Smith KD, Overhage J, Hancock RE, and Turvey SE

Journal of immunology (Baltimore, Md. : 1950) 180(11):7764-73, 2008 Jun 1 - Who cited this? | PubMed ID: 18490781 | Fulltext

Lipid-specific binding of the calcium-dependent antibiotic daptomycin leads to changes in lipid polymorphism of model membranes.

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Jung D, Powers JP, Straus SK, and Hancock RE

Chemistry and physics of lipids, 2008 May 1 - Who cited this? | PubMed ID: 18489906 | Fulltext

Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance.

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Overhage J, Bains M, Brazas MD, and Hancock RE

Journal of bacteriology 190(8):2671, 2008 Apr - Who cited this? | PubMed ID: 18245294 | Fulltext

Pseudomonas 2007.

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Goldberg JB, Hancock RE, Parales RE, Loper J, and Cornelis P

Journal of bacteriology 190(8):2649, 2008 Apr - Who cited this? | PubMed ID: 18165299 | Fulltext

Effect of divalent cations on the structure of the antibiotic daptomycin.

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Ho SW, Jung D, Calhoun JR, Lear JD, Okon M, Scott WR, Hancock RE, and Straus SK

European biophysics journal : EBJ 37(4):421-33, 2008 Apr - Who cited this? | PubMed ID: 17968536 | Fulltext

Metabolic Changes Associated With Adaptive Diversification in Escherichia coli.

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Le Gac M, Brazas MD, Bertrand M, Tyerman JG, Spencer CC, Hancock RE, and Doebeli M

Genetics 178(2):1049-60, 2008 Feb - Who cited this? | PubMed ID: 18245349 | Fulltext

InnateDB: facilitating systems-level analyses of the mammalian innate immune response.

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Lynn DJ, Winsor GL, Chan C, Richard N, Laird MR, Barsky A, Gardy JL, Roche FM, Chan TH, Shah N, Lo R, Naseer M, Que J, Yau M, Acab M, Tulpan D,

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Molecular systems biology 4:218, 2008 - Who cited this? | PubMed ID: 18766178 | Fulltext

QSAR modeling and computer-aided design of antimicrobial peptides.

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Jenssen H, Fjell CD, Cherkasov A, and Hancock RE

Journal of peptide science : an official publication of the European Peptide Society 14(1):110-4, 2008 Jan - Who cited this? | PubMed ID: 17847019 | Fulltext

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances.

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Wiegand I, Hilpert K, and Hancock RE

Nature protocols 3(2):163-75, 2008 - Who cited this? | PubMed ID: 18274517 | Fulltext

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